New Insights into the Modifications and Bioactivities of Indole-3-Carboxaldehyde and its Derivatives as a Potential Scaffold for Drug Design: A Mini-Review.

Indole, a ubiquitous structural motif in bioactive compounds, has played a pivotal role in drug discovery. Among indole derivatives, indole-3-carboxaldehyde (I3A) has emerged as a particularly promising scaffold for the development of therapeutic agents. This review delves into the recent advancements in the chemical modification of I3A and its derivatives, highlighting their potential applications in various therapeutic areas.

Biomimetic Fe3O4 Nanozymes Promote Apoptosis in Breast Cancer Cell Lines via Free Radical Scavenging and Inhibition of RelA/p65.

Introduction: Iron oxide nanozyme was synthesized from the fruit peel extract of pomegranate, which served as a reducing agent during the green synthesis. The scavenging of reactive oxygen species is often accompanied by immunomodulation following antiproliferative effects due to the crosstalk between the proteins involved in the inter-related signaling pathways.

Method: In the current study, the green synthesized nanozyme was studied for its ability to induce apoptosis in breast cancer cell lines.

Tipping the balance between and ligand conformers in multinuclear ethylzinc cyclophosphazenates.

Hexaanionic cyclophosphazenate ligands [(RN)PN] provide versatile platforms for the assembly of multinuclear metal arrays due to their multiple coordination sites and highly flexible ligand core structure. This work investigates the impact of incrementally increasing the steric demand of the ligand periphery on the coordination behavior of ethylzinc arrays. It shows that the increased congestion around the ligand sites is alleviated by progressive condensation with the elimination of diethylzinc.

Light-activated nanocomposite thin sheet for high throughput contactless biomolecular delivery into hard-to-transfect cells.

High throughput intracellular delivery of biological macromolecules is crucial for cell engineering, gene expression, therapeutics, diagnostics, and clinical studies; however, most existing techniques are either contact-based or have throughput limitations. Herein, we report a light-activated, contactless, high throughput photoporation method for highly efficient and viable cell transfection of more than a million cells within a minute. We fabricated reduced graphene oxide (rGO) nanoflakes that was mixed with a polydimethylsiloxane (PDMS) nanocomposite thin sheet with an area of 3 cm and a thickness of ∼600 μm.

Technology and Dementia Preconference.

Background And Objectives: Telemedicine, including teleneurology, has emerged as a valuable tool for providing healthcare services remotely, particularly in situations where distance plays a critical role. Teleneurology has the potential to increase access to care, improve patient outcomes, and reduce healthcare costs, especially for patients in rural and underserved areas. We aimed to investigate patients and health care providers satisfaction with teleneurology for dementia.

Presence of Fragmented Intratumoral Thrombosed Microvasculature in the Necrotic and Peri-Necrotic Regions on SWI Differentiates IDH Wild-Type Glioblastoma From IDH Mutant Grade 4 Astrocytoma.

Background: Isocitrate dehydrogenase (IDH) wild-type (IDH) glioblastomas (GB) are more aggressive and have a poorer prognosis than IDH mutant (IDH) tumors, emphasizing the need for accurate preoperative differentiation. However, a distinct imaging biomarker for differentiation mostly lacking. Intratumoral thrombosis has been reported as a histopathological biomarker for GB.

Dynamic Navigation in Dental Implantology.

Implant placement for dental rehabilitation has gained more popularity among patients in the recent past. Dental Implants are the workhorse of dentistry. Previously, the implants were placed with the help of the traditional freehand approach.

A Combination of Fruit Rind and Seed Extracts Enhances Sexual Function in Aging Males in a Randomized, Double-blind, Placebo-controlled Study.

LN18178 is a standardized, synergistic combination of fruit rind and seed extracts, which has been reported to increase serum testosterone levels in young and aging males. The present 84-day randomized, double-blind, placebo-controlled study assessed the efficacy of LN18178 on the sexual function of aging male volunteers (age: 40-70 years; serum total testosterone: ≥ 300 ng/dL). The subjects with mild to moderate erectile dysfunction [5-item version of the International Index of Erectile Function (IIEF-5) scores 17-25] and low sexual desire (score < 3 on items 11 and 12 of IIEF) participated in this investigation.

Comparison of the role of vitamin D in normal organs and those affected by COVID-19.

