Influence of different print orientations on properties and behavior of additively manufactured resin dental devices: A systematic review and meta-analysis.

Statement Of Problem: Different factors affect 3-dimensionally (3D) printed resin products. However, evidence on the effect of the print orientation on resin dental devices is lacking.

Purpose: The purpose of this systematic review and meta-analysis was to assess the impact of print orientation on the properties and accuracy of 3D printed implant surgical guides, occlusal devices, clear orthodontic retainers, and aligners.

Insights on the Mesembryanthemum forsskalii phenotype and study of the effects of several exogenous plant growth regulators via plant tissue culture.

Background: Samh (Mesembryanthemum forsskalii, M. cryptanthum) belongs to Aizoaceae family and is found in northern Saudi Arabia, primarily in desert or dry shrubland habitats. M.

HPO promoted reactions of thioamides with 2-substituted benzyl alcohols.

In this study, we have investigated the reactivity of thioamides with alcohols by utilizing HPO as a low-toxicity, cost-effective Brønsted acid catalyst. This report includes a methodology for the synthesis of thioesters from thioamides and 2-hydroxyaryl alcohols. Thioesters are emerging as a notable class of organic molecules due to their biological relevance, extensive use in drug discovery, and industrial applications.

C-reactive protein (CRP) levels in people with eating disorders: A systematic review and meta-analysis.

Studies suggest that there is a relationship between inflammatory diseases, inflammatory markers such as C-reactive protein (CRP) and psychiatric disorders. In eating disorders, cross-sectional studies have recently examined peripheral CRP levels in blood serum and plasma, which allow a comprehensive meta-analysis. This systematic review and meta-analysis examined studies from three databases, measuring CRP levels in people with eating disorders, following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines.

Assessing the Causes of Acceptance or Refusal of Breast Cosmetic Procedures Among Saudi Women When They Get to Age of Menopause: A Cross Sectional Study-Saudi Arabia.

Introduction: Cosmetic breast surgery encompasses a variety of procedures aimed at enhancing breast appearance and is increasingly popular globally. Despite this trend, the acceptance of such surgeries among Saudi women approaching menopause remains understudied. This research aims to explore the attitudes and perceptions toward cosmetic breast surgery in this demographic, considering cultural and religious influences in Saudi Arabia.

Efficacy of Duloxetine for Postspine Surgery Pain: A Systematic Review and Meta-Analysis.

Background: Duloxetine, a serotonin and norepinephrine reuptake inhibitor (SNRI), is used to treat various health conditions, including major depressive disorder, generalized anxiety disorder, fibromyalgia, and off-label for chemotherapy-induced pain. We conducted this systematic review and meta-analysis aiming to test the current evidence regarding effectiveness and safety of duloxetine for postspine surgeries pain.

Methods: We searched the Cochrane Central Register of Controlled Trials, PubMed, Scopus and Web of science databases for relevant articles up to March 2024.

RAP-2 and CNH-MAP4 Kinase MIG-15 confer resistance in bystander epithelium to cell-fate transformation by excess Ras or Notch activity.

Induction of cell fates by growth factors impacts many facets of developmental biology and disease. LIN-3/EGF induces the equipotent vulval precursor cells (VPCs) in to assume the 3˚-3˚-2˚-1˚-2˚-3˚ pattern of cell fates. 1˚ and 2˚ cells become specialized epithelia and undergo stereotyped series of cell divisions to form the vulva.

Managing Early Childhood Caries: A Comparative Review of Preventive and Restorative Approaches.

Early childhood caries (ECC), one of the most common health problems among children aged six years and below, is considered present when one or more surfaces of a tooth are decayed, missing, or filled. Not only does ECC cause pain for a long time, but it also has short- and long-term health consequences in children. In order to treat ECC, holistic management that includes preventive, restorative, and prosthetic intervention is necessary.

Barriers and Facilitators to Colorectal Cancer Screening: Providers' Perspective.

Background: Colorectal cancer ranks as the third most prevalent cancer worldwide and the second most prevalent cancer in Saudi Arabia. Additionally, it stands as the second leading cause of cancer-related mortality globally. There is an increasing incidence of colorectal cancer worldwide.

Gallic Acid: A Potent Metabolite Targeting Shikimate Kinase in .

is a highly multidrug-resistant pathogen resistant to almost all classes of antibiotics; new therapeutic strategies against this infectious agent are urgently needed. Shikimate kinase is an enzyme belonging to the shikimate pathway and has become a potential target for drug development. This work describes the search for Food and Drug Administration (FDA)-approved drugs and natural compounds, including gallic acid, that could be repurposed as selective shikimate kinase inhibitors by integrated computational and experimental approaches.

Virtual Versus Traditional Learning: A Comparison of Dental Students' Perception and Satisfaction.

Comparing the effectiveness of virtual and traditional learning methods is crucial for understanding their impact on knowledge transmission in different subjects. The objective of this cross-sectional study was to explore dental students' perceptions and satisfaction levels with their experiences in virtual learning compared to traditional classroom learning. A cross-sectional survey was administered to all dental students in the College of Dentistry across preclinical (3rd and 4th year) and clinical (5th and 6th year) levels using Google Forms.

