Prone Position Video Laryngoscopy for the Successful Intubation of Penetrating Back Injury: A Report of Two Cases.

Airway management in the prone position presents significant challenges and carries the risk of encountering a difficult airway situation. Here, we present two adults who sustained traumatic knife injuries to the back and required surgical intervention. Due to the potential life-threatening complications associated with dislodging the knife, traditional supine and lateral decubitus positions were not feasible for airway management.

Giant Retroperitoneal Liposarcoma: A Rare Surgical Occurrence.

Retroperitoneal liposarcoma is a rare malignancy that arises from adipocytes and can expand significantly before manifesting clinical symptoms. Instances of giant retroperitoneal liposarcoma, defined as tumors larger than 30 cm, are extremely rare, with fewer than 20 reported cases. This case report presents a 68-year-old patient with a significant abdominal mass, ultimately identified and treated as a well-differentiated retroperitoneal liposarcoma.

A Rare Case of Bartter Syndrome Type 3 Presenting With New-Onset Diabetes Mellitus.

Bartter syndrome is a rare genetic disorder that often presents in the early phase of life and is caused by mutations in multiple genes encoding the transporters and channels, which are responsible for the reabsorption of various ions in the nephrons. Clinically, it presents with vomiting, failure to thrive, and dehydration. Rare instances of acquired Bartter syndrome have been linked to sarcoidosis, tuberculosis, and autoimmune diseases.

Romiplostim Reduces Platelet Transfusion Needs in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation.

Background: There is no standard treatment to accelerate recovery from melphalan-induced thrombocytopenia in multiple myeloma (MM) patients undergoing autologous stem cell transplantation (ASCT). Romiplostim, a thrombopoietin receptor agonist, has been developed to upregulate platelet production.

Objective: This study aimed to assess the efficacy and safety of romiplostim in reducing platelet transfusions post-ASCT in MM patients.

5'-Amino-Formyl-Thieno[3,2-]thiophene End-Label for On-Strand Synthesis of Far-Red Fluorescent Molecular Rotors and pH-Responsive Probes.

The ability to label synthetic oligonucleotides with fluorescent probes has greatly expanded their nanotechnological applications. To continue this expansion, it is essential to develop approachable, modular, and tunable fluorescent platforms. In this study, we present the synthesis and incorporation of an amino-formyl-thieno[3,2-]thiophene (AFTh) handle at the 5'-position of DNA oligonucleotides.

Recent advances in ruthenium (III) complex-loaded nanomaterial for enhanced cancer therapy efficacy.

Objective: Amid the escalating global cancer incidence, the development of effective and safe anticancer drugs is a critical priority in medical research. Addressing the clinical shortcomings of ruthenium-based anticancer drugs are currently a prominent focus of research.

Significance And Methods: Since the pioneering work with platinum derivatives, significant progress has been made in the fundamental studies of metal complexes for the treatment of a wide range of cancers, and there has been a growing interest in their properties and biomedical applications.

Optimizing voriconazole-loaded thermoresponsive hydrogel: tools and studies.

Objective: The present study aims to develop and evaluate the voriconazole-loaded thermoresponsive hydrogel using tools.

Methods: Poloxamer 407 and PEG 400 were selected as the components from studies for thermoresponsive hydrogel of voriconazole. The cohesive energy density (CED) and solubility parameters (SP) were calculated using Biovia Material Studio 2022 software to predict the polymer-polymer miscibility and drug-polymer miscibility.

Comparison Between Molecular Dynamics Potentials for Simulation of Graphene-Based Nanomaterials for Biomedical Applications.

Objective: This article provides a substantial review of recent research and comparison on molecular dynamics potentials to determine which are most suitable for simulating the phenomena in graphene-based nanomaterials (GBNs).

Significance: GBNs gain significant attention due to their remarkable properties and potential applications, notably in nanomedicine. However, the physical and chemical characteristics toward macromolecules that justify their nanomedical applications are not yet fully understood.

Efficacy and Safety of F-Biotic™ in Combination With Metformin for Type 2 Diabetes Mellitus: Results From a Randomized, Double-Blind Clinical Trial.

Introduction: This study evaluated the effectiveness, safety, and tolerability of F-Biotic™ (Arishina Life Sciences, Karnataka, IND), a prebiotic containing 60% resistant starch derived from natural sources, in patients with Type 2 diabetes mellitus (T2DM) on stable metformin therapy.

