3,512 results match your criteria: "Immunoglobulin M Deficiency"
Immunol Res
December 2024
Disciplina de Imunologia Clínica, Faculdade de Medicina, Centro Universitário FMABC, Avenida Lauro Gomes, 2000, Santo Andre, SP, 09060.870, Brazil.
Selective IgM deficiency (SIgMD) has recently been included in the inborn errors of immunity classification. SIgMD has conflicting diagnostic criteria and diverse clinical and immunological findings. We aimed to assess the clinical and laboratory profiles of patients with SIgMD and to compare the data of patients diagnosed using two inclusion criteria.
View Article and Find Full Text PDFJ Neuroinflammation
December 2024
Centre for Neuroscience and Stereology, Department of Neurology, Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital, Nielsine Nielsens Vej 6B, Entrance 11B, 2. floor, Copenhagen, NV, DK-2400, Denmark.
Int J Mol Sci
November 2024
Laboratory of Molecular Cell Biology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
TNF receptor-associated factors (TRAFs) function as intracellular adaptor proteins utilized by members of the TNF receptor superfamily, such as CD40. Among the TRAF family proteins, TRAF5 has been identified as a potential regulator of CD40. However, it remains unclear whether TRAF5 regulates the generation of germinal center (GC) B cells and antigen-specific antibody production in the T-dependent (TD) immune response.
View Article and Find Full Text PDFSci Immunol
November 2024
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Endogenous retroviruses (ERVs), comprising a substantial portion of the vertebrate genome, are remnants of ancient genetic invaders. ERVs with near-intact coding potential reactivate in B cell-deficient mice. To study how B cells contribute to host anti-ERV immunity, we used an antigen-baiting strategy to enrich B cells reactive to ERV surface antigens.
View Article and Find Full Text PDFEur J Immunol
December 2024
Experimental Surgical Research Laboratory, Department of General Surgery, Visceral, Thoracic and Vascular Surgery, Universitätsmedizin Greifswald, Greifswald, Germany.
B-1 cells are crucially involved in immune defense and regulation of inflammation and autoimmunity. B-1 cells are predominantly located in the peritoneal and pleural cavities, although body cavity B-1 cells recirculate systemically under steady-state conditions. The chemokines CXCL12 and CXCL13 have been identified as the main regulators of peritoneal B-cell trafficking.
View Article and Find Full Text PDFVet Res
September 2024
Institute of Immunology, Centre for Infectious Diseases, Faculty of Veterinary Medicine, BBZ, University of Leipzig, Leipzig, Germany.
Allergy Asthma Proc
September 2024
Turk J Gastroenterol
July 2024
Division of Gastroenterology, Department of Internal Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Turk J Gastroenterol
June 2024
Department of Internal Medicine, Hacettepe University Medical Faculty, Ankara, Türkiye.
Cite this article as: Balaban YH, Ismail M, Nur Ayar Ş. Selective immunoglobulin M deficiency in patients with autoimmune liver diseases. Turk J Gastroenterol.
View Article and Find Full Text PDFBMC Pulm Med
August 2024
Department of Internal Medicine, Faculty of Medicine, Haiphong University of Medicine and Pharmacy, Haiphong city, Vietnam.
Objective: The study aimed to characterize serum immunoglobulin (Ig) concentrations and their relationship with clinical and paraclinical features in patients with COPD group E in the stable stage. Additionally, the study focused on evaluating the relationship between serum Ig levels and the risk of exacerbations over the next 12 months, thereby clarifying the role of serum Ig deficiency in affecting the future risk for these patients.
Methods: A prospective observational study assessed IgG, IgA, IgM, and IgE levels in 67 COPD patients and 30 healthy controls at Military Hospital 103 from October 2017 to August 2020.
Transplantation
August 2024
Department of Surgery, Division of Transplantation, The Johns Hopkins School of Medicine, Baltimore, MD.
Background: Xenotransplantation using pig organs is now a clinical reality. However, the process for xenograft recipient screening lacks clarity and scientific rigor: no established thresholds exist to determine which levels of preformed antipig natural antibodies (Nabs) will be safe for clinical xenograft transplantation, and hyperacute rejection (HAR) or acute humoral xenograft rejection (AHXR), which still impacts pig-to-primate kidney xenograft survivals, may impede broader application of pig-to-human clinical xenograft transplantation.
Methods: We retrospectively examined 28 cases of pig-to-baboon kidney xenotransplantation using GalTKO±human complement regulatory protein (hCRP)-transgenic (Tg) pig donors, as well as 6 cases of triple-KO multi-Tg (10GE) pig donors, and developed screening algorithms to predict risk of HAR/AHXR based on recipient antipig Nab levels.
Int Wound J
July 2024
Department of Plastic Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Selective IgM deficiency is a rare immunological disorder, with patients presenting with recurrent infections and allergic manifestations. However, the association with early postoperative infection has not been widely reported in the literature. We describe a rare case of a patient who had an early wound infection 1 day after excision of a Merkel cell carcinoma from his right buttock and was later found to have decreased IgM levels.
View Article and Find Full Text PDFAdv Exp Med Biol
July 2024
Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing, China.
Cureus
April 2024
Department of Dermatology, Graduate School of Medicine, The University of Tokyo, Tokyo, JPN.
