A core outcome set for best care for the dying person: Results of an international Delphi study and consensus meeting.

Background: Outcome measurement is essential to progress clinical practice and improve patient care.

Aim: To develop a Core Outcome Set for best care for the dying person.

Design: We followed the Core Outcome Measures in Effectiveness Trials (COMET) Initiative guidelines, which involved identifying potential outcomes via a systematic literature review (n = 619 papers) and from participants in the "iLIVE" project (10 countries: 101 patients, 37 family members, 63 clinicians), followed by a two-round Delphi study, and a consensus meeting.

Clinical and non-clinical aspects of reimbursement policy for orphan drugs in selected European countries.

Objectives: The aim of the study was to assess the reimbursement policy for orphan drugs (ODs) in selected European countries in relation to the availability and impact of clinical evidence, health technology assessment (HTA) procedures and reimbursement decision-making.

Materials And Methods: A list of authorized ODs was extracted from a web-based registry of the European Medicines Agency, including information on active substance, Anatomical Therapeutic Chemical (ATC) classification code, and therapeutic area. A country-based questionnaire survey was conducted between September 2022 and September 2023 among selected experts from 12 European countries.

Let´s Swing it -The Interaction Between Participation-Related Shoulder Load and Pre-season Trunk Rotation Power on Shoulder Problems in Male Handball Players.

Background: Little is known about the influence of kinetic chain strength and power on shoulder problems in handball players or the impact of participation-related shoulder load (PSL) during a season. Suboptimal activity of the kinetic chain during throwing might make the shoulder more vulnerable.

Purpose: The purpose of this study was to assess 1) the association between pre-season measurements and shoulder problems among handball players and 2) whether pre-season strength and power influence the association between PSL and severity of shoulder problems.

Endotypic Traits Characterizing Obesity and Sleep-related Hypoventilation in Patients with Obstructive Sleep Apnea.

Rationale: Sleep-related hypoventilation disorder (SHD) is common among obese patients with obstructive sleep apnea (OSA), but the pathological endotypes associated with obesity and SHD remain unclear.

Objectives: To investigate relationship between endotypes with body mass index (BMI) among patients with OSA, and to explore endotypic traits of patients with comorbid SHD.

Methods: We prospectively collected polysomnographic studies of 1364 patients with OSA, and overnight transcutaneous CO2 (TcCO2) measurements among 420 obese patients.

On the feasibility of country-specific and country-general explanations for the increase over time in psychosomatic complaints among Nordic adolescents.

Aims: This study examines the evidence for similar increases in psychosomatic complaints among 15-year-olds in the Nordic countries over the period 2002-2022. A distinction is made between the level and shape of these time trends.

Methods: A dataset from the Health Behaviour in School-aged Children survey from 2002 to 2022 was used.

Secondary Sclerosing Cholangitis due to Drugs With a Special Emphasis on Checkpoint Inhibitors.

Background: Secondary sclerosing cholangitis (SSC), is one of the phenotypes of DILI first described in the 1980s. Check point inhibitors (CPIs) are currently the most frequent cause of SCC.

Aims: To describe the epidemiology, clinical and biochemical features at presentation, differential diagnoses, pathophysiology, imaging, histological characteristics and management associated with SSC.

[Food as migraine trigger].

Background And Aims: Migraine is a neurological disorder that is characterized by severe headaches and temporary motor and sensory disturbances. Migraine triggers are internal or external factors that can increase the likelihood of a migraine attack. Some individuals with migraine associate their attacks with the consumption of certain types of food, but no have been conducted in Iceland.

Corroborating written history with ancient DNA: The case of the Well-man described in an Old Norse .

The potential of ancient DNA analyses to provide independent sources of information about events in the historical record remains to be demonstrated. Here we apply palaeogenomic analysis to human remains excavated from a medieval well at the ruins of Sverresborg Castle in central Norway. In , the Old Norse of King Sverre Sigurdsson, one passage details a 1197-CE raid on the castle and mentions a dead man thrown into the well.

Proteome-wide forced interactions reveal a functional map of cell-cycle phospho-regulation in .

Dynamic protein phosphorylation and dephosphorylation play an essential role in cell cycle progression. Kinases and phosphatases are generally highly conserved across eukaryotes, underlining their importance for post-translational regulation of substrate proteins. In recent years, advances in phospho-proteomics have shed light on protein phosphorylation dynamics throughout the cell cycle, and ongoing progress in bioinformatics has significantly improved annotation of specific phosphorylation events to a given kinase.

Changes in short-term variation of antenatal cardiotocography to identify intraamniotic infection: a historical cohort study.

Introduction: Intraamniotic infection (IAI) is one of the main possible complications of preterm prelabor rupture of membranes (PPROM) and can lead to severe consequences for the neonate, such as early onset neonatal sepsis (EONS). Available diagnostic tools for IAI have poor diagnostic performance, which may result in both over- and underdiagnoses of IAI. In a search for better diagnostic tools, we have examined short-term variation (STV) in fetal heart rate.

Versatile unsupervised design of antennas using flexible parameterization and computational intelligence methods.

Developing contemporary antennas is a challenging endeavor that requires considerable engineering insight. The most laborious stage is to devise an antenna architecture that delivers the required functionalities, e.g.

The European Union summary report on surveillance for the presence of transmissible spongiform encephalopathies (TSE) in 2023.

This report presents the results of surveillance on transmissible spongiform encephalopathies in cattle, sheep, goats, cervids and other species, and genotyping in sheep and goats, carried out in 2023 by 27 Member States (MS, EU27), the United Kingdom (in respect of Northern Ireland, (XI)) and other eight non-EU reporting countries: Bosnia and Herzegovina, Iceland, Montenegro, North Macedonia, Norway, Serbia, Switzerland (the data reported by Switzerland include those of Liechtenstein) and Türkiye. In total, 948,165 cattle were tested by EU27 and XI (-3%, compared with 2022), with five atypical BSE cases reported (four H-type: two in Spain, one in France and one in Ireland; one L-type in the Netherlands); and 46,096 cattle by eight non-EU reporting countries with two atypical BSE cases reported by Switzerland. Three additional atypical BSE cases were reported by UK (1), USA (1) and Brazil (1).

Weakening of the AMOC and strengthening of Labrador Sea deep convection in response to external freshwater forcing.

The Atlantic Meridional Overturning Circulation (AMOC) is a key player in climate. Here, we employ an ensemble of water hosing experiments to examine mechanisms of AMOC weakening and its subsequent impact on the Labrador Sea open-ocean deep convection. The subpolar AMOC decline in response to the external freshwater flux released over the southern Nordic Sea is dominated by that across the eastern subpolar North Atlantic, and the largest subpolar AMOC decline is at the relatively dense level around .

Target selection during "snapshot" foraging.

While previous foraging studies have identified key variables that determine attentional selection, they are affected by the global statistics of the tasks. In most studies, targets are selected one at a time without replacement while distractor numbers remain constant, steadily reducing the ratios of targets to distractors with every selection. We designed a foraging task with a sequence of local "snapshots" of foraging displays, with each snapshot requiring a target selection.

Soil microbiomes show consistent and predictable responses to extreme events.

Increasing extreme climatic events threaten the functioning of terrestrial ecosystems. Because soil microbes govern key biogeochemical processes, understanding their response to climate extremes is crucial in predicting the consequences for ecosystem functioning. Here we subjected soils from 30 grasslands across Europe to four contrasting extreme climatic events under common controlled conditions (drought, flood, freezing and heat), and compared the response of soil microbial communities and their functioning with those of undisturbed soils.