937 results match your criteria: "Imaging in Ganglioglioma"

Article Synopsis
  • - The article discusses a rare finding of atypical pathological features in the brains of patients with drug-resistant epilepsy, revealing a mix of ganglioglioma and focal cortical dysplasia, which hasn't been documented before.
  • - Comprehensive tests including histopathological staining and molecular genetic analysis were conducted, and MRI scans showed unusual patterns such as "transmantle" distribution and local alterations in the brain structure.
  • - The findings suggest the presence of a new subgroup of gangliogliomas characterized by cellular atypia, indicating a potential link between different types of neuronal-glial tumors that could reshape our understanding of epilepsy-related brain pathology.
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Child Neurology: Simple Motor Tics Associated With Thalamic Ganglioglioma.

Neurology

December 2024

From the Department of Pediatric Neurology (Y.C.), Guizhou Branch of Shanghai Children's Medical Center of Shanghai Jiaotong University School of Medicine; Department of Pediatric Neurology (Y.C.), Guizhou Provincial People's Hospital; School of Public Heath (M.Y.), the Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang; and Department of Rehabilitation (H.Z.), Children's Hospital of Fudan University, Shanghai, China.

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Phenotypic and epigenetic heterogeneity in FGFR2-fused glial and glioneuronal tumours.

Neuropathol Appl Neurobiol

December 2024

Neuroradiological RENOCLIP-LOC network: A. Bani-Sadr (Lyon), J.M. Constans (Amiens), D. Galanaud (Paris), R. Guillevin (Poitiers), N. Menjot (Montpellier), S. Grand (Grenoble), F.D. Ardelier (Strasbourg), E. Schmitt (Nancy), B. Testud (Marseille), L. Mondot (Nice).

Article Synopsis
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Epilepsy is a prevalent neurological disorder in children, with 30-35% of cases developing into intractable epilepsy despite appropriate anti-seizure medications (ASMs). Advanced imaging is crucial for early diagnosis, especially in detecting structural causes like gangliogliomas, which are associated with drug-resistant focal epilepsy. We report a 5-year-old boy with recurrent seizures, initially undetected by EEG.

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Article Synopsis
  • Mesial temporal lobe epilepsy (MTLE), primarily characterized by hippocampal sclerosis (HS), is often linked with rare mutations, specifically in this case concerning the BRAFV600E mutant protein found in neurons.
  • A 31-year-old male patient with severe epilepsy showed typical MRI and EEG signs of mesial temporal sclerosis, and surgical analysis revealed altered neuron orientations and specific cell types associated with the mutation, despite their low overall presence.
  • The patient's condition improved significantly post-surgery, and findings indicate that understanding the early genetic changes in HS could enhance research on potential early tumors or lesions, suggesting routine mutation screenings in clinical trials for MTLE-HS cases.
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Pediatric autoimmune retinopathy and optic neuropathy: a case report and a review of the literature.

Front Ophthalmol (Lausanne)

December 2023

Abrahamson Pediatric Eye Institute, Division of Pediatric Ophthalmology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.

Article Synopsis
  • The study presents a rare case of pediatric bilateral optic neuropathy and retinopathy linked to autoimmune retinopathy, along with a review of existing literature on similar pediatric cases.* -
  • It involves a case report of one original subject and data from five others identified in recent literature, utilizing various diagnostic methods such as imaging, electrophysiologic testing, and autoantibody testing.* -
  • Results showed that all subjects had retinal abnormalities, with optic nerve issues in most; three subjects had abnormal electrophysiologic test results, and four exhibited underlying neoplastic disorders.*
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Unraveling morphology, methylation profiling, and diagnostic challenges in BRAF-Mutant pediatric glial and glioneuronal tumors.

Neurosciences (Riyadh)

July 2024

From the Department of Pathology, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia, and from the Department of Pathology and Laboratory Medicine, Western University, London, ON, Canada.

Objectives: To elucidate the relationship between DNA methylation profiling (DMP) and pathological diagnosis (PD) in pediatric glial and glioneuronal tumors with B-Raf proto-oncogene, serine/threonine kinase mutations, addressing their diagnostic challenges.

Methods: This retrospective study, conducted in Saudi Arabia, analyzed 47 cases from the Children's Brain Tumor Network online database using scanned images, next-generation sequencing data, and methylation profiles processed using the Heidelberg methylation brain tumor classifiers v12.5 and v12.

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Imaging of pediatric glioneuronal and neuronal tumors.

Childs Nerv Syst

October 2024

Division of Neuroradiology, Department of Diagnostic and Interventional Radiology, The Hospital for Sick Children, 170 Elizabeth Street, Toronto, ON, M5G 1E8, Canada.

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[Clinicopathological characteristics of gangliogliomas with anaplastic morphology].

Zhonghua Bing Li Xue Za Zhi

June 2024

Department of Pathology, Xuanwu Hospital, Capital Medical University, Beijing Geriatric Medical Research Centre, Beijing 100053, China National Center for Neurological Disorders, National Center for Neurological Disorders and Clinical Research Center for Epilepsy, Capital Medical University, Beijing 100053, China.

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Imaging manifestations of papillary glioneuronal tumors.

Neurosurg Rev

April 2024

Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.

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Preoperative 11 C-Methionine PET-MRI in Pediatric Infratentorial Tumors.

Clin Nucl Med

May 2024

From the Department of Pediatric Neurosurgery, Hôpital Femme Mère Enfant, Hospices Civils de Lyon.

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Article Synopsis
  • Pilocytic astrocytomas (PA) are tumors that have unique features based on where they are located in the brain or spine.
  • Doctors face challenges in telling PAs apart from similar tumors, especially in the brain's hemispheric region.
  • A study looked at different types of PAs, and found that they often affect kids and can show various patterns in medical tests, highlighting the need for careful examination for accurate diagnosis.
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Experience in treating children with ocular dyskinesia and hemifacial spasm secondary to pontine tumours adjacent to the fourth ventricle and systematic review.

Childs Nerv Syst

May 2024

Department of Neurosurgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No.56 Nanlishilu, West District, Beijing, 100045, China.

Objective: To investigate the treatment plan and prognosis of children with ocular dyskinesia and hemifacial spasm secondary to pontine tumours adjacent to the fourth ventricle.

Methods: In this retrospective study, the clinical information of 10 consecutively collected children with ocular dyskinesia and hemifacial spasm secondary to pontine tumours adjacent to the fourth ventricle was analyzed. All 10 children underwent pontine tumour resection through a trans-cerebellomedullary fissure approach; 4 children underwent preoperative diffusion tensor imaging scans to determine the relationship between the tumour and facial nerve nucleus, and the other 6 children underwent intraoperative deep electroencephalography (EEG) tumour monitoring, in which the tumour electrical discharge activity of the tumour was recorded.

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