Benign mid-gap halide vacancy states in 2D-bismuth-based halide perovskite microcrystals for enhanced broadband photodetectors.

Lead halide perovskites are widely recognized for their exceptional defect tolerance, setting the benchmark for high-performance optoelectronic applications. Conversely, low-toxicity perovskite-inspired materials (PIMs) typically exhibit suboptimal optoelectronic performance, primarily due to their intrinsic susceptibility to defects. In this study, we address this limitation by exploring the effects of halide vacancies in PIMs through the synthesis of non-stoichiometric CsBiBrI microcrystals (MCs) with a trigonal crystal structure, incorporating iodine vacancies.

A Comprehensive Analysis of Market Forms and Analytical Methods for Metformin Formulations.

Metformin has been a cornerstone in the management of type 2 diabetes mellitus (T2DM) for more than 50 years, either alone or in combination with other therapies. This oral antihyperglycemic agent, also known as dimethylbiguanide, plays a crucial role in regulating noninsulin-dependent diabetes mellitus and is widely prescribed globally for various medical conditions. Recent advancements in its formulations have aimed to increase its effectiveness, tolerance, and nonglycemic effects.

3D Printable Self-Healing Mineralized Hydrogels Loaded With Diclofenac Sodium: In Vitro and In Vivo Assessment.

The use of self-healing mineralized hydrogels in 3D printing has demonstrated significant advantages, including enhanced printing accuracy and the ability to maintain high shape fidelity throughout the printing process. After conducting an initial optimization study, we incorporated our self-healing mineralized hydrogel into semi-solid extrusion-based 3D printing to print diclofenac-loaded oral films. The dependence of the print speed on the nature of the material was established by varying the print speed.

Disruption of ER-mitochondria contact sites induces autophagy-dependent loss of P-bodies through the Ca2+-CaMKK2-AMPK pathway.

P-bodies (PBs) and stress granules (SGs) are conserved, non-membranous cytoplasmic condensates of RNA-protein complexes. PBs are implicated in post-transcriptional regulation of gene expression through mRNA decay, translational repression and/or storage. Although much is known about the de novo formation of PBs and SGs involving liquid-liquid phase separation through multiple protein-protein and protein-RNA interactions, their subcellular localization and turnover mechanisms are less understood.

Efficacy of Comprehensive Foot Strengthening Program on Foot Biomechanics and Plantar Pressure to Reduce Lower Limb Injury Risk in Male Bhangra Dancers: A Randomized Controlled Trial Protocol.

Background: Bhangra dance is vibrant and energy demanding art form involving dynamic footwork, jumps, kicks and rapid movements. Poor biomechanics and uneven plantar pressure is a crucial factor for injury among dancers thus, this study protocol aimed at evaluating the efficacy of comprehensive foot strengthening program in improving faulty foot biomechanics and plantar pressure distribution to reduce the risk of lower limb injuries among male Bhangra dancers.

Methods: A single-blinded randomized controlled trial (RCT) will be performed.

Medial opening wedge valgus intertrochanteric osteotomy for femoral neck nonunion: a femoral anatomy-preserving surgical approach.

Background: Valgus osteotomy is a femoral head-preserving surgery to treat femoral neck non-union in young, active patients. The traditional approach, however, causes medialisation of the femoral shaft during valgus correction, which alters femoral anatomy and complicates conversion to total hip arthroplasty if head osteosynthesis fails. This study aims to outline a novel surgical technique, medial opening wedge valgus intertrochanteric osteotomy (VITO), and evaluate its clinical and radiographic outcomes, focusing on restoring hip biomechanics and improving union rates.

External validation of web-based calculator to predict cesarean delivery after induction of labor.

Objective: To externally validate a prediction model for the risk of a cesarean section after induction of labor (IOL) using a web-based cesarean risk calculator in a tertiary perinatal center and to compare the performance of three calculators in predicting the cesarean risk after IOL based on their sensitivity and specificity.

Methods: This was a prospective observational study of 577 women over a period of 1 year at a tertiary perinatal center in India. Women with singleton-term pregnancies with intact membranes that underwent induction were included.

