1 results match your criteria: "Illinois. Feinberg Cardiovascular Institute at Northwestern University Feinberg School of Medicine[Affiliation]"
Melanoma Cells Block PEDF Production in Fibroblasts to Induce the Tumor-Promoting Phenotype of Cancer-Associated Fibroblasts.
Cancer Res
April 2016
Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Northwestern University Center for Developmental Therapeutics, Evanston, Illinois. Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois. Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Feinberg Cardiovascular Institute at Northwestern University Feinberg School of Medicine, Chicago, Illinois Illinois.
Loss of pigment epithelium-derived factor (PEDF, SERPINF1) in cancer cells is associated with poor prognosis and metastasis, but the contribution of stromal PEDF to cancer evolution is poorly understood. Therefore, we investigated the role of fibroblast-derived PEDF in melanoma progression. We demonstrate that normal dermal fibroblasts expressing high PEDF levels attenuated melanoma growth and angiogenesis in vivo, whereas PEDF-depleted fibroblasts exerted tumor-promoting effects.
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