Interplay of canonical and LIMK mediated non-canonical BMP signaling is essential for regulating differential thickness and invagination during chick forebrain roof plate morphogenesis.

Telencephalic hemisphere formation is a complex and precisely timed process, which begins in the chick forebrain with an invagination in the middle of the roof plate. However, the factor(s) that determine the position/site of invagination in the roof plate remain to be elucidated. In this study, we have demonstrated that as development proceeds, a region of lower thickness appears in the middle of the roof plate, which marks the position where the invagination begins.

Estimating the epidemiological and economic impact of providing nutritional care for tuberculosis-affected households across India: a modelling study.

Background: Approximately 20% of global tuberculosis incidence is attributable to undernutrition, increasing to more than a third in India. Targeting nutritional interventions to tuberculosis-affected households is a policy priority, but understanding of epidemiological and economic impacts is limited. We aimed to estimate the population-level epidemiological and economic effect of such an intervention.

Aspirin after completion of standard adjuvant therapy for colorectal cancer (ASCOLT): an international, multicentre, phase 3, randomised, double-blind, placebo-controlled trial.

Background: Aspirin is a simple, globally available medication that has been shown to reduce the incidence of colorectal cancer. We aimed to evaluate the safety and efficacy of aspirin in the secondary prevention of colorectal cancer.

Methods: This phase 3, randomised, double-blind, placebo-controlled trial was conducted at 66 centres across 11 countries and territories (ten in Asia-Pacific; one in the Middle East).

Synergistic suppression of cell growth: Phenmiazine derivatives targeting p53 and MDM2 unveiled through hybrid computational method.

Lung cancer is the leading cause of mortality in both men and women due to genetic and epigenetic modifications. Our study focuses on fabricating phenmiazine ring leads by a functional group-based drug design to inhibit p53 -7A1W and MDM2-7AU9 proteins responsible for cancer cell growth. One hundred molecules are designed and allowed to bind inside the active site of 7A1W and 7AU9 protein using a glide dock platform and subjected to find MMGBSA.

Ligand-based cheminformatics and free energy-inspired molecular simulations for prioritizing and optimizing G-protein coupled receptor kinase-6 (GRK6) inhibitors in multiple myeloma treatment.

Multiple myeloma (MM) is the second most frequently diagnosed hematological malignancy, presenting limited treatment options with no curative potential and significant drug resistance. Recent studies involving genetic knockdown established the crucial role of GRK6 in upholding the viability of MM cells, emphasizing the need to identify potential inhibitors. Computational exploration of GRK6 inhibitors has not been attempted previously.

Evaluating the effects of zinc oxide nanoparticles on a sentinel aquatic invertebrate species: Transcriptomic analysis and potential implications for ecosystem health.

The widespread use of zinc oxide nanoparticles (ZnO NPs) in various products raises significant ecological concerns due to their potential toxic effects in aquatic environments. This study employed the Asian green mussel (Perna viridis) as a model to explore the molecular and ecological risks of ZnO NP exposure using transcriptomics. Mussels exposed to ZnO NPs (5, 10, and 15 mg/L) for 28 days showed significant gene expression changes in gill tissues, affecting immune response, calcium homeostasis, and cellular stress.

Accumulation of microplastics in relation to the sediment grain size distribution in seagrass meadows in the coastal areas of Tuticorin, southeast coast of India.

This research investigated the relationship between microplastic accumulation and the sediment texture in seagrass meadows across the selected coastal regions of Tuticorin. Sixteen sediment samples were collected by SCUBA divers utilizing a stainless steel grab sampler. Findings indicate significantly elevated microplastic concentrations in seagrass sediments when compared to unvegetated areas.

Role of riverbed sand mining on planform and cross-sectional morphology of Mayurakshi River, India.

