83 results match your criteria: "Imperial College London UK.[Affiliation]"
Acta Med Port
March 2020
Department of Community Medicine, Information and Health Decision Sciences (MEDCIDS). Center for Health Technology and Services Research (CINTESIS). University of Porto. Porto. Portugal. Institute of Global Health Innovation. Imperial College London. UK. United Kingdom.
Bicaudal D1 (BICD1), an adaptor for the dynein-dynactin motor complex, has been identified as a susceptibility gene in chronic obstructive pulmonary disease (COPD). Autophagy, an essential cellular homeostasis process, is defective in COPD, in which oxidative stress-induced misfolded proteins accumulate into toxic aggregates dependent on the accumulation of the autophagic cargo receptor p62. Defective autophagy can be caused by mutations in the dynein and dynactin motor complex suggesting a possible link between BICD1 and defective autophagy in COPD.
View Article and Find Full Text PDFRSC Adv
January 2020
Barrer Centre, Department of Chemical Engineering, Imperial College London UK
Carbon monoxide (CO) purification from syngas impurities is a highly energy and cost intensive process. Adsorption separation using metal-organic frameworks (MOFs) is being explored as an alternative technology for CO/nitrogen (N) and CO/carbon dioxide (CO) separation. Currently, MOFs' uptake and selectivity levels do not justify displacement of the current commercially available technologies.
View Article and Find Full Text PDFBackground: Primary hyperparathyroidism (PHPT), caused by an ectopic mediastinal parathyroid adenoma, is uncommon. In the past, when the adenoma was not accessible from the neck, median sternotomy was advocated for safe and successful parathyroidectomy. Video-assisted thoracoscopic surgical (VATS) parathyroidectomy represents a modern alternative approach to this problem.
View Article and Find Full Text PDFDyspnea is a common presentation in upper and lower airway obstructive causes. However, biphasic stridor and hoarseness should prompt evaluation of the upper airway. Nasendoscopy carried out by the otolaryngology team is a quick and an effective way of evaluating the upper airway.
View Article and Find Full Text PDFEndocrinol Diabetes Metab
October 2019
Nutrition and Dietetic Research Group, Faculty of Medicine Imperial College London UK.
Introduction: Type 2 diabetes (T2D) is multifactorial involving lifestyle, environmental and genetic risk factors. This study aims to investigate the impact of genetic interactions with alcohol and diet quality on glycated haemoglobin A1c (HbA1c) independent of obesity, in a British population.
Methods: Cross-sectional study of 14 089 white British participants from Airwave Health Monitoring Study and a subsample of 3733 participants with dietary data.
Objective: To study the effectiveness and tolerability of antiepileptic drugs (AEDs) commonly used in juvenile myoclonic epilepsy (JME).
Methods: People with JME were identified from a large database of individuals with epilepsy, which includes detailed retrospective information on AED use. We assessed secular changes in AED use and calculated rates of response (12-month seizure freedom) and adverse drug reactions (ADRs) for the five most common AEDs.
J R Stat Soc Ser A Stat Soc
February 2019
Ashkirk UK.
Analysis of longitudinal randomized clinical trials is frequently complicated because patients deviate from the protocol. Where such deviations are relevant for the estimand, we are typically required to make an untestable assumption about post-deviation behaviour to perform our primary analysis and to estimate the treatment effect. In such settings, it is now widely recognized that we should follow this with sensitivity analyses to explore the robustness of our inferences to alternative assumptions about post-deviation behaviour.
View Article and Find Full Text PDFBMC Neurol
February 2019
Department of Neurology, University Hospital Würzburg, Josef-Schneider-Str. 11, 97080, Würzburg, Germany.
Background: Atrial fibrillation (AF) is present in 15-20% of patients with acute ischemic stroke. Oral anticoagulation reduces the risk of AF-related recurrent stroke but clinical guideline recommendations are rather vague regarding its use in the acute phase of stroke. We aimed to assess the current clinical practice of medical stroke prevention in AF patients during the acute phase of ischemic stroke.
View Article and Find Full Text PDFArrhythm Electrophysiol Rev
December 2018
Department of Bioengineering, Imperial College London UK.
