Isolated fallopian tube torsion with hydrosalpinx in a 14 year old girl: A case report.

Introduction: Isolated fallopian tube torsion (IFTT) is an exceedingly rare but serious cause of acute abdominal pain, especially in pediatric patients, with a reported prevalence of 1 in 1.5 million women. It occurs when the fallopian tube twists around its own axis, leading to venous and lymphatic obstruction, ischemia, and potential necrosis, without involving the ipsilateral ovary.

Beyond arrhythmias in the ECG: Is there any correlation between QT interval and stroke subtype and severity?

Background: The QT interval in ECG is susceptible to autonomic fluctuations, a known occurrence in acute ischemic stroke (AIS). Previous research has highlighted QT interval changes between ischemic and haemorrhagic strokes. However, there is scarce literature on the differential effect of AIS subtypes on QT interval.

A pyrene-based fluorescent sensor for the discrimination and estimation of hydrazine and hydrogen sulfide and its application in assessing food spoilage.

Hydrazine (NH) and hydrogen sulfide (HS) are environmental contaminants that adversely affect human health. Fluorescence-based detection methods for these analytes utilize their nucleophilicity and reducing ability. Therefore, fluorescent sensors capable of detecting and distinguishing hydrazine and HS are highly beneficial.

Linear-no-threshold concept for evaluating arsenic toxicity in rice grains.

Arsenic (As) is a potent carcinogen that enters the human food chain mainly through rice, which is one of the staple food crops worldwide. During February 2022, a market survey was conducted and 500 samples of rice grains were collected across 41 different locations in Mumbai/Navi-Mumbai. On the basis of grain As-accumulation, samples were grouped into three categories including low- (0-30 ng g DW), medium- (31-70 ng g DW) or high- (>71 ng g DW).

Impact of seasonal anoxic events on phytoplankton dynamics over the Western Indian shelf: An intra- and inter-annual study.

Coastal deoxygenation impacts phytoplankton communities crucial for marine productivity. The inter- and intra-annual variability in phytoplankton communities at a shallow (27 m) station over the Western Indian Shelf (CaTS site, off Goa) during deoxygenation events of the late southwest monsoon (LSWM September-October) were studied from 2020 to 2023. The water column (0-27 m depth) experienced seasonal hypoxia/anoxia at subsurface depths (0-1.

In Silico design and molecular dynamics analysis of imidazole derivatives as selective cyclooxygenase-2 inhibitors.

Cyclooxygenase-2 (COX-2), a key enzyme in the inflammatory pathway, is the target for various nonsteroidal anti-inflammatory drugs (NSAIDs) and selective inhibitors known as coxibs. This study focuses on the development of novel imidazole derivatives as COX-2 inhibitors, utilizing a Structure-Activity Relationship (SAR) approach to enhance binding affinity and selectivity. Molecular docking was performed using Autodock Vina, revealing binding energies of -6.

Estimating the ovarian cancer CA-125 preclinical detectable phase, in-vivo tumour doubling time, and window for detection in early stage: an exploratory analysis of UKCTOCS.

Background: The ovarian cancer (OC) preclinical detectable phase (PCDP), defined as the interval during which cancer is detectable prior to clinical diagnosis, remains poorly characterised. We report exploratory analyses from the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS).

Methods: In UKCTOCS between Apr-2001 and Sep-2005, 101,314 postmenopausal women were randomised to no screening (NS) and 50,625 to annual multimodal screening (MMS) (until Dec-2011) using serum CA-125 interpreted by the Risk of Ovarian Cancer Algorithm (ROCA).

Distribution of organic matter and diatom frustules (diversity, flux) along the western Indian continental shelf related to contrasting physicochemical settings.

The western Indian continental shelf (eastern Arabian Sea) exhibits contrasting biogeochemical features. This area becomes highly productive due to summer monsoon-driven coastal upwelling in the south and winter monsoon-induced convective mixing in the north. Additionally, in the northern self, the eastern boundary of the Oxygen Minimum Zone (OMZ) persists but is absent in the south.

