The application of cyclodextrins in drug solubilization and stabilization of nanoparticles for drug delivery and biomedical applications.

Nanoparticles (NPs) have gained significant attention in recent years due to their potential applications in pharmaceutical formulations, drug delivery systems, and various biomedical fields. The versatility of colloidal NPs, including their ability to be tailored with various components and synthesis methods, enables drug delivery systems to achieve controlled release patterns, improved solubility, and increased bioavailability. The review discusses various types of NPs, such as nanocrystals, lipid-based NPs, and inorganic NPs (i.

Absolute beta power in exercisers and nonexercisers in preparation for the oddball task.

Background:  High levels of physical conditioning are associated with improvements in cognitive performance. In this sense, electroencephalographic (ECG) correlates are used to investigate the enhancing role of physical exercise on executive functions. Oscillations in the β frequency range are proposed to be evident during sensorimotor activity.

No association between migraine and HLA alleles in a cohort of 13,210 individuals with migraine from the Danish Blood Donor Study.

Objective: To determine the association between human leukocyte antigen (HLA) alleles and migraine, migraine subtypes, and sex-specific factors.

Background: It has long been hypothesized that inflammation contributes to migraine pathophysiology. This study examined the association between migraine and alleles in the HLA system, a key player in immune response and genetic diversity.

Prokinetic agents in adult intensive care unit patients (PATIENCE)-An international inception cohort study protocol.

Background: Feeding intolerance is common in critically ill patients and can lead to malnutrition. Prokinetic agents may be used to enhance the uptake of nutrition. However, the evidence on the effectiveness and safety of prokinetic agents is sparse, and there is a lack of data on their use in intensive care units (ICU).

A compact circularly polarized dielectric resonator antenna with MIMO characterizations for UWB applications.

Ultra-wideband (UWB) technology is extensively used in indoor navigation, medical applications, and Internet of Things devices due to its low power consumption and resilience against multipath fading and losses. This paper examines a multiple-input multiple-output (MIMO), circularly polarized (CP) dielectric resonator antenna for UWB systems. Compact form factor, high gain, wideband response, improved port isolation, and high data rates are the major design goals.

Developmental language disorder - heritability and genetic correlations with other disorders affecting language.

Developmental language disorder (DLD) is a neurodevelopmental disorder primarily affecting language in the absence of a known biomedical condition, which may have a large impact on a person's life and mental health. Family-based studies indicate a strong genetic component in DLD, but genetic studies of DLD are scarce. In this study we estimated the heritability of DLD and its genetic correlations with related disorders and traits in sample of >25,000 individuals from the Danish Blood Donor Study for whom we had both genotype data and questionnaire data on language disorder and language support.

Polyethylene wear and cup migration of cemented total hip arthroplasty with femoral heads made of oxidized zirconium, steel, or cobalt chromium: a 10-year secondary analysis from a randomized trial using radiostereometry.

Background And Purpose: We aimed to evaluate polyethylene (PE) wear, cup migration, and clinical outcome over 10 years in total hip arthroplasties (THA) using different articulations.

Methods:  This is a secondary analysis of 150 patients randomized into 5 groups, using different articulations: Charnley/Charnley Ogee for steel and conventional polyethylene (CPE), or Spectron EF/Reflection with either CPE or highly cross linked polyethylene (XLPE) cups, paired with heads made of either cobalt-chromium (CoCr) or oxidized zirconium (OxZr). All cups were cemented.

The effect of , , and on ruminal methanogenesis and metagenomic functional profiles .

Unlabelled: The ruminant-microorganism symbiosis is unique by providing high-quality food from fibrous materials but also contributes to the production of one of the most potent greenhouse gases-methane. Mitigating methanogenesis in ruminants has been a focus of interest in the past decades. One of the promising strategies to combat methane production is the use of feed supplements, such as seaweeds, that might mitigate methanogenesis via microbiome modulation and direct chemical inhibition.

Methodological approach to investigating spatial cognition in Arctic charr (Salvelinus alpinus).

