8 results match your criteria: "Ilinois 60611; Jesse Brown Veterans Affairs Medical Center[Affiliation]"

Background: Altered levels of miRNAs might affect the pathogenesis of oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMD). This study evaluated the diagnostic potential of salivary miRNA-21 and miRNA-184 in OSCC and OPMD.

Methods: We recruited a total of 90 subjects including OSCC, OPMD, and healthy controls.

View Article and Find Full Text PDF

Cancer cells can invade in three-dimensional collagen as single cells or as a cohesive group of cells that require coordination of cell-cell junctions and the actin cytoskeleton. To examine the role of Gα13, a G12 family heterotrimeric G protein, in regulating cellular invasion in three-dimensional collagen, we established a novel method to track cell invasion by membrane type 1 matrix metalloproteinase-expressing cancer cells. We show that knockdown of Gα13 decreased membrane type 1 matrix metalloproteinase-driven proteolytic invasion in three-dimensional collagen and enhanced E-cadherin-mediated cell-cell adhesion.

View Article and Find Full Text PDF

Cerebral microvascular occlusion is a common phenomenon throughout life that might require greater recognition as a mechanism of brain pathology. Failure to recanalize microvessels promptly may lead to the disruption of brain circuits and significant functional deficits. Haemodynamic forces and the fibrinolytic system are considered to be the principal mechanisms responsible for recanalization of occluded cerebral capillaries and terminal arterioles.

View Article and Find Full Text PDF

Congruency sequence effects and cognitive control.

Cogn Affect Behav Neurosci

December 2007

Feinberg School of Medicine, Northwestern University, Chicago, Ilinois 60611, USA.

Congruency effects in selective attention tasks are subject to sequential modulation: They are smaller following an incongruent stimulus than following a congruent one. This congruency sequence effect has been interpreted as reflecting conflict-driven adjustments in cognitive control (conflict adaptation) or, alternatively, episodic memory effects of stimulus-response association (feature integration). The present article critically reviews support for these rival accounts in the experimental literature and discusses the implications thereof for assessing behavioral and neural signatures of cognitive control processes.

View Article and Find Full Text PDF

Purpose Of Review: The aim of this article is to describe recent advances in our understanding of lifetime risks for cardiovascular disease and their implications for lipid guidelines.

Recent Findings: Recent studies have indicated that, among younger and middle-aged adults, there is a large subset with low 10-year risk but high lifetime risk for cardiovascular disease. Individuals with high lifetime risks can be identified on the basis of single adverse risk factors or on the basis of overall risk factor burden.

View Article and Find Full Text PDF

Direct activation of innate and antigen-presenting functions of microglia following infection with Theiler's virus.

J Virol

October 2001

Department of Microbiology-Immunology and Interdepartmental Immunobiology Center, Northwestern University Medical School, Chicago, Ilinois 60611, USA.

Microglia are resident central nervous system (CNS) macrophages. Theiler's murine encephalomyelitis virus (TMEV) infection of SJL/J mice causes persistent infection of CNS microglia, leading to the development of a chronic-progressive CD4(+) T-cell-mediated autoimmune demyelinating disease. We asked if TMEV infection of microglia activates their innate immune functions and/or activates their ability to serve as antigen-presenting cells for activation of T-cell responses to virus and endogenous myelin epitopes.

View Article and Find Full Text PDF

Phosphorylation of the proteins of the extracellular matrix of mineralized tissues by casein kinase-like activity.

Crit Rev Oral Biol Med

January 1998

Department of Basic and Behavioral Sciences, Northwestern University Dental School, Chicago, Ilinois 60611, USA.

The extracellular matrix of the connective tissue contains non-collagenous proteins (NCP) which are acidic in character. The NCP of mineralizing systems (bone, dentin) differ from those of the non-mineralizing systems (skin, tendon) in that the mineralized tissue NCP are frequently phosphorylated. The phosphorylated proteins have been implicated in various aspects of the mineralization process.

View Article and Find Full Text PDF