An emotionally intelligent haptic system - An efficient solution for anxiety detection and mitigation.

Background: Anxiety is a psycho-physiological condition associated with an individual's mental state. Long-term anxiety persistence can lead to anxiety disorder, which is the underlying cause of many mental health problems. As such, it is critical to precisely identify anxiety by automated, effective, and user-bias-free ways.

Implementation of machine learning tool for continued process verification of process chromatography unit operation.

Recent advancements in technology, such as the emergence of artificial intelligence (AI) and machine learning (ML), have facilitated the progression of the biopharmaceutical industry toward the implementation of Industry 4.0. As per the guidelines set by the USFDA, process validation for biopharmaceutical production consists of three stages: process design, process qualification, and continuous process verification (CPV).

Identification and discrimination of human keratinized tissues using ATR-FTIR and chemometrics.

In forensic investigations, human keratinized tissues like skin and nails are commonly encountered as trace evidence, yet the use of vibrational spectroscopy for their identification and differentiation has been underexplored. This research utilized ATR-FTIR to distinguish between human nails and skin samples collected from a group of 50 participants, employing advanced chemometric analysis techniques. The spectral signatures of human keratinized tissues, such as nails and skin, exhibit similarities consistent with previous studies.

Can morphometrics and shell preference behaviour be a tool for hermit crab species identification?

The hermit crabs are 'ecosystem engineers' and are a critical link in the oceanic food web. Six species of genus Coenobita are reported in the group of Andaman and Nicobar Islands namely, Coenobita rugosus, C. brevimanus, C.

Schizophrenia detection using distributed activation function-based statistical attentional bidirectional-long short-term memory.

Schizophrenia detection involves identifying the schizophrenia by analyzing specific patterns in Electroencephalogram (EEG) signals, which reflect brain activity associated with symptoms, like hallucinations and cognitive impairments. Existing models face challenges due to the complex and variable nature of EEG data, which may struggle to accurately capture critical temporal dependencies and relevant features. Traditional approaches often lack adaptability, limiting their ability to differentiate schizophrenia patterns from other brain activities.

Novel nanomaterials-based combating strategies against drug-resistant bacteria.

Numerous types of contemporary antibiotic treatment regimens have become ineffective with the increasing incidence of drug tolerance. As a result, it is pertinent to seek novel and innovative solutions such as antibacterial nanomaterials (NMs) for the prohibition and treatment of hazardous microbial infections. Unlike traditional antibiotics (e.

Analysis of heat induced changes in dental tissue for forensic application: A scanning electron microscope study.

Introduction: In the forensic field, having accurate understanding of the macroscopic and microscopic alterations that occur in teeth when exposed to temperatures has remarkable significance. The preservation of delicate incinerated teeth is crucial in fire investigations that pertain to the temperature exposed, as well as the identification of victims. This preservation is necessary in order to conduct macroscopic and microscopic ultra-structural examinations, which provide valuable insights into the structural alterations that dental tissues undergo when exposed to low to high temperatures.

Thermocontrolled Radical Nucleophilicity vs Radicophilicity in Regiodivergent C-H Functionalization.

The temperature-dependent switching behavior of the saccharin radical is demonstrated, enabling the regiodivergent C-H and C-H functionalization of quinoxalin-2(1)-ones. The saccharin radical was generated through N-Br bond cleavage in -bromosaccharin (NBSA) and was observed to transition between radical and radicophile roles. At -10 °C, it was utilized as a radicophile, resulting in 100% C-amination, while at +35 °C, it acted as a radical, leading to exclusive C-bromination.

Low-Level Laser Therapy with Pharmacotherapy in the Management of Myofascial Pain Dysfunction Syndrome with or without Other Temporomandibular Disorders.

Background And Aim: Myofascial pain dysfunction syndrome (MPDS) is one of the most important facial muscle disorders comprising signs and symptoms including pain during function, tenderness in the muscles of mastication and restricted jaw movement. The purpose of this study was to assess and compare the effectiveness of low-level laser therapy (LLLT) and combination therapy of LLLT and pharmacotherapy in the treatment of myofascial pain with or without other TMD (temporomandibular disorders).

Materials And Methods: Forty patients with MPDS were randomly divided into two groups.

Utility of Toll-Free Interactive Voice Response System (IVRS) Helpline under National Oral Health Program (NOHP) - A Cross-Sectional Hospital Based Study.

Background: India launched the National Oral Health Program (NOHP) in the year 2014-15 to support the states for improved oral healthcare delivery and reduce the burden of oral diseases. The toll-free Interactive Voice Response System (IVRS) with contact number 1800112032, was initiated to deliver oral health-related information to users and guide them for proper treatment on World Oral Health Day on 20th March 2017. There is scarcity of data regarding the utility and perception of users about IVRS.

Side-On Bound Beryllium Dinitrogen Complex: A Precursor for Complete Conversion of Dinitrogen to Ammonia Mediated by -Heterocyclic Carbene.

The complete conversion of dinitrogen to ammonia mediated by a side-on N-bound carbene-beryllium complex, [NHC-Be(η-N)] has been studied considering both the symmetric and unsymmetric pathways. -heterocyclic carbenes complexed with Be(η-N) moieties were considered substrates in our study. We found that two mechanistic pathways were possible for the reduction of dinitrogen to form ammonia.

Early detection of carcinoma: correlating quantifiable tumor biomarkers with high-resolution microscopy (HRME) findings.

