Comparison of the Effect of Weekly Cisplatin Versus Three Weekly Cisplatin in Concurrent Chemoradiotherapy of Head and Neck Cancer: A Pilot Study.

Patients with squamous cell carcinoma of the head and neck (HNSCC) often present with advanced locoregional disease. Combined modality treatment with definitive concurrent chemoradiotherapy (CTRT) has become the standard of care for these cancers. We compared the efficacy and toxicity profile of weekly cisplatin regime compared to a three-weekly cisplatin regime in the setting of definitive CTRT for locally advanced HNSCC (LAHNSCC).

To Evaluate the Success of Sialendoscopy Assisted Intraoral Approach for Removal of Submandibular Hilar Stones.

To assess the success of sialendoscopy assisted intraoral approach for removal of hilar stone of submandibular gland. To evaluate the ductal system for any concomitant pathology. Conventionally the treatment for submandibular hilar stones has been gland excision.

Pioneering Clinical Investigation: Beta Defensin Expression in Patients of Squamous Cell Carcinoma of Oral Cavity as a Forward-Looking Validation for Molecular Treatment.

Human defensins are peptides coded by certain genes released as a part of immune response that act differently to tumorigenic cells according to the class. A varied cellular response has been documented in the world literature concerning the role of defensins in the cancer cell lines, though the exact role in the internal human milieu and the role specific to head and neck cancers is still understudied. This study explores the possible role of Human Beta Defensin (HBD) 1 and 3 in head and neck squamous cell carcinoma in disease progression and their potential as biomarkers/prognostic markers.

Videonystamography Findings in Dizziness Patients with Background Anxiety Disorder.

This study was conducted to describe the videonystagmography findings in dizziness patients with background anxiety disorders. It was a hospital-based, descriptive analytical study, conducted among 64 adult patients with diagnosed anxiety disorders presenting with complaint of dizziness attending the vertigo clinic run by the Department of ENT at St. John's Medical College and Hospital, Bangalore, over a period of 24 months.

Paediatric Head and Neck Hemangiomas: Scopes, Challenges and Outcome of Surgical Management.

Haemangiomas are benign vascular tumours frequently encountered in head and neck region. The different systems of nomenclature leading to terminological confusion and management protocols for vascular lesions have been contentious issues and have undergone substantial paradigm shift over the years. A policy has been the mainstay of treatment owing to spontaneous regression of majority of paediatric hemangiomas along with sclerotherapy, laser therapy, drug therapy and radiotherapy.

Elderly Female with Cranial Polyneuropathy.

Unlabelled: The recrudescence of Varicella Zoster Virus in the head and neck region often manifests as Ramsay Hunt Syndrome, characterised by facial nerve palsy, vesicular rash in the distribution of facial nerve and neuralgia. Rarely it causes cranial polyneuropathy (CP). We present a case of herpes zoster with CP, highlighting the diagnostic challenges and management in a resource-limited setting.

A comparative study of pre- and post-rhinoplasty patients' quality of life (QOL) in the lower socio-economic demography.

Objective: Rhinoplasty also popularly known among people as plastic surgery performed on nose.it is the most commonly performed plastic surgery procedures for both functional and aesthetic purposes according to the statistics of the American Society of Plastic Surgeons [1]. This study is aimed to investigate the changes in the psychological impact of rhinoplasty on day-to-day life & on quality of life after the rhinoplasty surgery.

Odontogenic Sinusitis: Endoscopic Management of this Iatrogenic Entity.

Odontogenic maxillary sinusitis (OMS) is a condition presenting to both the dental and otolaryngologic practitioner. Common causes of OMS include dental implants, displacement of a maxillary tooth root tip during extraction, migration of materials used in root canal therapy or graft material in sinus lift procedure. A 68-year-old male patient presented with complaints of repeated episodes of sinusitis for about 3 months which was not responding to conservative management.

Health risk assessments of heavy metals in dust samples collected from classrooms in Ilorin, Nigeria and its impact on public health.

