Neurological Soft Signs in Type I Bipolar Disorder and Bipolar Spectrum Patients and Their Unaffected First-Degree Relatives: A Cross-Sectional Study.

Background And Aims: This study aimed to compare neurological soft signs (NSSs) in type 1 bipolar disorder (BD), bipolar spectrum (BS) patients, and their unaffected first-degree relatives.

Methods: This descriptive cross-sectional study involved participants referred to the Psychiatric Department of Imam Hossein Hospital. Five groups ( = 25): patients with type 1 BD, patients with BS, unaffected first-degree relatives of the two groups, and a control group were evaluated using the Neurological Evaluation Scale (NES).

A Systematic Review of the Outcomes of Utilization of Artificial Intelligence Within the Healthcare Systems of the Middle East: A Thematic Analysis of Findings.

Background And Aims: The rapid expansion of artificial intelligence (AI) within worldwide healthcare systems is occurring at a significant rate. In this context, the Middle East has demonstrated distinctive characteristics in the application of AI within the healthcare sector, particularly shaped by regional policies. This study examined the outcomes resulting from the utilization of AI within healthcare systems in the Middle East.

Acute cardiovascular effects of electronic cigarettes: a systematic review and meta-analysis.

Electronic cigarette (EC) is widely advertised as a safe alternative to traditional cigarette (TC). We aimed to investigate the cardiovascular effect of EC with/without nicotine compared with TC. We systematically searched PubMed/MEDLINE, EMBASE, and Cochrane CENTRAL for randomized controlled trials that compared the effect of different smoking modalities on cardiovascular function up to 1 October 2024.

Transforming agents: The power of structural modifications in glioblastoma multiforme therapy.

Glioblastoma (GBM) is a very deadly type of brain tumor with a poor prognosis and a short survival rate. Recent advancements in understanding GBM's molecular and genetic characteristics have led to the development of various therapeutic and diagnostic strategies. Key elements such as microRNAs, lncRNAs, exosomes, angiogenesis, and chromatin modifications are highlighted, alongside significant epigenetic alterations that impact therapy and diagnosis.

Genital self-image and sexual distress in married women with and without sexual intimate partner violence experience in Iran.

Objectives: The impact of sexual intimate partner violence (SIPV) on female genital self-image and sexual distress is not well understood. We aimed to assess whether women with and without SIPV experiences differed in terms ofgenital self-image and sexual distress.

Methods: An online survey was conducted among married, reproductive-age women registered at healthcare centers in Amol, northern Iran.

The Effect of Sevoflurane and Propofol on the Status of Renal Complications in Traumatic Injury Patients Following Laminectomy Surgery.

Objectives: Laminectomy is one of the most prevalent back surgeries. Considering the importance of controlling and minimizing surgical complications, this study was conducted to determine the effect of Sevoflurane and Propofol on the state of renal complications in patients undergoing laminectomy surgery.

Methods: This clinical trial was conducted in Ilam (Iran).

A Systematic Review on the Outcomes of Climate Change in the Middle-Eastern Countries: The Catastrophes of Yemen and Syria.

The Middle East is facing serious climate change challenges, rendering it as one of the most affected regions worldwide. This paper aimed to investigate the outcomes of climate change in the Middle East. In 2024, a qualitative study was conducted employing a methodology that integrated systematic review for data collection and thematic analysis for data analysis.

Sexual health promotion interventions in Iranian postmenopausal women: A systematic review of randomized controlled trials.

This study aimed to systematically review published articles on sexual health promotion interventions in postmenopausal Iranian women. Five databases including PubMed, ProQuest, Web of Science, Science Direct, and Google Scholar, as well as three Iranian databases, including SID, IranDoc, and Magiran, were searched without a time limit for sexual health promotion interventions in Iranian postmenopausal women. The risk of bias was assessed using the Jadad scale.

The Coronary Angiography and Angioplasty Registry (CAAR) in Iran: Registry Protocol and Results of the Pilot Study.

Background: The current registry system aims to design a database that can be used for future research as a tool to produce and update new protocols for the diagnosis, treatment, management, and prevention of heart diseases.

Methods: In this hospital-based registry system, established on 27 July 2021, all the adult patients (age ≥18 years old) with signs and symptoms of cardiac diseases under coronary angiography or angioplasty in the cardiac ward of Imam Hossein Hospital of Tehran, Iran were recruited and followed-up until 30 days after discharge in the pilot phase. All data were collected using a researcher-made checklist from face-to-face interviews with patients and their medical records.

