1,328 results match your criteria: "Incontinentia Pigmenti"
BMC Pediatr
October 2019
Children's Hospital, University of Würzburg, Würzburg, Germany.
Background: Incontinentia Pigmenti is a rare disease affecting multiple organs. Fifty of patients show affection of the eye with retinopathy and possible amaurosis being the worst outcome. Treatment has commonly been panretinal laser coagulation but intravitreal application of bevacizumab as VEGF-inhibitor has shown to effectively suppress retinal neovascularization.
View Article and Find Full Text PDFAnn Dermatol
October 2019
Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.
Hypomelanosis of Ito (HI) is a neurocutaneous disorder, also known as incontinentia pigmenti achromians. HI has been associated with chromosomal abnormalities, especially mosaicism. Herein, we report a case of HI with multiple congenital anomalies.
View Article and Find Full Text PDFAm J Dermatopathol
October 2019
Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, PA.
Eur J Med Genet
March 2020
Department of Pediatrics, St. Marianna University School of Medicine, Kawasaki, Japan.
We describe a female infant with incontinentia pigmenti complicated by severe pulmonary arterial hypertension that was markedly improved by tadalafil administration. The infant was referred to our institution because of neonatal seizures and generalized skin rash at the age of 1 day. She was diagnosed with incontinentia pigmenti on skin biopsy findings.
View Article and Find Full Text PDFAm J Dermatopathol
September 2019
Department of Dermatopathology, Shanghai Skin Disease Hospital affiliated to Tongji University, Shanghai, China.
J Pediatr
December 2019
Division of Dermatology, Loyola University Medical Center, Maywood, Illinois.
Eur J Hum Genet
December 2019
Institute of Genetics and Biophysics "Adriano Buzzati-Traverso", IGB-CNR, Naples, 80131, Italy.
Int J Dermatol
November 2019
Department of Dermatology and Venereology, All India Institute of Medical Sciences, Rishikesh, India.
Eur J Hum Genet
October 2019
Institute of Genetics and Biophysics "A. Buzzati Traverso" CNR, 80131, Naples, Italy.
Incontinentia pigmenti (IP; OMIM#308300) is a rare genetic disease resulting in neuroectodermal defects, which can lead to disability. At present, there is neither definitive cure available nor are there any sufficiently reliable insights to predict the severity of the disease. We launched the Incontinentia Pigmenti Genetic Biobank (IPGB) project ( http://www.
View Article and Find Full Text PDFPediatr Neurol
October 2019
Department of Pediatrics, Fukushima Medical University, Fukushima, Japan.
Indian J Ophthalmol
June 2019
Department of Ophthalmology, Government Medical College and Hospital, Sector 32, Chandigarh, India.
Indian J Ophthalmol
June 2019
Retina and Uvea Services, Sadguru Netra Chikitsalaya, Chitrakoot, Madhya Pradesh, India.
Indian J Ophthalmol
June 2019
Shri Bhagwan Mahavir Vitreoretinal Services, Sankara Nethralaya, Chennai, Tamil Nadu, India.
Indian J Ophthalmol
June 2019
Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Purpose: To describe the utility of RetCam ultra-wide-field fundus fluorescein angiography in pediatric retinal vascular diseases.
Methods: A retrospective chart review was carried out in 43 eyes of 22 pediatric patients who were diagnosed or suspected to have a retinal vascular disease. Fluorescein angiography was carried out using the 130 degree lens of RetCam 3.
Am J Med Genet A
August 2019
Department of Pediatrics, Division of Genetics and Metabolism, University of Texas Southwestern Medical Center, Dallas, Texas.
Incontinentia Pigmenti (IP; MIM 308300) is an X-linked dominant genodermatosis caused by pathogenic variant in IKBKG. The phenotype in adults is poorly described compared to that in children. Questionnaire survey of 99 affected women showed an age at diagnosis from newborn to 41 years, with 53 diagnosed by 6 months of age and 30 as adults.
View Article and Find Full Text PDFAn Pediatr (Engl Ed)
January 2020
Departamento de Dermatología, Hospital Materno Infantil, Málaga, España.
