Effect of platelet-rich plasma versus placebo or corticosteroid for knee osteoarthritis: A systematic review and meta-analysis of randomized controlled trials.

Background: The effectiveness of intra-articular platelet-rich plasma (IA-PRP) injections for managing pain in knee osteoarthritis (KOA) remains inconsistent. Therefore, this study aimed to systematically review randomized controlled trials (RCTs) assessing the efficacy of IA-PRP.

Methods: A total of 21 studies meeting the inclusion criteria were selected from various scientific databases, all of which compared PRP to either a placebo or an active comparator, such as corticosteroids (CS), in the treatment of KOA.

Revolutionizing green catalysis: a novel amla seed derived biochar modified g-CN·SOH catalyst for sustainable and versatile synthesis of bis-indoles.

Catalysis plays a vital role in green chemistry by improving process efficiency, reducing waste, and minimizing environmental impact. A biochar-modified g-CN·SOH (BCNSA) catalyst was developed using biochar derived from amla seed powder and CNSA. CNSA was synthesized the reaction of g-CN with chlorosulfonic acid.

Scan and share to register outpatients, India.

Problem: To address the long waiting times patients incur when visiting outpatient departments in India.

Approach: In 2022, the National Health Authority in India developed a paperless service, called Scan and Share, leveraging mobile technology and QR (quick-response) codes to streamline outpatient department appointments. Patients can use a mobile application (app) to scan QR codes at health facilities, generating tokens linked to registration counters.

On some integral inequalities of Grüss type involving the generalized fractional Saigo -integral operator.

Using the generalized Saigo fractional integral operator, the authors of this study prove several novel fractional integral inequalities of the Grüss type. By fixing the values of functions, specific situations derived from previously established findings are shown. The ultimate purpose of this work is to investigate the Grüss-type integral inequalities with the Saigo -integral operator, a more generalized integral operator.

Dynamic nonlinear control strategies for resilient heterogeneous vehicle platooning and handling Byzantine attacks in communication networks.

This paper addresses the challenges of maintaining stability in heterogeneous vehicle platooning under the influence of communication disruptions caused by Byzantine attacks within a leader-follower framework. To enhance resilience, we propose a nonlinear control strategy tailored for a third-order heterogeneous dynamic model, integrating leader-follower interconnections with adaptable control gains. Utilizing a constant time headway spacing policy with gap adjustments, we derive control gains that secure internal platoon stability.

A review of recent advancements in the impact response of fiber metal laminates.

Fiber metal laminates (FMLs) have garnered significant attention due to their exceptional impact resistance, making them attractive for various structural applications. This review presents recent advancements in understanding the impact behavior of FMLs under low- and high-velocity impact scenarios. Low-velocity impacts, commonly encountered during manufacturing, handling, and tool drops, are discussed, with a focus on damage mechanisms, energy absorption capabilities, and influential factors such as impactor geometry and boundary conditions.

Transforaminal lumbar interbody fusion (TLIF) surgery: A finite element analysis of open and minimally invasive approach on L4-L5 segment.

Background: To compare the effect of minimally invasive and open transforaminal lumbar interbody fusion (TLIF) approaches in fusing the L4-L5 segment and predicting the potential risk of adjacent segment degeneration (ASD).

Methods: A computed tomography scan image was processed and the three-dimensional model of the L1-L5 spine was reconstructed. The minimally invasive and Open TLIF finite element models were constructed.

"Leaving no one behind": digital empathy and inclusive media literacy education for young adults on the autism spectrum.

The paper advocates for the necessity of inclusive media literacy education (MLE) and equal opportunities for young adults with autism spectrum disorder (ASD), which is in alignment with the United Nations Convention on the Rights of Persons with Disabilities (UNCRPD) 2008 and the Sustainable Development Goal 4 Quality Education (SDG, 2030). It underscores the commitment to 'leaving no one behind', a core tenet of the SDGs, by focusing on developing digital empathy and inclusive MLE for young adults with ASD in the digital age. The study aims to empower young adults with ASD in Chennai, India, with media literacy and digital empathy through a one-day hands-on workshop and to assess the impact of this educational intervention on their understanding and application of media literacy in their daily lives.

