Optimization of protocol for analysis of dicarboxylic acids in ambient aerosol samples using GC-MS: method comparison and application.

Dicarboxylic acids (DCAs), with their deliquescence and hygroscopic nature, can function as cloud condensation nuclei (CCN) and ice nuclei (IN), affecting rainfall patterns. DCA analysis can serve as organic molecular markers for anthropogenic and biogenic sources. Very few studies deal with the optimization of the protocol for qualitative and quantitative analysis of DCAs using gas chromatography-mass spectrometry (GC-MS).

Evaluation of sources, spatial and temporal distribution, ecological and health risk associated with CAF (Caffeine) and DEET (N, N-diethyl-meta-toluamide) contamination in the urban groundwater parts of Vellore city, Tamilnadu, India.

Urban environments are heavily influenced by various activities, leading to contamination of water sources by emerging contaminants (ECs). Among these, caffeine (CAF) and N, N-diethyl-meta-toluamide (DEET) are notable ECs frequently found in domestic sewage due to human activities. Despite extensive research on emerging contaminants, limited studies have focused on the seasonal variations, human health and ecological risks of CAF and DEET in urban groundwater, particularly in Indian cities.

Molecular and genetic analysis of methicillin-resistant Staphylococcus aureus (MRSA) in a tertiary care hospital in Saudi Arabia.

Methicillin-resistant Staphylococcus aureus (MRSA) continues to pose significant challenges in healthcare settings due to its multi-drug resistance (MDR) and virulence. This retrospective study examines the molecular and resistance profiles of MRSA isolates from a tertiary care hospital in Saudi Arabia, providing valuable insights into regional epidemiology. A total of 190 MRSA strains were analysed to assess antimicrobial susceptibility, genetic diversity, and virulence factors.

Evaluation of anticancer efficacy of survivin si-RNA functionalized combined drug-loaded mesoporous silica nanoparticles in a lung cancer mouse model.

Lung cancer continues to be the leading cause of mortality globally. Nanotechnology-mediated targeted drug delivery approach is one of the promising strategies for the treatment of lung cancer. Due to their multifactorial role, mesoporous silica nanoparticles (MSNs), have attracted a lot of attention for drug delivery.

Molecular characterization of an endophytic strain of Bacillus subtilis with plant growth promoting properties from a wild relative of Papaya.

Aim: Bacillus subtilis is usually found in soil, and their biocontrol and plant growth promoting capabilities are being explored more recently than ever. However, knowledge about metabolite production and genome composition of endophytic Bacillus subtilis from seeds is limited. In the present study, Bacillus subtilis EVCu15 strain isolated from the seeds of Vasconcellea cundinamarcensis (mountain papaya) was subjected to whole genome sequencing, and detailed molecular and functional characterization.

Hypoparathyroidism: Similarities and differences between Western and Eastern countries.

Backgroud: Hypoparathyroidism (hypoPT) is characterized by acute and chronic complications due to insufficient parathyroid hormone (PTH) production or action. Several management guidelines have been developed, but mostly based on evidence from Western countries. Data from Eastern countries have not been systematically compared with those from Western countries.

Molecular mechanisms underlying allosteric behavior of Escherichia coli DgoR, a GntR/FadR family transcriptional regulator.

GntR/FadR family featuring an N-terminal winged helix-turn-helix DNA-binding domain and a C-terminal α-helical effector-binding and oligomerization domain constitutes one of the largest families of transcriptional regulators. Several GntR/FadR regulators govern the metabolism of sugar acids, carbon sources implicated in bacterial-host interactions. Although effectors are known for a few sugar acid regulators, the unavailability of relevant structures has left their allosteric mechanism unexplored.

A lossless reference-free sequence compression algorithm leveraging grammatical, statistical, and substitution rules.

Deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) sequence compressors for novel species frequently face challenges when processing wide-scale raw, FASTA, or multi-FASTA structured data. For years, molecular sequence databases have favored the widely used general-purpose Gzip and Zstd compressors. The absence of sequence-specific characteristics in these encoders results in subpar performance, and their use depends on time-consuming parameter adjustments.

Digitalized alarming sensor attached to the dental operating stool in prevention and progression of musculoskeletal disorder: A clinico-biochemical study.

