Therapeutic Effectiveness of a Novel Cranial Remolding Helmet (baby band2) for Positional Plagiocephaly: A Multicenter Clinical Observational Study.

This multicenter study evaluated the efficacy and safety of a novel cranial remolding helmet (baby band2), which is completely custom-made based on the shape of an infant's cranium. The study included 224 full-term infants from moderate to very severe positional plagiocephaly in Japan. Cranial geometry was assessed before and after helmet therapy using a three-dimensional scanner, and changes in the cranial vault asymmetry index (CVAI) were analyzed.

Clinical Usefulness of Immunohistochemical Staining of p57 kip2 for the Differential Diagnosis of Complete Mole.

Objective: Can polymer-based immunohistochemical staining of p57(kip2) replace DNA analysis as an inexpensive means of differentiating complete mole from partial mole or hydropic abortion?

Methods And Materials: Original paraffin-embedded tissue blocks from 14 equivocal cases were turned over to our laboratory and examined by immunohistochemical staining of p57(kip2).

Results: Four of the 14 cases showed clearly negative nuclear staining in cytotrophoblasts and villous stromal cells: these results were fully concordant with the control staining. The remaining 10 cases showed apparently positive staining in cytotrophoblasts and villous stromal cells.

Recurrent gestational trophoblastic disease in a case of suspected quiescent gestational trophoblastic disease: a case report.

Background: In Japan there are no reported cases of phantom human chorionic gonadotropin (hCG) or quiescent gestational trophoblastic disease (GTD). GTD is managed well in Japan according to Japanese guidelines for the treatment of GTD, and we have almost conquered this disease during recent decades. Furthermore, the incidence of GTD is decreased today, associated with the decrease of birth rate in Japan.