Over the past three decades, heavy metals (HMs) in indoor dust have been a significant focus due to their environmental and health risks. This study assessed HM contamination (Co, Pb, Cd, Cr, Ni, and As) in classroom and lecture theatre dust in Ilorin, Nigeria, across dry and rainy seasons. Dust samples from primary, secondary, and university settings were analyzed using atomic absorption spectrometry and ICP-OES.

Clinical and physiological evaluation of free-ranging snow leopards immobilized with ketamine-xylazine in emergency situations.

The current study presents data on the immobilization and physiological responses of 26 distressed free-ranging snow leopards () in the trans-Himalayan regions of Ladakh, India, spanning three years from October 2020 to December 2023. Ketamine and xylazine were utilized in a drug mixture for rescue, rehabilitation, health assessment, and other capture purposes, with average doses of 6.535 ± 0.

Prion protein fragment (106-126) activates NLRP3 inflammasome and promotes platelet-monocyte/neutrophil interactions, potentially contributing to an inflammatory state.

Introduction: Prion diseases are neurodegenerative disorders where infectious prion proteins (PrP) featuring an amyloidogenic amino acid sequence, PrP (106-126), accumulate in the brain leading to neuroinflammation while it can also access circulation by breaching the blood-brain barrier. Platelets are highly sensitive cells in blood, which have been widely employed as "peripheral" model for neurons. In addition to their stellar roles in hemostasis and thrombosis, platelets are also known to function as immune cells and possess necessary components of functional inflammasome.

and Gene Polymorphisms in Systemic Sclerosis.

The complex cytokine network plays an important role in disease susceptibility and development, therefore single-nucleotide polymorphisms (SNPs) in or near cytokine genes may be relevant to development of systemic sclerosis (SSc). We in this study investigated 22 SNPs in 13 cytokine genes of SSc patients, and their association with disease susceptibility. Twenty-three clinically diagnosed SSc patients were enrolled for this purpose along with 80 healthy volunteers for comparisons.

HLA allele and haplotype frequencies of eight Indian populations based on 130,518 registered stem cell donors.

Introduction: In hematopoietic stem cell transplantation, optimal results are achieved when donors and patients are matched regarding their human leukocyte antigen (HLA) genes. Population-specific HLA allele and haplotype frequency distributions determine the probabilities to find matched donors in a stem cell donor registry of given size and ethnic composition.

Methods: To evaluate the needs of Indian patients with regard to future donor recruitment, we analyzed a large data set of =130,518 potential stem cell donors registered with DKMS-BMST, a Bangalore-based donor registry with nationwide donor recruitment activities.

Impact of Coinfection on Disease Severity and Treatment Outcomes in Pulmonary Tuberculosis.

Background: This study investigates how (Ss) infection impacts pulmonary tuberculosis (PTB) treatment outcomes, disease severity, and bacterial burdens in PTB patients with Ss coinfection.

Methods: We used chest x-rays and sputum smear grades to assess lung conditions and bacterial loads in 483 PTB patients. Ss infection was confirmed by seropositivity, and cytokine and profibrotic factor levels were analyzed using multiplex enzyme-linked immunosorbent assay.

Advancements in cache management: a review of machine learning innovations for enhanced performance and security.

Machine learning techniques have emerged as a promising tool for efficient cache management, helping optimize cache performance and fortify against security threats. The range of machine learning is vast, from reinforcement learning-based cache replacement policies to Long Short-Term Memory (LSTM) models predicting content characteristics for caching decisions. Diverse techniques such as imitation learning, reinforcement learning, and neural networks are extensively useful in cache-based attack detection, dynamic cache management, and content caching in edge networks.

Symptom networks of common mental disorders in public versus private healthcare settings in India.

We present a series of network analyses aiming to uncover the symptom constellations of depression, anxiety and somatization among 2,796 adult primary health care attendees in Goa, India, a low- and middle-income country (LMIC). Depression and anxiety are the leading neuropsychiatric causes of disability. Yet, the diagnostic boundaries and the characteristics of their dynamically intertwined symptom constellations remain obscure, particularly in non-Western settings.