Clinical Evaluation of Faricimab in Real-World Diabetic Macular Edema in India- A Multicenter Observational Study.

Purpose: To evaluate the efficacy of faricimab in real-world clinical settings in India for treating diabetic macular edema (DME) in treatment-naïve and recalcitrant eyes.

Patients And Methods: This retrospective study involved 39 eyes (16 treatment-naive and 23 recalcitrant) treated with intravitreal faricimab at four centers in India. Patients received three monthly loading doses followed by a pro-re-nata regimen, with outcomes measured for best-corrected visual acuity (BCVA), central macular thickness (CMT), intraretinal fluid (IRF), subretinal fluid (SRF), and hyperreflective foci (HRF).

Ultrasound B-Scan for Posterior Segment and Extraocular Evaluation in Ocular Cysticercosis.

Purpose: Cysticercosis, caused by Taenia solium larvae, can affect various ocular and extraocular structures, leading to significant morbidity. Ultrasound B-scan imaging plays a pivotal role in diagnosing and classifying cysticercosis lesions. The aim of the study was to describe the ultrasound B-scan characteristics of ocular and extraocular cysticercosis, proposing a classification system based on anatomical localization to enhance understanding and management.

Protocol of the Nutritional, Psychosocial, and Environmental Determinants of Neurodevelopment and Child Mental Health (COINCIDE) study.

Background: Over 250 million children are developing sub-optimally due to their exposure to early life adversities. While previous studies have examined the effects of nutritional status, psychosocial adversities, and environmental pollutants on children's outcomes, little is known about their interaction and cumulative effects.

Objectives: This study aims to investigate the independent, interaction, and cumulative effects of nutritional, psychosocial, and environmental factors on children's cognitive development and mental health in urban and rural India.

Understanding the vaginal microbiome among women with different genotypes of human papillomavirus infection in remote Andaman islands.

Background: Human papillomavirus (HPV) is a viral infection, and its acquisition and persistence are significantly influenced by the vaginal microbiota. Understanding and comparing the vaginal microbiome of HPV infected women in Andaman and Nicobar Islands is crucial.

Methods: The study involved collecting vaginal swabs and extracting DNA using the QIAamp DNA Minikit.

COVID-19's impact on food environment in the Indian states of Telangana, Maharashtra, West Bengal, Tamil Nadu and Punjab: a descriptive qualitative study to build further research in India's food environment resilience building.

Background And Aim: Globally, COVID-19 has had a profound impact on food and nutrition security. This paper aims to gather the perspective from Transforming India's Green Revolution by Research and Empowerment for Sustainable food Supplies (TIGR2ESS) Flagship Project 6 (FP-6) team on the impact of COVID-19 on the food systems in India. The responses collected will be used for further research projects after TIGR2ESS ends in March 2022.

Knowledge, attitude and practices of ayurvedic medicine practitioners in Kerala towards millets and millet-based diet: a prospective cross-sectional online survey study.

Introduction: Diet and lifestyle play pivotal roles in Ayurveda's preventive and therapeutic principles. The rich culinary heritage of Kerala harmoniously aligns with Ayurvedic dietetic principles. With the recent designation of 2023 as the International Year of Millets, there has been a surge of interest in integrating millets into dietary practices worldwide.

Efficacy and Safety of a Novel Low-Dose Water-Dispersible Turmeric Extract in the Management of Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

Purpose: Turmeric extract is a well-known nutraceutical ingredient recognized for its benefits in managing musculoskeletal health. This study evaluated the efficacy and safety of a novel low-dose water-dispersible turmeric extract containing 60% natural curcuminoids (WDTE60N) in participants with mild-to-moderate knee osteoarthritis.

Patients And Methods: This double-blind, randomized, placebo-controlled trial was conducted at two orthopedic centers in Uttar Pradesh, India (July 2023-November 2023).

Peptide-based amyloid-beta aggregation inhibitors.

Aberrant protein misfolding and accumulation is considered to be a major pathological pillar of neurodegenerative disorders, including Alzheimer's and Parkinson's diseases. Aggregation of amyloid-β (Aβ) peptide leads to the formation of toxic amyloid fibrils and is associated with cognitive dysfunction and memory loss in Alzheimer's disease (AD). Designing molecules that inhibit amyloid aggregation seems to be a rational approach to AD drug development.

