Investigation on the Heating Effects of Intra-Tumoral Injectable Magnetic hydrogels (IT-MG) for Cancer Hyperthermia.

Capacitive-based radiofrequency (Rf) radiation at 27 MHz offers a non-invasive approach for inducing hyperthermia, making it a promising technique for thermal cancer therapy applications. To achieve focused and site-specific hyperthermia, external material is required that efficiently convert Rf radiation into localized heat. Nanomaterials capable of absorbing Rf energy and convert into heat for targeted ablation are of critical importance.

Analysis of a class of two-delay fractional differential equation.

The differential equations involving two discrete delays are helpful in modeling two different processes in one model. We provide the stability and bifurcation analysis in the fractional order delay differential equation Dαx(t)=ax(t)+bx(t-τ)-bx(t-2τ) in the ab-plane. Various regions of stability include stable, unstable, single stable region (SSR), and stability switch (SS).

Tipping events in a fear-affected symbiotic ecological system with adaptive hunting strategy.

Experimental observations and field data demonstrated that predators adapt their hunting strategies in response to prey abundance. While previous studies explored the impact of predation risk on predator-prey interactions, the impact of symbiotic relationships between fear-affected prey and non-prey species on system dynamics remains unexplored. This study uses a mathematical approach to investigate how different symbiotic relationships govern system dynamics when predators adapt to prey availability.

Controlling spiral wave dynamics of the BZ system in a modified Oregonator model: From suppression to turbulence.

Spirals are a special class of excitable waves that have its significance in the understanding of cardiac arrests and neuronal transduction. In a theoretical model of the chemical Belousov-Zhabotinsky reaction system, we explore the dynamics of the spatiotemporal patterns that emerge out of competing reaction and diffusion phenomena. By modifying the existing mathematical models of the reaction kinetics, we have been able to explore the explicit effect of hydrogen ion concentration in the system, so as to achieve various regimes of wave activity, from stable spirals to oscillation death.

Preliminary study on the ejection of microplastics from different types of face masks.

Face masks are strongly believed to be the best precaution to reduce the transmission of the SARS-CoV-2 virus, which resulted in an unprecedented surge in the production and use of personal respiratory protective equipment. Unfortunately, this surge led to improper disposal of used masks. This study aimed to assess the occurrence of microplastics (MPs) in used and unused surgical and cloth masks and N95 respirators.

Empowering canine genomics: Design and validation of a High-Density SNP array for Indian dogs.

India harbours a substantial population of 9.43 million dogs, showcasing diverse phenotypes and utility. Initiatives focusing on awareness, conservation and informed breeding can greatly enhance the recognition and welfare of the unique Indian canine heritage.

Mechanistic Cooperation of the Two Pore-Forming Transmembrane Motifs Regulates the β-Barrel Pore Formation by Listeriolysin O.

Listeriolysin O (LLO) is a potent membrane-damaging pore-forming toxin (PFT) secreted by the bacterial pathogen . LLO belongs to the family of cholesterol-dependent cytolysins (CDCs), which specifically target cholesterol-containing cell membranes to form oligomeric pores and induce membrane damage. CDCs, including LLO, harbor designated pore-forming motifs.

Cyanobacterial phycoremediation: a sustainable approach to dairy wastewater management.

The dairy industry is a significant sector within the food industries, known for its high-water consumption and consequent generation of dairy wastewater (DWW), which is rich in pollutants like Chemical Oxygen Demand (COD) and Biological Oxygen Demand (BOD). Improper disposal of DWW poses serious environmental challenges, including eutrophication and highlighting the need for sustainable biological treatment methods. This study investigates the potential of indigenous cyanobacterial strains , , , and for the bioremediation of DWW.

Implementing psychosocial interventions for teachers' mental health: Protocol for integrating scoping review with teachers lived experiences in LMICs.