Financial cost of end-of-life cancer care in palliative care units (PCUs) and non-PCUs in Iran: insights from low- and middle-income countries.

Background: End-of-life care for patients with advanced cancer can impose a significant financial burden. However, data on the economic impact of end-of-life care in low- and middle-income countries are limited.

Objective: This study aims to compare the costs associated with palliative care units (PCUs) and non-PCU settings for cancer patients in Iran.

Impact of cognitive-aerobic exercise training on brain-derived neurotrophic factor, dual-tasking abilities, and mood state in individuals with multiple sclerosis.

Objectives: Multiple sclerosis (MS) is a chronic neurological disorder characterized by demyelination and neurodegeneration, leading to various physical, cognitive, and emotional challenges. Dual-task (DT) training, involving performing mental and physical tasks simultaneously, addresses the complex interaction between motor and cognitive functions.

Purpose: Given the extensive physical, cognitive, and mood-related issues in this population, this study aimed to examine the effects of combined aerobic-cognitive training (Brythonic) and aerobic training on brain-derived neurotrophic factor (BDNF), DT performance, and mood state in MS patients.

Upadacitinib and Cardiovascular Adverse Events in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis.

Background: Upadacitinib, a Janus kinase (JAK) inhibitor used in rheumatoid arthritis treatment, has prompted safety concerns due to potential cardiovascular adverse events. However, current evidence does not provide a definitive conclusion.

Methods: We conducted a comprehensive systematic review of the literature up until March 15, 2024, utilizing databases like PubMed/Medline, Embase, and Cochrane CENTRAL.

A Review on the Approach to Herbal Medicine in Cuban Healthcare System.

Cuban healthcare system, emphasizing a holistic approach with herbal medicine as a key component, has achieved significant advancements in a multitude of health indicators. The aim of this study was to investigate the approach of Cuban healthcare system to Herbal medicine. The study conducted a review in the year 2024 in accordance with the guidelines set by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).

MicroRNAs in Aseptic Loosening of Prosthesis: Pathophysiology and Potential Therapeutic Approaches.

Objectives: Aseptic loosening (AL) is one of the leading causes of total joint arthroplasty (TJA) revision. Discovering the roles of microRNAs (miRNA/miR) in ontogenesis and osteolysis has attracted more attention to diagnosing and treating bone disorders. This review aimed to summarize miRNA biogenesis and describe the involvement of miRNAs in AL of implants.

Efficacy and Safety of Pembrolizumab Monotherapy or Combined Therapy in Patients with Metastatic Triple-negative Breast Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Background: Metastatic Triple-negative Breast Cancer (mTNBC) is the most aggressive form of breast cancer, with a greater risk of metastasis and recurrence. Research studies have published in-depth analyses of the advantages and disadvantages of pembrolizumab, and early data from numerous trials suggests that patients with mTNBC have had remarkable outcomes. This meta-analysis compares the data from numerous relevant studies in order to evaluate the safety and efficacy of pembrolizumab monotherapy or combination therapies for mTNBC.

Investigating the Effect of High-Dose Vitamin D3 Administration on Inflammatory Biomarkers in Patients with Moderate to Severe Traumatic Brain Injury: A Randomized Clinical Trial.

Background: Traumatic brain injury (TBI) is one of the most common neurological disorders worldwide. We aimed to investigate the efficacy of high-dose vitamin D3 on inflammatory biomarkers in patients with moderate to severe TBI.

Methods: Thirty-five moderate to severe TBI patients were randomly assigned to intervention and control groups.

Healthcare professionals' needs when providing perinatal bereavement care: A qualitative study.

Background: Caring for and supporting bereaved parents with fetal loss requires preparation, training, and attention to a set of needs of health workers to provide optimal services. This is although it has been less addressed in the educational curriculum and in-service training. This study aims to investigate the experiences of Iranian healthcare professionals regarding the needs related to the care of bereaved parents with perinatal loss.

Association between Sleep Quality and Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Patients with Bipolar Disorder.

Background: Many patients with bipolar disorder (BD) experience sleep problems. Sleep abnormalities are associated with immune dysfunction, which may be reflected by hematological indices. Purpose: This study aimed to investigate the association between sleep quality and the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) in patients with BD.