Introduction: Cancer ranks as the second most prevalent cause of death worldwide, responsible for approximately 9.6 million deaths annually. Approximately one out of every six deaths is caused by cancer.

Chronic pulmonary aspergillosis in tea population of Assam.

Background: Chronic pulmonary aspergillosis (CPA) is a disease commonly caused by Aspergillus fumigatus and other Aspergillus species characterized by cavitary lung lesions. Tea garden population is an agrarian population of Assam, mostly associated with tea plantations. Assam is a major tea-producing state with 803 tea gardens producing approximately 50% of the total tea in India, of which 177 are present in the Dibrugarh district alone.

An Anthracene-imidazoanthraquinone Conjugate Exhibiting Ratiometric Fluorescence Turn - On Behavior with CN- and F- Anions.

A new conjugate, 2-(4-(anthracen-9-yl) phenyl)-[1,2-d]imidazole-1H-anthraquninone (AQI) has been designed and synthesized as a molecular probe 4. The photophysical and electrochemical behavior of the probe in the absence and presence of different class of ions were examined in acetonitrile solution. The probe 4 with F- and CN- anions showed ratiometric fluorescence "turn - On" response due to variation in ICT processes.

Ferric Chloride Mediated Dearomative Spirocyclization of Biaryl Ynones: Synthesis of 3,3-Spiroindanones.

Ferric chloride mediated dearomative spirocyclization of biaryl ynones for the synthesis of new series of densely functionalized 3,3-spiroindanone derivatives has been reported. This study is the first to describe the regioselective synthesis of a five-membered ring from biaryl ynones. The scope of the reaction is broad and the spirocyclic products were obtained in moderate to good yields (up to 87%) and with high stereoselectivities.

Synthesis of a Gemcitabine Prodrug and its Encapsulation into Polymeric Nanoparticles for Improved Therapeutic Efficacy.

Gemcitabine (GEM), a chemotherapeutic agent, is widely utilized in treating various neoplasm conditions, such as pancreatic, lung, breast, and ovarian cancers. However, its therapeutic effectiveness is often hindered by its hydrophilic nature, short half-life and susceptibility to enzymatic degradation. To address these limitations, in this research, five new prodrugs of GEM were synthesized by conjugating its N-4 amino group with five different acids [4-decenoic acid (4Dec), lipoic acid (Lipo), lauric acid (Laur), 5-benzyl N-(tert-butoxycarbonyl)- L-glutamate (Glu), and decanoic acid (Dec)].

A Copolymer of Benzoquinone and Pyrrole as High Rate, Durable Polymer Electrode for Aqueous Zn- and Mg-ion Based Batteries.

The growing energy demands have led to an increased attention towards the development of efficient energy storage devices. In this direction, aqueous rechargeable batteries have attracted considerable attention due to their affordability, environmental friendliness and quite importantly, safety. In the present studies, a two-dimensional copolymer of benzoquinone and pyrrole that is insoluble in aqueous solutions is explored as an electrode for aqueous, rechargeable divalent ion storage.

Safety assessment of turmeric-boswellia-sesame formulation in healthy adult volunteers: An open-label prospective study.

Background: Turmeric and boswellia supplements have gained popularity for their anti-inflammatory and antioxidant properties. It is important to critically assess the safety of such supplements for prolonged use.

Objectives: To assess the safety and tolerability of turmeric-boswellia-sesame oil formulation (TBSF) in healthy human volunteers.

New Pyranopyrazole-Based Indolin-2,3-dione Hybrid as Effective Inhibitors of Xanthine Oxidase: Synthesis, In Vitro, and Molecular Modelling Approaches.

In the current study, new pyranopyrazole analogues (9a-d and 10a-d) were synthesized through a one-pot condensation reaction of 2-arylacetohydrazide. The inhibitory abilities were investigated against the XO enzyme through experimental and molecular docking analyses. The synthesis studies were based on ultrasound-mediated condensation reactions of four-component systems containing 2-arylacetohydrazide, ethyl acetoacetate, indoline-2,3-dione, and ethyl 2-cyanoacetate/malononitrile in various solvents and catalysts to yield pyranopyrazole analogues (9a-d and 10a-d) in a short reaction time and remarkably favorable yields ranging from 79-92%.

Unraveling the Relationship Between Vitamin D and Noncommunicable Diseases: A Systemic Review and Meta-Analysis.

Background: Subclinical vitamin D insufficiency is frequent in both developing and developed countries. Even after rickets was eliminated in the 1930s by fortifying milk, up to 1 billion people worldwide suffer from subclinical vitamin D deficiency (VDD). Numerous noncommunicable diseases (NCDs), including depression, autoimmune illnesses, diabetes, osteoporosis, and cardiovascular disease, are linked to this deficiency.

Protein Based Hybrid Materials of Metal Phosphate Nanoflowers and Gels for Water Remediation: Perspectives and Prospects.

Water pollution is a critical environmental issue affecting ecosystems and human health worldwide. Contaminants such as heavy metals, dyes, antibiotics, and microplastics enter water bodies from the disposals of industrial, agricultural, and domestic waste. The development of new and advanced technologies for addressing water remediation has turned out to be a dire need.

Regioisomeric π-Extended Nanographene with Long-lived Phosphorescence Afterglow.

The cutouts of graphene sheets, particularly those with a nonplanar topology, present vast opportunities for advancement. Even a slight deviation from the planar structure can lead to intriguing (chiro)optical features for helically twisted nanographenes. In this context, we introduce two regioisomeric π-extended nanographenes that exhibit distinct excited-state characteristics.