Ripple mapping is a novel method of 3D intracardiac electrogram visualisation that allows activation of the myocardium to be tracked visually without prior assignment of local activation times and without interpolation into unmapped regions. It assists in the identification of tachycardia mechanism and optimal ablation site, without the need for an experienced computer-operating assistant. This expert opinion presents evidence demonstrating the benefit of Ripple Mapping, compared with traditional electroanatomic mapping techniques, for the diagnosis and management of atrial and ventricular tachyarrhythmias during electrophysiological procedures.
View Article and Find Full Text PDFEcography
September 2018
Inst. de Recherche pour le Développement Health and Societies Dept, UMR MIVEGEC IRD-CNRS-Montpellier Univ. France.
Biogeography is an implicit and fundamental component of almost every dimension of modern biology, from natural selection and speciation to invasive species and biodiversity management. However, biogeography has rarely been integrated into human or veterinary medicine nor routinely leveraged for global health management. Here we review the theory and application of biogeography to the research and management of human infectious diseases, an integration we refer to as 'pathogeography'.
View Article and Find Full Text PDFRSC Adv
June 2018
Barrer Centre, Department of Chemical Engineering, Imperial College London UK
A comprehensive scientometric approach was adopted to study the research on ion exchange membranes. The statistical analysis was conducted based on 21 123 publications which were related to the topic of ion exchange membranes. Specifically, from 2001 to 2016, over 18 000 articles were published on ion exchange membranes, indicating researchers' great interest in this topic.
View Article and Find Full Text PDFEur Heart J
June 2018
Centre for International Cardiovascular Health, Imperial College London UK.
The Academic Research Consortium (ARC)-2 initiative revisited the clinical and angiographic end point definitions in coronary device trials, proposed in 2007, to make them more suitable for use in clinical trials that include increasingly complex lesion and patient populations and incorporate novel devices such as bioresorbable vascular scaffolds. In addition, recommendations for the incorporation of patient-related outcomes in clinical trials are proposed. Academic Research Consortium-2 is a collaborative effort between academic research organizations in the United States and Europe, device manufacturers, and European, US, and Asian regulatory bodies.
View Article and Find Full Text PDFEpidemiol Prev
February 2019
Unità di epidemiologia, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milano.
Pulmonary arterial hypertension (PAH) is characterised by remodelling of the pulmonary vasculature leading to right ventricular hypertrophy. Here, we show that miR-322-5p (the rodent orthologue of miR-424-5p) expression is decreased in the right ventricle of monocrotaline-treated rats, a model of PAH, whereas a putative target insulin-like growth factor 1 (IGF-1) is increased. IGF-1 mRNA was enriched 16-fold in RNA immunoprecipitated with Ago2, indicating binding to miR-322-5p.
View Article and Find Full Text PDFMed Image Comput Comput Assist Interv
September 2018
We propose a new Patch-based Iterative Network (PIN) for fast and accurate landmark localisation in 3D medical volumes. PIN utilises a Convolutional Neural Network (CNN) to learn the spatial relationship between an image patch and anatomical landmark positions. During inference, patches are repeatedly passed to the CNN until the estimated landmark position converges to the true landmark location.
View Article and Find Full Text PDFESC Heart Fail
February 2017
The National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College London UK.
Background: Previous studies have shown that xanthine oxidase inhibitors (XOI) might improve outcome for patients with cardiovascular disease. However, more evidence is required.
Methods And Results: We published a meta-analysis of trials conducted before 2014 examining the effects of XOI on mortality in patients with cardiovascular disease.
