Ligand-free palladium-catalyzed synthesis of 3-(2,2-dialkyl-2-chromen-4-yl)-2-phenylimidazo[1,2-]pyridine derivatives: molecular docking investigation of their potential as DNA gyrase inhibitors and evaluation of their antibacterial activities.

Palladium-catalyzed reactions between imidazo[1,2-]pyridine derivatives and 4-bromo-2,2-dialkyl-substituted 2-chromenes under microwave irradiation at 100 W, 120 °C for 20-30 min provided a series of new 3-(2,2-dialkyl-2-chromen-4-yl)-2-phenylimidazo[1,2-]pyridine derivatives in good to excellent yields. The structures of the synthesized compounds were confirmed through spectroscopic techniques (NMR and HRMS). The X-ray single-crystal structure of compound 16e was also determined.

α-ketoglutarate ameliorates colitis through modulation of inflammation, ER stress, and apoptosis.

Colitis is an inflammatory disorder of the gastrointestinal tract. A widely consumed dietary nutrient, α-ketoglutarate (α-KG) is known to play a crucial role in cellular metabolism and provide protection to intestinal epithelium under various pathophysiological conditions. In this study, 2,4,6-trinitrobenzenesulfonic acid (TNBS) was used to induce colitis in Wistar rats.

Corrigendum to "From prescription to pollution: The ecological consequences of NSAIDs in aquatic ecosystems" [Toxicol. Rep. 13 (2024) 101775].

[This corrects the article DOI: 10.1016/j.toxrep.

Exploring the composition of placental microbiome and its potential origin in preterm birth.

Introduction: For years, the placenta was believed to be sterile, but recent studies reveal it hosts a unique microbiome. Despite these findings, significant questions remain about the origins of the placental microbiome and its effects on pregnancy and fetal health. Some studies suggest it may originate from the vaginal tract, while others indicate that oral bacteria can enter the maternal bloodstream and seed the placenta.

In perennial allergic rhinitis, RQLQ is improved similarly by Azelastine 0.15 and mometasone furoate.

Unlabelled: Some double-blind, placebo-controlled trials have shown that Azelastine (Aze) high dose (0.15%) was effective in seasonal (SAR) and perennial allergic rhinitis (PAR). However, there was no long-term comparison between Aze 0.

Understanding Diabetic Cardiomyopathy: Insulin Resistance and Beyond.

Diabetic cardiomyopathy (DC) is a syndrome of heart failure occurring in patients with diabetes mellitus (DM), independent of other risk factors. It is a relatively underdiagnosed condition with a prolonged subclinical phase. There is an abundance of studies put forward to explain the underlying pathogenic mechanisms observed in this condition.

Mpox Virus as a Global Public Health Emergency: A Scoping Review.

The monkeypox (Mpox) virus has emerged as a global public health emergency of international concern recently. The virus that was endemic in West and Central Africa has now been reported with chains of global transmission to several countries. A scoping review was carried out from the relevant literature available from PubMed, Scopus and Web of Science.

Anticancer activity of , a rare and endemic species of holly in Northeast India, against murine lymphoma.

Purkay. is a lesser-known species of holly (family Aquifoliaceae) that is endemic to Northeast India. Designated as critically endangered, the plant is used in the treatments of bacterial infections, cancer, intestinal helminthiasis, tuberculosis, and viral infections.

Exploring the application of dietary antioxidant index for disease risk assessment: a comprehensive review.

Oxidative stress contributes to the development of cardiometabolic diseases and cancers. Numerous studies have highlighted the adverse effects of high reactive oxygen species (ROS) levels in the progression of chronic noncommunicable diseases and also during infections. On the other hand, antioxidants play a crucial role in preventing oxidative stress or postponing cell damage via the direct scavenging of free radicals or indirectly via the Keap1/Nrf2/ARE pathway, among others.

Insights into the electronic, magnetic structure, and photocatalytic activity of YCuMnO double perovskite.

This research aims to develop YCuMnO double perovskite, using a citrate auto combustion method, to be used as a photocatalyst for the degradation of organic dyes and antibiotics. XRD and Raman characterization revealed the synthesis of pure-phase YCuMnO double perovskite. The X-ray photoelectron spectroscopy results show the presence of +4 and +2 oxidation states of Mn and Cu ions.

Construction of a hydrazine electrochemical sensor using Ag@ZIF as the electrode material.

In recent years, the fabrication of hydrazine sensors has received extensive attention because of the toxicity of hydrazine to the environment and human beings. It is thus important to design and develop efficient electrode modifiers for the construction of hydrazine electrochemical sensors. Herein, we reported the benign synthesis of a silver (Ag)-doped zinc-based zeolitic imidazolate framework (ZIF-8).

Hepcidin: A missing link at the interface of malaria and hypertension.

Malaria and hypertension are seemingly unrelated communicable and non-communicable diseases, both highly pervasive in the global south. There is a debate about the potential connection between these two disorders beyond any obvious factors. The emerging evidence suggests an emerging genetic selection pressure for hypertension in malaria-endemic regions.

A physicochemical investigation of the complex formation by β-cyclodextrin with Triton X-100 and Triton X-114 and their aggregation behaviour in aqueous solution: an experimental approach.

