British Cardiovascular Intervention Society Training Culture Focus Group Position Statement: Bringing Trainees and Trainers Together.

Unprofessional behaviour within cardiology has been well documented and commonly occurs within the cardiac catheterisation laboratory, with higher rates in interventional subspecialities. While most trainees have positive experiences and encounters within the catheterisation laboratory, around one in five report experiencing bullying. This not only has a significant negative impact on the individuals directly involved, but also on the wider multidisciplinary team; importantly, it will have a deleterious effect on patient safety.

Planetary Health Booms: Unpacking the Surge in Research Across the Globe Through Joint-Point Analysis.

Planetary Health (PH) is a relatively new field that studies the sciences behind the interaction between the environment, living organisms, and human health. The number of publications in this field has increased exponentially in the past few years. This study analyzed the trend of using the term "PH" in literature.

Understanding the long-term impact of the COVID-19 pandemic on non-muscle-invasive bladder cancer outcomes: 12-Month follow-up data from the international, prospective COVIDSurg Cancer study.

Objective: The objective of this study was to report the 12-month oncological outcomes for patients with non-muscle-invasive bladder cancer (NMIBC) within the prospective, international COVIDSurg Cancer study.

Patients And Methods: Eligible patients were aged ≥18 years and scheduled for elective surgical management of NMIBC with curative intent (transurethral resection of bladder tumour [TURBT] or bladder biopsy) from 21 January to 14 April 2020. The primary outcome was disease recurrence within 12 months of previous elective TURBT/bladder biopsy.

The private market for antimicrobials: an exploration of two selected mining and frontier areas of Guyana.

Objective: To identify challenges that may raise pathogens' resistance to antimicrobial drugs by exploring the private market for antimicrobials in two selected mining and frontier areas of Guyana.

Methods: The private sector supply was mapped by approaching all authorized pharmacies and informal outlets, e.g.

Impact of water solvation on the charge carrier dynamics of organic heterojunction photocatalyst nanoparticle dispersions.

Organic heterojunction nanoparticles (NP) have recently gained significant interest as photocatalysts for visible light-driven hydrogen production. Whilst promising photocatalytic efficiencies have been reported for aqueous NP dispersions, the underlying dynamics of photogenerated charges in such organic heterojunction photocatalysts and how these might differ from more widely studied dry heterojunction films remain relatively unexplored. In this study, we combine transient optical spectroscopies over twelve orders of magnitude in time, using pulsed and continuous light illumination, to elucidate the differences in the charge carrier dynamics of heterojunction NP dispersions, dried NP films, and bulk heterojunction films prepared by spin coating.

Promise and Peril of a Genotype-First Approach to Mendelian Cardiovascular Disease.

Precision medicine, which among other aspects includes an individual's genomic data in diagnosis and management, has become the standard-of-care for Mendelian cardiovascular disease (CVD). However, early identification and management of asymptomatic patients with potentially lethal and manageable Mendelian CVD through screening, which is the promise of precision health, remains an unsolved challenge. The reduced costs of genomic sequencing have enabled the creation of biobanks containing in-depth genetic and health information, which have facilitated the understanding of genetic variation, penetrance, and expressivity, moving us closer to the genotype-first screening of asymptomatic individuals for Mendelian CVD.

Naturally acquired adaptive immunity to is impaired in rheumatoid arthritis patients.

Objectives: Patients with rheumatoid arthritis (RA) have an increased susceptibility to infections, including those caused by . Why RA is associated with increased susceptibility to is poorly understood. This study aims to assess the effects of RA and B-cell depletion therapy on naturally acquired antibody responses to 289  protein antigens using a novel protein array.

Occurrence and Strength of Instantaneous and Intracohort Density-Dependence in Northeast Atlantic Fish Stocks.

Biological reference points (BRPs) used in fisheries management do not include density-dependent (DD) growth, with DD processes only considered in the stock recruitment relationship. Not accounting for DD on somatic growth has led to criticism that such BRPs underestimate the compensatory effects of DD at low stock size, and therefore risk foregone catch opportunities. Here, we analyse 81 stocks from the Northeast Atlantic for evidence of DD growth, defined as the process in which stock size affects somatic weight.

Allometric Growth and Scaling of Body Form of the Spadenose Shark ().

The versatility of the shark body form is suggested to be one of the key factors underlying their evolutionary success and persistence. Nevertheless, sharks exhibit a huge diversity of body forms and morphological adaptations. More subtly, it is increasingly evident that in many species, morphology varies through ontogeny.

Sulfur/carbon cathode material chemistry and morphology optimisation for lithium-sulfur batteries.

Lithium-sulfur batteries (LSBs) are a promising alternative to lithium-ion batteries because sulfur is highly abundant and exhibits a high theoretical capacity (1675 mA h g). However, polysulfide shuttle and other challenges have made it difficult for LSBs to be commercialised. Here, a sulfur/carbon (S/C) composite was synthesised and cathodes were fabricated scalable melt diffusion and slurry casting methods.

