87 results match your criteria: "Idiopathic Guttate Hypomelanosis"
Deciphering the role of skin aging in pigmentary disorders.
Free Radic Biol Med
December 2024
Department of Dermatology, Huashan Hospital, Fudan University, No.12 Wulumuqi Zhong Road, Shanghai 200040, PR China. Electronic address:
Article Synopsis
- * The review highlights how skin aging can lead to pigmentary disorders, such as hyperpigmentation (like melasma) and hypopigmentation (like vitiligo).
- * It discusses the mechanisms behind how aging affects skin pigmentation and proposes possible treatment strategies for managing skin aging and related pigmentary issues.
The correlation between dermoscopic patterns and histopathological features in idiopathic guttate hypomelanosis at a tertiary care center.
Acta Dermatovenerol Alp Pannonica Adriat
September 2024
Department of Dermatology, Akash Institute of Medical Sciences and Research Centre, Devanahalli, Bangalore, Karnataka, India.
Article Synopsis
- Idiopathic guttate hypomelanosis (IGH) is a common skin condition mainly seen in older adults, prompting a study to analyze its dermoscopic features and how they relate to histopathological findings.*
- The study assessed 100 patients, noting that the average age was around 65 years, with common dermoscopic patterns being nebuloid (33.3%) and petaloid (26.7%), primarily located on the abdomen and legs.*
- The findings revealed that IGH has unique dermoscopic patterns that, when combined with clinical and histopathological evaluations, enhance accurate diagnosis and differentiation from similar skin conditions, making dermoscopy a valuable diagnostic tool.*
Biomedical applications of tyrosinases and tyrosinase inhibitors.
Enzymes
September 2024
Neurofarba Department, Pharmaceutical and Nutraceutical Section, University of Florence, Sesto Fiorentino, Florence, Italy. Electronic address:
Article Synopsis
- Tyrosinase is linked to various skin conditions, including both hypopigmentation disorders like vitiligo and hyperpigmentation disorders like melasma, and is also implicated in melanoma progression.
- Current treatments for hyperpigmentation include hydroquinone, azelaic acid, and tretinoin, while new tyrosinase inhibitors are being researched for potential anti-melanoma effects.
- Kojic acid and vitamin C are commonly used in cosmetics to prevent food browning, and bacterial enzymes show promise in biomedical applications, including the production of L-DOPA, a medication for Parkinson’s disease.
Evaluation of diagnostic accuracy of dermoscopy in some common hypopigmented skin diseases.
Arch Dermatol Res
August 2024
Department of Dermatology and Venereology, Faculty of Medicine, Tanta University Hospital, 31527, Al-Bahr St., Tanta, Egypt.
Article Synopsis
- Diagnosis of cutaneous hypopigmentation can be challenging, but dermoscopy shows promise in distinguishing between various conditions like vitiligo and pityriasis alba.
- The study evaluated 168 patients to identify dermoscopic features unique to different hypopigmented conditions and assessed their diagnostic accuracy.
- Key findings included that certain patterns like starburst and micro-koebnerization are specific to vitiligo, while other conditions exhibited different patterns; overall, dermoscopy was most effective for conditions such as nevus depigmentosus and pityriasis alba, showing high sensitivity rates.
Diffuse hyperpigmentation with guttate hypopigmentation: a new pigmentary disorder.
Eur J Dermatol
April 2024
Department of Dermatovenereology, Chengdu Second People's Hospital, Chengdu, Sichuan, China.
Article Synopsis
- Diffuse hyperpigmentation with guttate hypopigmentation (DHGH) is a newly identified skin disorder, primarily reported in Chinese females ages 6 to 24, characterized by hypopigmented spots on areas of diffuse hyperpigmentation.
- A detailed study analyzed nine cases, revealing distinct clinical, dermoscopic, and histopathological features, including blurred pigmented patches and abnormal epidermal pigment.
- DHGH is poorly understood, with unclear causes and mechanisms, suggesting that it might be more common than previously thought and requiring further research for better recognition and treatment.
Efficacy and Safety of 5-Fluorouracil Tattooing to Repigment Idiopathic Guttate Hypomelanosis: A Split-Body Randomized Trial.
Dermatol Surg
June 2023
Department of Dermatology, São Paulo Federal University (Universidade Federal de São Paulo-UNIFESP), São Paulo, Brazil.
