Primary Thyroid Tuberculosis Diagnosed with CBNAAT.

Tuberculosis is a common disease in India but even then Primary tuberculosis of Thyroid gland is an extremely rare clinical scenario. Diagnosis of this rare disease requires very high level of clinical suspicion as the clinical features have no distinct characteristics and usually mimic with bacterial thyroiditis, thyrotoxicosis, thyroid carcinoma, lymphoma etc. Historically most of patients were diagnosed through histopathology in post operative thyroidectomy specimens.

Itraconazole in Medical Management of Patients with AFRS.

Allergic fungal rhinosinusitis is a non-invasive disease most commonly found in immunocompetent host. In present study we aim to study the role of itraconazole as primary medical management in Allergic Fungal rhinosinusitis in improving treatment outcome and its role in avoidance of surgery. Total of 50 patients of clinically diagnosed AFRS equally divided into 2 groups, one group receiving 3 months of itraconazole and other receiving steroids in tapering dose.

Evaluation of an Otoscopy Simulator and Traditional Learning with Observation in Teaching Ear Diseases to Phase III Part I Medical Students.

Simulation, in medical education has provided a novel way to impart education which will help students acquire the required skills to achieve their learning objectives. The aim of our study was to evaluate the performance of students exposed to otoscopy simulator-based learning versus traditional learning with observation and also to know the students' perceptions via a questionnaire at the end of the module. This was a prospective interventional study, conducted on third-year medical students, sixty in number, divided into two groups by the lottery method.

Sinonasal and Laryngeal Presentations of Pituitary Adenoma.

Pituitary adenomas, the second most common intracranial pathology, often exhibit symptoms beyond the classic triad of headache, visual disturbances, and hormonal imbalances. Unusual presentations involve sinonasal pathology, cranial nerve involvement, and mass effects on adjacent structures like the skull base. Secretory adenomas may manifest hormonal changes and their effects.

Successful Primary Oral Isavuconazole Therapy in Acute Invasive Fungal Sinusitis with Triple Fungal Species and Multiple Comorbidities.

Reporting the first successful treatment with oral Isavuconazole as primary antifungal agent following debridement, in an immunocompromised adult male with acute invasive fungal sinusitis involving multiple simultaneous fungal species. His comorbidities were retroviral and COVID infections, uncontrolled diabetes, ketoacidosis, and renal failure. A two-year follow-up revealed no recurrence.

Navigating a Giant Thyroglossal cyst: A Compelling Case Study.

Thyroglossal duct cysts are congenital neck cysts, formed as a result of the failure of the thyroglossal duct to involute during embryogenesis. We present a case of a 55- year-old male who presented with a history of a large anterior neck mass measuring 11 x 8.5 cm.

Management of a Huge Arteriovenous Malformation of the Tongue with the Submandibular Gland Flap: A Case Report.

AVMs commonly manifest in childhood or adolescence, and can occur at any area of the body. The management could be conservative or surgical. Surgical excision of a tongue AVM requires adequate reconstruction and Submandibular gland proves to be an excellent modality for the same.

"Golden Hour" in Road Traffic Accident Victims: Hurdles and Impact on Mortality.

Introduction Road traffic accident (RTA)-related death and disability are alarming health issues globally, which are rapidly increasing in developing countries. Timely presentation to a health center and prompt medical care are needed to prevent mortality and morbidity related to RTAs. This study was conducted to find out the hurdles in the golden hour arrival of RTA victims and to study its impact on RTA mortality at a tertiary health institute.

Prevalence and Correlates of Osteoporosis and Metabolic Syndrome Among Patients With Chronic Obstructive Pulmonary Disease at a Rural Tertiary Healthcare Center in India.

Background Chronic obstructive pulmonary disease (COPD) results from chronic inflammation triggered by various risk factors. This inflammation can also impact other organ systems. COPD patients often have comorbidities such as osteoporosis and metabolic syndrome.

Exploring the potential anti-senescence effects of soybean-derived peptide Soymetide in mice hippocampal neurons via the Wnt/β-catenin pathway.

Soybean-based foods enhance cognitive functions by influencing hippocampal mechanisms. These salutary effects have so far been attributed to isoflavones present in soybeans. Considering cellular senescence contributes to cognitive decline and that no specific soy-derived peptides are known for their potential to mitigate senescence, we examined the efficacy of a thirteen amino acid soy-derived peptide, Soymetide, on a doxorubicin-induced senescence mice model.

Unveiling the cancer epidemic in India: a glimpse into GLOBOCAN 2022 and past patterns.

Background: The Global Cancer Observatory (GLOBOCAN) 2022 estimates highlight cancer as a significant global health problem. In the South-East Asia-region, India ranks third in terms of cancer incidence, second for mortality, and 121 in terms of crude rates globally. As cancer risks increase with age, particularly affecting older individuals, this study explores the current cancer burden in India by analyzing the cancer landscape across different age groups, determining the population's risk of cancer diagnosis and death, and projecting the future cancer burden aligned with past mortality patterns.

Comprehensive in-silico characterization and expression pattern of calmodulin genes under various abiotic and biotic stresses in Indian mustard ().