Appl Immunohistochem Mol Morphol
April 2017
*Department of Laboratory Medicine and Pathobiology, University of Toronto Departments of †Pathology §§§§Laboratory Hematology, University Health Network, Toronto, ON §§Vancouver General Hospital, University of British Columbia, Vancouver, BC ###Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB ∥∥∥∥Canadian Immunohistochemistry Quality Control (CIQC)/Canadian Association of Pathologists National Standards Committee for High Complexity Testing/Immunohistochemistry, Canada ‡Poundbury Cancer Institute §Dorset County Hospital NHS Foundation Trust ∥Cancer Diagnostic Quality Assurance Services (CADQAScic), Dorchester ¶¶Department of Surgery & Cancer, Division of Cancer, Imperial College London ***UK National External Quality Assessment Scheme (UK NEQAS), University College London, London, UK ∥∥International Quality Network for Pathology (IQN Path), Luxembourg City, Luxembourg ¶School of Medicine, Institute of Pathology, Charité-University Hospital Berlin, Berlin, Germany #Griffith University, Gold Coast ††Genomics For Life, Brisbane, Qld **RCPA Quality Assurance Program, Sydney, NSW, Australia ‡‡Phenopath, Seattle, WA ##Brigham and Women's Hospital, Harvard Medical School, Boston, MA ****Keck School of Medicine, University of Southern California, Los Angeles, CA †††Center of Predictive Molecular Medicine ‡‡‡Center for Excellence on Ageing and Translational Medicine, University of Chieti-Pescara, Chieti, Italy §§§Department of Pathology, Radboud University Medical Centre, Nijmegen, The Netherlands ∥∥∥Institute of Pathology, Aalborg University Hospital and Department of Clinical Medicine, Aalborg University ¶¶¶Nordic Immunohistochemistry Quality Control (NordiQC), Aalborg, Denmark ††††Department of Pathology, Beijing Friendship Hospital, Capital Medical University, Beijing ‡‡‡‡Chinese Committee for Pathologists-Immunohistochemistry Quality Control, China.
The numbers of diagnostic, prognostic, and predictive immunohistochemistry (IHC) tests are increasing; the implementation and validation of new IHC tests, revalidation of existing tests, as well as the on-going need for daily quality assurance monitoring present significant challenges to clinical laboratories. There is a need for proper quality tools, specifically tissue tools that will enable laboratories to successfully carry out these processes. This paper clarifies, through the lens of laboratory tissue tools, how validation, verification, and revalidation of IHC tests can be performed in order to develop and maintain high quality "fit-for-purpose" IHC testing in the era of precision medicine.
View Article and Find Full Text PDFLearn Health Syst
January 2017
Department of Learning Health Sciences, Medical School University of Michigan Ann Arbor Michigan.
A significant fraction of the energy released by magnetotail reconnection appears to go into ion heating, but this heating is generally anisotropic. We examine ARTEMIS dual-spacecraft observations of a long-duration magnetotail exhaust generated by antiparallel reconnection in conjunction with particle-in-cell simulations, showing spatial variations in the anisotropy across the outflow far (>100 ) downstream of the X line. A consistent pattern is found in both the spacecraft data and the simulations: While the total temperature across the exhaust is rather constant, near the boundaries dominates.
View Article and Find Full Text PDFJ Cachexia Sarcopenia Muscle
September 2016
Section of Molecular Medicine National Heart and Lung Institute, Imperial College London London UK.
Background: Loss of muscle mass is a co-morbidity common to a range of chronic diseases including chronic obstructive pulmonary disease (COPD). Several systemic features of COPD including increased inflammatory signalling, oxidative stress, and hypoxia are known to increase the expression of growth differentiation factor-15 (GDF-15), a protein associated with muscle wasting in other diseases. We therefore hypothesized that GDF-15 may contribute to muscle wasting in COPD.
View Article and Find Full Text PDFThe Windjana drill sample, a sandstone of the Dillinger member (Kimberley formation, Gale Crater, Mars), was analyzed by CheMin X-ray diffraction (XRD) in the MSL Curiosity rover. From Rietveld refinements of its XRD pattern, Windjana contains the following: sanidine (21% weight, ~Or); augite (20%); magnetite (12%); pigeonite; olivine; plagioclase; amorphous and smectitic material (~25%); and percent levels of others including ilmenite, fluorapatite, and bassanite. From mass balance on the Alpha Proton X-ray Spectrometer (APXS) chemical analysis, the amorphous material is Fe rich with nearly no other cations-like ferrihydrite.
View Article and Find Full Text PDFAustralas J Ultrasound Med
February 2016
Tommy's National Miscarriage Centre Queen Charlotte's & Chelsea Hospital, Imperial College London UK.