Strain engineering tuned vibrational dynamics of 2D transition metal dichalcogenide heterostructures: A first-principles investigation.

Controlling vibrational modes and energy gap by creating van der Waals (vdW) heterostructures through strain engineering is a novel approach to tailor the vibrational and electronic properties of two-dimensional (2D) materials. Numerous theoretical and experimental studies have significantly contributed to analysing the properties of transition metal dichalcogenides (TMDs), known for their multifunctional applications. In this study, we investigate the strain and stacking dependent vibrational properties of WSe2/MoSe2 and MoSe2/WSe2/MoSe2 vdW heterostructures using first-principles based density functional theory calculations.

Design and synthesis of a carbohydrate-derived chemosensor for selective Ni(II) ion detection: A turn-off approach.

Nickel, an essential transition metal, plays a vital role in biological systems and industries. However, exposure to nickel can cause severe health issues, such as asthma, dermatitis, pneumonitis, neurological disorders, and cancers of the nasal cavity and lungs. Due to nickel's toxicity and extensive industrial use, efficient sensors for detecting Ni ions in environmental and biological contexts are essential.

Evolving glacier patterns in the Chenab River Basin (1993-2021): Drivers and environmental implications.

Glaciers of Jammu and Kashmir are retreating faster than those in the broader northwestern Himalayas, yet some glaciers in the Chenab River basin display signs of periodic advancement and mass gain (2005-2007). These features, such as coalescing lobate structures and blocked meltwater streams, raise intriguing questions about localized glacier dynamics. While global concerns over climate change and glacier retreat persist, the lack of detailed evidence regarding glacier advance in this region warrants further investigation.

Novel therapeutic approaches targeting cancer stem cells: Unveiling new frontiers in breast cancer treatment.

Breast cancer remains the leading cause of mortality among women with cancer. This article delves into the intricate relationship between breast cancer and cancer stem cells (CSCs), emphasizing advanced methods for their identification and isolation. The key isolation techniques, such as the mammosphere formation assay, surface marker identification, Side Population assay, and Aldehyde Dehydrogenase assay, are critically examined.

An Explorative Study on Knowledge, Attitudes, and Coronavirus Disease 2019 Vaccine Intention among Parents in India.

India's National COVID Vaccination Program recommended vaccination of children ages 6-12 years in April 2022. This study assessed vaccine acceptance among mothers to better understand potential barriers and facilitators of national acceptance of pediatric coronavirus disease 2019 (COVID-19) vaccination. Qualitative data were collected through three focus group discussions (FGDs) with mothers who had children younger than 12 years of age; FGD-1 was composed of mothers who worked at a tertiary medical center in India, whereas FGD-2 and FGD-3 were composed of mothers who sought care at urban and rural community health centers.

Clinical and Microbiological Profile of Melioidosis in a Tertiary Care Hospital in Kerala, India.

Melioidosis is a neglected tropical infection caused by the Gram-negative bacterium Burkholderia pseudomallei, which is found in soil and water across tropical countries. The infection spectrum ranges from mild localized lesions to severe sepsis. The clinical presentation, severity, and outcome are influenced by the route of infection, bacterial load, strain virulence, and specific virulence genes of B.

Susceptibility of temephos against Aedes aegypti and Anopheles stephensi mosquito larvae in Dehradun of Uttarakhand, India.

Background Objectives: Temephos is being used regularly to control immature of vector borne diseases in various states in India.

Methods: World Health Organization method was used to evaluate larval susceptibility status of Aedes aegypti and Anopheles stephensi against temephos in Dehradun of Uttarakhand.

Results: The results of the study revealed that the larval mortality in different localities ranged from 67.

Predictors of severity factors associated with severe scrub typhus among children in a Tertiary Care Hospital.

Background Objectives: Scrub typhus is an acute febrile zoonotic disease caused by the obligate intracellular gram-negative bacteria Orientia tsutsugamushi. Growing data over the last few years on the Indian subcontinent suggest that it is one of the most widespread but under-reported diseases. The study aimed to document the clinical and paraclinical profile and evaluate complications of scrub typhus in severe and nonsevere pediatric age groups.