Human interventions in the form of riverbed sand mining are escalating worldwide, especially in the humid tropics with excess population pressure exerting an elevated demand for sand as construction materials. Naturally, channel morphological alterations are observed for the tropical fluvial systems to a large extent. The present work examines the riverbed sand mining of the Mayurakshi River (India) during the last fifty years (1970-2020) using topographical maps, satellite images and field-based cross-sectional measurements.

Climate change and food security nexus in Ghana: The role of renewable energy.

Climate change is aggravating hunger, which is miserable in Sub-Saharan African nations like Ghana. Yet evidence of the effect of climatic variables on hunger, particularly multidimensional food security, is less illuminated in Ghana. Moreover, the decoupling effect of renewable energy on emissions and food security is rare in the Ghanaian context.

Delineating the emergence of thermally tolerant Symbiodiniaceae genotypes across the dominant coral species of a turbid reef: Adaptation and resilience strategy.

Climate change-induced rise in sea surface temperatures has led to an increase in the frequency and severity of coral bleaching events, ultimately leading to the deterioration of coral reefs, globally. However, the reef-building corals have an inherent capacity to acclimatize to thermal stress on pre-exposure to high temperatures by altering their endosymbiotic Symbiodiniaceae community composition towards a thermal tolerant composition. This reorganisation may become an important tool in coral's resilience to rapid environmental change.

Anthocyanin and phenolic landscape of Syzygium cumini extracts via green extraction.

This study determined the anthocyanin and phenolic profile of Syzygium cumini bioactive compounds, including anthocyanins and other flavonoids, alongside diverse phenolic compounds. The study optimized a green extraction technique (ultrasound-assisted enzymatic extraction (UAEE)) to obtain anthocyanin-rich extract from the fruit pulp of S. cumini using the pectinase enzyme.

Nano-interface enhanced electrochemical sensing of hazardous organochlorine pesticides and prospects with ZnO based nanomaterials.

Detection and analysis of organochlorine pesticides (OCP) residue is getting significant research importance because of their extensive use despite their hazardous effects on the health of people and the ecosystem. Despite the implementation of regulations and bans to safeguard human health and the environment, reports frequently reveal the continued use of these harmful chemicals in quantities exceeding the recommended limits set by regulatory boards. Data on the use of OCP from India, the most populous country, and African countries is not very encouraging.

Investigation into the vibrational characteristics of monolayered ruddlesden-popper compounds (Sr, Ba)HfO.

The analysis of Raman and Infrared (IR) phonons in monolayered tetragonal (Sr, Ba)HfO compounds, which exhibit D symmetry and belong to the I4/mmm phase of space group 139 with Z = 2, has been conducted using normal coordinates. The SrHfO and BaHfO compounds are the first members of the Ruddlesden-Popper (RP) series denoted as (Sr, Ba)HfO with n = 1. Nine Short-Range Force Constants (SRFC) have been included in theoretical calculations to analyze the optical phonons of SrHfO and BaHfO compounds within the I4/mmm phase.

Angular dependence of random laser emission by using ZnO-CuO heterostructure as scatterer and its applications in biocompatible imaging.

The angular dependence of random laser (RL) generation in a commercially available rhodamine 6G (Rh6G) dye has been demonstrated using ZnO-CuO heterostructure as passive scatterers. The grass-like superstructure formed at a 1M:1M molar ratio of ZnO-CuO significantly enhances scattering, resulting in RL spikes with a full width at half maximum (FWHM) of just a few nanometer and a noticeable reduction in the RL threshold. RL emission spectra were collected over an angular spread of 0-180 degrees, revealing a remarkable shift in RL emission from 566 nm to 580 nm.

Thick and Short Fetal Corpus Callosum on Ultrasound: Added Value of Fetal Magnetic Resonance Diffusion Tensor Imaging With Tractography.

Background: Thick fetal corpus callosum (CC) is a rare finding and its significance in isolation is not clear. In this retrospective study, we aim to gain insight into the microarchitecture of CC in a cohort of fetuses with thick and short CC (isolated or associated with mild extra-/intracranial abnormalities) as seen on ultrasound (US), by using prenatal magnetic resonance (MR) diffusion tensor imaging (DTI) with fiber tractography, thereby allowing better characterization for postnatal prognosis.