The complexation behavior and binding affinity of Triton X-100 (TX-100) and Triton X-114 (TX-114) with β-cyclodextrin (β-CD) were extensively studied in an aqueous medium using a comprehensive suite of experimental techniques. These techniques allowed for the evaluation of key physicochemical parameters, including critical micelle concentration (cmc), aggregation number (), Stern-Volmer constant, and particle size distribution. These metrics were instrumental in understanding the underlying mechanism of the host-guest interaction between β-CD and Triton-X.

Transcatheter tricuspid valve-in-valve implantation in a paediatric patient: a case report.

Percutaneous interventions have become significant in the management of congenital heart diseases, with transcatheter procedures being increasingly used for valve dysfunction, particularly for cases requiring repetitive surgeries. This abstract presents a successful transcatheter valve-in-valve implantation in a 16-year-old patient with severe tricuspid regurgitation following a bioprosthetic tricuspid valve replacement. The procedure involved transcatheter tricuspid valve implantation using the Mammoth 25x40 mm balloon catheter and the 26 mm Myval transcatheter heart valve system (Meril Life Sciences Pvt.

HFIP-mediated, regio- and stereoselective hydrosulfenylation of ynamides: a versatile strategy for accessing ketene ,-acetals.

Herein, we report an HFIP-mediated, versatile, sustainable, atom-economical, and regio- and stereoselective hydro-functionalization of ynamides with various -nucleophiles (1 equiv.) such as thiols, thiocarboxylic acids, carbamates, xanthates, and ,-diethyl -hydrogen phosphorothioate to access a wide variety of stereodefined trisubstituted ketene ,-acetals under mild conditions. This protocol requires only HFIP, which plays multiple roles, such as acting as a Brønsted acid to protonate the ynamide regioselectively at the carbon to generate the reactive keteniminium intermediate, stabilizing the intermediate as solvent through H-bonding.

Molecular simulation of newly designed Mannich-based ciprofloxacin derivative as the promising scaffold for dihydropteroate synthase and DNA gyrase inhibitor.

The increasing incidence of bacterial infections has led to rise in antimicrobial resistance (AMR), a significant concern in public health across the globe. Henceforth, there is an urgency to address the AMR catastrophe, including developing new antibiotics, promoting the appropriate use of existing antibiotics, and investing more in research and development. Development of potent antibiotic derivatives is the call of the day.

Kinetic estimated glomerular filtration rate and drug dosing in critically ill patients with acute kidney injury-A prospective observational study.

Objective: To study the impact of kinetic glomerular filtration rate (kGFR) on clinical decision making and its implications on drug dosing compared to that of estimated GFR (eGFR) using chronic kidney disease epidemiology collaboration (CKD-EPI) equation in critically ill patients with acute kidney injury (AKI) admitted in a tertiary level intensive care unit (ICU).

Methods: Cross-sectional, prospective, observational study design. All patients admitted to Medical ICU, Fortis Hospital, Bangalore with AKI defined as per AKI network (AKIN) criteria.

A starch-polyvinyl alcohol polymer film-based on-site sensor for ammonia: a cost effective day-to-day technique for monitoring fish and meat spoilage.

Ammonia or biogenic amines released by protein degradation during food spoilage have various ill effects on human health and the environment. Herein, an economical colorimetric bisphenol-based sensor was developed from inexpensive reagents and a simple synthetic method for detecting ammonia and monitoring food spoilage. The slightest addition of NH significantly changed the absorption of BP, which was reflected in the detection limit value for NH (7.

Effects of titanium oxide nanoparticles on growth, biochemical composition, and photosystem mechanism of marine microalgae COR-A3.

The widespread utilization of titanium oxide nanoparticles (TiONPs) in various industrial applications has raised concerns about their potential ecological risks in marine environment. Assessing the toxicity of TiONPs on primary producers is essential to understand their impact on marine ecosystem. This study investigates the acute toxicity effect of TiONPs on COR-A3 cells, focusing on structural and physiological changes that can compromise algal viability and ecological function.

Physical effects of crowdant size and concentration on collective microtubule polymerization.

The polymerization of cytoskeletal filaments is regulated by both biochemical pathways, as well as physical factors such as crowding. The effect of crowding in vivo emerges from the density of intracellular components. Due to the complexity of the intracellular environment, most studies are based on either in vitro reconstitution or theory.

Artificial intelligent based control strategy for reach and grasp of multi-objects using brain-controlled robotic arm system.

Brain-controlled robotic arm systems are designed to provide a method of communication and control for individuals with limited mobility or communication abilities. These systems can be beneficial for people who have suffered from a spinal cord injury, stroke, or neurological disease that affects their motor abilities. The ability of a person to control a robotic arm to reach and grasp multiple objects using their brain signals.

-mutated AML: Immune Evasion Through Exosome-Mediated Mechanisms and innovative combination therapies targeting Immune escape.

Introduction: Acute Myeloid Leukemia is a heterogeneous hematological malignancy characterized by the uncontrolled proliferation of abnormal myeloid cells. Besides several other genetic abnormalities developed in AML, FLT3 mutations are significant due to their worse prognostic impacts and therapeutic resistance. As a result, these mutations enable AML cells to develop mechanisms for evading immune surveillance.