Unlabelled: Calcium (Ca⁺) as a secondary messenger has a multidimensional role, including the growth and development of plants and the adaptive response to stress conditions. Calmodulin (CaM), a calcium-binding protein, uniquely binds with these Ca⁺ ions and transmits Ca⁺ signals. Calmodulin proteins have been well-reported in various plants for playing a role in abiotic and biotic stress signaling; however, a comprehensive analysis of the genes of Indian mustard () has not been studied much.

Eavesdropping the pivotal defensive representatives of plant-thrips interaction.

The substantial economic impact of thrips on crop yield and productivity enthused us to review comprehensive research findings associated with plant-thrips interaction. An attempt has been made to summarize a broad spectrum of knowledge on thrips infestation in different crops regarding defensive traits including plant morphological features, biochemical alterations and transcriptional profiling of defensive genes along with effective thrips management strategies. Thrips feeding mechanism involves puncturing the outer (epidermal) layer of host tissue and evoking the plant defence mechanism.

Comparative translational reprogramming of during mechanical wounding.

Unlabelled: (soybean) is a highly protein-rich legume that also contains oils and vitamins. Unfortunately, soybean faces many biotic and abiotic stresses including heat, drought, pests, wounds, infections, and salinity, which limits the crop productivity. Among these, mechanical wounding (MW) causes significant harm to plants, creates a passage for invading pathogens, and disrupts plant metabolism.

Comparative efficacy of advanced and traditional wound dressings in post-operative orthopaedic care for hip and knee surgeries: A randomized controlled trial.

Background: This randomized controlled study aimed to evaluate the efficacy of three advanced dressings (Aquacel Ag®, Opsite® Post-Op, and Mepilex Border Post-Op®) versus traditional dressings in post-operative care for patients undergoing orthopaedic hip or knee surgeries.

Methods: Conducted between August and December 2022 at a tertiary care orthopaedic centre, 314 patients were randomized into four groups. Group A received Aquacel Ag®, Group B received Opsite® Post-Op, Group C received Mepilex Border Post-Op®, and Group D received traditional dressings.

Outcomes of COVID-19-associated mucormycosis epidemic in India: A prospective 2-year follow-up study.

Objectives: The objective of this study was to study the various outcomes among coronavirus disease 2019 (COVID-19)-associated mucormycosis (CAM) in terms of morbidity and mortality.

Methods: A prospective study was done on 107 patients (60 male, 47 female) in the Department of Otolaryngology and Head and Neck Surgery, Government Medical College, Patiala, India, diagnosed with CAM from April 2021 to August 2021. The patients were managed both medically and surgically.

Mechanistic investigation on cellular internalization triggering structure-induced conformational modulation of boron-nitrogen luminogens.

Exploring the effects of electron donor (D) and acceptor (A) functional groups in tuning the condensed state properties has been a challenging yet efficient approach to reveal promising materials for cutting-edge applications. Herein, a series of boron-nitrogen (BN) incorporated organic congeners (NBNMe2, NBOMe, NBF, NBCl, NBBr, NBCN, NBPy) appended with functional groups having various degrees of D/A characteristics were developed and their potential in controlling supramolecular assembly and condensed state luminescence features (>90 nm redshift in ) was explored. Despite the minor structural engineering in BN-based small molecules, they effectively modulated conformational orientation and molecular packing, leading to the directed growth of distinct and highly ordered self-assembly patterns, , nanosheets, nanospheres, nanowires, and nanorods.

Major heme proteins hemoglobin and myoglobin with respect to their roles in oxidative stress - a brief review.

Oxidative stress is considered as the root-cause of different pathological conditions. Transition metals, because of their redox-active states, are capable of free radical generation contributing oxidative stress. Hemoglobin and myoglobin are two major heme proteins, involved in oxygen transport and oxygen storage, respectively.

Retraction: Bismuth-based nanoparticles and nanocomposites: synthesis and applications.

[This retracts the article DOI: 10.1039/D4RA05637J.].

Onion peel derived carbon nanoparticles incorporated polysulfone membranes: enhanced dye removal from water.

The ongoing discharge of hazardous dyes from industrial processes has intensified global water pollution, posing serious threats to aquatic ecosystems and human health. Addressing this challenge, our study explores the potential of bio-based carbon nanomaterials (CNM), synthesized from onion peel biowaste and designated as ON11, as effective agents in dye removal. These CNMs were incorporated into a mixed matrix membrane (MMM), using polysulfone (PSU) as the membrane substrate, to enhance dye adsorption.

Green energy production: hydroprocessing of waste plastic to diesel fuel using bimetal of Mn/Zn supported on activated carbon.

This research introduces a Mn/Zn-activated carbon (AC) bimetallic catalyst for hydroprocessing polypropylene pyrolysis oil (PPO) into hydroprocessed polypropylene pyrolysis oil blend (HPPO-B), which closely mimics commercial diesel. Under optimized conditions (70 bar, 350 °C), the catalyst efficiently converts PPO into iso-alkanes, -alkanes, and aromatics, achieving a 95% compositional match with diesel. HPPO-B meets European EN590 diesel standards, with viscosity (3.

Lipid-based nanoformulations in onychomycosis therapy: addressing challenges of current therapies and advancing treatment.

Onychomycosis significantly impacts approximately 20% of the global population. The physical barriers of the nail structure make fungal infections a persistent therapeutic challenge. Traditional approaches, including topical and oral antifungal agents, have limitations such as toxicities, low nail permeability, adverse effects, and high recurrence rates.