Photoregulation of the biosynthetic activity of fungus using colloidal solutions of biogenic metal nanoparticles and low-intensity laser radiation.

This article presents new data on the integrated use of colloidal solutions of nanoparticles and low-intensity laser radiation on the biosynthetic activity of the medicinal mushroom . Traditional mycological methods, colloidal solutions of biogenic metals, and unique photobiological methods have also been used. It was found that colloidal solutions of nanoparticles of all metals used increased the growth characteristics of (55-60%), while irradiation of the fungal inoculum with laser light in a medium with nanoparticles reduced the growth activity of mycelia by 12.

The Application of Supervised Machine Learning Algorithms for Image Alignment in Multi-Channel Imaging Systems.

This study presents a method for aligning the geometric parameters of images in multi-channel imaging systems based on the application of pre-processing methods, machine learning algorithms, and a calibration setup using an array of orderly markers at the nodes of an imaginary grid. According to the proposed method, one channel of the system is used as a reference. The images from the calibration setup in each channel determine the coordinates of the markers, and the displacements of the marker centers in the system's channels relative to the coordinates of the centers in the reference channel are then determined.

Plant miRNAs for Improved Gene Regulation in a Wide Range of Human Cancers.

Determining the relationships between miRNA expression, target genes, and cancer development is critical to cancer research. The possibility of correlating miRNA expression with plant or artificial ones provides prerequisites for cancer treatment. Based on the broad database of human miRNA expression for all cancer types, we grade human miRNAs by their expression level.

Exploring the Potential Imaging Biomarkers for Parkinson's Disease Using Machine Learning Approach.

Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor and neuropsychiatric symptoms resulting from the loss of dopamine-producing neurons in the substantia nigra pars compacta (SNc). Dopamine transporter scan (DATSCAN), based on single-photon emission computed tomography (SPECT), is commonly used to evaluate the loss of dopaminergic neurons in the striatum. This study aims to identify a biomarker from DATSCAN images and develop a machine learning (ML) algorithm for PD diagnosis.

Crystal structure and Hirshfeld surface analysis of the layered hybrid metal halide poly[bis-(2-iodoethyl-ammonium) [di-μ-iodido-di-iodido-germanate(II)]].

The title compound is a germanium-based hybrid metal halide that represents a less-toxic alternative to more popular lead-based analogues in optoelectronic applications. {(2-ICHNH)[GeI]} is composed of infinite inorganic layers that are formed by [GeI] octa-hedra connected in a corner-sharing manner with four equatorial I atoms. The organic (2-ICHNH) cations inter-leave the inorganic layers.

Amperometric Biosensor Based on Glutamate Oxidase to Determine Ast Activity.

This work presents the development of an amperometric biosensor for detecting aspartate aminotransferase (AST) activity in biological fluids using a platinum disk electrode as the working transducer. Optimal concentrations of substrates (aspartate, α-ketoglutarate) and the coenzyme (pyridoxal phosphate) were determined to ensure efficient biosensor operation. A semi-permeable poly-m-phenylenediamine membrane was applied to enhance selectivity against electroactive interferents.

Fast barrier-free switching in synthetic antiferromagnets.

We analytically solve the Landau-Lifshitz equations for the collective magnetization dynamics in a synthetic antiferromagnet (SAF) nanoparticle and uncover a regime of barrier-free switching under a short small-amplitude magnetic field pulse applied perpendicular to the SAF plane. We give examples of specific implementations for forming such low-power and ultra-fast switching pulses. For fully optical, resonant, barrier-free SAF switching we estimate the power per write operation to be  pJ, 10-100 times smaller than for conventional quasi-static rotation, which should be attractive for memory applications.

Problems of harmonization of the criminal legislation of the certain continental law countries to ensure the protection of the circulation of medicinal products.

Objective: Aim: To find out the problems of the harmonization of the criminal legislation of the certain continental law countries to ensure the protection of the circulation of medicinal products.