Article Synopsis
- Idiopathic guttate hypomelanosis (IGH) is a common skin condition lacking a standard treatment, prompting a study on the efficacy of 5-fluorouracil (5FU) compared to saline.
- In a randomized trial, 29 participants received 5FU on one limb and saline on the other, with significant reductions in achromic lesions observed in both groups but greater improvement in the 5FU-treated limbs.
- Results indicated high patient satisfaction with 5FU treatment, showing it is a safer and more effective option for repigmenting IGH lesions, with no reported adverse events.
Idiopathic guttate hypomelanosis-like macules co-localizing to sites of topical photochemotherapy for vitiligo in children: Clinical and dermoscopic findings.
Indian J Dermatol Venereol Leprol
April 2023
Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.
Melanocytes in idiopathic guttate hypomelanosis disappear and are senescent.
J Eur Acad Dermatol Venereol
April 2023
Department of Dermatology, Ajou University School of Medicine, Suwon, South Korea.
Unveiling idiopathic guttate hypomelanosis: pathology, immunohistochemistry, and ultrastructural study.
Int J Dermatol
August 2022
Department of Dermatology, São Paulo Federal University (Universidade Federal de São Paulo - UNIFESP), São Paulo, Brazil.
Treatment of idiopathic guttate hypomelanosis with a tattoo device versus a handheld needle.
JAAD Int
June 2021
Department of Dermatology, São Paulo Federal University (Universidade Federal de São Paulo-UNIFESP), São Paulo, São Paulo.
Idiopathic guttate hypomelanosis: Presentation and Management.
J Cosmet Laser Ther
February 2021
Private Practitioner, Ahmedabad, India.
Idiopathic guttate hypomelanosis (IGH) is a benign, typically asymptomatic, acquired leukoderma characteristically affecting mature individuals. Although the etiopathogenesis is unclear, chronic sun exposure and senile degeneration are important triggers. Researchers have been engaged in a continuous effort to unveil the gray areas encompassing different aspects of IGH pathogenesis.
View Article and Find Full Text PDFDermoscopy of acquired pigmentary disorders: a comprehensive review.
Int J Dermatol
January 2022
Keck School of Medicine of University of Southern California, Los Angeles, California, USA.
Article Synopsis
- Dermoscopy is gaining traction not only for diagnosing skin cancers but also for evaluating various pigmentary disorders, as recent studies have shown its effectiveness in this area.
- A comprehensive review of literature from PubMed examined numerous pigmentary conditions, including melasma, vitiligo, and several others, to explore their unique dermoscopic features.
- The findings suggest that dermoscopy can help clinicians differentiate between these disorders, which can be challenging to diagnose clinically and may cause significant emotional distress for patients.
Idiopathic Guttate Hypomelanosis Treated with 308-nm Excimer Light and Topical Bimatoprost.
J Cutan Aesthet Surg
January 2021
Everything Skin Clinic, Cheadle, UK.
Article Synopsis
- Idiopathic guttate hypomelanosis (IGH) is a skin condition marked by white spots on the shins and forearms, causing cosmetic concerns despite being asymptomatic.
- A 48-year-old woman with an 8-year history of IGH who did not respond to topical treatment underwent a new combination therapy using excimer light and topical bimatoprost.
- After several treatment sessions, she showed significant improvement, especially on smaller spots, suggesting this combination approach might be an effective option for managing IGH, which currently has few treatment alternatives.
Dermatoses in the Elderly: Clinico-Demographic Profile of Patients Attending a Tertiary Care Centre.
Indian J Dermatol
January 2021
Department of Dermatology, All India Institute of Medical Sciences, Patna, Bihar, India.
Article Synopsis
- * The findings revealed that the most common skin issues were infections (30%) and dermatitis (29.6%), with hypertension and diabetes being significant associated comorbidities.
- * Additionally, aging signs like xerosis and wrinkling were prominent, showing a correlation between outdoor activity levels and increased signs of photoaging.
Do oxidative stress and melanin accumulation contribute to the pathogenesis of idiopathic guttate hypomelanosis: A prospective case-control study.
J Cosmet Dermatol
March 2022
Department of Skin & V.D, Nalanda Medical College and Hospital, Patna, India.
Article Synopsis
- The study investigates oxidative stress levels in patients with Idiopathic Guttate Hypomelanosis (IGH) compared to healthy controls, finding significantly higher levels of oxidative stress markers in the affected group.
