Antiurolithic activity of Zaleya pentandra (L.) C Jeffrey in ethylene glycol-induced calcium oxalate crystal rat model; A scientific validation of traditional use for kidney stone prevention.

Ethnopharmacological Relevance: Traditional herbal remedies have been used for treating nephrolithiasis, but the relevant scientific evidence is limited. Zaleya pentandra (L.) C.

Solvent- and Catalyst-Controlled Regioselective - and -Alkylation of 2-Pyridones by 2-Azirines.

The synthesis of -substituted 2-hydroxypyridines and -substituted 2-pyridones, crucial for many bioactive compounds and drugs, faces challenges due to the tautomeric nature of 2-pyridones, which complicates selective alkylation. Here we developed an efficient method for regioselective - and -alkylation of 2-pyridones using Bro̷nsted acid-catalyzed ring opening of 2-azirines. The process involves triflic acid for -alkylation and -toluenesulfonic acid for alkylation, achieving high yields under optimized conditions.

Awareness of Current Surgical Practice for Congenital Scoliosis and Optimal Timing of Treatment Among Physicians and Patients' Families in Saudi Arabia.

Background: Congenital scoliosis (CS) is a developmental spinal deformity characterized by an abnormal curvature of the spine, affecting one in 1,000 births. The mainstay of treatment involves either observation or surgery in significant curve progression. The optimal timing of surgical intervention is debated, with early intervention preferred.

ChatGPT as a psychotherapist for anxiety disorders: An empirical study with anxiety patients.

this study aims to investigate the role of ChatGPT as a psychotherapist for anxiety disorders, examining its effectiveness, acceptability, and potential benefits among individuals with anxiety disorders. a quasi-experimental design was adopted, involving a 4-week intervention where participants used ChatGPT as a therapeutic tool. The study included outpatients aged above 18 years from public hospitals in Saudi Arabia.

Factors related to spontaneous space closure following early first permanent molar extraction: A systematic review.

Background: Dental caries and molar-incisor hypomineralization (MIH) are primary reasons for the extraction of first permanent molars (M1) in children, which can lead to significant dental and facial development issues such as a midline shift and temporomandibular joint disorder.

Aim: This systematic review aimed to identify key factors influencing spontaneous space closure following the early extraction of first permanent molars (M1) in children aged 5-15.

Design: We conducted a comprehensive search across Scopus, PubMed, Dimensions, Web of Science, and Cochrane databases, including the literature from 1960 to 2024.

Chromosomal gene order defines several structural classes of Staphylococcus epidermidis genomes.

The original methodology for describing the pangenome of a prokaryotic species is based on modeling genomes as unordered sets of genes. More recent findings have underlined the importance of considering the ordering of genes along the genetic material as well, when making comparisons among genomes. To further investigate the benefits of gene order when describing genomes of a given species, we applied two distance metrics on a dataset of 84 genomes of Staphylococcus epidermidis.

Simultaneously Promoted Water Resistance and CO Selectivity in Methanol Oxidation Over Pd/CoOOH: Synergy of Co-OH and the Pd-O-Co Interface.

Catalytic purification of industrial oxygenated volatile organic compounds (OVOCs) is hindered by the presence of water vapor that attacks the active sites of conventional noble metal-based catalysts and the insufficient mineralization that leads to the generation of hazardous intermediates. Developing catalysts simultaneously with excellent water resistance and a high intermediate suppression ability is still a great challenge. Herein, we proposed a simple strategy to synthesize a Pd/CoOOH catalyst that contains abundant hydroxyl groups and lattice oxygen species, over which a negligible effect was observed on CHOH conversion with 3 vol % water vapor, while a remarkable conversion reduction of 24% was observed over Pd/CoO.

Perceived Burden and Quality of Life in Caregivers of Patients with Schizophrenia in Saudi Arabia's Eastern Province: A Cross-sectional Study.

Background And Aims: Family Caregivers (FCGs) of patients with schizophrenia (PwS) may face unanticipated sources of stress and responsibility, which can negatively impact their quality of life (QoL). This study aimed to assess FCGs' QoL and the impact of clinical characteristics of patients and sociodemographic factors on their QoL.

Patients And Methods: A cross-sectional questionnaire-based study surveyed 340 FCGs from outpatient clinics of PwS in two large psychiatric hospitals in Saudi Arabia's eastern province using a convenience sampling approach.

Quality of life and psychological distress in end-stage renal disease patients undergoing hemodialysis and transplantation.

