Multimodal Metaverse Healthcare: A Collaborative Representation and Adaptive Fusion Approach for Generative Artificial-Intelligence-Driven Diagnosis.

The metaverse enables immersive virtual healthcare environments, presenting opportunities for enhanced care delivery. A key challenge lies in effectively combining multimodal healthcare data and generative artificial intelligence abilities within metaverse-based healthcare applications, which is a problem that needs to be addressed. This paper proposes a novel multimodal learning framework for metaverse healthcare, MMLMH, based on collaborative intra- and intersample representation and adaptive fusion.

Increasing jute ( L.) fiber yield through hybridization and combining ability studies to break the yield plateau.

The growing global demand and shift from synthetic to natural fibers highlight the need to overcome the yield plateau in jute production. Despite being a sustainable alternative to plastic, jute faces declining cultivation, making yield improvement crucial to meet increasing demand. In this direction, the study was designed to explore hybridization and combining ability to improve the genetic yield potential of jute.

Diastolic Dysfunction Unveiling Cardiac Light-Chain Amyloidosis: A Case Report.

Background: Cardiac light-chain amyloidosis represents a critical component of this multi-systemic disease, significantly impacting prognosis. The extent of cardiac free light-chain deposition is the primary determinant of survival.

Case Presentation: We report the case of a 67-year-old male with a 10-year history of diabetes mellitus and arterial hypertension who presented with a two-day history of chest discomfort and difficulty lying down or sleeping, along with a two-month history of progressively worsening exertional dyspnea.

Biomimetic syntheses of kadcoccitane H and kadcotrione C methyl ester.

Kadcotriones and kadcoccitanes, renowned for their intricate 6/6/5-tricyclic and 6/6/5/6-tetracyclic ring systems, respectively, exhibit promising biological activities. This work proposes a biosynthetic pathway that elucidates how nature synthesizes these triterpenoids from lanosterol. Inspired by this pathway, we present the first biomimetic syntheses of kadcoccitane H and kadcotrione C methyl ester.

Influence of arbuscular mycorrhizal fungi on morpho-biochemical characteristics, nutrient uptake, and transcriptomic profile of L. plant.

Unlabelled: The present study was carried out to observe the interaction between L. with AMF treatments at morphological, biochemical, and molecular levels. The plant was inoculated with , , , and , and also two consortia of  +  and  +  Morphological and biochemical parameters such as shoot height, root length, shoot fresh weight, shoot dry weight, fruit fresh weight, fruit dry weight, root fresh weigh, root dry weight, chlorophyll a and b, total soluble sugars, total soluble proteins were examined in this study.

Maternal and fetal outcomes in gestational diabetes mellitus: a narrative review of dietary interventions.

Introduction: Gestational diabetes mellitus (GDM) is associated with a myriad of maternal and fetal complications that severely compromise the mother and child's future health. Dietary interventions are effective in reducing the risk of GDM. However, when diagnosed with GDM in 2nd and 3rd the effectiveness of these interventions on maternal and fetal health remains unexplored.

A 5G network based conceptual framework for real-time malaria parasite detection from thick and thin blood smear slides using modified YOLOv5 model.

Objective: This paper aims to address the need for real-time malaria disease detection that integrates a faster prediction model with a robust underlying network. The study first proposes a 5G network-based healthcare system and then develops an automated malaria detection model capable of providing an accurate diagnosis, particularly in areas with limited diagnostic resources.

Methods: The proposed system leverages a deep learning-based YOLOv5x algorithm to detect malaria parasites in thick and thin blood smear samples.

Cranberry-derived bioactives for the prevention and treatment of urinary tract infections: antimicrobial mechanisms and global research trends in nutraceutical applications.

Introduction: Urinary tract infections (UTIs) are a global health concern, increasingly complicated by antibiotic resistance. Cranberry-derived bioactive compounds, particularly proanthocyanidins (PACs), have emerged as a promising non-antibiotic strategy for UTI prevention. This review examines their efficacy, mechanisms of action, and the evolving research landscape through bibliometric analysis.

Affordable and Sustainable Biosensing Technology.

A growing need for rapid disease detection worldwide highlights the importance of innovative approaches to ensure prompt diagnosis and more effective patient care. As of now, various nanobioengineered systems have been developed and applied for disease diagnosis at an early stage, and a few are in clinical trials currently. However, the affordability and sustainability of diagnostic systems "Biosensors" are still being questioned in the translational research.

Structural Dynamics of OATP1A2 in Mediating Paclitaxel Transport Mechanism in Breast Cancer.

Breast cancer remains a significant global health challenge, with drug resistance and poor bioavailability of chemotherapeutic agents like paclitaxel (PTX) presenting obstacles to effective treatment. This study investigates the potential role of the Solute Carrier Organic Anion Transporter Polypeptide 1A2 (OATP1A2) in PTX transport using computational approaches. We employed computational modeling, molecular docking, and molecular dynamics (MD) simulations to elucidate the structural dynamics of OATP1A2 and its interaction with PTX.

An Overview of the Genetic Mechanisms of Colistin-Resistance in Bacterial Pathogens: An Indian Perspective.

Colistin resistance in bacteria is a growing global issue, given its role as a critical last-resort antibiotic, particularly for treating Gram-negative bacterial infections. Pathogens adopt multiple resistance mechanisms, mediated either by plasmids or chromosomal changes. Some of the most frequently observed strategies include the occurrence of plasmid-borne mobile colistin resistance (mcr) genes, enhanced efflux pump activity, mutations in the regulatory systems, and alterations in the lipid A structure.