Patients And Methods: Materials and Methods: This study is based on the analysis of the international legal acts, in particular, the Directives of the EU, as well as Medicrime Convention, national acts of criminal legislation of the certain continental law countries (Germany, Austria, Switzerland, Ukraine, etc.), national judicial practice, data on the number of criminal proceedings in the courts of Ukraine, criminal and medical law legal doctrine (38 normative legal acts and 15 court judgments), data of the Office of the Prosecutor General of Ukraine.

Transitions in growing networks using a structural complexity approach.

Structure changes or transitions are common in growing networks (complex networks, graphs, etc.) and must be precisely determined. The introduced quantitative measure of the structural complexity of the network based on a procedure similar to the renormalization process allows one to reveal such changes.

Development and optimisation of the biosensor for aspartate aminotransferase blood level determination.

This work presents the development and optimisation of an amperometric biosensor for determining aspartate aminotransferase (AST) activity in blood serum, using glutamate oxidase and platinum disc electrodes. AST is a key biomarker for diagnosing cardiovascular and liver diseases. The biosensor's bioselective membrane composition and formation protocol and the working solution (aspartate 8 mM, α-ketoglutarate 2 mM, pyridoxal-5-phosphate 100 µM) were optimised.

Light-enabled scalable synthesis of bicyclo[1.1.1]pentane halides and their functionalizations.

In 2012, bicyclo[1.1.1]pentanes were demonstrated to be bioisosteres of the benzene ring.

Physicochemical and Biological Evaluation of gem-Difluorinated Saturated Oxygen Heterocycles as Bioisosteres for Drug Discovery.

A comprehensive study on the physicochemical properties of gem-fluorinated O-heterocyclic substituents is reported. Systematic additive effects of introducing O- and gem-CF group introduction on acidic properties (pK) of the corresponding carboxylic acids/protonated primary amines were demonstrated. The impact of the O/CF moieties on lipophilicity (LogP) was found to be complex; significant mutual influence of the corresponding polar moieties governed the compound's overall properties in this case.

Oxidative stress-modifying effects of TiOnanoparticles with varying content of Ti(Ti) ions.

Nanoparticles (NPs) with reactive oxygen species (ROS)-regulating ability have recently attracted great attention as promising agents for nanomedicine. In the present study, we have analyzed the effects of TiOdefect structure related to the presence of stoichiometric (Ti) and non-stoichiometric (Tiand Ti) titanium ions in the crystal lattice and TiONPs aggregation ability on HO- and tert-butyl hydroperoxide (tBOOH)-induced ROS production in L929 cells. Synthesized TiO-A, TiO-B, and TiO-C NPs with varying Ti(Ti) content were characterized by x-ray powder diffraction, transmission electron microscopy, small-angle x-ray scattering, x-ray photoelectron spectroscopy, and optical spectroscopy methods.

Estimation of the Structure of Hydrophobic Surfaces Using the Cassie-Baxter Equation.

The effect of extreme water repellency, called the lotus effect, is caused by the formation of a Cassie-Baxter state in which only a small portion of the wetting liquid droplet is in contact with the surface. The rest of the bottom of the droplet is in contact with air pockets. Instrumental methods are often used to determine the textural features that cause this effect-scanning electron and atomic force microscopies, profilometry, etc.

UV Resistance and Wetting of PLA Webs Obtained by Solution Blow Spinning.

In this work, the resistance of polylactide-based non-wovens produced by solution blow spinning to environmental factors was investigated. An average contact angle of up to 136° was achieved with an average fiber diameter of 340 nm at the optimal material density and nozzle-substrate distance. When exposed to ultraviolet (UV) radiation, the polylactide non-wovens rapidly lose their hydrophobic properties due to changes in surface morphology resulting from fiber melting.

Cryogenic Investigations into the Effect of Impact-Oscillatory Loading on Changes in the Mechanical Properties and Structural Condition of VT23M Two-Phase Titanium Alloy.

