Gold/silver-catalyzed synthesis of functionalized indoles from -allyl-2-alkynylanilines and α-diazo compounds 1,3-allyl migration.

Gold-catalyzed synthesis of decorated indoles has been developed through carbene insertion into N-H bonds of -allyl-2-(aryl/alkyl ethynyl)anilines using α-diazo compounds followed by cyclization and concomitant 1,3 migration of allyl fragments. The developed protocol tackles the inherited challenge of direct C3 functionalization and eliminates the need for a tertiary aniline precursor for the 1,3-migration reaction. The applicability of this transformation is showcased through the practical synthesis of analogs of small drug-like and pharmaceutically relevant molecules such as ibuprofen, estradiol, menthol, and borneol, The mechanism is well supported by control experiments and isolation of the reaction intermediate.

A well-defined phosphine-free metal-ligand cooperative route for -alkylation of aromatic amines activation of renewable alcohols catalyzed by NNN pincer cobalt(II) complexes.

This study presents the direct -alkylation of aromatic amines using greener primary alcohols as alkyl donors, catalyzed by base metal-derived Co(II) catalysts the borrowing hydrogen (BH) method. Two well-defined phosphine-free NNN-type pincer ligands (L1 and L2) were synthesized and utilized to prepare cobalt(II) catalysts C1 and C2. The catalysts were well characterized by UV-vis, IR, HRMS, and single-crystal X-ray diffraction studies.

Dual Functional Electroconductive Biofortified Electrospun Scaffold Functionalized With MWCNTs and Bacopa Monnieri for Accelerated Peripheral Nerve Regeneration.

Peripheral nerve injuries (PNIs) often lead to semi or complete loss of motor, sensory and autonomic functions. Although autografts are still the best option for PNI repair, their use is restricted due to the morbidity and availability of donor nerves. Because electrospun scaffolds may replicate the structure of native extracellular matrix (ECM), they provide a viable alternative.

Orchestrating Intracellular Calcium Signaling Cascades by Phosphosite-Centric Regulatory Network: A Comprehensive Analysis on Kinases CAMKK1 and CAMKK2.

Intracellular calcium signaling is a cornerstone in cell biology and a key molecular target for human health and disease. Calcium/calmodulin dependent protein kinase kinases, CAMKK1 and CAMKK2 are serine/threonine kinases that contribute to the regulation of intracellular calcium signals in response to diverse stimuli. CAMKK1 generally has stable dynamics, whereas CAMKK2 dysregulation triggers oncogenicity and neurological disorders.

Assessment of Risk of Malignancy by Application of the Proposed IAC-IARC-WHO Cytopathology System for Classification and Reporting of Soft Tissue Lesions: An Experience From Tertiary Care Center From India.

Introduction: Soft tissue lesions encompass a diverse category of diseases from benign to malignant, and their morphology might overlap; therefore, accurate categorization is needed to approach the reporting of soft tissue cytology. The cytology of these lesions is helpful in detecting the features of malignancy, which helps in guiding further management. In this study, we applied the proposed IAC-IARC-WHO cytopathology system to assess the risk of malignancy (ROM) and diagnostic accuracy (DA) for the determination of its clinical and diagnostic utility.

A multi-objective function for deep learning-based automatic energy efficiency power allocation in multicarrier noma system using hybrid heuristic improvement.

Non-Orthogonal Multiple Access (NOMA) is the successive multiple-access methodologies for modern communication devices. Energy Efficiency (EE) is suggested in the NOMA system. In dynamic network conditions, the consideration of NOMA shows high computational complexity that minimizes the EE to degrade the system performance.

MXenes and MXene-based composites for biomedical applications.

MXenes, a novel class of two-dimensional materials, have recently emerged as promising candidates for biomedical applications due to their specific structural features and exceptional physicochemical and biological properties. These materials, characterized by unique structural features and superior conductivity, have applications in tissue engineering, cancer detection and therapy, sensing, imaging, drug delivery, wound treatment, antimicrobial therapy, and medical implantation. Additionally, MXene-based composites, incorporating polymers, metals, carbon nanomaterials, and metal oxides, offer enhanced electroactive and mechanical properties, making them highly suitable for engineering electroactive organs such as the heart, skeletal muscle, and nerves.

Development of a multi-epitope vaccine candidate to combat SARS-CoV-2 and dengue virus co-infection through an immunoinformatic approach.

Background: Although the SARS-CoV-2 and dengue viruses seriously endanger human health, there is presently no vaccine that can stop a person from contracting both viruses at the same time. In this study, four antigens from SARS-CoV-2 and dengue virus were tested for immunogenicity, antigenicity, allergenicity, and toxicity and chosen to predict dominant T- and B-cell epitopes.

Methods: For designing a multi-epitope vaccine, the sequences were retrieved, and using bioinformatics and immunoinformatics, the physicochemical and immunological properties, as well as secondary structures, of the vaccine were predicted and studied.

Correction: Green synthesis of ZnO nanoparticles using for photocatalytic degradation of malachite green and reduction of 4-nitrophenol.

[This corrects the article DOI: 10.1039/D4RA08632E.].

Role of metal(ii) hexacyanocobaltate(iii) surface chemistry for prebiotic peptides synthesis.

Double metal cyanide (DMC), a heterogeneous catalyst, provides a surface for the polymerization of amino acids. Based on the hypothesis, the present study is designed to evaluate favorable environmental conditions for the chemical evolution and origin of life, such as the effects of temperature and time on the oligomerization of glycine and alanine on metal(ii) hexacyanocobaltate(iii), MHCCo. A series of MHCCo complexes were synthesized and characterized by XRD and FT-IR techniques.

