Simultaneous Activation of Bicyclobutanes and Indolyl Alcohols with HFIP: Access to Indole-Fused Bicyclo[3.1.1]heptanes.

The concept of strain release to unleash unique reactivity that drives a wide range of synthetically valuable transformations has long intrigued chemists. Among the various strained systems, highly reactive bicyclo[1.1.

Pair cross-correlation analysis for assessing protein co-localization.

Measuring co-localization of different types of molecules is essential to understand molecular organization in biological systems. The pair cross-correlation (PCC) function computed from two-color microscopy images provides a measure of co-localization between differently labeled molecules. Here, we compute a theoretical expression for the PCC function between two molecules using two-dimensional Gaussian distributions as the effective point spread functions for single molecules.

Illustrator-anatomist-clinician triad based pedagogical model in anatomy education: An auxiliary resource amidst lack of hands-on human dissection.

Adherence to the highest ethical standards is mandatory while handling precious human tissues received through the altruistic act of body donation. In 2019, misconduct at the Body Donation Center in Paris led to its closure. This adversely affected the hands-on human dissection sessions within the anatomy education program at Université Paris-Saclay.

Usefulness of delayed primary closure in unplanned caesarean section to reduce surgical site infection in a resource-poor high population country: a randomised controlled trial.

Objective: Surgical site infection (SSI) is a common complication, especially following emergency caesarean section (CS) leading to maternal morbidity and prolonged hospital stay. Results are conflicting regarding the ideal method of skin closure after abdominal surgery in clean contaminated and contaminated wound. To compare the outcome of wound health between primary and delayed primary closure (DPC) of skin incision in emergency CS.

A Comparative Analysis of Revision Rates in Surgical Treatments for Lumbar Isthmic Spondylolisthesis.

Study DesignRetrospective Cohort Study.ObjectiveIsthmic spondylolisthesis is frequently encountered in spine surgical practice, though there is a significant variation in surgical management strategies. We sought to evaluate revision rates between patients who underwent anterior-approach lumbar interbody fusion (ALIF) alone, posterolateral fusion (PLF) alone, PLIF/TLIF, and ALIF+PSF.

Genetic Insights Into Recurrent Granular Cell Tumours in an Adolescent: The Role of Cytology and Next-Generation Sequencing in the Diagnosis of RASopathies.

Rasopathies are a group of genetic disorders that involve abnormal Ras/mitogen-activated protein kinase (RAS/MAPK) pathway signalling, which has a mechanistic approach to defining genetic syndromes and makes them unique. Noonan syndrome, a form of RASopathy, occurs with advanced paternal age and has an autosomal dominant inheritance. It has been suggested that aberrant RAS/MAPK pathway cell signalling may cause multiple benign granular cell tumours.

A new sesquiterpene lactone isolated from and cytotoxic activity against the A549 cancer cell line.

A new sesquiterpene lactone ainslialide and eighteen known compounds were isolated from aq. methanolic extract of Mattf (Compositae). All the isolates were structurally elucidated by the analysis of spectroscopic data 1D, 2D-NMR, HR-ESI-MS and previously reported literature for the known compounds.

Bacteriocins from Lactic Acid Bacteria Could Modulate the Wnt Pathway: A Possible Therapeutic Candidate for the Management of Colorectal Cancer- An In silico Study.

Introduction: Colorectal cancer (CRC) is a type of cancer that develops due to abnormal cell growth in the colon and rectum. Existing conventional CRC treatment strategies have side effects. Hence, exploring new and advanced techniques for bacterial CRC therapy is crucial.

Surgical Management of Postcholecystectomy Strasberg Type E4 Bile Duct Injuries.

Introduction: High-biliary injuries are associated with worse outcomes. Most series do not mention failure rates specific to the injury grade. In our experience, Strasberg E4 injuries are associated with a higher failure rate.

Nutritional Status of Children Under Five Years in the Slums of West Bengal, India: A Cross-Sectional Study on Prevalence, Characteristics, and Determinants.

With rapid urbanization in countries like India, understanding the nutritional status and needs of urban populations, particularly among underprivileged groups such as people living in slums, is crucial. This study investigates the prevalence, characteristics, and determinants of child malnutrition in the urban slums of the Kolkata Municipal Corporation (KMC) and Siliguri Municipal Corporation (SMC) in West Bengal, India. A cross-sectional study was conducted among 736 children aged 6-59 months.

A Comprehensive, Analytical Narrative Review of Polysaccharides from the Red Seaweed : Pharmaceutical Applications and Mechanistic Insights for Human Health.

species, a widely distributed genus of red macroalgae, have gathered significant attention for their diverse medical applications attributable to their bioactive sulphated polysaccharides (SPs). This review examines the global narrative of various SP applications in terms of their therapeutic potential and mechanistic insights into the use of these SPs against a range of medical conditions, including cancer, inflammation, neurodegenerative disorders, diabetes, and immune dysfunctions. SPs extracted from and have demonstrated potent anti-tumour activities by inducing apoptosis through various mechanisms, including the upregulation of CD8 T cells and IL-2, inhibition of EGFR/MAPK/ERK signalling pathways, and activation of the Fas/FasL pathway.

Mushrooms as Nutritional Powerhouses: A Review of Their Bioactive Compounds, Health Benefits, and Value-Added Products.