Methods: Seventy participants with T2DM, aged 25-70 years, were randomized into two groups: one receiving F-Biotic™ and the other a placebo, both administered daily for 12 weeks. Key outcomes included fasting blood sugar (FBS), postprandial blood sugar (PPBS), glycated hemoglobin (HbA1c), fasting insulin, insulin resistance (HOMA-IR), GLP-1 levels, lipid profile, and quality of life.

Factors Associated With the Development of Heart Failure Following Acute Coronary Syndrome: A Systematic Review and Meta-Analysis.

Acute coronary syndrome (ACS) remains a major global health burden, encompassing a spectrum of conditions from unstable angina to acute myocardial infarction. Despite advancements in early detection and management, ACS is often complicated by the development of heart failure. This systematic review and meta-analysis aimed to identify factors associated with the development of heart failure following acute coronary syndrome.

The Impact of an Early Mobility Protocol on Recovery Outcomes in Patients Undergoing Abdominal Surgeries.

Background:  According to the World Health Organization (WHO), early mobilization is a critical component of healthcare that significantly impacts patient recovery and outcomes. Despite evidence supporting the benefits of early mobilization for abdominal surgery patients, standardized protocols remain scarce across many healthcare environments.

Aim:  This study evaluates the feasibility and impact of an early mobility protocol (EMP) on improvement in mobility and patient satisfaction in abdominal surgery patients.

Bibliometric Analysis of Research on Lip Prints.

Lip prints, or cheiloscopy, are unique patterns of grooves and wrinkles, gaining prominence in forensic science as reliable tools for personal identification, akin to fingerprints and DNA profiling. Advances in imaging techniques have enhanced their forensic applicability. This study conducts a bibliometric analysis to explore global research trends, key contributors, and thematic developments in lip print research.

Evaluation of the Safety and Efficacy of Trastuzumab Emtansine (T-DM1) Biosimilar in Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer: Findings From a Single-Center Retrospective Analysis in India.

Background Human epidermal growth factor receptor 2 (HER2)-positive breast cancer is a highly aggressive subtype characterized by a high recurrence rate. Trastuzumab emtansine (T-DM1), an antibody-drug conjugate targeting HER2, has shown improved outcomes; however, its effectiveness in cases with brain metastases remains unclear. The T-DM1 biosimilar has emerged as a cost-effective treatment option.

Antimicrobial Utilization, Adverse Drug Reactions, and Associated Cost of Care in a Tertiary Care Hospital in Eastern India.

Background Antimicrobials considerably reduce infectious conditions, but their overuse and misuse contribute to various adverse drug reactions (ADRs) and antimicrobial resistance. In 2019, India adopted a national program to reduce antibiotic resistance for 2019-2021. Assessing antibiotic consumption among the out-patient and in-patient departments is paramount because it is the foundation for implementing and assessing antibiotic stewardship initiatives.

Safety and Efficacy of Ferric Carboxymaltose for Iron Deficiency Anemia in Inflammatory Bowel Disease: A Systematic Review.

Ulcerative colitis and Crohn's disease, two types of inflammatory bowel disease (IBD), often cause anemia, primarily due to iron deficiency and chronic inflammation. Anemia negatively affects patients' daily functioning and quality of life, causing symptoms including headaches, exhaustion, and dyspnea. In IBD, iron deficiency arises from reduced intake, chronic blood loss, and impaired absorption.

Failed Spinal Anesthesia: Incidence and Associated Factors.

Introduction Spinal anesthesia, a commonly used technique for lower abdominal, pelvic, and lower extremity surgeries, involves injecting a local anesthetic into the subarachnoid space to temporarily block sensory, motor, and sympathetic nerves. Despite its high success rate, the failure of spinal anesthesia, which can lead to adverse patient outcomes, remains a concern. The failure rate varies widely, from 1% to 17%, influenced by factors such as technical challenges, patient anatomy, and practitioner experience.

Seronegative Autoimmune Encephalitis With Rapidly Progressive Parkinsonism.