A Prospective Study on Anemia in Hypothyroidism and Hyperthyroidism.

Anemia is a common condition associated with thyroid diseases but the causal relationship between these disorders remains unclear. Thyroid hormones play a crucial role in erythropoiesis by stimulating the expression of the erythropoietin gene and erythropoietin production. An excess of thyroid hormones is also linked to altered iron metabolism or oxidative stress.

Detection of Oral Submucous Fibrosis at the Crossroads of Altering Nucleogeometry, Nuclear Spatial Distribution and Nuclear Molecular Abundance.

The manuscript concentrates on spatial distribution and various nucleomorphometric parameters of epithelium to diagnose Oral Submucous Fibrosis (OSF). Histologically confirmed OSF and normal submucosa tissue samples were procured and stained with diamidino phenylindole (DAPI) to visualize nuclei. E-cadherins and p63 were also immunohistochemically stained.

Clinico-Pathological Study of Symptomatic Hyperparathyroidism: Is it a Different Phenotype Expression of Hyperparathyroidism?

Despite the popularity of auto analyzers in urban areas of the country the incidence of asymptomatic hyperparathyroidism has not markedly increased and symptomatic diseases are regularly seen in all major institutions. The present single-institution analysis of proven hyperparathyroidism in the last 16 years was aimed at comparing the demographic, clinical, and pathological characteristics of symptomatic and asymptomatic primary hyperparathyroidism and comparing those with the asymptomatic diseases seen in developed countries. A retrospective chart review of 332 patients was done and 29 (8.

Clinical Profile of Vestibular Migraine- Insights from a Retrospective Study.

Introduction: Vestibular migraine (VM) is a subtype of migraine characterized by recurrent episodes of vertigo or dizziness, often accompanied by nausea, light and sound sensitivity, and other vestibular symptoms. It primarily affects females at a 5:1 ratio, with episodes lasting from minutes to 72 h, occurring with or without headaches. VM is one of the more frequent causes of recurrent vertigo, affecting around 1% to 2.

Pneumoparotitis: A Rare Case Report.

Pneumoparotitis, a rare condition characterized by the presence of air within the parotid gland, typically arises due to an accumulation of air in the salivary ducts. Pneumoparotitis is a rare entity which affects children and young adolescents. This case report presents a rare instance of pneumoparotitis occurring in a 14-year-old female.

Giant Ossifying Fibroma (Epulis) in an Elderly Patient-A Case Report.

This is a case report of a 64-year-old male with swelling over the right side of the face due to swelling in the oral cavity with a peduncle attached to the gingiva. On the basis of radiological and histopathological features, we diagnosed the growth as a giant peripheral ossifying fibroma and proceeded with surgical management.

A Correlational Study of Tinnitus Handicap Inventory (THI) Scores and Otoacoustic Emissions (OAE) Among Tinnitus Patients.

To determine the level of disability in patients suffering from tinnitus using the Tinnitus Handicap Inventory (THI) score, to evaluate the changes in otoacoustic emissions in a patient with tinnitus and evaluate the co-relation of the Tinnitus Handicap Inventory score with the Otoacoustic emission result This is an observational study done over a period of 6 months, in which patients aged more than 18 years who presented to the ENT OPD of our institute with complaints of tinnitus were considered for inclusion in the study. Patients with primary tinnitus, who consented to be part of the study were assessed for handicap caused by tinnitus using the Tinnitus Handicap Inventory (THI) score. All patients were subjected to Pure Tone Audiometry (PTA) and Screening OAE to look for the "Pass" or "Refer" in the OAE result.

Effect of Smoking on Electron Microscopic Structure of Nasal Mucosa.

The present study aimed to assess and compare the effect of smoking on ultrastructure morphology of nasal mucosa between smokers and nonsmokers. The study included 50 subjects aged 25-62 years who were planned for rhinological surgical procedures. Subjects were divided into 3 groups- group 1 (nonsmoker), group 2 (smokers taking 1 pack/day or less), group 3 (smokers taking 2 pack/day or more).