1,018 results match your criteria: "Imaging in Twin-to-Twin Transfusion Syndrome"

Article Synopsis
  • Fetal echocardiography studies show that twins affected by twin-to-twin transfusion syndrome (TTTS) exhibit impaired cardiac function, highlighting a need for further investigation post-birth.
  • In a study comparing donor-recipient twin pairs to singleton infants, significant differences in cardiac structure and function were observed, particularly between the recipient twins and singletons.
  • The findings indicate that both cardiac function and arterial properties are compromised in TTTS twins, suggesting a necessity for ongoing monitoring after birth to address potential cardiovascular issues.
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Fetal MRI findings, etiology, and outcome in prenatally diagnosed schizencephaly.

AJNR Am J Neuroradiol

October 2024

From the Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA (EG, OAG), Department of Neurology, University of California, San Francisco, CA (RV, DG), Albert Einstein College of Medicine, Bronx, NY (YY), Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, CA (MET), Department of Pediatrics, University of California San Francisco (DG).

Article Synopsis
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Real-time placental vessel segmentation in fetoscopic laser surgery for Twin-to-Twin Transfusion Syndrome.

Med Image Anal

January 2025

Harvard Medical School, Boston, MA, United States of America; Center for Advanced Medical Computing and Simulation, Massachusetts General Hospital, Boston, MA, United States of America. Electronic address:

Article Synopsis
  • Twin-to-Twin Transfusion Syndrome (TTTS) affects 15% of identical twins sharing a placenta, and the standard treatment is fetoscopic laser photocoagulation (FLP), which improves fetal survival by correcting abnormal blood vessel connections.
  • The proposed solution, TTTSNet, is a network architecture that enhances visualization of placental vessels during FLP surgery, utilizing advanced techniques for accurate vessel segmentation and addressing specific challenges encountered during the procedure.
  • Trained on a dataset of video frames from fetoscopic procedures, TTTSNet showed significant performance growth over existing methods, achieving high accuracy and speed, which could enable real-time surgical applications.
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Article Synopsis
  • - This study looked into how different MRI injury patterns in fetuses with intraparenchymal hemorrhage (IPH) relate to their causes and outcomes, using data from cases diagnosed between 1996 and 2022.
  • - Researchers analyzed 44 fetuses, noting that most IPH cases were supratentorial and often linked with conditions like twin-twin transfusion syndrome and certain genetic variants (COL4A1/2).
  • - The findings showed a high prevalence of neurological issues in surviving infants, with many developing cerebral palsy, developmental delays, and epilepsy, emphasizing the need for genetic evaluations in unexplained cases of fetal IPH.
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Evaluation of the efficacy of intrauterine treatments of twin-to-twin transfusion syndrome using myocardial performance index.

Quant Imaging Med Surg

August 2024

Department of Ultrasound, West China Second University Hospital, Sichuan University, Chengdu, China.

Article Synopsis
  • The study focused on evaluating fetal cardiac function in cases of twin-to-twin transfusion syndrome (TTTS) using the myocardial performance index (MPI) and considered the impact of different intrauterine treatments.
  • Data from 68 TTTS cases were compared to 68 healthy monochorionic diamniotic (MCDA) twins, examining MPI before and after treatments like amnioreduction, fetoscopic laser photocoagulation, and selective reduction.
  • Results showed that while recipients had higher MPI values compared to control twins, only fetoscopic laser photocoagulation and selective reduction led to a significant decrease in MPI values post-treatment, suggesting improvements in cardiac function following these interventions.
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Article Synopsis
  • The study aimed to evaluate the hemodynamics of twin-to-twin transfusion syndrome (TTTS) by measuring intraventricular pressure difference (IVPD) using fetal echocardiography in monochorionic diamniotic twins.
  • Twenty-eight twins diagnosed with TTTS underwent fetoscopic laser photocoagulation (FLP), and their cardiac IVPD was assessed before and after the procedure, revealing significant increases in IVPD in both the recipient and donor twins' left ventricles.
  • The findings suggest that IVPD is a sensitive indicator of changes in myocardial function and could be valuable for monitoring heart issues in TTTS cases.
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Article Synopsis
  • * The text emphasizes the need for proper monitoring and management of twin-twin transfusion syndrome and twin anemia-polycythemia sequence in monochorionic pregnancies, with specific ultrasound surveillance recommendations starting at 16 weeks.
  • * The Society for Maternal-Fetal Medicine recommends routine assessments and advanced treatments like fetoscopic laser surgery for severe cases of twin-twin transfusion syndrome, depending on the stage of the condition and other factors.
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Monochorionic Twin Complications and Fetoscopic Interventions.