A comprehensive dataset of above-ground forest biomass from field observations, machine learning and topographically augmented allometric models over the Kashmir Himalaya.

Accurate estimates of forest dynamics and above-ground forest biomass for the topographically challenging Himalaya are crucial for understanding carbon storage potential, assessing ecosystem services, and guiding conservation efforts in response to climate change. This dataset provides a manually delineated multi-temporal forest inventory and a comprehensive record of above-ground biomass (AGB) across the Kashmir Himalaya, generated from field observations, advanced remote sensing and machine learning. Data were collected and generated through remote sensing techniques and extensive in-situ measurements of 6220 trees (n=275 plots), including tree diameter at breast height, species composition, and tree density to map forest area and model AGB across varied terrain.

Determining the Correlation Between Blood Loss and Clinical Findings Among Patients with Postpartum Hemorrhage.

Background: There is a need for signs that will help the midwives or the health care providers attending deliveries to prevent the patient from going into hypovolemic shock, especially when immediate testing is not possible. The study aims to find the correlation between the clinical symptoms and blood loss in women with postpartum hemorrhage.

Methods: It is a descriptive observational study conducted at the Department of Obstetrics and Gynecology, Maternity Hospitals.

A cross-sectional study of parental perspectives on children about COVID-19 and classification using machine learning models.

Background And Objective: This study delves into the parenting cognition perspectives on COVID-19 in children, exploring symptoms, transmission modes, and protective measures. It aims to correlate these perspectives with sociodemographic factors and employ advanced machine-learning techniques for comprehensive analysis.

Method: Data collection involved a semi-structured questionnaire covering parental knowledge and attitude on COVID-19 symptoms, transmission, protective measures, and government satisfaction.

Effectiveness of a technical support program with women's self-help groups in catalyzing health and nutrition behaviors in Bihar-a multicomponent analysis.

Introduction: Bihar Rural Livelihoods Promotion Society launched the JEEViKA program in 2007 to improve livelihoods through the Self-Help Group (SHG) platform. Women's SHGs have shown members' health improvements by promoting awareness, practices and access to services. This study investigates whether Health & Nutrition (HN) interventions delivered by JEEViKA Technical Support Program (JTSP) via SHG platforms could improve maternal and newborn health and nutritional behaviors in rural Bihar.

Pediatric simple triage score: A simplified approach for triaging pediatric patients with fever in the emergency department.

Introduction: The initial 24-h period following admission to a hospital holds profound significance for pediatric patients, representing a critical window where proactive interventions can substantially influence outcomes. We devised a simple triage system, pediatric simple triage score (PSTS), to see whether rapid triage of sick pediatric patients with fever can be done using the new triage system in the emergency department (ED) to predict hospital admission.

Methods: This was a prospective observational study, conducted at the department of emergency medicine of a tertiary care teaching hospital in southern India.

Melioidosis - An under-recognized dreaded disease in Southeast Asia.

Melioidosis is a disease endemic to India but often goes unrecognized, leading to considerable illness and death. We present the case of a 31-year-old man who had a fever of unknown origin, abnormal renal and liver function tests, and negative tests for dengue, typhoid, leptospirosis, and scrub typhus. Imaging revealed multiple splenic infarcts.

Effect of botanical powders and the assassin bug, Mont. and Sign. (Hemiptera: Reduviidae) against Lesne (Coleoptera: Bostrichidae) infesting yam chips.

Background: Lesne (Coleoptera: Bostrichidae) is the main pest of stored dried yam chips that causes significant losses in less than 3 months. The assassin bug, (Montrouzier & Signoret) (Hemiptera: Reduviidae) and the African mahogany ( (Desv.) A.

Lung Ultrasound Score for Prognosticating Ventilator-associated Pneumonia (VAP): Evidence and Wisdom.

Clerk AM. Lung Ultrasound Score for Prognosticating Ventilator-associated Pneumonia (VAP): Evidence and Wisdom. Indian J Crit Care Med 2024;28(11):991-992.