Introduction: Incontinentia pigmenti is a rare genodermatosis of inheritance linked to the Xchromosome that affects tissues derived from ectoderm. The aim of the study is to review, as completely as possible, the cases diagnosed in paediatric patients in two hospitals.
Material And Methods: A retrospective cross-sectional study was carried out, using the clinical, analytical, radiological, and genetic data of paediatric patients diagnosed with incontinentia pigmenti from 2004 to 2018.
J Obstet Gynaecol Res
July 2019
Clinical Laboratory Department, Xuanwu Hospital, Capital Medical University, Beijing, China.
Aim: In this study, a questionnaire survey was conducted to find the relationship between preeclampsia (PE) and incontinentia pigmenti (IP).
Methods: Using a questionnaire survey of 147 women whose children were diagnosed with IP, this study first investigated their clinical manifestations and complications during pregnancy. The manifestations included high blood pressure, proteinuria and edema after 20 weeks of gestation.
Int J Dermatol
August 2019
Department of Dermatology, Venereology, and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Arch Argent Pediatr
June 2019
Sección de Oftalmología Pediátrica. Hospital Universitario 12 de Octubre, Madrid, España.
Incontinentia pigmenti is a rare neurocutaneous disorder with a frequency of 1 in 40,000 newborn; it is associated with mutations in IKBKG gene in Xq28, inherited as an X-linked dominant trait. Clinical manifestations detected since the newborn period are highly variable, with skin, teeth, eyes, and nervous system manifestations, and each with a characteristic differential diagnosis. We present a pediatric patient diagnosed with incontinentia pigmenti at the first week of life.
View Article and Find Full Text PDFZhonghua Yan Ke Za Zhi
April 2019
Beijing Key Laboratory of Vision Loss and Restoration, Ministry of Education, Department of Ophthalmology, People's Hospital, Peking University, Beijing 100044, China.
To investigate the treatment of retinopathy of incontinentia pigmenti by anti-vascular endothelial growth factor. Retrospective study of 5 patients(8 eyes) diagnosed retinopathy of incontinentia pigmenti from 2005 to 2017, including 0 males and 5 females (8 eyes involved) with an average age of 2.4 months(range, 1-5 months).
View Article and Find Full Text PDFArch Oral Biol
May 2019
Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, 22 Zhongguancun South Avenue, Haidian District, Beijing 100081, PR China. Electronic address:
Objective: To explore the gene mutation in an incontinentia pigmenti (IP) patient with syndromic tooth agenesis.
Methods: Long-range polymerase chain reaction (PCR) and Sanger sequencing were used to detect inhibitor of nuclear factor kappa-B kinase subunit gamma (IKBKG) mutation in the IP patient. We used the nuclear factor kappa B (NF-κB) reporter gene to assess activation of NF-κB, after transfecting an empty vector, wild-type, or mutant NF-κB essential modulator (NEMO) plasmid into IKBKG-deficient HEK293T cells, respectively.
J Am Acad Dermatol
November 2019
Division of Pediatric Medicine, Section of Dermatology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada. Electronic address:
Background: Incontinentia pigmenti (IP) is a rare X-linked dominant genodermatosis that affects multiple systems with highly variable phenotypic expressivity. Although most affected individuals carry a common pathogenic variant on the IKBKG gene, approximately 20% have no identifiable mutation.
Objective: To describe clinical characteristics and genotype of IP patients and compare clinical differences between IKBKG pathogenic variant positive and negative cohorts.
JAMA Ophthalmol
March 2019
Department of Ophthalmology and Laboratory for Visual Science, National Center for Child Health and Development, Tokyo, Japan.
Int J Dermatol
September 2019
Department of Dermatology, Cleveland Clinic Foundation, Cleveland, OH, USA.
Iran J Kidney Dis
January 2019
Departments of Pediatric Nephrology, Mersin University Faculty of Medicine, Mersin, Turkey.
Multicystic dysplastic kidney is a congenital kidney malformation consisting of multiple cysts of various sizes without a normal kidney morphology. Incontinentia pigmenti is a rare X-linked dominant genodermatosis, which is usually lethal in males, that presents clinically in 4 stages. Here, we report a case of multicystic dysplastic kidney with ureterovesical junction obstruction and incontinentia pigmenti.
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