Idiopathic polyarteritis nodosa-does it still exist? Viewpoint 2: idiopathic polyarteritis nodosa is rare, but still exists.

Polyarteritis Nodosa (PAN), is the firstly described vasculitis and can be seen in paediatric and adult age. PAN has a heterozygous clinical picture including cutaneous, constitutional, musculoskeletal, gastrointestinal, and renal involvement. Description and splitting of other vasculitis, makes this medium vessel vasculitis, a very rare disease.

Randomized controlled trial to assess medication adherence and health-related quality of life through a collaborative pharmacist-psychiatrist approach to patient education in patients with depression in India.

Background: Depression is a common but severe mental health disorder affecting individuals globally. Medication non-adherence and low health-related quality of life (HRQoL) are the major challenges associated with the treatment of patients with depression.

Materials And Methods: A prospective Randomized Controlled Trial (RCT) was conducted in the psychiatry outpatient department of a tertiary care hospital for six months.

Case of endocarditis triggering both ischemic and haemorrhagic stroke: A rare clinical presentation from eastern India.

We report a rare clinical presentation of a 54-year-old male diagnosed with infective endocarditis caused by , a nutritionally variant streptococcus (NVS) characterized by unique growth requirements and high pathogenic potential. The patient presented with prolonged fever and residual hemiparesis following an ischemic stroke. Blood culture confirmed , and imaging identified vegetations on a bicuspid aortic valve.

Impact of Enterococcus infection in HSCT recipients: a national analysis.

Background: Enterococci are the third most common cause of healthcare-associated infections in the United States, affecting 10-12% of all transplant recipients worldwide. Enterococcal bacteremia complicates the post-transplant recovery and raises mortality to 18%. This study aims to identify factors linked to mortality in hematopoietic stem cell transplant (HSCT) recipients with Enterococcus infection.

Scrub Typhus in Kerala: Demographic, Clinical, and Laboratory Predictors of ICU Admission in a Tertiary Care Setting.

Background: Scrub typhus, a mite-borne infection caused by , is endemic in South and Southeast Asia, including India. Although increasing awareness and improved healthcare access have reduced mortality, the disease remains a significant public health concern. Kerala, a southern Indian state, has reported scrub typhus cases for decades; however, comprehensive data on its clinical profile and severity indicators are limited.

New antibiotics targeting Gram-negative bacilli.

Antimicrobial resistance (AMR) is an emerging global threat. It increases mortality and morbidity rates and places a heavy burden on healthcare systems. Healthcare professionals can address the increasing issue of AMR by advocating responsible antibiotic use and supporting the development of new medications.

"Optimizing sEMG Gesture Recognition with Stacked Autoencoder Neural Network for Bionic Hand".

This study presents a novel deep learning approach for surface electromyography (sEMG) gesture recognition using stacked autoencoder neural network (SAE)s. The method leverages hierarchical representation learning to extract meaningful features from raw sEMG signals, enhancing the precision and robustness of gesture classification.•Feature Extraction and Classification MODWT Decomposition: The sEMG signals were decomposed using the MODWT DECOMPOSITION(Maximal Overlap Discrete Wavelet Transform) to capture various frequency components.

Bio-electrosynthesis of polyhydroxybutyrate and surfactants in microbial fuel cells: a preliminary study.

Microbial Electrochemical Technology (MET) offers a promising avenue for CO utilization by leveraging the ability of chemolithotrophic microorganisms to use inorganic carbon in biosynthetic processes. By harnessing the power of electroactive bacteria, METs can facilitate the conversion of inorganic carbon into organic compounds. Therefore, this work combines biosurfactant production at the anode and PHB production at the cathode of Microbial Fuel Cells (MFCs), while testing the efficiency of Microbial Electrosynthesis Cells (MECs), and traditional culture in liquid media.

An integrated proteo-transcriptomics approach reveals novel drug targets against multidrug resistant .

Infections due to multidrug-resistant (MDR) are associated with severe morbidity and mortality, worldwide. Microbial drug resistance is a complex phenomenon which is conditioned by an interplay of several genomic, transcriptomic and proteomic factors. Here, we have conducted an integrated transcriptomics and proteomics analysis of MDR to identify genes which are differentially expressed at both mRNA and protein levels.