Background: Among diverse profound impacts on patients' quality of life (QoL), end-stage renal disease (ESRD) frequently results in increased levels of depression, anxiety, and stress. Renal replacement therapies such as hemodialysis (HD) and transplantation (TX) are intended to enhance QoL, although their ability to alleviate psychological distress remains uncertain. This research posits the existence of a significant correlation between negative emotional states and QoL among ESRD patients, with varying effects observed in HD and TX patients.

Effects of anodal transcranial direct current stimulation on postural stability in subacute stroke: A randomized control trial.

Anodal transcranial direct current stimulation (tDCS) promotes neuromodulation and neuroplasticity in the brain. The aim of this study was to determine the long-term effects of the anodal tDCS on postural and trunk stability, physical performance, anticipatory postural adjustment and quality of life in sub-acute stroke patients. Thirty-six participants with sub-acute stroke were divided into experimental and control groups using sealed envelope randomization.

Multicomponent Approaches to Reduce Multidrug-Resistant Organisms in Critical Care: Determining the Ideal Strategy.

Although there is ample proof of the advantages of infection prevention and Control (IPC) in acute-care hospitals, there is still some questions about the efficacy of IPC interventions for multidrug-resistant organisms (MDROs), and there is a need for the development of evidence-based practices. No healthcare facility has found a single effective technique to reduce MDRO. However, a multicomponent intervention that included improved barrier protection, chlorhexidine bathing, microbiological monitoring, and staff involvement significantly decreased the likelihood of infection in the patient surroundings with multidrug-resistant organisms.

Strategical Ways for Dental Anxiety Management Prior to Third Molar Extraction.

A patient experiencing moderate to severe anxiety often skips regular check-ups, choosing to visit only when necessary. As a result, their oral health worsens. Various variables can affect anxiety such as age, gender, culture, and previous experiences.

Expression of concern: A well-defined S-g-CN/Cu-NiS heterojunction interface towards enhanced spatial charge separation with excellent photocatalytic ability: synergetic effect, kinetics, antibacterial activity, and mechanism insights.

Expression of concern for 'A well-defined S-g-CN/Cu-NiS heterojunction interface towards enhanced spatial charge separation with excellent photocatalytic ability: synergetic effect, kinetics, antibacterial activity, and mechanism insights' by Haya A. Abubshait , , 2022, , 3274-3286, https://doi.org/10.

Production and Antibacterial Activity of Atypical Siderophore from sp. QCS59 Recovered from .

Among sixty-eight pseudomonads, isolate QCS59 from the rhizosphere of was selected based on its siderophore level. Production was optimal in Kings B supplemented with 2% peptone and 0.5% fructose at pH 6.

Preliminary study on heart response and locomotor parameters in Donkeys (Equus asinus) during exercise using fitness tracker (Equimetre).

The welfare of donkeys remains a compelling subject for researchers, with limited literature available on the response of the donkey cardiovascular system during strenuous exercise. The study aimed to address two primary objectives. Firstly, to assess the reliability of wearable devices in detecting heart rate (HR) and ECG readings.

COVID-19 and Cancer Care: A Review and Practical Guide to Caring for Cancer Patients in the Era of COVID-19.

COVID-19, a novel infectious disease caused by the emergence of the SARS-CoV-2 virus in 2020, has had a profound impact on healthcare, both at the individual and population level. The impact at the population level was felt most acutely during the emergency phase of the pandemic, with hospital capacity issues leading to widespread disruptions and delays in the delivery of healthcare services such as screening programs and elective surgeries. While hospitals are no longer being acutely overwhelmed by COVID-19 patients, the impact of the virus on vulnerable patient populations such as cancer patients continues to be of ongoing consequence.

Bond Strength of Nanocomposite Hard Liner to CAD-CAM Milled, 3D Printed, and Conventionally Fabricated Denture Base Resins.

Background: To investigate the effect of zirconium dioxide nanoparticles (ZrONPs) on the shear bond strength (SBS) of hard denture lines bonded to different denture base resins.

Methods: Five different denture bases were used in this study: conventional heat-cured resin, IvoCad, AvaDent, NextDent, and FormLabs, in acrylic specimens of 10 × 10 × 2.5 mm (N = 150, n = 10).

The Use of Artificial Intelligence in Caries Detection: A Review.

Advancements in artificial intelligence (AI) have significantly impacted the field of dentistry, particularly in diagnostic imaging for caries detection. This review critically examines the current state of AI applications in caries detection, focusing on the performance and accuracy of various AI techniques. We evaluated 40 studies from the past 23 years, carefully selected for their relevance and quality.