Background: The efficiency and productivity of dentists are affected due to musculoskeletal disorders. Efforts should be made to monitor and reduce these disorders so that proper relation is maintained between body and work.

Aims And Objectives: This research evaluates and compares the level of creatine kinase (CK) in operators working in ergonomically correct posture and incorrect posture using a newly developed digitalized alarm sensor attached to a dental operating stool.

An comparison of the fracture resistance of MOD inlay restorations using different lithium disilicates.

Objective: The objective of this study was to evaluate and compare the fracture resistance of MOD inlay preparations restored with two different lithium disilicate glass ceramics.

Materials And Methods: Standardized MOD inlay cavities were prepared on 64 human permanent premolar teeth and divided into two groups to be restored with lithium disilicate glass-ceramic materials, i.e.

Phase transformation and metallurgical characterization of heat-treated nickel-titanium rotary instruments using differential scanning calorimetry, X-ray diffraction, and energy dispersive spectrometry.

Objective: The present study aimed to evaluate the phase transformation behavior and elemental analysis of thermomechanical-treated nickel-titanium (NiTi) rotary instruments, TruNatomy (Dentsply Sirona), HyFlex CM (coltene, Whaledent), and Neoendo Flex (Orikam healthcare India), using differential scanning calorimetry (DSC), X-ray diffraction (XRD), and energy dispersive X-ray spectrometry.

Materials And Methods: A total of 18 NiTi rotary instruments, TruNatomy, Hyflex CM, Neoendo Flex, taper. 04, size 25 (except TruNatomy, size 26) were selected and were divided into three groups ( = 6).

Clinical efficacy of platelet-rich fibrin, injectable platelet-rich fibrin, and advanced platelet-rich fibrin in regenerative endodontics: A case series.

Background: This series investigates the efficacy of regenerative endodontic therapy (RET) using various platelet-rich fibrin (PRF) formulations in treating apical periodontitis and necrotic pulp in immature permanent teeth.

Aim: This study aims to evaluate the effectiveness of different PRF formulations in RET.

Materials And Methods: Three cases involving patients aged 15-16 with immature teeth and necrotic pulp were treated with RET using PRF, injectable PRF, and advanced PRF.

Effect of glutathione on bond strength of composite resin to enamel following extracoronal bleaching.

Background: Bleaching is a conservative treatment option to deliver esthetic smile makeover for discoloured tooth. Various concentration of bleaching agents can influence the bonding of the restoration to the tooth.

Aims And Objectives: The aim of the study was to determine the effect of glutathione on bond strength of composite resin to enamel following extra coronal bleaching at two different time intervals.

Root caries: Prevalence, risk indicators, and clinical characteristics - A cross-sectional study.

Objectives: The objectives of this study were to determine the prevalence of root caries (RC) in South Coastal population of India, to identify the risk indicators associated with it and to describe some clinical characteristics of RC lesions.

Materials And Methods: A cross-sectional study was conducted with a sample size of 1062 subjects to assess the prevalence of RC. Each subject underwent an oral examination, performed by a single-calibrated examiner.

Postoperative pain in patients following endodontic treatment by XP-endo Shaper files: A systematic review and meta-analysis.

Context: Postoperative pain occurs in 25%-60% of patients following endodontic treatment. It can significantly impact a patient's quality of life and requires timely management or, preferably, prevention.

Aims: The present systematic review was conducted aiming to analyze randomized controlled trials that compared postoperative pain in patients whose canals were shaped by XPS versus other endodontic file systems.

Comparative evaluation of microleakage in Class II cavities restored with snowplow technique using flowable or preheated packable bulk-fill composite resin as gingival increment by dye extraction method: An study.

Context: One of the undesirable characteristics of dental composite resin is the polymerization shrinkage and the associated microleakage. The snowplow technique of placement and the preheating of the composite resins are methods to minimize microleakage.

Aim: The aim of this study was to comparatively evaluate microleakage in Class II cavities restored with snowplow technique using either preheated packable or flowable bulk-fill composite resin.

"Comparative evaluation of cytotoxicity of three herbal endodontic irrigants at three intervals of time" - An study.

Aim: The aim of the study was to evaluate and compare the cytotoxicity of 25% of neem leaf extract (), 20% of guava leaf extracts (), and 20% of cinnamon extract () irrigants at three intervals of time.