Comprehensive overview of the toxicities of small-molecule cryoprotectants for carnivorous spermatozoa: foundation for computational cryobiotechnology.

Background: The specific and non-specific toxicities of cryoprotective agents (CPAs) for semen or spermatozoa cryopreservation/vitrification (SC/SV) remain challenges to the success of assisted reproductive technologies.

Objective: We searched for and integrated the physicochemical and toxicological characteristics of small-molecule CPAs as well as curated the information of all extenders reported for carnivores to provide a foundation for new research avenues and computational cryobiology.

Methods: The PubMed database was systematically searched for CPAs reported in SC/SV of carnivores from 1964 to 2024.

Enticing Dimples: A Novel Observational Study Comparing the Preexisting Landmarks for Facial Dimple Creation Using 3D-Scanned Facial Images.

 Dimpleplasty, a cosmetic procedure for creating dimples, is gaining popularity. However, the ideal site for dimple creation remains subjective. This study aimed to determine the optimal dimple placement using a three-dimensional (3D) model, reviewing panelists' preferences based on facial proportions and average ratings.

Accessory Penile Frenulum: May Go Unnoticed throughout the Journey to Graveyard.

An accessory frenulum of the penis is so rare that only four cases have been documented so far. We came across a case of 45-year-old, sexually active man who sought medical attention for right foot injury caused by a road traffic accident. During a detailed clinical evaluation, he was discovered to have double frenulum in his penis.

Lateral Calcaneal Artery Perforator/Propeller Flap in the Reconstruction of Posterior Heel Soft Tissue Defects.

 Posterior heel soft tissue defects with/without tendoachilles injury are difficult to reconstruct because of bony prominence, limited expendable local soft tissues, and significant donor site morbidity. In this study, we evaluate the lateral calcaneal artery (LCA) perforator/propeller flap for posterior heel soft tissue defect reconstruction.  A preliminary cadaveric study was done on 22 specimens to study the course of the LCA and its perforators.

Application of Combined SCIP and Free Fibula Flaps for Reconstruction of a Massive Composite Oromandibular Defect: A Pioneering Approach.

Resection of advanced oral malignancies often leads to extensive composite tissue defects, which may involve skin, oral mucosa, mandible, and a significant amount of soft tissue. While the free fibula flap remains the primary choice of reconstruction, there are instances where a second flap is necessary for coverage. In such cases, the anterolateral thigh (ALT) flap is commonly employed as a second free flap.

The "Opercular" Approach to Orbital Reconstruction after Orbital Exenteration Following Rhino-Orbital-Cerebral Mucormycosis: A Novel Method.

 Rhino-orbital cutaneous mucormycosis (ROCM) leading to orbital exenteration can be debilitating functionally as well as psychosocially. Orbital reconstruction following exenteration for mucormycosis has centered on volume filling with local, regional, or free flaps. This case series is built on the original idea of a bilayered operculum at the orbital inlet.

Bilateral Lower Limb Injuries and the Need for Two Free Flaps: Simultaneous or Sequential.

  To determine the choice of flap cover for patients presenting with bilateral lower limb trauma requiring free flap cover and to derive a step-wise guide to the planning of bilateral lower limb free flaps.  This was a retrospective study of patients over a 20 year period from 2000 to 2020 who presented with bilateral lower limb defects following trauma and were managed with two free flaps for wound cover, done either simultaneously or sequentially in the same admission.  Of the 11 cases with 22 defects, there were 3 re-explorations with 1 flap loss managed with delayed fasciocutaneous flap cover.

Delayed Maxillary Reconstruction with Free Osteocutaneous Fibula Flap Using CAD-CAM Technology.

 Maxillary reconstruction poses unique challenges for the reconstructive surgeon because of the complex three-dimensional (3D) anatomy of the maxilla. Undertaking this endeavor on secondary reconstruction makes it more difficult due to problems in recreating the true defect. This study is an attempt to demonstrate the role of virtual surgical planning (VSP), 3D printing, and mock surgery in reconstructing such defects using free fibula flaps.

Tailoring of physical properties of RF-sputtered ZnTe films: role of substrate temperature.

In this study, zinc telluride (ZnTe) films were grown on quartz substrates at room temperature, 300 °C, 400 °C, 500 °C, and 600 °C using RF sputtering. The thickness of the films has been found to decrease from 940 nm at room temperature to 200 nm at 600 °C with increasing substrate temperature. The structural investigation using grazing incidence angle X-ray diffraction revealed that films deposited at room temperature are amorphous; those deposited at other substrate temperatures are polycrystalline with a cubic zincblende structure and a preferred orientation along the [111] direction.

A global survey about undiagnosed rare diseases: perspectives, challenges, and solutions.

Background: Undiagnosed rare diseases (URDs) are a complex and multifaceted challenge, especially in low-and medium-income countries. They affect individuals with unique clinical features and lack a clear diagnostic label. Although the Undiagnosed Diseases Network International (UDNI) definition of URDs is not universally accepted, it is widely recognized.

Persistent homology for MCI classification: a comparative analysis between graph and Vietoris-Rips filtrations.

Introduction: Mild cognitive impairment (MCI), often linked to early neurodegeneration, is associated with subtle disruptions in brain connectivity. In this paper, the applicability of persistent homology, a cutting-edge topological data analysis technique is explored for classifying MCI subtypes.

Method: The study examines brain network topology derived from fMRI time series data.