The outbreak of COVID-19 has opened up new avenues for exploring the importance of vitamin D in immunity, in addition to its role in calcium absorption. Recently, vitamin D supplementation has been found to enhance T regulatory lymphocytes, which are reduced in individuals with COVID-19. Increased risk of pneumonia and increases in inflammatory cytokines have been reported to be major threats associated with vitamin-D deficiency.

SProtFP: a machine learning-based method for functional classification of small ORFs in prokaryotes.

Small proteins (≤100 amino acids) play important roles across all life forms, ranging from unicellular bacteria to higher organisms. In this study, we have developed SProtFP which is a machine learning-based method for functional annotation of prokaryotic small proteins into selected functional categories. SProtFP uses independent artificial neural networks (ANNs) trained using a combination of physicochemical descriptors for classifying small proteins into antitoxin type 2, bacteriocin, DNA-binding, metal-binding, ribosomal protein, RNA-binding, type 1 toxin and type 2 toxin proteins.

Clinical implications of mineralocorticoid receptor overactivation.

The mineralocorticoid receptor (MR) is a nuclear transcription factor that plays a critical role in regulating fluid, electrolytes, blood pressure, and hemodynamic stability. In conditions such as chronic kidney disease (CKD) and heart failure (HF), MR overactivation leads to increased salt and water retention, inflammatory and fibrotic gene expression, and organ injury. The MR is essential for transcriptional regulation and is implicated in metabolic, proinflammatory, and pro-fibrotic pathways.

S6K1 is a Targetable Vulnerability in Tumors Exhibiting Plasticity and Therapy Resistance.

Most tumors initially respond to treatment, yet refractory clones subsequently develop owing to resistance mechanisms associated with cancer cell plasticity and heterogeneity. We used a chemical biology approach to identify protein targets in cancer cells exhibiting diverse driver mutations and representing models of tumor lineage plasticity and therapy resistance. An unbiased screen of a drug library was performed against cancer cells followed by synthesis of chemical analogs of the most effective drug.

Vitamin C-Based Gingival Depigmentation Versus Surgical Depigmentation: A Randomized Clinical Trial.

This study aimed at comparing gingival depigmentation by locally injected vitamin C with surgical depigmentation, in terms of effectiveness and patient acceptability. Forty-two patients presenting with ethnicity-related hyperpigmentation were randomly divided into two groups, Group I ( = 21) was treated with locally injected vitamin C and Group II ( = 21) was treated by surgical depigmentation. The outcome was assessed using Gingival Pigmentation Index (GPI) and Skin Hyperpigmentation Index (SHI).

Finite element analysis and its application in Orthopaedics: A narrative review.

Orthopedic surgery and traumatology necessitate cost-effective approaches that can be replicated across multiple venues. Finite Element (FE) simulation models have evolved as a solution, allowing for consistent investigations into biomechanical systems. Finite Element Analysis (FEA), which began in the 1950s aviation industry, has since expanded into orthopedics.

Acceptance of Parents toward Hand-over-mouth Exercise and Other Behavior Management Techniques for Pediatric Dental Care in the 21st Century: A Systematic Review and Meta-analysis of Observational Studies.

Background: Hand-over-mouth exercise (HOME) is an aversive technique for child behavior management in a dental office. HOME has been omitted from various guidelines and certain teaching curricula due to legal and ethical issues. This systematic review meta-analysis (SRMA) was undertaken to understand the acceptance of parents toward HOME in comparison with that of other behavior management techniques (BMTs).

Comparison of Conventional Syringe with Camouflaged Syringe and Vibration-assisted Syringe for Pain and Fear Perception during Local Anesthetic Administration in Children: A Split-mouth Randomized Controlled Trial.

Aim And Background: Although local anesthesia (LA) eliminates pain and instills a positive dental attitude, the physical appearance of its syringe is highly fear provoking and often intolerable. Therefore, the purpose of this study was to evaluate the pain and fear perception in camouflaged syringe (CS) and vibration-assisted syringe (VA) when compared with conventional syringe and with each other (VACS) during local anesthetic administration in pediatric patients aged between 6 and 12 years.

Materials And Methods: Eighty-five subjects were randomly assigned into three groups: CS group ( = 7), VA group ( = 26), and VACS group ( = 27).