Methodology: Four groups were formed ( = 15), Group 1 (control group) - normal saline solution, Group 2 - 25% of neem extract, Group 3 - 20% of guava extract, and Group 4 - 20% of cinnamon extract. Each group was further divided into three subgroups based on intervals ( = 5).

Treating apical fenestration in a previously endodontically treated tooth.

Apical fenestration is a defect in the alveolar cortical plate, exposing the root without involving the alveolar bone margin, often linked to trauma, periodontal disease, and orthodontic treatment, leading to symptoms such as pain and abscesses from endodontic infections. This case report describes managing a mucosal fenestration in an endodontically treated tooth with nonsurgical root canal therapy and periodontal surgery. A 44-year-old male presented with mucosal fenestration and pain in the upper front jaw due to trauma and an inadequately treated root canal.

Evaluation of microtensile bond strength and marginal adaptation of fiber-reinforced composites.

Background: Long-term durability of a restoration relies on the marginal integrity and its ability to withstand the occlusal forces. Fiber-reinforced composites (FRCs) exhibited superior properties in terms of fracture toughness, flexural strength, and wear resistance.

Aim: The aim of this study was to assess and compare marginal adaptation and microtensile bond strength (µTBS) of posterior FRCs comparing with a condensable composite.

A comparative evaluation of the effect of matrix metalloproteinase inhibitor on the fracture resistance of endodontically treated teeth restored with Everstick-reinforced composite resin: An study.

Aim: To evaluate the effect of applying a matrix metalloproteinase (MMP) inhibitor on the fracture resistance of root-filled teeth restored with Everstick fiber-reinforced composite resin.

Subjects And Methods: After the selection of 60 freshly extracted human mandibular first molar, root canal access and standard uniformly sized mesio-occluso-distal (MOD) cavities were made and the teeth were randomly assigned into three groups ( = 20 each): Group I, the MOD cavity was first lined with flowable composite resin and then restored with composite resin. In Group II, Everstick fiber was placed into the bed of flowable composite in buccal-pulpal-lingual direction before the composite restoration was placed.

Shear bond strength evaluation of bioactive restorative materials on pretreated carious dentin-influence on silver diamine fluoride, potassium iodide, and glutathione.

Background: Silver diamine fluoride (SDF) has gained popularity for its caries-arresting properties, yet its tendency to cause esthetic concerns due to black-staining limits its widespread acceptance.

Aim: The aim of the study was to evaluate and compare the shear bond strength of Activa BioActive and Giomer restorative material with different protocols of SDF pretreatment on carious dentin.

Materials And Methods: Ninety-two extracted teeth were decoronated at the cementoenamel junction, sectioned 1 mm into dentin, mounted in acrylic resin and randomly divided into four ( = 8) control and six ( = 10) experimental groups.

Comparative evaluation of removal of oil-based calcium hydroxide intracanal medicaments with two calcium chelators: An cone-beam computed tomography volumetric analysis.

Background: Intracanal medicament (ICM) eliminates remaining bacteria and their toxins that were not removed by chemomechanical preparation during endodontic treatment.

Aim: The aim of this study was to compare and evaluate the removal of ozonated oil-based, silicone oil-based, and distilled water-based ICM with two calcium chelators, i.e.

Influence of apical patency in endodontic treatment outcome - A systematic review of clinical studies.

Objective: The aim of this systematic review was to evaluate the influence of maintaining apical patency (AP) in endodontic treatment outcome.

Methodology: An electronic database search was performed in PubMed, Cochrane Library, LIVIVO, LILACS, and EBSCO host from inception till July 2024. The data from the included articles were extracted and the quality was assessed using the Cochrane Collaboration tool and ROBINS-I tool.

Impact of gamma radiation on marginal adaptation of nanohybrid composite and composition of dental hard tissues - Scanning electron microscopy and X-ray diffraction analysis: An pilot study.

Aims: This pilot study aimed to compare the marginal adaptation of composite resin at the tooth-restoration interface, before and after radiation.

Subjects And Methods: Fifteen extracted premolars were divided into 2 experimental groups (based on the timing of irradiation) and 1 control group of 5 teeth each. In Group I (control group), teeth were restored but not exposed to radiation at any stage, Group II: teeth were irradiated before cavity preparation and restoration, and Group III: after cavity preparation and restoration employing selective etch technique, teeth were exposed to radiation.