Methods: Twelve fetuses met the inclusion criteria on US.

MoS nanoflowers surface decorated with CuS nanorods and carbon dots for fluorescent and ultrasound imaging in cancer therapy.

In recent years, the design of various ultrasound responsive echogenic nanomaterials offers many advantages such as deep tissue penetration, high signal intensity, colloidal stability, biocompatibility and less expensive for ultrasound-based cancer cell imaging while providing the option to monitor the progress of tumor volume during the treatment. Further, the ability of nanomaterials to combine photo-thermal therapy (PTT) and chemotherapy has opened a new avenue in the development of cancer theranostics for synergistic cancer therapy. Herein, we report MoS nanoflowers (NFs) surface decorated with CuS nanorods (NRs) and folic acid-derived carbon dots (FACDs) using cystine-polyethyleneimine (PEI) linker for PTT-chemotherapy.

Strategic evaluation of European Inland transport companies for European green deal compliance: A multi-criteria decision making-analysis.

The purpose of this study is to evaluate the readiness of European inland transport companies for the European Green Deal by analyzing the causal relationships between key factors essential for EGD implementation. The research identifies six critical factors: Investment in Green Technologies, Policy Alignment and Compliance, Stakeholder Collaboration, Resource Management, Employee Training and Engagement, and Emission Reduction Initiatives. This research offers the first integrated evaluation of EGD readiness utilizing a combination of fuzzy-DEMATEL, multiple regression analysis, and Structural Equation Modeling aimed at uncovering systemic interactions among the factors in the system.

Advanced environmental remediation using enhanced performance of hollow ZnO@SnInS core-shell nanorod arrays for hazardous ion and organic pollutant removal.

Herein, novel hollow ZnO and ZnO@SnInS core-shell nanorods (NRs) with controlled shell thickness were developed via a facile synthesis approach for the efficient photocatalytic remediation of organic as well inorganic water pollutants. The introduction of SnInS shell layer coating over ZnO enhances visible light absorption, efficient exciton-mediated direct charge transfer, and reduces the band gap of ZnO@SnInS core-shell nanorods. The ZnO@SnInS core-shell nanorods show efficient solar-light driven catalytic efficiency for the disintegration of industrial dye (orange G), degradation of tetracycline, and reduction of hazardous Cr (VI) ions in aquatic systems.

Ayurvedic management of recurrent lumbar pain, disability, and leg pain after posterior decompression with transforaminal lumbar interbody fusion in prolapsed intervertebral disc: A case report.

Prolapsed intervertebral disc (PIVD) can lead to debilitating pain and functional limitations. While surgical interventions like Transforaminal Lumbar Interbody Fusion (TLIF) are often employed, recurrence of symptoms is not uncommon. This case report presents the successful Ayurvedic management of a 45-year-old female who developed recurrent lumbar radiculopathy six months after TLIF for PIVD.

Dual-targeting inhibitors involving tubulin for the treatment of cancer.

Combination therapies play a pivotal role in cancer treatment due to the intricate nature of the disease. Tubulin, a protein crucial for cellular functions, is a prime target in tumor therapy as it regulates microtubule dynamics. Combining tubulin inhibitors with other different inhibitors as dual targeting inhibitors has shown synergistic anti-tumor effects, amplifying therapeutic outcomes.

Development of a novel modified selective medium cefixime-tellurite-phosphate-xylose-rhamnose MacConkey agar for isolation of Escherichia albertii and its evaluation with food samples.

Since cefixime and tellurite are known to inhibit most bacteria belonging to Enterobacterales, we found that addition of tellurite inhibited E. albertii growth in Luria Bertani broth but not in tryptic soy broth (TSB), and addition of phosphate and soy peptone enhanced E. albertii growth in TSB in presence of tellurite.