Introduction: Teachers are pivotal in shaping educational environments and student development but face significant occupational stress and high rates of mental problems. Despite the availability of various psychosocial interventions, comprehensive evidence of their effectiveness and implementation is limited for this occupational group, especially in low- and middle-income countries (LMICs). This mixed methods study aims to conduct a scoping review of characteristics, effectiveness, and implementation outcomes of psychosocial interventions for teachers' mental health and mental problems, integrating these with teachers' lived experiences to inform the implementation of mental health interventions in LMICs.

Identification of key regulators in pancreatic ductal adenocarcinoma using network theoretical approach.

Pancreatic Ductal Adenocarcinoma (PDAC) is a devastating disease with poor clinical outcomes, which is mainly because of delayed disease detection, resistance to chemotherapy, and lack of specific targeted therapies. The disease's development involves complex interactions among immunological, genetic, and environmental factors, yet its molecular mechanism remains elusive. A major challenge in understanding PDAC etiology lies in unraveling the genetic profiling that governs the PDAC network.

Low-power artificial neuron networks with enhanced synaptic functionality using dual transistor and dual memristor.

Artificial neurons with bio-inspired firing patterns have the potential to significantly improve the performance of neural network computing. The most significant component of an artificial neuron circuit is a large amount of energy consumption. Recent literature has proposed memristors as a promising option for synaptic implementation.

Enhanced Intracellular Delivery via a Titanium-Coated TiO Microstructure Device: Leveraging an Infrared Laser for Optimal Efficiency.

This study presents a novel optoporation technique using a titanium-coated TiO microstructure (TMS) device activated by an infrared diode laser for highly efficient intracellular delivery. The TMS device, fabricated with 120 nm titanium coating on a titanium dioxide (TiO) microstructure containing microneedles (height ∼2 μm and width ∼4.5 μm), demonstrates enhanced biocompatibility and thermal conductivity compared to the conventional TiO microstructure (MS).

Flexible and Durable Conducting Fabric Electrodes for Next-Generation Wearable Supercapacitors.

This study presents the fabrication of highly conducting Au fabric electrodes using a layer-by-layer (LBL) approach and its application toward energy storage. Through the ligand-exchange mechanism, the alternating layers of tris(2-aminoethyl)amine (TREN) and gold nanoparticles (Au NPs) encapsulated with tetraoctylammonium bromide (TOABr) ligands (Au-TOABr) were deposited onto the fabric to achieve a highly conducting Au fabric (0.12 Ω/□) at room temperature in just two LBL cycles.

Ion-Ion Structural Correlation and Dynamics of Water in Aqueous NaCl Solutions with a Wide Range of Concentrations.

The behavior of water in concentrated ionic solutions, including supersaturated conditions, is crucial for numerous material and energy conversion processes and fundamental research. All electrolytes whether they "structure-make" or "structure-break" the water structure lead to slower water motion. This study investigates the structure and dynamics of aqueous NaCl solutions across a wide range of concentrations.

Isopropylmalate synthase regulatory domain removal abolishes feedback regulation at the expense of leucine homeostasis in plants.

In the leucine (Leu) biosynthesis pathway, homeostasis is achieved through a feedback regulatory mechanism facilitated by the binding of the end-product Leu at the C-terminal regulatory domain of the first committed enzyme, isopropylmalate synthase (IPMS). In vitro studies have shown that removing the regulatory domain abolishes the feedback regulation on plant IPMS while retaining its catalytic activity. However, the physiological consequences and underlying molecular regulation on Leu flux upon removing the IPMS C-terminal domain remain to be explored in plants.

Intramolecular Redox-driven Synthesis of Mono- and Diradical Iridium(III) Complexes: Insights into Molecular and Electronic Structure, Electrochemistry, and Spin-Communication.

Two π-radical complexes containing bisazo-aromatic-centered radical anion (1•-) were synthesized through in-situ electron transfer from metal-to-ligand using [IrI] and 2-(2-Pyridylazo)azobenzene (1) in inert hydrocarbon solvent. These are characterized as diradical [IrIII(1•-)2]+[2]+ and monoradical [IrIII(1•-)Cl2(PPh3)] 3. In contrast, a rare metal-mediated hydrolytic cleavage of the C(sp2)-N bond occurred in protic solvent resulting in quaternary radical complex [IrIII(1•-)(1')(PPh3)]+(4)+.