Magn Reson Imaging Clin N Am

August 2024

Richard D. Wood Jr. Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, 7th Floor, Philadelphia, PA 19104, USA; Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA; Department of Radiology, Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, 3rd Floor, Philadelphia, PA 19104, USA. Electronic address:

Article Synopsis
  • Monochorionic twins face several potential complications due to shared placental blood vessels, which can lead to conditions like twin-twin transfusion syndrome and selective fetal growth restriction.
  • Ultrasound is the main method used to monitor these complications during pregnancy, but MRI is also valuable for detecting other issues like neurological injuries.
  • The article discusses ultrasound findings related to these complications, management strategies, and how MRI can be utilized in managing monochorionic twin pregnancies.
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Article Synopsis
  • - Twin reversed arterial perfusion (TRAP) sequence is a serious condition that poses a high risk of mortality to one of the twins (the "pump twin") due to abnormal blood flow to the acardiac twin.
  • - A case study involved a pregnant woman diagnosed with Stage IIb TRAP Sequence at 20 weeks, who successfully underwent a microwave ablation procedure to interrupt the blood supply to the acardiac mass at 21 weeks.
  • - The procedure was effective, leading to the safe delivery of a healthy baby at 33 weeks and showcasing the potential benefits of using microwave ablation in managing TRAP sequence.
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Patient-specific placental vessel segmentation with limited data.

J Robot Surg

June 2024

Multi-Scale Robotics Lab, ETH Zurich, 8092, Zurich, Switzerland.

A major obstacle in applying machine learning for medical fields is the disparity between the data distribution of the training images and the data encountered in clinics. This phenomenon can be explained by inconsistent acquisition techniques and large variations across the patient spectrum. The result is poor translation of the trained models to the clinic, which limits their implementation in medical practice.

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Maternal "mirror" syndrome: Evaluating the benefits of fetal therapy.

Prenat Diagn

July 2024

Fetal Medicine Unit, Department of Obstetrics & Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

Article Synopsis
  • This study aimed to assess maternal and perinatal outcomes in cases of fetal intervention complicated by maternal "mirror" syndrome, which involves maternal swelling due to fetal conditions like hydrops.
  • Researchers analyzed medical records from 21 pregnancies with fetal hydrops treated between 1995 and 2022, identifying causes like fetal lung issues and twin-twin transfusion syndrome.
  • The findings showed that post-intervention, maternal symptoms improved significantly in about 38% of cases, indicating the need for closer monitoring of mothers undergoing fetal treatment due to the potential emergence of "mirror" syndrome.
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Objectives: This systematic review explores cardiac adaptation in monochorionic (MC) twins with twin-twin transfusion syndrome (TTTS) or selective fetal growth restriction (sFGR) and assesses the risk of congenital heart defects (CHDs).

Methods: Adhering to PRISMA guidelines, 63 studies were reviewed (49 on cardiac adaptation, 13 on CHD, one on both). A narrative synthesis of cardiac adaptation patterns was performed.

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Autonomous Magnetic Navigation in Endoscopic Image Mosaics.

Adv Sci (Weinh)

May 2024

Multi-Scale Robotics Lab, ETH Zurich, Tannenstrasse 3, Zurich, 8092, Switzerland.

Endoscopes navigate within the human body to observe anatomical structures with minimal invasiveness. A major shortcoming of their use is their narrow field-of-view during navigation in large, hollow anatomical regions. Mosaics of endoscopic images can provide surgeons with a map of the tool's environment.

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Fetal and neonatal neuroimaging in twin-twin transfusion syndrome.

Ultrasound Obstet Gynecol

June 2024

Department of Pediatrics, Division of Neonatology, Leiden University Medical Center, Leiden, The Netherlands.

Objectives: To describe the types of brain injury and subsequent neurodevelopmental outcome in fetuses and neonates from pregnancies with twin-twin transfusion syndrome (TTTS). Additionally, to determine risk factors for brain injury and to review the use of neuroimaging modalities in these cases.

Methods: This was a retrospective cohort study of consecutive TTTS pregnancies treated with laser surgery in a single fetal therapy center between January 2010 and January 2020.

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Fetoscopic Laser Coagulation (FLC) for Twin to Twin Transfusion Syndrome is a challenging intervention due to the working conditions: low quality images acquired from a 3 mm fetoscope inside a turbid liquid environment, local view of the placental surface, unstable surgical field and delicate tissue layers. FLC is based on locating, coagulating and reviewing anastomoses over the placenta's surface. The procedure demands the surgeons to generate a mental map of the placenta with the distribution of the anastomoses, maintaining, at the same time, precision in coagulation and protecting the placenta and amniotic sac from potential damages.

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Fetoscopy laser photocoagulation is a widely adopted procedure for treating Twin-to-Twin Transfusion Syndrome (TTTS). The procedure involves photocoagulation pathological anastomoses to restore a physiological blood exchange among twins. The procedure is particularly challenging, from the surgeon's side, due to the limited field of view, poor manoeuvrability of the fetoscope, poor visibility due to amniotic fluid turbidity, and variability in illumination.

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Article Synopsis
  • Fetal phonocardiogram (fPCG) is a safe and accessible method for monitoring fetal heart sounds and wellbeing, with potential for identifying twin pregnancies.* -
  • In this study, fPCG data was used to train K-Nearest Neighbor (KNN) and support vector machine (SVM) classifiers, achieving high accuracy in identifying singleton and twin pregnancies.* -
  • The ability to detect twin pregnancies using fPCG could be especially beneficial in rural or low-income areas where ultrasound is less accessible, helping prevent complications associated with twins.*
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