- Conducted in Northern India, the research included 30 patients diagnosed with IGH through clinical and histopathological evaluation.
- Results suggest that increased oxidative stress correlates with patient age and the number of lesions, although the correlation with lesion count was not statistically significant.
5-Fluorouracil in Dermatology: The Diverse Uses Beyond Malignant and Premalignant Skin Disease.
Dermatol Surg
March 2021
Vernova Healthcare CIC, Macclesfield, United Kingdom.
Article Synopsis
- 5-fluorouracil (5-FU) is commonly used for treating skin cancers but its off-label applications in other skin conditions are not well-documented.* -
- A literature review was conducted to explore these off-label uses, prioritizing studies based on the strength of their evidence.* -
- The findings suggest that 5-FU may effectively treat various noncancerous skin issues like scarring, pigment disorders, infections, inflammatory skin diseases, and even cosmetic concerns with potentially fewer side effects than traditional treatments.*
[Treatment of pigmentation disorders in association with systemic diseases].
Hautarzt
December 2020
Carol-Davila-Universität für Medizin und Pharmazie, Bukarest, Rumänien.
Article Synopsis
- Pigmentation disorders affect skin color due to abnormal melanin levels and can be either genetic or acquired; they include both hypermelanosis (excess pigment) and hypomelanosis (less pigment).
- The article discusses various forms of hypermelanosis and hypomelanosis, as well as non-melanin pigmentation caused by external factors like chemicals and drugs.
- Treatment strategies depend on the underlying cause and can include topical treatments, chemical peels, systemic medications, and laser therapy; sun protection is also important and some treatments may have side effects, necessitating careful management.
Prevalence and pattern of skin diseases in patients with diabetes mellitus at a tertiary hospital in Northern Nigeria.
Niger J Clin Pract
July 2020
Department of Medicine, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria.
Article Synopsis
- - Diabetes mellitus is a widespread metabolic disorder affecting individuals across different ages and socioeconomic backgrounds, with skin lesions commonly observed in diabetic patients.
- - A study conducted at Barau Dikko Teaching Hospital analyzed 100 diabetic patients to identify the prevalence and types of skin diseases they experienced.
- - The results showed that 61% of patients had idiopathic guttate hypomelanosis, followed by infections (30%), diabetic dermopathy (17%), palmoplantar hyperpigmentation (13%), pruritus (12%), and xerosis (10%), highlighting the high occurrence of skin disorders in this population.
Use of 50% trichloroacetic acid in the treatment of idiopathic guttate hypomelanosis.
J Am Acad Dermatol
January 2022
Chennai, India.
Role of senescent fibroblasts in the development of idiopathic guttate hypomelanosis.
Br J Dermatol
June 2020
Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Low-fluence fractional CO laser in the treatment of idiopathic guttate hypomelanosis: a pilot study.
Br J Dermatol
February 2020
Department of Dermatology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Dermoscopy is a new diagnostic tool in diagnosis of common hypopigmented macular disease: A descriptive study.
Dermatol Reports
January 2019
Faculty of Medicine, Mutah University, Jordan.
Article Synopsis
- The study explored the usefulness of dermoscopy to diagnose common hypopigmented skin conditions like vitiligo and pityriasis alba.
- It identified distinctive dermoscopic features for each condition, such as specific color patterns and textures.
- The findings highlight how dermoscopy can help differentiate between various hypopigmented diseases, improving diagnosis and treatment in dermatology.
Peripilar "Guttate" Hypopigmentation of the Scalp and Idiopathic Guttate Hypomelanosis in Frontal Fibrosing Alopecia.
Skin Appendage Disord
February 2019
Department of Dermatology and Cutaneous Surgery University of Miami L. Miller School of Medicine, University of Miami L. Miller School of Medicine, Miami, Florida, USA.
Article Synopsis
- Frontal fibrosing alopecia (FFA) involves progressive hair loss at the frontotemporal hairline and irreversible eyebrow loss, with cases showing either hyper- or hypopigmentation.
- A document highlights a unique case of a 57-year-old Hispanic woman with FFA presenting symptoms of peripilar hypopigmentation and idiopathic guttate hypomelanosis on her arms.
- This case is notable as it's the first recorded instance of peripilar white halos in a White Hispanic patient, suggesting that FFA is linked to pigmentation issues, as indicated by previous studies' findings.