Conscience at the End of Life.

Background/objectives: Caring for patients at the end of life can involve issues that are ethically and legally fraught: withholding or withdrawing artificial nutrition and hydration, pain control that could hasten death, aggressive treatment that is continued when it seems only to be prolonging suffering, patients who request medical assistance in dying, and so forth. Clinicians may find that their deeply held ethical principles conflict with law, institutional policy, or patients' choices. In these situations, they may consider either refusing to participate in procedures that they find morally abhorrent (conscientious refusal) or providing care that they believe to be ethically obligatory despite being contrary to law or policy (conscientious commitment).

Interpersonal Violence, Emotion Regulation, and Trauma-Coping Self-Efficacy as Predictors of Posttraumatic Stress Disorder, Substance Use, and Risk Engagement Among Women in Jail.

Women in jail report significantly higher rates of interpersonal violence, posttraumatic stress disorder (PTSD) symptoms, and substance use disorders compared to the general population. Exposure to interpersonal violence is associated with PTSD and maladaptive behaviors such as substance use and engagement in risky behaviors. However, less is known about mechanisms, such as emotion regulation and trauma-coping self-efficacy, that might increase or decrease the likelihood of these maladaptive behavioral health outcomes in this population.

Sleep Characteristics Among Children with a Parental History of Alcohol Use Disorder.

Purpose Of Review: The purpose of the review was to examine findings on sleep characteristics among children with a parental history of alcohol use disorder (CPHAUDs) in different age groups. We identified unanswered questions and discussed directions for future research. We also discussed the implications of these current findings on alcohol prevention and intervention programs.

Food-web dynamics of a floodplain mosaic overshadow the effects of engineered logjams for Pacific salmon and steelhead.

Food webs vary in space and time. The structure and spatial arrangement of food webs are theorized to mediate temporal dynamics of energy flow, but empirical corroboration in intermediate-scale landscapes is scarce. River-floodplain landscapes encompass a mosaic of aquatic habitat patches and food webs, supporting a variety of aquatic consumers of conservation concern.

It Can No Longer Be Optional-Medical Billing in the PharmD Curriculum.

Pharmacists across the United States are rapidly gaining the ability to bill the medical benefit, increasing their ability to optimally and sustainably contribute to patient care. Medical billing is the process by which a provider submits a claim for reimbursement to the medical insurance benefit based on services provided to a patient. As pharmacists lean into new and expanding opportunities related to medical billing, pharmacy educators must also prepare graduates who can explain the importance of and execute skills related to medical billing.

Approaching ethical issues in the developmental biology classroom.

Over the past decades, Developmental Biology has been moving steadily from a rather academic subject to an increasingly practical discipline. It has played a role in the development of contraceptive and conceptive (e.g.

Reduced resting-state periodic beta power in adults who stutter is related to sensorimotor control of speech execution.

Objective: The primary aim of the current study was to determine whether adults who stutter (AWS) present with anomalous periodic beta (β) rhythms when compared to typically fluent adults in the eyes-open resting state. A second aim was to determine whether lower β power in the RS is related to a measure of β event-related desynchronization (ERD) during syllable sequence execution.

Methods: EEG data was collected from 128 channels in a 5 min, eyes-open resting state condition and from a syllable sequence repetition task.

Bidirectional relationships between chronotype and sleep hygiene in children with and without parental history of alcohol use disorder.

Study Objectives: Children with evening chronotype may be at risk for insufficient sleep because their chronotype makes it difficult to sustain healthy sleep habits. We evaluated bidirectional relationships between chronotype and sleep hygiene.

Methods: Two hundred forty-six children (n = 246 at T1, n = 200 at T2, n = 147 at T3), with a mean age of 9.

Perspective on the health effects of unsaturated fatty acids and commonly consumed plant oils high in unsaturated fat.

Epidemiological and clinical trial evidence indicates that -6 polyunsaturated fatty acid (PUFA) intake is cardioprotective. Nevertheless, claims that -6 PUFA intake promotes inflammation and oxidative stress prevail. This narrative review aims to provide health professionals with an up-to-date evidence overview to provide the requisite background to address patient/client concerns about oils containing predominantly unsaturated fatty acids (UFA), including MUFA and PUFA.

Developmental Changes in Locomotion and Sensorimotor Reflexes Following Spinal Cord Transection.