Selective immunoglobulin M (IgM) deficiency (sIgMD) is a rare immunodeficiency disorder characterized by decreased serum levels of IgM. Symptoms of sIgMD include repeated infections and allergic manifestations such as asthma and allergic rhinitis. The etiology and pathology of sIgMD remain largely unknown.
View Article and Find Full Text PDFAnimals (Basel)
May 2024
School of Life Science and Engineering, Southwest University of Science and Technology, Mianyang 621010, China.
Due to the degradation of pasture and strict restrictions on grazing ranges in recent years, copper (Cu) deficiency in Yudong black goats has been occurring, mainly manifested as emaciation, anemia, loss of appetite and lack of spirit. To explore the main causes of Cu deficiency in Yudong black goats, 40 black goats (1 year old, 25.11 ± 0.
View Article and Find Full Text PDFVet Pathol
November 2024
Department of Veterinary Medicine and Animal Sciences, University of Milan, Lodi, Italy.
The mouse is a well-established model of X-linked hyper-immunoglobulin M (IgM) syndrome, an immunodeficiency disorder of human beings characterized by the lack of expression of the CD40 ligand (CD40L) on activated T-cells, predisposing to infections with opportunistic pathogens like . The aim of our study was to describe the pulmonary lesions in mice experimentally infected with , in comparison with naturally infected severe combined immunodeficient (SCID) mice. Formalin-fixed paraffin-embedded lungs from 26 , 11 SCID, and 5 uninfected mice were examined by histology and immunohistochemistry for the presence of the pathogen and for leukocyte populations (CD3, CD4, CD45R/B220, CD8a, Iba-1, Ly-6G, CD206, MHC II, and NKp46/NCR1).
View Article and Find Full Text PDFAm J Hematol
June 2024
Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Houston, Texas, USA.
Early mortality in sickle cell disease (SCD) is attributed to increased infections due to loss of splenic function. Marginal zone B cells are important for initial opsonization of pathogens and can be absent in spleen histopathology in SCD. The frequency of unswitched memory B cells (UMBC), the circulating correlate of marginal zone B cells, reflects the immunologic function of the spleen.
View Article and Find Full Text PDFJ Allergy Clin Immunol
September 2024
Division of Immunology and Allergy, Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Pediatrics, Perelman School of Medicine, Philadelphia, Pa; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa. Electronic address:
Eur Ann Allergy Clin Immunol
April 2024
Department of Allergy and Clinical Immunology, Coimbra Hospital and University Centre, Coimbra, Portugal.
Autoimmunity
December 2024
Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany.
Unlike Fc receptors for switched immunoglobulin (Ig) isotypes, Fc receptor for IgM (FcµR) is selectively expressed by lymphocytes. The ablation of the FcµR gene in mice impairs B cell tolerance as evidenced by concomitant production of autoantibodies of IgM and IgG isotypes. In this essay, we reiterate the autoimmune phenotypes observed in mutant mice, ie IgM homeostasis, dysregulated humoral immune responses including autoantibodies, and Mott cell formation.
View Article and Find Full Text PDFCardiovasc Res
March 2024
Department of Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
Aims: The adaptive immune response plays an important role in atherosclerosis. In response to a high-fat/high-cholesterol (HF/HC) diet, marginal zone B (MZB) cells activate an atheroprotective programme by regulating the differentiation and accumulation of 'poorly differentiated' T follicular helper (Tfh) cells. On the other hand, Tfh cells activate the germinal centre response, which promotes atherosclerosis through the production of class-switched high-affinity antibodies.
View Article and Find Full Text PDFAnim Nutr
March 2024
State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
The present study was to explore the Ile requirement of piglets fed 18% crude protein (CP) diets. Two hundred and fifty 28-day-old Duroc × Landrace × Yorkshire piglets (8.37 ± 1.
View Article and Find Full Text PDFCell Mol Biol (Noisy-le-grand)
December 2023
Department of Dermatology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital Fuzhou 350001, Fujian Province, China.
It was to analyze the clinical characteristics of atopic dermatitis (AD) in children and its relationship with immunoglobulin (IgG, IgA, IgM, IgE) levels. 400 children with AD in the dermatology clinic of Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital(SCMC-FMU) were the study subjects, and 200 normal children were enrolled as the blank control. The clinical data of the included children were collected, and the serum immunoglobulin levels and other related indicators were measured.
View Article and Find Full Text PDFMol Immunol
February 2024
Department of Immunology, National Institute of Infectious Diseases, Shinjuku, Tokyo 162-8640, Japan.
During B cell development, pre-B cell receptor (pre-BCR), comprising the immunoglobulin heavy chain (HC) and surrogate light chain (SLC), plays a crucial role. The expression of pre-BCR serves as a certification of HC quality, confirming its ability to associate with the SLC and light chain (LC). In mice lacking SLC, the absence of this quality control mechanism leads to a distorted repertoire of HCs in the spleen and bone marrow.
View Article and Find Full Text PDFFront Immunol
January 2024
Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
Lack of complement factor C1q of the classical pathway results in severely impaired primary antibody responses. This is a paradox because antibodies, especially IgM, are the most efficient activators of the classical pathway and very little specific IgM will be present at priming. A possible explanation would be that natural IgM, binding with low affinity to the antigen, may suffice to activate complement.
View Article and Find Full Text PDF