Dementia Care Research and Psychosocial Factors.

Background: The dual-cyclical relationship between language and cognition, encapsulated in linguistic relativity, underscores the reciprocal influence of thoughts on communication and vice-versa. This study explores the intricate changes in pragmatics, a fundamental aspect of human communication, during the aging process, considering changes in sensory abilities, cognition, and language.

Method: Sixty participants, aged ≥50 years with a minimum of five years of formal education, were included, excluding those with neurological or psychological illnesses.

Dementia Care Research and Psychosocial Factors.

Background: With increased for promoting neuroplasticity in older adults through Cognitive training (CT), the study aimed to develop culturally relevant caregiver-driven model of CT for dementia called the Individualized Cognitive Augmentation Regimen for Elderly (iCARE).

Method: The study has three phases- 1. Development Phase- Included a) literature review, b) item generation, c) expert rating, d) field trial (n = 3), and e) feedback and modification.

Dementia Care Research and Psychosocial Factors.

Background: Sleep patterns and disruptions may associate with increased dementia risk and contribute to its progression and cognitive decline. Understanding the complexity of the sleep-dementia relationship is crucial for developing interventions that may delay cognitive decline and enhance the well-being of individuals with dementia. This study seeks to explore how the sleeping patterns of patients with dementia impact them and aims to provide insights to help improve the sleep patterns of individuals affected by dementia.

Dementia Care Research and Psychosocial Factors.

Background: Dementia is a mental condition defined by a severe loss of intellectual ability that interferes with one's occupational or social activities. The rapid increase in the number of patients with dementia and Alzheimer's disease (AD) will result in tremendous consequences for our society and economy. Hypoxanthine is a purine compound that is implicated in the progression of AD.

Dementia Care Research and Psychosocial Factors.

Background: With the worldwide geriatric population steadily increasing, identifying older adults in need of treatment for cognitive difficulties is imperative. Limited specialty resources makes it particularly important to identify which individuals would most benefit from further evaluation and treatment, including in countries where dementia care is limited, such as India. Self-report measures are timely and cost effective tools that can assist providers in identifying individuals at risk of cognitive decline.

Harnessing the immunomodulatory potential of ashwagandha (Withania somnifera) against epizootic ulcerative syndrome: a sustainable approach for hill aquaculture.

The present study evaluated the immunomodulatory and disease resistance-enhancing effects of dietary supplementation of Withania somnifera root powder in Labeo rohita (22.10 ± 3.30 g, 12.

Dementia Care Research and Psychosocial Factors.

Background: This ethnographic inquiry offers a nuanced exploration into the lives of individuals contending with dementia in India, utilizing data from the Harmonized Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-DAD). Recognizing dementia as a complex global health challenge, we delve into its unique manifestations within India's diverse regional and cultural landscape. While LASI-DAD provides valuable quantitative insights into prevalence and risk factors, our research complements these statistics by providing an in-depth understanding of the daily lives and lifestyles of those affected.

Dementia Care Practice.

Background-: An estimated 8.8 million Indians older than 60 years have dementia. The increase in number of people living with dementia is causing difficultly to meet the need for care and support, particularly people with early-stage dementia.

Dementia Care Practice.

The population of older adults in India is projected to increase from the current estimate of 150 million to 350 million by the year 2050. The prevalence of older adults with mental health problems including dementia is also increasing rapidly. The socio-cultural changes in the joint family system have necessitated the increasing requirement of formal caregivers for supporting the care of older adults in home as well as residential care institutions.

Dementia Care Practice.

Background: India has a mixed public-private healthcare system however most care is out-of-pocket. Despite projections that the older population is expected to rise from current 138 million to 194 million by 2031, services catering to the needs of people living with dementia remain limited. Ailing family members and older adults have traditionally been cared for in an intergenerational joint family system where members reside together.

Dementia Care Practice.

Background: Dementia, a major concern in India (1-10% prevalence), is challenging, particularly in rural areas with a significant treatment gap. Community psychiatry offers a promising solution, aiming to provide essential dementia care in underserved rural India, reflecting innovative approaches to extend mental health services equitably.

Methods: This study, employing a descriptive approach, examines the impact of Rythm community psychiatry clinics, an initiative by IQRAA International Hospital and Research Centre, on dementia care.

Dementia Care Practice.

Background: Dementia is a progressive clinical syndrome which is marked by pervasive cognitive impairment and deterioration. With the ever-increasing number of people living with dementia, it has become a global concern. Current medications focus on slowing the progression of dementia and managing the comorbidities and not on directly enhancing memory.

Dementia Care Practice.

Background: India is unfortunately the "Diabetes Capital" of the world with estimated 101 million and 136 million patients suffering from diabetes and prediabetes respectively. Prediabetes is a transition state between euglycemia and diabetes. Although diabetes is associated with cognitive decline, studies that link prediabetes and cognition have been scarce and inconclusive especially from the Low and Middle Income (LMIC) countries.

Dementia Care Practice.

Introduction: Punding is a unique stereotypical, repetitive, non-goal-directed behavior characterized by an intense fascination with daily objects. This behavior although commonly seen in dementia patients is relatively less studied. In this study, we aimed to assess the effectiveness of combination treatment of escitalopram and risperidone treatment in the punding behavior of dementia patients.