Antiseizure Medications in Poststroke Seizures: A Systematic Review and Network Meta-Analysis.

Background And Objectives: The most effective antiseizure medications (ASMs) for poststroke seizures (PSSs) remain unclear. We aimed to determine outcomes associated with ASMs in people with PSS.

Methods: We systematically searched electronic databases for studies on patients with PSS on ASMs.

Design and Synthesis of Topoisomerases-Histone Deacetylase Dual Targeted Quinoline-Bridged Hydroxamates as Anticancer Agents.

The multifactorial nature of cancer requires treatment that involves simultaneous targeting of associated overexpressed proteins and cell signaling pathways, possibly leading to synergistic effects. Herein, we present a systematic study that involves the simultaneous inhibition of human topoisomerases (hTopos) and histone deacetylases (HDACs) by multitargeted quinoline-bridged hydroxamic acid derivatives. These compounds were rationally designed considering pharmacophoric features and catalytic sites of the cross-talk proteins, synthesized, and assessed for their anticancer potential.

Unveiling Intramolecular [3+2] Cycloaddition Reactions Leading to Functionalized Heterocycles in the Light of Molecular Electron Density Theory.

The relative reactivity and cis/trans selectivity of the intramolecular [3+2] cycloaddition (IM32CA) reactions of nitrile oxide (NO), azide (AZ), nitrile sulfide (NS) and nitrile ylide (NY), leading to functionalized heterocycles are studied within the Molecular Electron Density Theory. The kinetically controlled IM32CA reactions are predicted to be cis stereospecific, while the reaction feasibility follows the order NY > NS > NO > AZ with the respective activation Gibbs free energies of 13.7, 17.

Nutritional assessment of adolescents: A cross-sectional study from public schools of North India.

Background: Technological advancements and globalization have shifted dietary behaviours, contributing to increased chronic disease prevalence in Low- and Middle-Income Countries (LMICs) like India. Adolescents are particularly vulnerable due to these changes, which can impact their lifelong health. This study aimed to assess the nutritional status of adolescents in public schools in Chandigarh, India.

Integrating intuitionistic fuzzy and MCDM methods for sustainable energy management in smart factories.

Improving energy efficiency is crucial for smart factories that want to meet sustainability goals and operational excellence. This study introduces a novel decision-making framework to optimize energy efficiency in smart manufacturing environments, integrating Intuitionistic Fuzzy Sets (IFS) with Multi-Criteria Decision-Making (MCDM) techniques. The proposed approach addresses key challenges, including reducing carbon footprints, managing operating costs, and adhering to stringent environmental standards.

Analysis of RL electric circuits modeled by fractional Riccati IVP via Jacobi-Broyden Newton algorithm.

This paper focuses on modeling Resistor-Inductor (RL) electric circuits using a fractional Riccati initial value problem (IVP) framework. Conventional models frequently neglect the complex dynamics and memory effects intrinsic to actual RL circuits. This study aims to develop a more precise representation using a fractional-order Riccati model.

Dynamic electroosmotic flow and solute dispersion through a nanochannel filled with an electrolyte surrounded by a layer of a dielectric and immiscible liquid.

The present article deals with the modulation of oscillatory electroosmotic flow (EOF) and solute dispersion across a nanochannel filled with an electrolyte solution surrounded by a layer of a dielectric liquid. The dielectric permittivity of the liquid layer adjacent to supporting rigid walls is taken to be lower than that of the electrolyte solution. Besides, the aforesaid liquid layer may bear additional mobile charges, , free lipid molecules, charged surfactant molecules , which in turn lead to a nonzero charge along the liquid-liquid interface.

Oxygen-Passivated Sulfur Vacancies in Monolayer MoS for Enhanced Piezoelectricity.

Modern-day applications demand onboard electricity generation that can be achieved using piezoelectric phenomena. Reducing the dimensionality of materials is a pathway to enhancing the piezoelectric properties. Transition-metal dichalcogenides have been shown to exhibit high piezoelectricity.