Introducing chirality in porous organic cages through solid-state interactions.

Molecular cages contain an internal cavity designed to encapsulate other molecules, resulting in applications in molecular separation, gas storage, and catalysis. Introducing chirality in cage molecules can improve the selective separation of chiral molecules and add new functionalities due to the realisation of chiral photophysical properties. It has recently been shown that solid-state supramolecular interactions between achiral cages can result in the formation of chiral cavities.

Widespread introduced species dominate the urban tree assemblage on the endemic-rich tropical island of São Tomé.

The Afrotropics are experiencing some of the fastest urbanisation rates on the planet but the impact of city growth on their rich and unique biodiversity remains understudied, especially compared to natural baselines. Little is also known about how introduced species influence β-diversity in these contexts, and how patterns coincide with native ranges of species. Here we investigated how tree assemblages of the endemic-rich Afrotropical island of São Tomé differed between urban, rural and natural zones.

Cautionary tales on the use of proxies to estimate body size and form of extinct animals.

Body size is of fundamental importance to our understanding of extinct organisms. Physiology, ecology and life history are all strongly influenced by body size and shape, which ultimately determine how a species interacts with its environment. Reconstruction of body size and form in extinct animals provides insight into the dynamics underlying community composition and faunal turnover in past ecosystems and broad macroevolutionary trends.

The mycobacterium lipid transporter MmpL3 is dimeric in detergent solution, SMALPs and reconstituted nanodiscs.

The mycobacterial membrane protein large 3 (MmpL3) transports key precursor lipids to the outer membrane of Mycobacterium species. Multiple structures of MmpL3 from both and in various conformational states indicate that the protein is both structurally and functionally monomeric. However, most other resistance, nodulation and cell division (RND) transporters structurally characterised to date are either dimeric or trimeric.

Biodegradation of hydroxylated boron nitride nanoplatelets, their toxic effect and drug delivery application.

Boron nitride is extensively used in various biomedical applications and often interacting with the blood circulatory system. However, the effect of its biotransformation in blood plasma, drug delivery applications, and antitumor effects remains unclear. Herein, we synthesized hydroxylated BN nanoplatelets (-OH/BNNPs) that are used to load doxorubicin (DOX) for cancer therapy.

Pregnancy complications and birth outcomes following low-level exposure to per- and polyfluoroalkyl substances in the vitamin D antenatal asthma reduction trial.

Per- and polyfluoroalkyl substances (PFAS) are a group of synthetic, highly fluorinated aliphatic compounds, commonly utilised in a wide variety of consumer products with diverse applications. Since the genesis of these compounds, a growing body of evidence has demonstrated adverse health effects associated with PFAS exposure. In a racially diverse cohort of 459 pregnant mothers, demographically weighted towards minority representation (black 44.

Dynamic and solid-state behaviour of bromoisotrianglimine.

Solid-state materials formed from discrete imine macrocycles have potential in industrial separations, but dynamic behaviour during both synthesis and crystallisation makes them challenging to exploit. Here, we explore opportunities for structural control by investigating the dynamic nature of a C-5 brominated isotrianglimine in solution and under crystallisation conditions. In solution, the equilibrium between the [3 + 3] and the less reported [2 + 2] macrocycle was investigated, and both macrocycles were fully characterised.

Coronary Sinus Reducer Therapy for Refractory Angina and its Role in Modern Interventional Practice: A Contemporary Review.

Coronary sinus reducer (CSR) implantation is an emerging treatment option for patients with refractory angina. This condition represents a major global cardiovascular healthcare challenge, with patients experiencing chronic anginal symptoms that significantly impair their quality of life and for whom few effective treatments exist. The clinical burden of refractory angina is only set to grow because of improved survival from coronary artery disease, increased life expectancy and the presence of residual angina after percutaneous or surgical coronary revascularisation.

Combining Intravenous Thrombolysis and Dual Antiplatelet Treatment in Patients With Minor Ischemic Stroke: A Propensity Matched Analysis of the READAPT Study Cohort.

Background: The optimal treatment for acute minor ischemic stroke is still undefined. and options include dual antiplatelet treatment (DAPT), intravenous thrombolysis (IVT), or their combination. We aimed to investigate benefits and risks of combining IVT and DAPT versus DAPT alone in patients with MIS.

Various Morphologies of Graphitic Carbon Nitride (g-CN) and Their Effect on the Thermomechanical Properties of Thermoset Epoxy Resin Composites.

This research aims to highlight the importance of diverse forms of graphitic carbon nitride (g-CN) as strengthening elements in epoxy composites. It explores the influence of three different forms of g-CN and their concentrations on the mechanical properties of the epoxy composites. Various characterization techniques, such as scanning electron microscopy (SEM), dynamic light scattering (DLS), thermogravimetric analysis (TGA), and Fourier-transform infrared spectroscopy (FTIR), were utilized to comprehend the effects of g-CN morphology and particle size on the physical and chemical characteristics of epoxy resin.