Intentional Reimplantation Combining the Benefits of Leukocyte- and Platelet-rich Fibrin and Biodentine™ for the Treatment of a Large Periapical Cyst: A Case Report.

Background: This case report examines the efficacy of intentional reimplantation (IR) in endodontics and explores the increased interest driven by recent advancements in regenerative techniques.

Case Presentation: A 14-year-old male patient reported pain in the lower left back tooth (tooth #36). The radiographic assessment revealed a 4 mm × 4 mm periapical cyst.

Survival of Silver Diamine Fluoride Varnish Treated Teeth among Children with Single/Multiple Applications: A Split-mouth Randomized Clinical Trial.

Introduction: Utilizing 38% silver diamine fluoride (SDF) has been demonstrated in clinical trials to prevent and halt early childhood caries (ECC). Based on a research evaluation, it has been found that 38% SDF can effectively prevent new tooth decay and stop existing tooth decay in children's primary teeth.

Objective: This study aimed to assess the survival of teeth treated with repeated applications of 38% SDF in children with ECC and to compare the outcomes between single and multiple applications.

Thaumaturgical Distraction as a Modality for Reducing Dental Anxiety in Children: A Systematic Review.

Background: Dental fear and anxiety have become a major obstacle for children to accept dental treatment. Dental anxiety ranks fifth among common fears.

Aim: The aim of this current systematic review is to assess the effect of thaumaturgical distraction in reducing anxiety in children undergoing dental procedures.

Clinical Effectiveness of Biomaterials in Indirect Pulp Therapy Treatment of Young Permanent Molars with Deep Carious Lesions: A Case-Control Study.

Aim: The present case-control study was planned to assess the comparative efficacy of resin-modified calcium silicate, resin-modified glass ionomer, and Dycal as pulp capping agents in indirect pulp therapy for deeply carious young permanent molars.

Materials And Methods: Thirty deeply carious young posterior teeth were treated by indirect pulp therapy. During the treatment, the cavity floor was lined with TheraCal or resin-modified glass ionomer cement (RMGIC) in the study group and with Dycal (control group) followed by GC IX and composite restoration.

Comparison of Debridement Efficacy of Two Irrigating Systems Endovac and Conventional Needle in Primary Tooth Root Canals: An Study.

Aim: The purpose of the study is to evaluate how well the Endovac system and conventional needle irrigation work to remove smear layers (SR) from primary teeth root canals.

Materials And Methods: Fifty extracted human primary teeth were divided into two equal sections vertically, then positioned within an acrylic model that was secured with screws. Group A (Endovac), = 25, and group B (traditional needle), = 25.

Comparative Evaluation of Apical Debris Extrusion in Primary Molars Using Three Different Pediatric Rotary Systems: An Study.

Aims And Background: Failure of the endodontic treatment might be due to various reasons like zipping, apical blockade, ledging, debris extrusion, etc. Apical debris extrusion in primary teeth is of major concern as it does not have a proper well-developed apex, that is, mature apex. This study aims to compare and evaluate the apical debris extrusion in primary molars using three different pediatric rotary file system.

Tech Bytes-Harnessing Artificial Intelligence for Pediatric Oral Health: A Scoping Review.

Aim And Background: The applications of artificial intelligence (AI) are escalating in all frontiers, specifically healthcare. It constitutes the umbrella term for a number of technologies that enable machines to independently solve problems they have not been programmed to address. With its aid, patient management, diagnostics, treatment planning, and interventions can be significantly improved.

Angioedema in a 9-year-old Child after Dental Treatment: A Rare Complication Explored through a Case Report.

Aim And Background: Angioedema is a nonpruritic swelling that typically affects the skin, mucous membranes of the face, and perioral soft tissues. It can be life-threatening, but it is usually not and can be treated conservatively unless the airway is compromised. This paper seeks to illuminate a rare case of hereditary angioedema (HAE) onset following dental procedures in a 9-year-old Indian boy.

Comparing the Existence of Golden Proportion Using Maxillary Anterior Teeth Dimensions in Primary and Permanent Dentition: A Cross-sectional Study.

Aims And Background: The golden proportion is based on the premise that there is a link between natural beauty and mathematics. The study aimed to analyze the mesiodistal width of maxillary anterior teeth in primary and permanent dentition to determine whether a golden proportion exists among them.

Materials And Methods: Sixty subjects were randomly selected in accordance with inclusion and exclusion criteria.