Dementia Care Practice.

Background And Objectives: Telemedicine, including teleneurology, has emerged as a valuable tool for providing healthcare services remotely, particularly in situations where distance plays a critical role. Teleneurology has the potential to increase access to care, improve patient outcomes, and reduce healthcare costs, especially for patients in rural and underserved areas. We aimed to investigate patients and health care providers satisfaction with teleneurology for dementia.

Cobalt-Catalyzed Enantioselective Reductive Coupling of Imines and Internal Alkynes.

Chiral allyl amines are important structural components in natural products, pharmaceuticals, and chiral catalysts. Herein, we report a cobalt-catalyzed enantioselective reductive coupling of imines with internal alkynes to synthesize chiral allyl amines. The reaction is catalyzed by a cobalt complex derived from commercially available bisphosphine ligand utilizing zinc as the electron donor.

Therapeutic Role of Scutellarein in Neurological Disorders.

Scutellarein, a flavone found in the perennial herb Scutellaria baicalensis, has a wide range of pharmacological actions, such as antioxidant, anti-inflammatory, and neuroprotective. Increasing evidence has emphasized the developing significance of scutellarein in several neurological illnesses, such as Alzheimer's and Parkinson's disease, cerebral ischemia, and neuroblastoma. This review is centered on the molecular processes that underlie the neuroprotective properties of scutellarein in various neurological disorders, as indicated by recent pre-clinical research.

Utilizing Plant Phytoconstituents in Metal Oxide Nanoparticle Synthesis for Cancer Therapies.

Background: The metal oxide nanoparticles possess unique properties such as biological compatibility, superior reactivity, and capacity to develop reactive oxygen species, due to this they have drawn significant interest in cancer treatment. The various MONPs such as cerium oxide, Copper oxide, Iron oxide, Titanium dioxide, and Zinc oxide have been investigated for several types of cancers including brain, breast, cervical, colon, leukemia, liver, lung, melanoma, ovarian, and prostate cancers. However, traditional physiochemical synthetic methods for MONPs commonly include toxic materials, a major concern that raises questions regarding their biocompatibility and safety.

Marine-Derived Compound Targeting mTOR and FGFR-2: A Promising Strategy for Breast, Lung, and Colorectal Cancer Therapy.

Introduction: The marine habitat is a plentiful source of diverse, active compounds that are extensively utilised for their medicinal properties. Pharmaceutical trends have currently changed towards utilising a diverse range of goods derived from the marine environment.

Method: This study aimed to examine the inhibitory effects of bioactive chemicals derived from marine algae and bacteria.

DRESS Mimicking Flushing Syndrome Associated with Vancomycin: A Case Report.

Background: The Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is a serious adverse reaction that occurs weeks after the onset of drug exposure. DRESS syndrome is commonly associated with antiseizure drugs, sulfa drugs, and antibiotics.

Case Presentation: This was a case report of a 20-year-old female who suffered from DRESS due to vancomycin with symptoms similar to the Redman syndrome.

Synthetic Strategies and Biological Activities of Teixobactin and its Analogs: A Review.

Antibiotics are a revolutionary discovery in modern medicine, enabling the successful treatment of bacterial infections that were once untreatable and deadly. Teixobactin, a "head-toside- chain" cyclodepsipeptide, shows great promise as a lead compound for developing new antibiotics to deal with multi-drug-resistant bacterial infections. The unique pharmacological profile and intriguing structural characteristics of teixobactin, including its unusual amino acid residues (three D-amino acids and L-allo-enduracididine), have drawn the attention of multiple research groups seeking to create new antibiotics with innovative mechanisms.

Benzimidazole Derivatives in Breast Cancer: Target-Specific Therapeutic Breakthroughs.

Despite ongoing advancements in drug design and developments, breast cancer remains a serious and devastating disease and is ranked as the second most common illness in women. Breast cancer rates have increased significantly during the last 40 years. This necessitates the development of novel treatment techniques.

Paederia Foetida Linn (Rubiaceae): Chemical Diversity, Phytopharmacological Potential, Quantitative Analysis and Clinical Approaches.

The discovery of novel counteractive pharmaceuticals, which have recently generated much interest, has played a significant role in the development of drugs derived from herbal medicines or botanical sources. Paederia foetida (P. foetida) is one such example of a role in both traditional and traditional medicine.

Molecular and Functional Significance of Growth Differentiation Factor-15: A Review on Cardiovascular-Kidney-Metabolic Biomarker.

Cardiovascular-kidney-metabolic (CKM) syndrome is the association between obesity, diabetes, CKD (chronic kidney disease), and cardiovascular disease. GDF-15 mainly acts through the GFRAL (Glial cell line-derived neurotrophic factor Family Receptor Alpha-Like) receptor. GDF-15 and GDFRAL complex act mainly through RET co-receptors, further activating Ras and phosphatidylinositol-3-kinase (PI3K)/Akt pathways through downstream signaling.

Natural Hydrogel-based Drug Delivery System: A Global Scenario, Current Development, and Future Prospective.

Pharmaceutical giants (e.g., Ashland, Bausch & Lomb, Johnson & Johnson, Medtronic, Neurelis, etc.