1 results match your criteria: "Illinois bDepartment of Medicine cDepartment of Psychiatry University of California[Affiliation]"
Plasma dickkopf-related protein 1, an antagonist of the Wnt pathway, is associated with HIV-associated neurocognitive impairment.
AIDS
June 2017
aDepartment of Immunology and Microbiology, Rush University Medical Center, Chicago, Illinois bDepartment of Medicine cDepartment of Psychiatry University of California, San Diego, California, USA.
Objective: Dickkopf-related protein 1 (DKK1) is a soluble antagonist of the Wningless (Wnt) pathway. It binds to and sequesters low-density lipoprotein receptor-related proteins 5/6 away from Wnts. Because the Wnt pathway regulates synaptic transmission and plasticity, we hypothesized that increased DKK1 would increase the risk for neurocognitive impairment (NCI) in HIV-positive (HIV) individuals.
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