A New Paradigm in Hospital Medicine: Evaluating the Effects of Geographical Cohorting on Health Care Delivery.

Background: Geographical cohorting in hospital settings represents a significant shift from traditional patient rounding practices and aims to enhance the efficiency of health care delivery. This model assigns hospitalists to a particular inpatient unit, where most of their patients are located. While this model has several benefits, including streamlining health care procedures, optimizing resource allocation, and fostering better provider communication, its implementation is not without its challenges.

Clinical Outcomes Among Patients Undergoing Open Abdominal or Orthopedic Surgery with Wound Closure Incorporating Triclosan-Coated Barbed Sutures: A Multi-Institutional, Retrospective Database Study.

Purpose: Determining the best suture for wound closure in high-tension areas by anatomical site and procedure type remains a challenge. This study assessed the cumulative incidence of clinical outcomes among patients undergoing procedures incorporating the STRATAFIX Symmetric PDS™ Plus Knotless Tissue Control Device (STRATAFIX Symmetric) for closure of high-tension areas, such as the abdominal fascia and hip and knee joint capsule, in the course of routine clinical practice.

Patients And Methods: Patients undergoing open abdominal or orthopedic surgery between October 1, 2016, and October 31, 2023, using size 0 or 1 STRATAFIX Symmetric were identified from the Premier Healthcare Database.

Unlocking the potential of ecofriendly guardians for biological control of plant diseases, crop protection and production in sustainable agriculture.

Several beneficial microbial strains inhibit the growth of different phytopathogens and commercialized worldwide as biocontrol agents (BCAs) for plant disease management. These BCAs employ different strategies for growth inhibition of pathogens, which includes production of antibiotics, siderophores, lytic enzymes, bacteriocins, hydrogen cyanide, volatile organic compounds, biosurfactants and induction of systemic resistance. The efficacy of antagonistic strains could be further improved through genetic engineering for better disease suppression in sustainable farming practices.

Beyond the genome: unveiling tissue-specific non-coding RNAs in clove ().

Clove (), valued for its role in food preservation and medicine, has recently drawn research interest for its noncoding RNAs (ncRNAs). This study discovers 3274 long noncoding RNAs (lncRNAs) and 2404 circular RNAs (circRNAs) from publicly available RNAseq data. We identified the regulation of 834 genes through miRNA-lncRNA-mRNA network interactions.

Crystal structure, Hirshfeld surface, DFT, mol-ecular docking of 1-[(6--butyl-2-oxo-2-chromen-4-yl)meth-yl]-4,4-di-methyl-piperidine-2,6-dione and cytotoxic effects on breast cancer (MDA-MB 231), human alveolar basal epithelial (A549) cell lines.

The title compound, CHNO, was synthesized by S2 reaction of bromo-methyl coumarin with 4,4-di-methyl-piperidine-2,6-dione. The mol-ecule crystalizes in the monoclinic system with space group 2/. The coumarin unit is almost planar with a dihedral angle between the aromatic rings of 0.

Synthesis, crystal structure, Hirshfeld surface analysis, density function theory calculations and photophysical properties of methyl 4'-[(4-bromobenzo-yl)-oxy]biphenyl-4-carboxyl-ate: a compound with bromine⋯oxygen contacts.

In the mol-ecular title compound, CHBrO, the dihedral angles between the aromatic bromo-benzene ring and the immediate neighbors (first and second aromatic ring of the biphenyl moiety) are 56.57 (2) and 50.91 (4)°.

Crystal structure and Hirshfeld-surface analysis of the pesticide etoxazole.

Etoxazole (CHFNO), systematic name 4-(4--butyl-2-eth-oxy-phen-yl)-2-(2,6-di-fluoro-phen-yl)-4,5-di-hydro-1,3-oxazole, is a fluorinated insecticide and acaricide that inhibits chitin biosynthesis, disrupting insect development by preventing proper exoskeleton formation. Widely used in agriculture since 1998, it is readily absorbed by plant tissues and translocates within leaves. Metabolic studies have identified several oxidative degradation products, while toxicol-ogical assessments have examined potential effects, including oxidative stress.