Impact-oscillatory loading of variable intensity was applied to the VT23M high-strength sheet two-phase titanium alloy in liquid nitrogen. This was carried out to investigate the effect of this loading type on changes in the mechanical properties and structural condition of the alloy upon subsequent static tensioning at normal temperature. Dynamic non-equilibrium process (DNP) realized at a temperature of liquid nitrogen proved to be unable to impair the strength properties of the VT23M titanium alloy compared to room temperature; however, they caused a significant decrease in ductility (down to 16%).

Corrosion Resistance of Coatings Based on Chromium and Aluminum of Titanium Alloy Ti-6Al-4V.

Improvement of wear, corrosion, and heat-resistant properties of coatings to expand the operational capabilities of metals and alloys is an urgent problem for modern enterprises. Diffusion titanium, chromium, and aluminum-based coatings are widely used to solve this challenge. The article aims to obtain the corrosion-electrochemical properties and increase the microhardness of the obtained coatings compared with the initial Ti-6Al-4V alloy.

Crystal structure of polymeric bis-(3-amino-1-pyrazole)-cadmium diiodide.

The reaction of cadmium iodide with 3-amino-pyrazole (3-apz) in ethano-lic solution leads to tautomerization of the ligand and the formation of crystals of the title compound, -poly[[di-iodido-cadmium(II)]-bis-(μ-3-amino-1-pyrazole)-κ : ;κ : ], [CdI(CHN)] or [CdI(3-apz)] . Its asymmetric unit consists of a half of a Cd cation, an iodide anion and a 3-apz mol-ecule. The Cd cations are coordinated by two iodide anions and two 3-apz ligands, generating -CdNI octa-hedra, which are linked into chains by pairs of the bridging ligands.

Health-promoting effect for students from physical loads of speed and strength orientation.

Objective: Aim: To investigate the impact of speed and strength physical loads on promoting health and reducing the biological age of student youth.

Patients And Methods: Materials and Methods: The research involved 180 students aged 18-19. The first stage provided for the study of the indicators of the biological age of 120 students, and the second stage covered substantiation of the methodology for martial arts training sessions, based on physical loads of speed and strength orientation.

Health-improving effect of running for students of technical specialties.

Objective: Aim: To study the dynamics of indicators of the functional state and health of technical specialties students during their long-term running engagement.

Patients And Methods: Materials and Methods: The research involved 112 students (59 men and 53 women) aged 17-20 years. Two groups of students were formed: group 1 included students who, in addition to compulsory academic physical education training sessions, were not engaged in any type of motor activity on their own; group 2 included students who independently were engaged in recreational running 3 times a week in extracurricular time.

Adaptation of Conductometric Monoenzyme Biosensor for Rapid Quantitative Analysis of L-arginine in Dietary Supplements.

The present study reports on the development, adaptation, and optimization of a novel monoenzyme conductometric biosensor based on a recombinant arginine deiminase (ADI) for the determination of arginine in dietary supplements with a high accuracy of results. Aiming for the highly sensitive determination of arginine in real samples, we studied the effect of parameters of the working buffer solution (its pH, buffer capacity, ionic strength, temperature, and protein concentration) on the sensitivity of the biosensor to arginine. Thus, it was determined that the optimal buffer is a 5 mM phosphate buffer solution with pH 6.

Benefits of a combined surgical technique for patients with secondary neovascular glaucoma.

Objective: Aim: To assess the effectiveness and safety of the proposed surgical technique for treating secondary neovascular glaucoma.

Patients And Methods: Materials and Methods: We examined 28 eyes of 28 patients (16 women and 12 men), aged 46}7,2 years, with secondary neovascular glaucoma. All patients underwent a comprehensive ophthalmological examination before and during treatment.

RIS-Assisted D2D Communication over Nakagami- Fading with RSMA.

In this study, we investigated reconfigurable intelligent surface (RIS)-assisted device-to-device (D2D) communication systems over Nakagami- fading channels. To enhance the reliability of RIS-assisted D2D communications, we utilized the rate-splitting multiple access (RSMA) technique to maximize the achievable ergodic rate for our considered systems. Specifically, both devices decoded the common symbol by treating private symbols as interference, and then each private symbol was decoded by treating the other as interference.