Tocilizumab for Cystoid Macular Edema Secondary to Immune Recovery Uveitis in a Patient with Contraindications to Long-Term Systemic Corticosteroid.

: To report a case of cystoid macular edema (CME) secondary to immune recovery uveitis (IRU) in a patient with previous history of cytomegalovirus (CMV) retinitis and leukemia, which was successfully treated with tocilizumab (TCZ), an interleukin-6 (IL-6) receptor antagonist. : The clinical records of the case were reviewed, focusing on demographics, image findings, and clinical course. : A 17-year-old female with a past medical history of T-cell acute lymphoblastic leukemia (T-ALL) undergoing chemotherapy for two years presented with active CMV retinitis.

Clinical outcomes of open reduction and internal fixation combined with sartorius muscle iliac bone graft transplantation for displaced femoral neck fractures in middle-aged and young adults: a retrospective analysis of 24 cases.

Objective: This study aimed to evaluate the clinical outcomes and complications of open reduction and internal fixation (ORIF) combined with sartorius muscle iliac bone graft transplantation (SIBFT) in the treatment of displaced femoral neck fractures in middle-aged and young adults.

Methods: A retrospective analysis was performed on 26 patients under the age of 60 with displaced femoral neck fractures (Pauwels III or Garden III-IV) treated at our institution between April 2019 to July 2022. All patients underwent open reduction and internal fixation (ORIF) through the Smith-Petersen (S-P) approach, augmented with a sartorius muscle iliac bone graft transplantation.

Long-term results of short stem total hip arthroplasty in patients with osteonecrosis of the femoral head.

Introduction: Short stem total hip arthroplasty (THA) is an alternative to conventional stem, designed to facilitate minimal-invasive surgery, physiological loading and preserve bone stock. However, there is insufficient evidence of the long-term outcomes in patients with osteonecrosis of the femoral head (ONFH). This study aims to analyze the clinical and radiographic results with a minimum follow-up of 10 years.

Bone biochemical markers, bone mineral density, and the risk of osteonecrosis of the femoral head: a Mendelian randomization study.

Background: Alterations in bone metabolism may play a significant role in the early stages of femoral head necrosis, yet the causal relationship remains unclear. This study utilizes a two-sample Mendelian randomization (MR) approach to explore the genetic causal links between biochemical markers of bone metabolism, bone mineral density, and the risk of femoral head necrosis.

Methods: This study utilizes publicly available genome-wide association study (GWAS) datasets, with exposure factors including biochemical bone markers (25OHD, calcium, and alkaline phosphatase) and bone mineral density (measured at the lumbar spine, heel, femoral neck, and total body).

Quantification of Empty Lacunae in Tissue Sections of Osteonecrosis of the Femoral Head Using YOLOv8 Artificial Intelligence Model.

Histomorphometry is an important technique in the evaluation of non-traumatic osteonecrosis of the femoral head (ONFH). Quantification of empty lacunae and pyknotic cells on histological images is the most reliable measure of ONFH pathology, yet it is time and manpower consuming. This study focused on the application of artificial intelligence (AI) technology to tissue image evaluation.

The ratio between the screw distance and femoral neck width on lateral radiography is a reliable predictor of femoral head necrosis: a clinical review and corresponding numerical simulations.

Background: Fixation instability serves as an initial trigger for femoral head necrosis in patients with femoral neck fractures undergoing internal fixation. The configuration of screw trajectories is critical in determining the stability of the fixation. Our previously published study indicates that abduction of screw trajectories may enhance postoperative angular stability.

[Relationship between cortical fragments and avascular necrosis of femoral head in young adult femoral neck fractures based on CT imaging].

Objective: To explore the effect of femoral neck cortical fragments and surfacial area on avascular necrosis(AVN) after internal fixation of femoral neck fractures based on CT imaging in young adult.

Methods: From January 2011 to January 2021, 218 young and middle-aged patients with femoral neck fractures were reverse triangle fixed with three cannulated lag screws, including 104 males and 114 females;aged 19 to 60 years old with a mean of (48.22±10.

Legg-Calve´-Perthes disease - diagnostic value of acetabular-femoral head match index.

Early treatment of Legg-Calve´-Perthes disease (LCPD)can improve hip joint activity and life management in adulthood. However, the current classification of LCPD is based on imaging findings in the fragmented stage of the disease, which is prone to delay treatment. Therefore the aim of this study is to evaluate the potential risk factors associated with poor radiological outcomes of LCPD, and to develop a new index for hip consistency evaluation, which can be used to speculate radiographic outcomes at the time of the first visit.

Pathological mechanisms and related markers of steroid-induced osteonecrosis of the femoral head.

Background: Osteonecrosis of the femoral head (ONFH) is a refractory orthopedic disease with a high disability rate. Long-term administration of steroids is the most common pathogenic factor for non-traumatic ONFH. Early diagnosis of steroid-induced osteonecrosis of the femoral head (SONFH) is difficult and mainly depends on imaging.

Femoral Head Fracture Fixation Using Femoral Head Cement Templating for Iliac Bone Graft and Biodegradable Screws via Ganz Surgical Dislocation of the Hip: A Case Report.

A 22-year-old Malaysian male presented with a closed posterior dislocation of the right hip with femoral head fracture (Pipkin II) after an alleged motor vehicle accident (MVA). This type of injury may pose future complications, such as avascular necrosis, post-traumatic osteoarthritis, or heterotopic ossification to the hip joint, and later affect joint function. After an immediate closed reduction of the hip, the patient underwent Ganz Surgical dislocation of the hip - a surgical method used to aid the reconstruction of the bony defect of the femoral head.

Multimodal radiomics and deep learning models for predicting early femoral head deformity in LCPD.

Purpose: To develop a predictive model combining clinical, radiomic, and deep learning features based on X-ray and MRI to identify risk factors for early femoral head deformity in Legg-Calvé-Perthes disease (LCPD).

Methods: This study involved 152 patients diagnosed with early unilateral LCPD across two centers between January 2013 and December 2023, and included an independent external validation set to assess generalizability. Four machine learning methods, including logistic regression (LR), random forest (RF), support vector machine (SVM), and extreme gradient boosting (XGBoost), were employed to develop radiomics deep learning signatures.

Plasma SQSTM1/p62 act as a biomarker for steroid-induced osteonecrosis of the femoral head.

Autophagy is closely associated with the onset and progression of steroid-induced osteonecrosis of the femoral head (SIONFH). SQSTM1/p62 is an important indicator of autophagic activity. The aim of this study was to investigate the role of SQSTM1/p62 in the development of SIONFH.