Linking structural and rheological memory in disordered soft materials.

Linking the macroscopic flow properties and nanoscopic structure is a fundamental challenge to understanding, predicting, and designing disordered soft materials. Under small stresses, these materials are soft solids, while larger loads can lead to yielding and the acquisition of plastic strain, which adds complexity to the task. In this work, we connect the transient structure and rheological memory of a colloidal gel under cyclic shearing across a range of amplitudes a generalized memory function using rheo-X-ray photon correlation spectroscopy (rheo-XPCS).

Intent to Leave Associated More Strongly with Workplace Belonging Than Leadership Behaviors of Supervisor in Women Health Care Professionals.

The attrition of health care professionals from institutions has historically been high, with reports of higher rates in women than men. High attrition jeopardizes the institution's financial stability, quality of patient care, and scholarly contributions to advancing health care. The disproportionate loss of women reduces the diversity of perspectives and skills needed to meet patient needs.

N-Degron PROTACs as a Potential Therapeutic Approach for Chronic Myeloid Leukemia.

Many oncoproteins are important therapeutic targets because of their critical role in inducing rapid cell proliferation, which represents one of the salient hallmarks of cancer. Chronic Myeloid Leukemia (CML) is a cancer of hematopoietic stem cells that is caused by the oncogene BCR-ABL1. BCR-ABL1 encodes a constitutively active tyrosine kinase protein that leads to the uncontrolled proliferation of myeloid cells, which is a hallmark of CML.

Retroperitoneal Teratoma in a Newborn: A Case Report and Diagnostic Insights.

Retroperitoneal teratomas are rare neoplasms in neonates, presenting with nonspecific symptoms and variable clinical features, making diagnosis challenging. Radiological investigations, particularly fetal ultrasound and contrast-enhanced computed tomography, play a critical role in their detection. Differential diagnoses include neuroblastoma, adrenal hemorrhage, and congenital cystic lesions, which share overlapping clinical and imaging features.

An Atypical Case of Marchiafava-Bignami Disease in a Young Chronic Alcoholic: Challenges in Diagnosis and Prognosis.

A 27-year-old male patient with chronic alcohol use disorder was diagnosed with Marchiafava-Bignami disease (MBD) after experiencing an episode of unconsciousness. MRI scans revealed lesions in the corpus callosum and adjacent white matter. Despite prompt initiation of intensive treatment with high-dose thiamine and corticosteroids, the patient only partially recovered, remaining disoriented and exhibiting persistent neurological deficits during follow-up.

A Preliminary Analysis of a Prosocial Intervention to Support Teachers and Staff Implementing Behavioral Interventions in a Specialized School Setting.

Prosocial is a systems-level intervention framework that incorporates elements of acceptance and commitment therapy (ACT) with Ostrom's core design principles (CDPs) guiding effective organizations and collective action (Ostrom, 1990). We evaluated a Prosocial intervention to support teachers and staff in a specialized school. AB analysis supported improvements in group cohesion and values-behavior alignment during the intervention and pre-post analyses showed significant improvements in psychological flexibility and perceived stress of participants.

Management of Anomalous Left Vertebral Artery During Open Total Arch Replacement.

Background: An anomalous left vertebral artery (aLVA) can complicate aortic arch surgery. We examined the safety of various aLVA revascularization strategies during open total arch replacement.

Methods: We retrospectively evaluated 92 patients undergoing total arch replacement from January 2018 to May 2023 and identified 11 patients with aLVA.

Human Applications of the Anstadt Cup: Implications for Non-Blood-Contacting Biventricular Support.

Background: Direct mechanical ventricular actuation (DMVA) with the Anstadt cup is effective for non-blood-contacting biventricular support. Pneumatic regulation of a silicone device augments ventricular pump function. Vacuum attachment facilitates diastolic augmentation critical for biventricular support.

Remote Perioperative Monitoring in Adult Cardiac Surgery: The Impact on 1000 Consecutive Patients.

Background: Our remote patient monitoring (RPM) program for adult cardiac surgery patients aims to remove barriers to access, provide continuity of expert care, and increase their time-at-home. The RPM program integrates novel biosensors, an application for audiovisual visits, messaging, biometric data tracking, patient-reported outcomes, and scheduling with the aim of reducing postoperative length of stay and 30-day readmissions, while simultaneously increasing the rate of patients discharged to home.

Methods: Our institutional database was utilized for this retrospective review of 1000 consecutive RPM patients who underwent coronary artery bypass, valve, and coronary artery bypass + valve, at 3 hospitals from July 2019 through April 2023.

Perceptions of Frailty and Prehabilitation Among Thoracic Surgeons: Findings From a National Survey.

Background: Frailty is associated with increased perioperative morbidity and mortality. How thoracic surgeons recognize, measure, and mitigate frailty in their daily clinical practice is unknown. We administered a national survey to determine the current practices of thoracic surgeons managing frail patients.

Spontaneous Pneumothorax Due to Ruptured Bulla of the Azygos Lobe.

