J Comput Assist Tomogr
June 1999
Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Neurilemomas and neurofibromas appear as round soft tissue masses at CT. Variable enhancement with either homogeneity or heterogeneity is seen in neurilemomas. Attenuation of the tumors on enhanced CT depends on histology: the extent of Antoni A or B tissue and the amount of myxoid or cystic degeneration or hemorrhage.
View Article and Find Full Text PDFEur J Nucl Med
April 1999
Department of Pediatrics, University Hospital Gent, Belgium.
Imaging with technetium-99m sestamibi offers a non-invasive approach to detect the presence of functional P-glycoprotein (Pgp), one of the major causes of multidrug resistance, in human malignancies. A clinical role for Pgp has been suggested in the subpopulation of primary neuroblastoma without amplification of the proto-oncogene MYCN. We wanted to evaluate the usefulness of 99mTc-sestamibi scintigraphy in the screening of neural crest tumours for the presence of Pgp.
View Article and Find Full Text PDFJ Exp Clin Cancer Res
December 1998
College of Biomedical Technology, Niigata University, Japan.
Based on a statistically reliable number of cases reported in international literature, this study aimed to analyze the present status of vipoma/diarrheogenic syndrome (DGS). Another purpose was to supply investigators in the field of pancreatic endocrinology with precise and extensive information for the future analysis and evaluation of this subject and related problems. We obtained a total of 241 patients with vipoma/DGS from the international literature of 179 with intrapancreatic vipomas, 48 with extrapancreatic neurogenic tumors such as ganglioneuroblastomas, ganglioneuromas and neuroblastomas, and 14 with extrapancreatic vipomas of non-neurogenic nature.
View Article and Find Full Text PDFChest
November 1997
Department of Radiology, University of Pittsburgh Medical Center, USA.
Lymphoma, mediastinal cysts, and neurogenic neoplasms are the most common primary middle and posterior mediastinal tumors. Lymphoma may involve the anterior, middle and/or posterior mediastinum, frequently as lymphadenopathy or as a discrete mass. Foregut cysts are common congenital mediastinal cysts and frequently arise in the middle mediastinum.
View Article and Find Full Text PDFJ Paediatr Child Health
June 1997
Department of Respiratory Medicine, The Royal Alexandra Hospital for Children, Camperdown, New South Wales, Australia.
Objective: To review the recent experience with biopsied mediastinal lesions in children and to assess the impact of recent advances in imaging and surgical techniques on diagnosis.
Methodology: The clinical and radiological features of 55 patients who had mediastinal biopsies at The Royal Alexandra Hospital For Children (RAHC) over 15 years were reviewed.
Results: Fifty-five patients presented to RAHC between 1978 and 1993 with lesions of the mediastinum requiring biopsy of that site.
J Nucl Med
June 1996
Department of Nuclear Medicine, Institut Curie, Paris, France.
Unlabelled: The somatostatin analog 111In-pentetreotide was evaluated in 11 children with sympathetic embryonic cell-derived tumors.
Methods: Six neuroblastomas, four ganglioneuroblastomas and one ganglioneuroma (benign) were imaged 4 and 24 hr after injection of 111In-pentetreotide (5 MBq/kg) and 24 hr after administration of 123I-metaiodobenzylguanidine (MIBG) (3.7 MBq/kg).
Br J Radiol
February 1996
Department of Radiology, Yamanashi Medical College, Japan.
12 patients who had histological proven ganglioneuromas were investigated by computed tomography (CT) and magnetic resonance (MR) imaging. CT scans (n = 11), conventional spin-echo MR images (n = 10) and dynamic MR images (n = 5) were acquired. All lesions showed a well defined, oval shape.
View Article and Find Full Text PDFJ Clin Endocrinol Metab
February 1996
Chair of Endocrinology, Federico II University Medical School, Naples, Italy.
The adrenal scintiscan with 123I-metaiodobenzylguanidine (MIBG), a reliable morphofunctional technique to evaluate catecholamine turnover in adrenal tumors, can be a useful method to investigate adrenal incidentalomas with arterial hypertension. A male patient, 44 yr old with diabetes, unstable arterial hypertension, and sudden paroxysms of tachycardia is described. The presence of a disomogeneous right juxta-adrenal neoplasm with calcifications was evidenced with ultrasound tomography and confirmed by computerized tomography (CT) scan.
View Article and Find Full Text PDFPediatrics
February 1996
Department of Radiology, Children's National Medical Center, Washington, DC 20010, USA.
Objective: Metaiodobenzylguanidine (MIBG) scans were studied to determine the impact of the scan results on the clinical treatment of pediatric patients with neural crest tumors.
Methods: Serial scans were reviewed retrospectively for 27 patients with neural crest tumors: 25 with initial diagnoses of neuroblastoma (NB), 1 with ganglioneuroblastoma, and 1 with ganglioneuroma (GN). Results were compared with bone scans and computed tomography scans, as well as surgical pathologic findings.
Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi
April 1996
Department of Medical Imaging, National Taiwan University Hospital, Taipei, R.O.C.
Eighteen magnetic resonance (MR) examinations were performed in 15 children with neuroblastoma in 6 patients, ganglioneuroblastoma in 4 and ganglioneuroma in 5. The MR images of neuroblastoma and ganglioneuroblastoma presented with ill-defined margins and heterogeneous signal intensity, while ganglioneuroma had well-demarcated outlines and more homogeneous signal intensity in all sequences. The extension of these tumors, invasion to adjacent organs and encasement of vessels could be clearly identified.
View Article and Find Full Text PDFEur J Nucl Med
April 1995
Institut de Pathologic, Lausanne, Suisse.