Seronegative autoimmune encephalitis is an infrequent entity in older patients, and its presentation as rapidly progressive parkinsonism is rarely seen in cases of autoimmune encephalitis. We present a case report of an older patient who presented with worsening Parkinson's-like symptoms over a month. We highlight the importance of considering autoimmune encephalitis as a potential cause of rapidly progressive parkinsonism and the importance of radiological findings when the entire autoimmune panel is negative in such patients.

Neuromodulatory Effect of Lactate on Visual Evoked Potential After Acute Exercise in Healthy Adult Males.

Background Lactate, once considered merely a byproduct of anaerobic metabolism, is now recognized as a crucial neuromodulator in the brain, particularly during high-energy demands. Recent studies have explored its role in neuroprotection, cognitive enhancement, and neural plasticity. This study investigates the effects of elevated blood lactate levels, induced by acute exercise, on visual evoked potentials (VEPs), which reflect neural activity in the visual cortex.

Idiopathic Optic Nerve Glioma: A Case Report.

Optic nerve gliomas are tumors that develop along the optic nerve pathway, most often classified as pilocytic astrocytomas. These growths are typically benign, especially in young children between the ages of one and six years, while the rarer malignant types are generally more aggressive and tend to appear in adults. Characteristically slow-growing, optic nerve gliomas are commonly located in the pre-chiasmal part of the optic nerve but can extend to post-chiasmal regions and into the brain if left untreated.

The Role of Adjuvant Therapies in Improving Outcomes for pT1-3N0 Oral Squamous Cell Carcinoma With Tumour-Free Margins and Perineural Invasion.

Introduction The role of concomitant chemoradiation therapy (CTRT) or radiation therapy (RT) is not well defined in operated cases of oral squamous cell carcinoma (OSCC) with positive perineural spread. The purpose of the study was to determine whether the use of concurrent CTRT or RT would enhance the five-year disease-free survival of patients with positive perineural invasion (PNI). Materials and methods Data were analysed retrospectively from January 2014 to December 2023.

Analgesic Efficacy Comparison Between Ultrasound-Guided Erector Spinae Plane Block and Retrolaminar Block in Patients Undergoing Modified Radical Mastectomy: A Randomized Controlled Trial.

Introduction: Breast cancer is the most common cancer in females. Surgery is the gold standard therapy, with modified radical mastectomy (MRM) being the most commonly performed procedure for breast cancer. Management of postoperative pain after MRM poses a clinical challenge and hence receives utmost priority.

A Comparative Study Between Posterolateral Lumbar Fusion and Transforaminal Lumbar Interbody Fusion for Degenerative Lumbar Spondylolisthesis.

Introduction Degenerative spondylolisthesis (DS) is a degenerative condition characterized by subluxation of one vertebral body anterior to the adjacent inferior vertebral body with an intact pars. Conservative treatment approaches, such as steroid injections and physical therapy, may work well at first, but in resistant situations, surgery is frequently necessary. Posterolateral lumbar fusion (PLF) has been widely used, but transforaminal lumbar interbody fusion (TLIF) offers theoretical advantages such as improved alignment and enhanced fusion rates.

Managing Arrhythmias in Cardiogenic Shock: Insights Into Milrinone and Dobutamine Therapy.

Shock is a state of inadequate perfusion that affects vital organs. Cardiogenic shock (CS) predisposes patients to various arrhythmias. The adverse effect depends on intervention and pharmacogenomics.

Developing a Discrete Choice Experiment Questionnaire to Design Health Policy Interventions for Rural Retention of Specialist Physicians in Rajasthan, India.

Background: Understanding the preferences of specialist physicians is essential to mitigate their critical deficiency in the Indian rural healthcare system. This necessitates an urgent focus to inform health policy interventions imperative to address and strengthen the vacancies of specialist physicians in the Indian rural healthcare system. The policy interventions should address the preferences of specialists, leading to their intention to stay in rural postings.

Beyond the Lung: A Rare Presentation of Tuberculosis in the Tarsometatarsal Joint Treated With Chemotherapy, Surgical Debridement, and Fusion.

Foot tuberculosis is rarely reported in the literature, with most tuberculosis of the foot being an uncommon manifestation of skeletal tuberculosis. Early diagnosis and timely medical and surgical intervention can significantly reduce morbidity. A 23-year-old male presented with persistent swelling and pain in his right foot for six months, accompanied by a discharging sinus over the affected area in the last week, making weight-bearing increasingly difficult.