Azygos lobe is an uncommon anatomic variant that is widely recognized, but rarely associated with pneumothorax. We present a successful surgical management of a spontaneous pneumothorax resulting from rupture of a bulla in an incidentally discovered azygos lobe. The patient is a 73-year-old man who presented with the first-time occurrence of a spontaneous right pneumothorax.

The Risk of Pretransplant Blood Transfusion for Primary Graft Dysfunction After Lung Transplant.

Background: Primary graft dysfunction (PGD) is the leading cause of short- and long-term mortality associated with lung transplantation. The impact of pretransplantation blood transfusions for recipients is not fully elucidated.

Methods: This is a retrospective review of 206 consecutive lung transplantations performed at a single academic center (Northwestern University Feinberg School of Medicine, Chicago, IL) from January 2018 to July 2022.

Portal Vein Recanalization Transjugular Intrahepatic Portosystemic Shunt for Noncirrhotic Chronic Portal Vein Thrombosis Leading to Successful Pregnancy: Case Report.

Portal vein recanalization transjugular intrahepatic portosystemic shunt (PVR-TIPS) is a safe and effective procedure for decompression of portal hypertension (PH). In this short case series, 2 women with chronic noncirrhotic portal vein thrombosis were treated with PVR-TIPS. Both patients hoped to conceive.

Treatment of Extreme Central Venous Occlusive Disease With Massive Esophageal Bleeding.

Central venous occlusions are common in the population of dialysis patients and develop as a result of arteriovenous access. Whereas these patients most commonly present with edema and varicosities, a rare presentation is esophageal varices. Here we present the case of a young man with life-threatening esophageal hemorrhage as a result of central venous occlusions, successfully treated with an azygos vein to right atrial bypass.

Orthotopic Heart Transplantation in a Patient With Hypertrophic Cardiomyopathy and Marfan Syndrome.

A 24-year-old man with Marfan syndrome and heart failure from hypertrophic cardiomyopathy was referred to our institution in cardiogenic shock for advanced therapies. He was supported by a femoral intra-aortic balloon pump, then bridged to orthotopic heart transplantation. This is a report of an orthotopic heart transplantation in a patient with both Marfan syndrome and heart failure from hypertrophic cardiomyopathy.

Unraveling climate change-induced compound low-solar-low-wind extremes in China.

China's pursuit of carbon neutrality targets hinges on a profound shift towards low-carbon energy, primarily reliant on intermittent and variable, yet crucial, solar and wind power sources. In particular, low-solar-low-wind (LSLW) compound extremes present a critical yet largely ignored threat to the reliability of renewable electricity generation. While existing studies have largely evaluated the impacts of average climate-induced changes in renewable energy resources, comprehensive analyses of the compound extremes and, particularly, the underpinning dynamic mechanisms remain scarce.

Complications Following Open Versus Minimally Invasive Resection of Gastric Adenocarcinoma.

Background And Objectives: Gastric adenocarcinoma (GA) is commonly treated with open or minimally invasive surgery (MIS). The preferred surgical approach remains unclear. This study sought to assess utilization over time, compare complication rates by surgical approach, and identify predictors of experiencing complications.

Miniscope Imaging of Nucleus Accumbens Neural Activity in Freely Behaving Rats: Virus Injection, Gradient Index Lens Implantation, Recording Strategies, and Analytical Methods.

In vivo calcium imaging in freely moving rats using miniscopes provides valuable information about the neural mechanisms of behavior in real time. A gradient index (GRIN) lens can be implanted in deep brain structures to relay activity from single neurons. While such procedures have been successful in mice, few reports provide detailed procedures for successful surgery and long-term imaging in rats, which are better suited for studying complex human behaviors.

Salidroside Improves Oocyte Competence of Reproductively Old Mice by Enhancing Mitophagy.

The decline of oocyte quality with advanced maternal age has a detrimental effect on female fertility. However, there is limited knowledge of therapeutic options and their mechanisms to improve oocyte quality in reproductively older women. In this study, we demonstrated that supplementation of salidroside improves the oocyte quality of reproductively old mice.

Platinum nanoparticles in cancer therapy: chemotherapeutic enhancement and ROS generation.

Platinum nanoparticles (PtNPs) offer significant promise in cancer therapy by enhancing the therapeutic effects of platinum-based chemotherapies like cisplatin. These nanoparticles improve tumor targeting, reduce off-target effects, and help overcome drug resistance. PtNPs exert their anti-cancer effects primarily through the generation of reactive oxygen species (ROS), which induce oxidative stress and apoptosis in cancer cells.

Interpretable identification of cancer genes across biological networks via transformer-powered graph representation learning.

Graph representation learning has been leveraged to identify cancer genes from biological networks. However, its applicability is limited by insufficient interpretability and generalizability under integrative network analysis. Here we report the development of an interpretable and generalizable transformer-based model that accurately predicts cancer genes by leveraging graph representation learning and the integration of multi-omics data with the topologies of homogeneous and heterogeneous networks of biological interactions.