3 results match your criteria: "Imabari City Hospital[Affiliation]"
A retrospective survey of patients who discontinued participation in the JPLSG HLH-2004 clinical trial.
Int J Hematol
September 2022
Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
Although clinical trials have reported an improvement in the prognosis of hemophagocytic lymphohistiocytosis (HLH), current treatment outcomes are unsatisfactory, especially in severe cases. Most clinical trial patients with severe disease discontinue participation due to complications associated with HLH or treatment-related toxicity. A retrospective survey of patients who discontinued participation in the JPLSG HLH-2004 clinical trial was conducted to review the detailed course of these cases to optimize HLH treatment and supportive care.
View Article and Find Full Text PDFVirus-triggered secondary hemophagocytic lymphohistiocytosis.
Acta Paediatr
October 2021
Director, Imabari City Hospital, Imabari, Ehime, Japan.
Article Synopsis
- * Viral HLH, particularly Epstein-Barr virus (EBV)-related HLH, is common in children, and distinguishing it from primary HLH is crucial for effective treatment.
- * Treatments vary, with non-EBV HLH often responsive to immunomodulatory agents, while severe EBV-HLH may require specialized regimens or HSCT, and new treatments like emapalumab can help reduce risks associated with traditional options.
Lister hooded rats as a novel animal model of attention-deficit/hyperactivity disorder.
Neurochem Int
December 2020
Department of Molecular and Cellular Physiology, Graduate School of Medicine, Ehime University, Japan. Electronic address:
Appropriate animal models are necessary to determine the molecular and cellular mechanisms underlying attention-deficit/hyperactivity disorder (ADHD). This study used a battery of behavioral tests to compare Lister hooded rats (LHRs), an old outbred strain frequently used for autistic epilepsy research, with Wistar rats and spontaneously hypertensive rats (SHRs), a commonly used ADHD model. The open field, elevated plus maze, light/dark box, and drop tests demonstrated that LHRs were the most hyperactive animals and displayed the most inattentive- and impulsive-like behaviors, which are characteristics of ADHD.
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