The purpose of this work was to compare technetium-99m-diphosphono-propanedicarboxylate (DPD) and iodine-123-metaiodobenzylguanidine (MIBG) scans in the diagnosis and follow-up of neuroblastoma, and to study the role of histological differentiation in the uptake of MIBG. The uptake of MIBG and of DPD were studied retrospectively in 27 patients with neuroblastoma (primary, residual and recurrent tumours as well as bone and bone marrow metastases). The findings were related to the histological classification of the tumours as neuroblastoma (N1), differentiating neuroblastoma (N2) or ganglioneuroblastoma (N3).
View Article and Find Full Text PDFClin Nucl Med
August 1992
Division of Nuclear Medicine, University of Michigan Medical Center, Ann Arbor 48109-0229.
The authors describe a 29-year-old man who had a 16-year history of neuroblastoma and uncommon manifestations. At age 13, he was diagnosed with stage III retroperitoneal ganglioneuroblastoma that was resected. Ten years later, bilateral testicular enlargement and a pelvic mass from infiltration of the neuroblastoma became palpable.
View Article and Find Full Text PDFAm Fam Physician
March 1992
Department of Radiology, Massachusetts General Hospital, Boston.
Ganglioneuroblastoma, although a rare neoplasm, is one of the most common causes of posterior mediastinal masses in children. This tumor occurs in children from one to 10 years of age. With intrathoracic involvement, the tumor may remain asymptomatic until it is large.
View Article and Find Full Text PDFNeuroradiology
October 1992
Department of Neurosurgery, Sapporo City General Hospital, Japan.
Radiol Med
September 1990
Servizio di Radiologia, Ospedale S. Carlo Borromeo, Milano.
Pediatrie
March 1991
Service de radiologie, clinique de l'Espérance, Liège, Belgique.
The authors report on a case of a large triangular calcification of the left adrenal gland that was incidentally detected in a 6-year-old girl. After a 9 month follow-up, the urinary levels of VMA and HVA and 131I MIBG scintigraphy were the determining factors for diagnosing a ganglioneuroblastoma and for subsequent choice of treatment.
View Article and Find Full Text PDFPediatr Radiol
November 1990
Department of Radiology, Flinders Medical Centre, Bedford Park, South Australia.
Vasoactive intestinal polypeptide (VIP) secreting neural crest tumours are an uncommon but important treatable cause of intractable childhood diarrhoea. The radiological appearances of two cases are presented with a review of radiological findings in childhood VIP secreting neural crest tumours. Twenty eight cases of childhood VIP secreting neural crest tumours were reviewed.
View Article and Find Full Text PDFJ Comput Assist Tomogr
October 1989
Department of Radiology, University of California School of Medicine, San Francisco.
The majority of pathologic lesions in the lung and mediastinum have relatively long T1 and T2 relaxation times and consequently yield medium to low signal intensity on T1-weighted images. Pulmonary lesions with high signal intensity on T1-weighted images are unusual and raise a special group of diagnostic considerations. In the current study, a mass with a lesion/fat signal intensity ratio of greater than 0.
View Article and Find Full Text PDFWe report on a patient diagnosed as having ganglioneuroblastoma, an uncommon disease entity. The results of clinical examination and complementary tests, including a descending urogram and ultrasound evaluation are presented. The surgical procedure employed is described and the result of pathological analysis of the surgical specimen is presented.
View Article and Find Full Text PDFActa Cytol
March 1989
Department of Pathology, University of Seville, Spain.
Fine needle aspiration performed on a large retroperitoneal mass in a 12-year-old boy showed neuroblasts in different stages of maturation intermingled with ganglion cells, leading to a cytologic diagnosis of ganglioneuroblastoma. This diagnosis was supported by electron microscopic study of the aspirate, which showed features of neuroblastic differentiation, and by histologic study of the resected tumor.
View Article and Find Full Text PDFClin Neurol Neurosurg
July 1989
Department of Neurology, University of Innsbruck, Austria.
The association of a syndrome of a degenerative nature such as syringomyelia and a neuroblastoma can be of clinical interest. We will describe the case of a young female suffering from a retroperitoneal neuroblastoma and secondary development of syringomyelia. The possible pathogenetic link between these two pathologies will be discussed.
View Article and Find Full Text PDFA patient with a pleomorphic intravascular leiomyosarcoma of the great vessels of the neck and mediastinum presented clinically with a superior vena cava syndrome. A latent period of 29 years elapsed between receiving orthovoltage radiation to the neck and right side of chest to treat recurrent ganglioneuroblastoma, and the appearance of a leiomyosarcoma and subsequent recurrences. The patient underwent partial resection of the tumor, received adjunct chemotherapy, and was shown to be free of disease by clinical tests and by magnetic resonance imaging (MRI) 17 months after completion of chemotherapy.
View Article and Find Full Text PDFFifteen patients with primary intrathoracic neurogenic tumours were evaluated using computed tomography (CT) scans. Schwannomas were demonstrated as homogeneous or slightly inhomogeneous densities on plain CT images; 4 of 5 schwannomas showed rim enhancement with some enhancement in the central portion of the tumour on post-enhancement CT images. Neurofibromas and ganglioneuromas were visualized as homogeneous densities on plain CT images.
View Article and Find Full Text PDFThorac Cardiovasc Surg
August 1986
Ninety-two cases of intrathoracic neurogenic tumors operated on between 1950 and 1982 are reviewed. The benign forms (86 cases, 93.5%) included 23 ganglioneuromas, 50 neurilemmomas and 13 neurofibromas.
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