Effectiveness of Remote Patient Monitoring Equipped With an Early Warning System in Tertiary Care Hospital Wards: Retrospective Cohort Study.

Background: Monitoring vital signs in hospitalized patients is crucial for evaluating their clinical condition. While early warning scores like the modified early warning score (MEWS) are typically calculated 3 to 4 times daily through spot checks, they might not promptly identify early deterioration. Leveraging technologies that provide continuous monitoring of vital signs, combined with an early warning system, has the potential to identify clinical deterioration sooner.

Aqueous Angiography Guided Bent Ab Interno Needle Goniectomy in High versus Low Aqueous Humor Outflow Regions in POAG: A Pilot RCT.

Prcis: Trabecular cutting minimally invasive glaucoma surgery like bent ab interno needle goniectomy (BANG) when performed in baseline aqueous angiography identified low aqueous humor outflow regions, results in greater success of intraocular pressure reduction.

Purpose: To study the efficacy of Bent Ab Interno Needle Goniectomy (BANG) in high versus low aqueous humor outflow (AHO) regions as determined by Aqueous Angiography(AA) in patients with primary open angle glaucoma (POAG).

Methods: A prospective, single-centre, pilot, randomized control trial recruited 30 eyes of 30 patients of POAG and visually significant cataract (45-80 y) and were randomised into two groups ("A": BANG performed in the high-flow regions and "B": BANG performed in the low-flow regions) of 15 each.

Enantiospecific Synthesis of Tetrahydroindolizines from Spiro-cyclopropanecarboxylated Sugars.

A facile two-step enantiospecific synthesis of 5,6,7,8-tetrahydroindolizine scaffolds has been developed via TMSOTf-promoted [3 + 2] cycloaddition between carbohydrate-derived spirocyclic donor-acceptor cyclopropanecarboxlates and alkyl/aryl nitriles followed by an intramolecular Mitsunobu reaction of the resulting chiral 2/5-(4-hydroxybutyl)pyrrole derivatives.

A combination regimen of Intravitreal clindamycin with dexamethasone, systemic co-trimoxazole and steroids for macular Toxoplasma retinochoroiditis in immunocompetent cases.

Purpose: To study the role of intravitreal clindamycin with dexamethasone as an adjuvant to systemic co-trimoxazole and steroids in macular Toxoplasma retinochoroiditis.

Methods: Retrospective study of Toxoplasma retinochoroiditis cases from January 2014 to December 2021 treated with a combination of oral and intravitreal therapy in immunocompetent patients.

Results: 39 eyes of 39 patients were included in this study after meeting the inclusion criteria with the mean age of presentation being 25.

Rational Design of Porous Organic Framework (POF) for Efficient Conversion of CO2 to Cyclic Carbonates and 2-Oxazolidinones at Atmospheric Pressure Conditions.

Carbon dioxide (CO2) capture and its subsequent catalytic fixation into usable compounds represent a potential approach for addressing the energy problem and the implications of global warming. Hence, it is necessary to develop effective catalytic systems required for the transformation of CO2 into valuable chemicals/fuels. Herein, we rationally designed a hydroxyl-functionalized porous organic framework (OH-POF) consisting of both acidic (OH) as well as basic N sites for the transformation of CO2 using epoxides for the production of cyclic carbonates (CCs), a useful commodity chemical under environmental-friendly, metal/solvent/co-catalyst-free conditions.

Energy-exergy and environ-economic (4E) analysis of heat storage-based single-slope solar stills integrated with solar air heater.

The energy-exergy and environ-economic (4E) analysis was conducted on a solar still with and without a hybrid thermal energy storage system (TESS) and a solar air heater. The proposed solar still was modified by integrating a rectangular aluminium box filled with paraffin wax and black gravel as the TESS and coupled with a solar air heater. Paraffin wax was selected due to its widespread availability and proven effectiveness in accelerating desalination, improving process uniformity, and maintaining optimal temperature levels.

Tuning the electronic structure and SMSI by integrating trimetallic sites with defective ceria for the CO reduction reaction.

Heterogeneous catalysts have emerged as a potential key for closing the carbon cycle by converting carbon dioxide (CO) into value-added chemicals. In this work, we report a highly active and stable ceria (CeO)-based electronically tuned trimetallic catalyst for CO to CO conversion. A unique distribution of electron density between the defective ceria support and the trimetallic nanoparticles (of Ni, Cu, Zn) was established by creating the strong metal support interaction (SMSI) between them.

Identification of novel cyclin-dependent kinase 4/6 inhibitors from marine natural products.

Cyclin-dependent kinases 4 and 6 (CDK4/6) are crucial regulators of cell cycle progression and represent important therapeutic targets in breast cancer. This study employs a comprehensive computational approach to identify novel CDK4/6 inhibitors from marine natural products. We utilized structure-based virtual screening of the CMNPD database and MNP library, followed by rigorous filtering based on drug-likeness criteria, PAINS filter, ADME properties, and toxicity profiles.

Gene expression analysis reveals mir-29 as a linker regulatory molecule among rheumatoid arthritis, inflammatory bowel disease, and dementia: Insights from systems biology approach.

Background: Rheumatoid arthritis (RA) is a degenerative autoimmune disease, often managed through symptomatic treatment. The co-occurrence of the reported extra-articular comorbidities such as inflammatory bowel disease (IBD), and dementia may complicate the pathology of the disease as well as the treatment strategies. Therefore, in our study, we aim to elucidate the key genes, and regulatory elements implicated in the progression and association of these diseases, thereby highlighting the linked potential therapeutic targets.

