Caregiver burden, perceived stress, and social support among parents of chronically Ill children in Saudi Arabia.

Background: Children with chronic illnesses pose a significant burden on parents who are directly involved in caregiving. Despite the high prevalence of chronic illnesses among children in Saudi Arabia, no study has examined caregiver burden and other related factors in the Saudi Population. Thus, this study determined the levels of caregiver burden, perceived social support, and perceived stress and their association among parents who provide care to their child with a chronic illness.

Olanzapine for young PEople with aNorexia nervosa (OPEN): results of a feasibility study.

Background: Despite the availability of evidence-based treatments for anorexia nervosa (AN), remission rates are moderate, and mortality is high. Olanzapine is used as adjunct therapy for AN in case of insufficient response to first-line treatments, even though the evidence is limited. Its effect on eating disorder (ED) psychopathology, its efficacy and tolerability, and its acceptability and adherence rate are unclear.

Assessing ChatGPT's cybersecurity implications in Saudi Arabian healthcare and education sectors: A comparative study.

Study Purpose: This study aims to critically evaluate ChatGPT's impact on cybersecurity in healthcare and education sectors.

Methods: This study employed a cross-sectional survey design, collecting data from healthcare and educational professionals in Saudi Arabia through a structured questionnaire, with 205 healthcare workers' and 214 educators. The survey assessed perceptions of ChatGPT's impact on cybersecurity opportunities and challenges, with data analyzed using descriptive statistics and ANOVA to explore differences across professional roles.

Accuracy, Marginal, and Internal Fit of Additively Manufactured Provisional Restorations and Prostheses Printed at Different Orientations.

Objectives: This systematic review aimed to assess the impact of printing orientation on the accuracy and properties of additively manufactured provisional restorations.

Materials And Methods: A systematic literature search databases (PubMed, Scopus, Web of Science, and Cochrane) were conducted in July 2024 without language restrictions. The included studies were evaluated using the modified CONSORT checklist, and the effect measures and synthetic methods were employed to assess the accuracy of resin provisional restorations printed at various orientations.

Telepharmacy and remote medication management: An empirical study from patients' perspectives.

Telepharmacy has emerged as a vital tool in healthcare, allowing remote medication management, especially for patients in rural areas. Despite its growing adoption, there is limited empirical evidence on its effectiveness and patient experiences in diverse healthcare settings. This study aims to investigate telepharmacy and remote medication management through the lens of patients, shedding light on their attitudes, challenges, and preferences.

Physio-Mechanic and Microscopic Analyses of Bioactive Glass-Based Resin Infiltrants.

This study aimed to investigate the efficacy and durability of bioactive glass-based dental resin infiltrants. Resin infiltrants were formulated by combining photoinitiated dimethacrylate monomers with three variations of bioactive glass: 45S5 Bioglass (RIS), boron-substituted (RIB), fluoride-substituted (RIF), and pure resins (PR), whereby TOOTH group (TH) and ICON (CN) served as commercial control groups. Teeth samples were prepared, and experimental and control infiltrants were applied on demineralized human-extracted teeth.

Correction: Sustainable polymeric adsorbents for adsorption-based water remediation and pathogen deactivation: a review.

[This corrects the article DOI: 10.1039/D4RA05269B.].

Nurse Educators and Faculty Members Challenges Towards Online Teaching During COVID-19 Pandemic Crisis: A Qualitative Descriptive Study.

Aim: The effects of COVID-19 have brought numerous changes in society in the past several months. Lifestyles, business sectors, educational facilities and healthcare services have been greatly affected, causing individuals to be alarmed about future repercussions. This study investigated the various challenges of nursing faculties in conducting online teaching during the COVID-19 pandemic crisis.

The application of medical ethics in the developing countries - A neurosurgical perspective.

Introduction: Neurosurgery is one of the rapidly evolving specialities of medical science, where the neurosurgeons have to provide evidence-based interventions in life threatening conditions maintaining the ethical standards.

Research Question: This narrative review sheds light on the current hindrances of the ethical aspects of neurosurgical practice in low and middle-income countries (LMICs) and provide some feasible solutions for future.

Material And Methods: A literature search was conducted using PubMed, Scopus and ISI web of knowledge focused on articles in English with the words "medical ethics" together with the words "neurosurgery", "ethical practice", "low and middle-income countries", "surgical innovation", "randomized clinical trials" and "outcome" alone or in combination.

Visual Outcome and Patient Satisfaction with Implantation of Trifocal Intraocular Lens After Radial Keratotomy.

Objective: To investigate the visual outcomes and patient satisfaction following trifocal intraocular lens (IOL) implantation after radial keratotomy (RK).

Methods: This was a retrospective chart review wherein we studied 14 eyes from 7 patients who had undergone cataract surgery and had trifocal intraocular lens (IOL) implanted in the Eastern Province of Saudi Arabia's King Fahd University Hospital and Kahhal private centre. Data such as demographic characteristics, the time between RK and cataract removal, intraoperative and postoperative complications, preoperative and postoperative uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), and refraction were evaluated.

Effectiveness of the Individualized Self-Care Program Based on Orem's Self-Care Theory: Impact on Learning Needs and Self-Care Behaviors Following Coronary Artery Bypass Surgery - A Randomized Controlled Trial.