Mushrooms are known to be a nutritional powerhouse, offering diverse bioactive compounds that promote and enhance health. Mushrooms provide a distinguishable taste and aroma and are an essential source of vitamin D, vitamin B complex, hydroxybenzoic acids (HBAs) and hydroxycinnamic acids (HCAs), terpenes, sterols, and β-glucans. Edible mushroom varieties such as , sp.

Analysis of Volatile and Non-Volatile Components of Dried Chili Pepper ( L.).

As an important crop in the world, dried pepper is widely used in various foods. However, the sensory quality, fruit shape index, edible index, nutrition index, and volatile components of dried pepper have not been comprehensively analyzed. This study elucidated the differences between different varieties of dried pepper and provided the basis for the selection of raw materials for different varieties of dried pepper products.

Fabrication of Cu/SiC Surface Composite via Thermo-Mechanical Process (Friction Stir Processing) for Heat Sink Application.

For the busting of heat, generated in electronic packages, relevant materials need to be developed. Metal matrix composites may be considered as an option to tailor the properties of a material (Cu) by incorporating an additional phase (SiC) for fulfilling the requirements of thermal management systems. The composite (Cu/SiC) was manufactured by friction stir processing.

Interplay Between Composition and Cycling Performance of Pre-Lithiated SiO-Si-C Composite Anodes for Lithium-Sulfur Full Cells.

Although silicon-based anodes have been identified as a potential alternative to conventional graphite anodes, the huge volume change (approximately 300%) that occurs in silicon while cycling still impedes this system from practical applications. In the case of silicon-suboxide (SiO)-based anode materials, both LiO and LiSiO are formed during the initial lithiation processes and act as a natural volume buffer matrix to accommodate volume changes and the formation of a stable SEI layer, which improves the cyclability and capacity retention. In this study, a series of SiO/Si/C-based electrodes composed of different amorphous SiO, Si, and graphitic carbon contents were prepared.

Metallurgical and Mechanical Properties of Stellite 6 Deposition Developed Through Friction Surfacing Technique.

Friction surfacing (FS) is a solid-state process for depositing metallurgically bonded coatings for corrosion and wear protection. It is particularly attractive for depositing coatings in materials that are difficult to fusion deposit. Stellite 6 is one such material, which is widely used as a protective coating on steel structures to combat wear and corrosion.

Investigating the Sources of Silver in 17th- and 18th-Century Silver Coins from the Shipwreck by Compositional Studies.

The colonisation of the Americas and the discovery of its rich ores had a great impact on the world economies, making them quickly become the main suppliers of precious metals in Europe. The compositional studies of several coins (ducatons, eight reales cob8, four reales cob4, eight reales pillar dollar, four reales half pillar dollars, rijderschellings and silver rijders) recovered from the 18th-century Dutch East India Company wreck by micro X-ray fluorescence (µXRF) spectroscopy revealed further knowledge about the silver trade and the silver sources used to produce coins in mints in the Low Countries over a wide timeframe (1618-1739). The results provided trace elemental 'fingerprints' of coins minted with silver from known mines, and matching against them revealed the silver sources used in coins, whose mint location could not be identified due to their poor state of preservation.

The Effect of Leisure-Time Exercise on Mental Health Among Adults: A Bibliometric Analysis of Randomized Controlled Trials.

Adequate levels of leisure-time exercise (LTE) are associated with mental health benefits. Despite increased research in recent years through randomized controlled trials (RCTs), a systematic literature review summarizing these findings is lacking. Here, we examined publication trends, impact, and research gaps regarding LTE's effects on mental health in the form of a bibliometric analysis.

Arthroscopy for Femoroacetabular Impingement in Athletes Versus Non-Athletes: Systematic Review and Meta-Analysis.

Background: Femoroacetabular impingement (FAI) is a frequently observed hip condition among young, active individuals-especially athletes-that can result in pain, restricted mobility, and a heightened risk of osteoarthritis. Hip arthroscopy has increasingly become the preferred surgical approach for managing FAI due to its ability to alleviate symptoms and improve function. However, potential differences in outcomes between athletes and non-athletes have not been thoroughly investigated.

Oral Health and Hygiene Practices from Baramulla District, Jammu and Kashmir, India: A Questionnaire-Based Cross-Sectional Observational Survey.

: Oral hygiene practices are important for good oral health and overall well-being. In this study, we surveyed people across age groups and genders to understand the oral hygiene practices of Baramulla district of the Union Territory of Jammu and Kashmir. 488 participants-229 males and 259 females-were randomly interviewed through a structured 20-item questionnaire.

Polyethylene Glycolylation of the Purified Basic Protein (Protamine) of Squid (): Structural Changes and Evaluation of Proliferative Effects on Fibroblast.

In recent years, arginine-rich basic proteins have garnered significant attention due to their essential roles in various biological processes. However, the potential of marine-derived proteins in this domain remains largely unexplored. This study presents, for the first time, the isolation and purification of a 14.

Omics Approaches in Understanding Insecticide Resistance in Mosquito Vectors.

In recent years, the emergence of insecticide resistance has been a major challenge to global public health. Understanding the molecular mechanisms of this phenomenon in mosquito vectors is paramount for the formulation of effective vector control strategies. This review explores the current knowledge of insecticide resistance mechanisms through omics approaches.