An ensemble deep learning framework for energy demand forecasting using genetic algorithm-based feature selection.

Accurate energy demand forecasting is critical for efficient energy management and planning. Recent advancements in computing power and the availability of large datasets have fueled the development of machine learning models. However, selecting the most appropriate features to enhance prediction accuracy and robustness remains a key challenge.

Personalized recommendation system to handle skin cancer at early stage based on hybrid model.

Skin cancer is one of the most prevalent and harmful forms of cancer, with early detection being crucial for successful treatment outcomes. However, current skin cancer detection methods often suffer from limitations such as reliance on manual inspection by clinicians, inconsistency in diagnostic accuracy, and a lack of personalized recommendations based on patient-specific data. In our work, we presented a Personalized Recommendation System to handle Skin Cancer at an early stage based on Hybrid Model (PRSSCHM).

Rational design and synthesis of atomically precise nanocluster-based nanocomposites: a step towards environmental catalysis.

Atomically precise metal nanoclusters (NCs) and metal-organic frameworks (MOFs) possess distinct properties that can present challenges in certain applications. However, integrating these materials to create new composite functional materials has gained significant interest due to their unique characteristics through a range of applications, particularly in catalysis. Considering MOFs as hosts and NCs as guests, several synergistic effects have been observed in composites, particularly in environmental catalytic reactions.

Can conformational flexibility influence the self-assembly behavior and sensing efficacy of fluorogenic amphiphiles? A case study with bisbenzimidazole-based probes.

In this work, we have explored the metal ion sensing properties of two bisbenzimidazole-based fluorescent probes, that differ in their conformational flexibility, in an aqueous medium. The compound with a flexible methyl spacer (1) experienced blue shifts in its absorption and emission maxima (along with a turn-off response) upon the addition of Hg ions. On the contrary, the compound with a relatively rigid structure (2) showed red shifts in both its absorption and emission maxima (along with a turn-off response) when treated with Hg under similar conditions.

Safety and Efficacy of Tranexamic Acid in General Surgery.

Importance: Perioperative bleeding is common in general surgery. The POISE-3 (Perioperative Ischemic Evaluation-3) trial demonstrated efficacy of prophylactic tranexamic acid (TXA) compared with placebo in preventing major bleeding without increasing vascular outcomes in noncardiac surgery.

Objective: To determine the safety and efficacy of prophylactic TXA, specifically in general surgery.

Novel pain assessment tool specific for pulp symptoms to aid diagnosis.

Aim: Although many pain assessment tools exist, none are specific to the relatively unique presentation of pulpal pain. The aim of this study was to develop and validate a novel pain assessment tool based on pulp symptoms.

Methodology: A preliminary list of items best-describing pulpitis was developed based on deductive and inductive approaches and the preliminary tool was piloted (n = 80).

KMT2C Polymorphism in Familial Hypospadias.

Hypospadias, a common congenital anomaly of male genitalia, shows significant heritability and familial recurrence, particularly in consanguineous families. This study explored the role of KMT2C polymorphisms in a Yemeni family with two affected siblings. Comprehensive analysis identified 475 unique SNPs in KMT2C, with 59 shared between parents, suggesting common ancestry.

Dosimetric impact of arc simulation angular resolution in single-isocentre multi-target stereotactic radiosurgery.

This study evaluates the dosimetric impact of arc simulation angular resolution in VMAT-based Single Isocentre Multiple Target (SIMT) SRS, focusing on their dependence on target size, isocentre distance, number of arcs, and arc type. A phantom study analysed angular resolution (0.5°, 1°, 2°) effects on dosimetric accuracy for PTVs of 0.

Discovery of novel 'sugarcane totivirus 1' from Saccharum officinarum by high-throughput sequencing.

Background: Sugarcane is cultivated globally and affected by more than 125 pathogens, which lead to various plant diseases. In recent years, high-throughput sequencing (HTS)-based genome analyses have been broadly adopted for the discovery of both characterized and un-characterized viruses from plant samples. In this study, the HTS data of sugarcane pooled sample retrieved from sequence read archive (SRA) were de novo re-assembled using CLC Genomic Workbench.

Role of Acorus calamus extract in reducing exosome secretion by targeting Rab27a and nSMase2: a therapeutic approach for breast cancer.

Background: Exosomes are extracellular vesicles released by cells that mediate intercellular communication and actively participate in cancer progression, metastasis, and regulation of immune response within the tumour microenvironment. Inhibiting exosome release from cancer cells could be employed as a therapeutic against cancer.

Methods And Results: In the present study, we have studied the effects of Acorus calamus in inhibiting exosome secretion via targetting Rab27a and neutral sphingomyelinase 2 (nSMase2) in HER2-positive (MDA-MB-453), hormone receptor-positive (MCF-7) and triple-negative breast cancer (MDA-MB-231) cells.

Sustainable remediation of abandoned coal mines using vermicompost: a case study in Ledo coal mine, India.

Coal mining in India, especially open-cast mining, substantially strengthens the economy while concurrently causing environmental deterioration, such as soil pollution with toxic chemicals and heavy metals. This study sought to examine the efficacy of vermicompost as a remediation technique for Mine Tailing Soil (MTS) in the Ledo Coal Fields. During a 120-day duration, different concentrations of vermicompost (20%, 30%, and 40%) were administered to MTS, and the impacts on soil physicochemical parameters, fertility, and plant growth were evaluated.