Purpose: This study aimed to investigate the specific learning needs of patients within the experimental group after receiving the Individualized Self-Care Program (ISCP) at two key time points: Time 2 (Day 2, Week 1) and Time 3 (Day 15, Week 3). Furthermore, it aimed to compare the effectiveness of the ISCP in improving self-care behavior between the experimental group and the control group, which received standard health education.

Methods: The study utilized a randomized controlled trial (RCT) design and included a consecutive sample of 128 patients who had undergone their first Coronary Artery Bypass Graft (CABG) procedure.

Streptozotocin- induced changes in aquaporin 1 and 4, oxidative stress, and autophagy in submandibular and parotid salivary glands and the possible ameliorative effect of intermittent fasting on these changes.

Salivary glands are highly responsible for maintaining oral tissue homeostasis by secreting saliva. This study was designed to investigate aquaporin 1 and 4, oxidative stress, and autophagy in submandibular and parotid salivary glands of diabetic rats and the possible ameliorative effect of intermittent fasting on these changes. Fifty adult male rats were divided into control and experimental groups.

A review on optimization of Wilms tumour management using radiomics.

Background: Wilms tumour, a common paediatric cancer, is difficult to treat in low- and middle-income countries due to limited access to imaging. Artificial intelligence (AI) has been introduced for staging, detecting, and classifying tumours, aiding physicians in decision-making. However, challenges include algorithm accuracy, translation into conventional diagnosis, reproducibility, and reliability.

Bibliometric analysis of the current status and trends in dental applications of glass fiber-reinforced composites from 1998 to 2022.

Over the last few years, considerable attention has been devoted to glass fiber-reinforced composites (GFRCs) in the field of dentistry. Glass fiber-reinforced composites are useful in prosthodontics, endodontics, restorative dentistry, orthodontics, and periodontics. This study considered various aspects related to GFRCs to assess the publications and citations on the subject from 1998 to 2022.

The evaluation of therapeutic outcomes of biologics in allergic fungal rhinosinusitis: a systematic review and meta-analysis.

Allergic fungal rhinosinusitis (AFRS) is a localized inflammatory, hypersensitivity reaction affecting the nasal cavity and its sinuses secondary to fungal colonization. The burden of surgical revisions and recurrence rates in this disease led to a recent hypothesized advancement in the medical management being experimented, which is the use of biologics. Therefore, this systematic review analyzed nine articles to highlight the significance of biologics in the management of AFRS through a comprehensive strategy, as seen in Supplementary Methods Section (1-9).

drug repurposing using molecular docking and dynamics to target the protein interaction between the SARS-CoV-2 S-glycoprotein and the ACE2 receptor.

The protein interaction between the viral surface S-glycoprotein and the host angiotensin converting enzyme-2 receptor (ACE2) is key to the virulent nature of SARS-CoV-2. The potential role that effective drug repurposing strategies may have to help stem the impact of future outbreaks has been brought to light in the recent COVID-19 pandemic. This study outlines a comprehensive approach towards drug discovery which aims to identify hit agents that can be suitably translated into a clinical setting.

Probing the Depths of Molecular Complexity: STAT3 as a Key Architect in Colorectal Cancer Pathogenesis.

Colorectal cancer (CRC) has become a significant threat in recent decades, and its incidence is predicted to continue rising. Despite notable advancements in therapeutic strategies, managing CRC poses complex challenges, primarily due to the lack of clinically feasible therapeutic targets. Among the myriad molecules implicated in CRC, the signal transducer and activator of transcription 3 (STAT3) stands out as a promising target tightly regulated by various genes.

Evaluating the Predictors of Persistent Long COVID Symptoms and Their Severity in COVID-19 Survivors 1 Year After Infection.

Introduction/objective: As the coronavirus disease 2019 (COVID-19) pandemic progressed, the virus was found to cause long-term health complications known as long COVID (LC). This study aimed to investigate LC symptom severity and the factors associated with the likelihood of persistence beyond 1 year among COVID-19 survivors in Saudi Arabia.

Methods: This descriptive, cross-sectional, questionnaire-based study was conducted via convenience sampling between December 1, 2023, and March 1, 2024.

Method development and validation for the extraction and quantification of sesquiterpene lactones in Dolomiaea costus.

Dolomiaea costus, commonly known as Indian costus, is a medicinal plant from the Asteraceae family. The root and powder of costus have been widely used to treat various health conditions. The primary bioactive compounds in this plant are sesquiterpene lactones, particularly costunolide and dehydrocostus lactone.

Effective deep brain stimulation for obsessive-compulsive disorder after failed anterior capsulotomy: illustrative cases.

Background: Obsessive-compulsive disorder (OCD) is a psychiatric condition characterized by recurrent, unwanted thoughts (obsessions) and repetitive behaviors (compulsions) performed to relieve distress related to the obsessions. For patients with severe illness refractory to first-line pharmacotherapy and psychotherapy, neurosurgical treatments such as deep brain stimulation (DBS) and stereotactic lesioning are an option. The choice between DBS and lesioning is often driven by patient preference, but these options are not mutually exclusive.