Exploring Cardiovascular Health: The Role of Dyslipidemia and Inflammation.

Background: Cardiovascular diseases (CVDs) are a major global health concern, with their prevalence rising significantly in developing regions like South India. This increase is driven by unique dietary patterns, lifestyle habits, and genetic predispositions contributing to the region's distinct cardiovascular risk profile. However, gaps remain in understanding the biochemical risk factors specific to this population.

Predictive Modeling Using Six-Month Performance Assessments to Forecast Long-Term Cognitive and Verbal Development in Pre-lingual Deaf Children With Cochlear Implants.

Objective This study aims to develop predictive models for speech outcomes at 6, 12, and 24 months post-cochlear implantation in pre-lingual deaf children. Using longitudinal Category of Auditory Performance (CAP), Speech Intelligibility Rating (SIR), and Parents' Evaluation of Aural/Oral Performance of Children (PEACH) scores, it seeks to forecast cognitive and verbal development. The study addresses the gap in correlating auditory performance with cognitive milestones by integrating longitudinal auditory data with cognitive and verbal benchmarks to identify predictive relationships.

Unique Variation of Superficial and Deep Palmar Arches: A Case Report With Literature Review.

The design and structure of the palmar vascular arches and their variations constitute some of the most intriguing and difficult areas of anatomy. Additionally, cardiac revascularisation is now being accomplished using radial artery harvesting, which necessitates collateral circulation in the hand through the palmar arches. In this case report, we outline a unique pattern of the superficial palmar arch (SPA) and deep palmar arch (DPA) in terms of their formation and branching pattern.

Triple-Negative, HER2/Neu, and Ki67 Markers in Breast Cancer Patients Undergoing Standard of Care Treatment in India: Real-World Evidence on Tumor Aggressiveness and Survival Outcomes.

Introduction: Breast cancer is among the most prevalent cancers in women globally, with patients' survival adversely impacted by Ki67 expression and triple-negative phenotypes. In this study, we examined the relationship between HER2/neu, triple-negative, and Ki67 phenotypes and tumor aggressiveness along with the survival of breast cancer patients from India.

Materials And Methods: A retrospective cohort study was performed using hospital-based data from a tertiary care center spanning January 2013 to August 2023.

Enhancing Cancer Screening and Early Diagnosis in India: Overcoming Challenges and Leveraging Emerging Technologies.

This review addresses the significant challenges and technological developments in cancer screening and early diagnosis in the context of India's diverse and resource-constrained healthcare landscape. Selected cancers like breast, cervical, oral, lung, and colorectal cancers are focused on, and established screening methods such as clinical breast examination (CBE), mammography, visual inspection with acetic acid (VIA), HPV DNA testing, and oral visual inspection (OVI) are reviewed. These are cost-effective strategies that are proven to reduce mortality.

Gum-on-a-Chip Exploring Host-Microbe Interactions: Periodontal Disease Modeling and Drug Discovery.

Periodontal disease is a pervasive and serious health issue, affecting millions globally and leading to severe oral and systemic health complications. This underscores the urgent need to thoroughly understand the complex host-microbe interactions involved. Developing models that allow crosstalk among various bacteria, periodontal component cells, and circulating immune cells is crucial for investigating periodontal disease and discovering new treatments.

Homodimerization of 3-substituted-2-oxindoles for the construction of vicinal all-carbon quaternary centers: chemical, photochemical and electrochemical approaches.

Advancements in organic synthesis are revolutionizing the synthesis of complex natural products, which are essential in biomedical research and drug discovery due to their intricate structures. Natural products such as chimonanthine, folicanthine, calycanthine, psychotriadine, ., with vicinal all-carbon quaternary stereocenters, are particularly significant for their strong binding properties and biological activities.

How an external electric field makes N2O a potent oxidizing agent.

The present work investigates the impact of the external electric field (EEF) on the oxidizing power of N 2 O, by employing kinetics and quantum chemical calculations. We have taken the oxidation of olefin (Ethene and cyclohexene) by N 2 O as a prototype to demonstrate the effectiveness of EEF. The investigation suggests that the reaction barrier is significantly reduced by choosing an electric field in an appropriate direction.

Cancer Targeting Radiopeptidomimetics in Molecular Nuclear Medicine.

Peptides are highly receptor-affine molecules exhibiting suitable pharmacokinetics. Additionally, low-cost production, simple protocols allowing easy modifications, and tolerance toward harsh reaction conditions make peptides ideal ligands for preparation of radiopharmaceuticals for cancer detection and treatment. However, natural peptides being substrates for enzymes are susceptible to proteolysis, which limits the lifetime and the target uptake.

Natural synthesis of β-glucan nanoparticles via microwave for breast cancer prevention: a study on oats-derived nanoparticles.

This study investigates the antibacterial and cancer-preventive properties of β-glucan nanoparticles (GNP) synthesised from oats using microwave energy, sodium tripolyphosphate (TPP), and silver (Ag). UV-visible spectroscopy indicated a strong surface plasmon resonance peak between 220 and 250 nm for GNP. FTIR analysis identified a band at 609 cm, signifying β linkage and confirming the presence of β-glucans.

Harnessing the anti-inflammatory potential of : a comprehensive study on a leafless parasitic weed using chromatographic, , and methods.

., a parasitic weed of the Convolvulaceae family, relies entirely on host plants for nutrients but possesses notable medicinal properties. This study explored the biologically active compounds in using traditional pharmacognostic methods combined with modern chromatographic, , and techniques.