Assessing cognitive traits poses consistent methodological challenges. We describe a method for testing Arctic charr by incorporating a T-maze into their housing, which reduced stress and improved the engagement of the tested fish in the task. We outline the phases of testing to evaluate learning efficiency and determine which orientation strategies, such as motor response versus beaconing, are prioritized by the animals.

Fast machine-learning-enabled size reduction of microwave components using response features.

Achieving compact size has emerged as a key consideration in modern microwave design. While structural miniaturization can be accomplished through judicious circuit architecture selection, precise parameter tuning is equally vital to minimize physical dimensions while meeting stringent performance requirements for electrical characteristics. Due to the intricate nature of compact structures, global optimization is recommended, yet hindered by the excessive expenses associated with system evaluation, typically conducted through electromagnetic (EM) simulation.

Second Partnership and Dementia Care in a Blended Family: Case Study of a Wicked Problem.

Dementia care research has largely ignored the challenges that may emerge from couple and family dynamics, especially about second partnerships in blended families. This paper details the case of a 79-year-old man, Hannes, in his second partnership who tried to handle the complexities of his wife's dementia care as her children and healthcare providers discounted his role as husband and decision maker. He faced difficult communications with family members and challenges to his role as decision maker by healthcare providers and legal system professionals.

Sequence Segmentation of Nematodes in Atlantic Cod with Multispectral Imaging Data.

Nematodes pose significant challenges for the fish processing industry, particularly in white fish. Despite technological advances, the industry still depends on manual labor for the detection and extraction of nematodes. This study addresses the initial steps of automatic nematode detection and differentiation from other common defects in fish fillets, such as skin remnants and blood spots.

Parents in Neonatal Pain Management-An International Survey of Parent-Delivered Interventions and Parental Pain Assessment.

Background: While parent-delivered pain management has been demonstrated to effectively reduce neonatal procedural pain responses, little is known about to what extent it is utilized. Our aim was to explore the utilization of parents in neonatal pain management and investigate whether local guidelines promote parent-delivered interventions.

Methods: A web-based survey was distributed to neonatal units worldwide.

Impact of HDAC inhibitors on macrophage polarization to enhance innate immunity against infections.

Innate immunity plays an important role in host defense against pathogenic infections. It involves macrophage polarization into either the pro-inflammatory M1 or the anti-inflammatory M2 phenotype, influencing immune stimulation or suppression, respectively. Epigenetic changes during immune reactions contribute to long-term innate immunity imprinting on macrophage polarization.

Staging peritoneal metastases in colorectal cancer: The correlation between MRI, surgical and histopathological peritoneal cancer index.

Introduction: DW-MRI is a non-invasive way to determine the peritoneal cancer index (PCI) in colorectal cancer (CRC) patients with peritoneal metastases (PM). However, like surgeons during surgery, radiologists struggle to differentiate between PM and fibrosis. This study aimed to investigate the agreement between the PCI as determined by MRI (mriPCI), during surgery (sPCI) and histopathology examination (pPCI) in CRC patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC).

Greenland Norse walrus exploitation deep into the Arctic.

Walrus ivory was a prized commodity in medieval Europe and was supplied by Norse intermediaries who expanded across the North Atlantic, establishing settlements in Iceland and Greenland. However, the precise sources of the traded ivory have long remained unclear, raising important questions about the sustainability of commercial walrus harvesting, the extent to which Greenland Norse were able to continue mounting their own long-range hunting expeditions, and the degree to which they relied on trading ivory with the various Arctic Indigenous peoples that they were starting to encounter. We use high-resolution genomic sourcing methods to track walrus artifacts back to specific hunting grounds, demonstrating that Greenland Norse obtained ivory from High Arctic waters, especially the North Water Polynya, and possibly from the interior Canadian Arctic.

[Eosinophilic esophagitis (EoE) in adults in Icelandic and international context].

Eosinophilic esophagitis (EoE) is a common cause of swallowing difficulties in both children and adults. The incidence of EoE has been increasing over the past decades, which cannot be solely attributed to improved diagnostic techniques. EoE is more common in adults than in children.