The developmental trajectory of weight-bearing locomotion and sensorimotor reflexes following a spinal cord injury, as well as the mechanisms for plasticity, remain unclear. In rats, the second postnatal week is a critical period for the development and recovery of spinal sensorimotor function. The purpose of the present study was to characterize developmental changes during this time frame to provide a basis for potential interventions and future research.

Development of phage-containing hydrogel for treating Enterococcus faecalis-infected wounds.

Background: Chronic wound infections caused by Enterococcus faecalis pose formidable challenges in clinical management, exacerbated by the emergence of vancomycin-resistant strains. Phage therapy offers a targeted approach but encounters delivery hurdles. Due to their biocompatibility and controlled release properties, hydrogels hold promise as carriers.

Empowering Pharmacy Graduates to Diagnose and Prescribe.

This commentary underscores the diagnosis and prescribing skills essential to the pharmacists' role on the healthcare team. It advocates for the integration of these skills into pharmacy curricula and emphasizes the urgent need for collaboration among pharmacy educators and the academy to address the omission of diagnosis and prescribing from key frameworks and standards, including the Pharmacists' Patient Care Process (PPCP), the Curricular Outcomes and Entrustable Professional Activities (COEPA), and the Accreditation Council for Pharmacy Education (ACPE) Draft Accreditation Standards 2025. The commentary draws on a case study of one college of pharmacy's integration of diagnosis and prescribing skills into its PharmD curriculum, in a state where pharmacists were granted full diagnostic and prescriptive authority.

Oxytocin Receptor Single-Nucleotide Polymorphisms Are Related to Maternal-Infant Co-Occupation and Infant Sensory Processing.

Background: Caregiver-infant reciprocity is related to infant/toddler development and health. However, there is a dearth of research on reciprocity variables like co-occupation and developmental variables such as infant/toddler sensory processing/preferences, and it is important to understand the biopsychosocial mediators of these relations. These include novel genetic markers like maternal oxytocin receptor single-nucleotide polymorphisms (OXTR SNPs).

MultiNet 2.0: A lightweight attention-based deep learning network for stenosis measurement in carotid ultrasound scans and cardiovascular risk assessment.

Background: Cardiovascular diseases (CVD) cause 19 million fatalities each year and cost nations billions of dollars. Surrogate biomarkers are established methods for CVD risk stratification; however, manual inspection is costly, cumbersome, and error-prone. The contemporary artificial intelligence (AI) tools for segmentation and risk prediction, including older deep learning (DL) networks employ simple merge connections which may result in semantic loss of information and hence low in accuracy.

Local adaptation to climate facilitates a global invasion.

Local adaptation may facilitate range expansion during invasions, but the mechanisms promoting destructive invasions remain unclear. Cheatgrass (), native to Eurasia and Africa, has invaded globally, with particularly severe impacts in western North America. We sequenced 307 genotypes and conducted controlled experiments.

Neuroimaging evaluations of olfactory, gustatory, and neurological deficits in patients with long-term sequelae of COVID-19.

The World Health Organization indicated that around 36 million of patients in the European Region showed long COVID associated with olfactory and gustatory deficits. The precise mechanism underlying long COVID clinical manifestations is still debated. The aim of this study was to evaluate potential correlations between odor threshold, odor discrimination, odor identification, and the activation of specific brain areas in patients after COVID-19.

Redefining Spectral Data Analysis with Immersive Analytics: Exploring Domain-Shifted Model Spaces for Optimal Model Selection.

Modern developments in autonomous chemometric machine learning technology strive to relinquish the need for human intervention. However, such algorithms developed and used in chemometric multivariate calibration and classification applications exclude crucial expert insight when difficult and safety-critical analysis situations arise, e.g.

Calcium Rescues D39 Δ Manganese-Sensitive Growth Phenotype.

Calcium (Ca) functions as a universal signal messenger in eukaryotes but in bacteria, the physiological roles for Ca are limited. Here, we examine the role of Ca in during manganese (Mn) intoxication. mutants, lacking the Mn efflux transporter, exhibit impaired growth due to accumulation of Mn when exposed to elevated exogenous Mn.

A randomized controlled trial of targeted vs. General direct-to-consumer marketing to address psychotherapy attitudes and stigma in military service members and Veterans.

Many military service members and Veterans who experience a psychological need do not seek psychotherapy, which may be due to negative attitudes and stigma toward mental health services. In this study, we investigated the effectiveness of a general vs. military-specific direct-to-consumer psychotherapy marketing video to address psychotherapy attitudes in a nationwide sample of military service members and Veterans ( = 262).