Metabolic Flexibility and Essentiality of the Tricarboxylic Acid Cycle in .

The complete tricarboxylic acid (TCA) cycle, comprising a series of 8 oxidative reactions, occurs in most eukaryotes in the mitochondria and in many prokaryotes. The net outcome of these 8 chemical reactions is the release of the reduced electron carriers NADH and FADH, water, and carbon dioxide. The parasites of the .

Stress regulatory hormones and cancer: the contribution of epinephrine and cancer therapeutic value of beta blockers.

The word "cancer" evokes myriad emotions, ranging from fear and despair to hope and determination. Cancer is aptly defined as a complex and multifaceted group of diseases that has unapologetically led to the loss of countless lives and affected innumerable families across the globe. The battle with cancer is not only a physical battle, but also an emotional, as well as a psychological skirmish for patients and for their loved ones.

Significance of gender, brain region and EEG band complexity analysis for Parkinson's disease classification using recurrence plots and machine learning algorithms.

Parkinson Disease (PD) is a complex neurological disorder attributed by loss of neurons generating dopamine in the SN per compacta. Electroencephalogram (EEG) plays an important role in diagnosing PD as it offers a non-invasive continuous assessment of the disease progression and reflects these complex patterns. This study focuses on the non-linear analysis of resting state EEG signals in PD, with a gender-specific, brain region-specific, and EEG band-specific approach, utilizing recurrence plots (RPs) and machine learning (ML) algorithms for classification.

Development and validation of recombinant A27L based indirect-ELISA for Sheeppox and Goatpox disease in India.

Sheeppox and Goatpox are highly contagious transboundary viral diseases of sheep and goats caused by Capripoxvirus, respectively. This study describes the development of indirect ELISA and its serodiagnostic potential as an alternative to the gold standard serum neutralization test (SNT). The homologue of vaccinia virus, ORF 117 (A27L) gene of the Romanian Fenner (RF) strain of Sheeppox virus (SPPV) was used for producing the full-length recombinant A27L (rA27L) protein (∼22 kDa) in a prokaryotic expression system.

Solvent influence on the optical absorption, frontier molecular orbitals, and electronic structure of 1-bromo adamantane.

Context: The study of the influence of solvent on 1-bromo adamantane (BAD) exposes prominent solvatochromatic shifts in the optical absorbance and substantial solvent effects on the electronic structure. This facilitates the molecular probe abilities for the BAD with respect to the surrounding environments such as dielectric constant and polarity. BAD exhibits positive solvatochromism for nonpolar solvents and negative solvatochromatic shifts for polar and aromatic solvents.

Phytoplankton-environment dynamics in a tropical estuary of the northeastern Arabian Sea: a Generalized Additive Model (GAM) approach.

Phytoplankton are diverse photosynthetic organisms in estuarine ecosystems and sensitive indicators of environmental changes. This study employed Generalized Additive Model (GAM) to explore the impact of environmental variables on the abundance of six dominant phytoplankton species in the tropical Karanja estuary, India. Data were collected from five sampling stations between January 2022 and March 2023.

Thick skin and thicker arteries: case report on a rare cause of hypertension.

Renovascular hypertension is the second leading cause of hypertension. Twenty-seven genes have been attributed to monogenic renovascular hypertension at present. We present a 15-year-old boy with facial dysmorphism, thick skin and renovascular hypertension with a novel gain-of-function variant in SMAD4 gene suggesting Myhre syndrome.

Unveiling the therapeutic journey of snail mucus in diabetic wound care.

A diabetic wound (DW) is an alteration in the highly orchestrated physiological sequence of wound healing especially, the inflammatory phase. These alterations result in the generation of oxidative stress and inflammation at the injury site. This further leads to the impairment in the angiogenesis, extracellular matrix, collagen deposition, and re-epithelialization.