Dental Practitioners' Knowledge and Attitudes Toward the Etiology, Diagnosis, and Treatment of Peri-Implantitis.

The objective of this study was to assess the level of knowledge and attitude about the etiology, diagnosis, and management of peri-implantitis among dental practitioners. An online cross-sectional study on 303 dentists in Saudi Arabia was conducted. A closed-ended survey consisting of 28 questions was designed.

Internal and marginal fits of 3D-printed provisional prostheses: comparative effect of different printing parameters.

Objectives: The influence of printing parameters on the marginal and internal fit of three-dimensional (3D) printed interim fixed partial dentures (IFPDs) has been understudied. This investigation sought to elucidate the impact of printing orientation and post-curing time on these critical factors.

Methods: A total of 260 3-Unit IFDPs were printed using two different resins (130/NextDent C&B MFH and 130/ASIGA DentaTOOTH).

Marginal zone lymphoma of mucosa associated lymphoid tissue-lymphoma of the lacrimal gland in a young patient with Klinefelter syndrome: a case report.

Background: Klinefelter syndrome is considered one of the most common sex chromosome disorders affecting males. The presence of an extra X chromosome can alter the tendency to develop various cancers, including lymphomas. Lacrimal gland lymphoma is a disease of the elderly, with a median age of presentation of 70 years.

Impact of 3D printing orientation on accuracy, properties, cost, and time efficiency of additively manufactured dental models: a systematic review.

Background: The evidence on the effect of printing orientation on dimensional accuracy and properties of resinous dental models is unclear. This systematic review aimed to assess the impact of printing orientation on the accuracy and properties of additively manufactured resinous dental models, besides the cost, material consumption, and time efficiency at different orientations.

Methods: A comprehensive web search (PubMed, Scopus, Cochrane) was performed in July 2024 without language restrictions.

Factors Affecting Vancomycin Trough Concentration; a Population Pharmacokinetic Model in Non-Critical Care Saudi Patients.

Background And Objective: Vancomycin is commonly prescribed in treatment of methicillin-resistant Staphylococcus aureus infections. While, vancomycins' pharmacokinetic vary among older patients, there is a paucity of data regarding specific characteristics influencing pharmacokinetics in Saudi adult patients. This study aims to establish a population-pharmacokinetic (Pop-PK) model for vancomycin in patients admitted to medical wards, with the focus on identification of patient characteristics influencing vancomycin trough concentrations.

Correction: The Impact of Microbiome Interventions on the Progression and Severity of Inflammatory Bowel Disease: A Systematic Review.

[This corrects the article DOI: 10.7759/cureus.60786.

Primary pleural schwannoma: a rare case report.

Schwannomas are peripheral nerve sheath tumors that rarely arise from autonomic nerves of the pleural lining. Most often, they present as slow-growing tumors and are asymptomatic. Herein, we describe the case of an elderly male patient who presented with severe chest pain.

Antimicrobial resistance pattern of isolated from imported frozen shrimp in Saudi Arabia.

Contamination of seafood products with multi-drug-resistant (MDR) bacteria is considered to be a potential source for the spread of MDR bacteria in communities. However, little is known about the extent of the contamination of seafood, in particular shrimp, with MDR bacteria in Saudi Arabia. In this study, imported frozen shrimp in retail markets were examined for the antimicrobial susceptibility patterns of .

Recent Advances in Regenerative Endodontics: A Review of Current Techniques and Future Directions.

Regenerative endodontics is a rapidly evolving discipline focused on biologically restoring the pulp-dentin complex to revive vitality in non-vital teeth. Unlike traditional endodontic therapies that rely on inert materials to preserve structure, regenerative techniques aim to re-establish natural structure and function by harnessing advancements in tissue engineering. This narrative review examines recent progress in stem cell applications, scaffold development, signaling molecules, and clinical protocols that contribute to successful regenerative outcomes.

An In-Depth Insight into Clinical, Cellular and Molecular Factors in COVID19-Associated Cardiovascular Ailments for Identifying Novel Disease Biomarkers, Drug Targets and Clinical Management Strategies.

COVID-19 was initially identified as a respiratory system disorder, but it has been reported to interact with and influence the cardiovascular system, in addition to many other body systems. Although COVID-19-associated cardiovascular (CV) complications are common, resulting in high acute phase mortality and a large number of morbidities in the chronic phase, thus severely impacting patients' quality of life and health outcomes, yet clinical, cellular, and molecular biological factors underlying the pathophysiology of cardiovascular complications associated with COVID-19 are poorly understood. This review investigates putative underlying clinical factors as well as cellular and molecular biological mechanisms by which COVID-19 leads to acute CV complications, including state-of-the-art genomic sequencing-based findings, and assessing the long-term CV consequences of COVID-19, aiming to shed light on developing strategies for differential diagnosis, risk prognostic stratification, prevention, and clinical management of CV sequels in COVID-19 patients.

Association of burnout and working environment conditions in respiratory care professionals in Saudi Arabia: a cross-sectional study.

Introduction: Burnout is a pervasive issue in healthcare, and it impacts both the wellbeing of healthcare professionals and the quality of patient care. This study examines factors associated with burnout and working environment among respiratory therapists in Saudi Arabia.

Methods: A structured questionnaire was used to collect data from respiratory therapists.