[Termination of pregnancy. Methods, results, and complications].

Introduction: Medical treatment for termination of pregnancy in the first trimester of pregnancy was first introduced in 2006 at Landspitali. This new method, which replaced surgery, slowly gained ground and now most abortions in Iceland are medically induced. It is therefore appropriate to evaluate the effectiveness and safety of this method.

[Nordic nutrition recommendations 2023 on diet for health and environment estimated for children].

Nordic nutrition recommendations 2023 (NNR2023) advised for the first time certain amounts of foods from food-groups based on scientific data on healthy and environment-friendly diet. The food-based-dietary-guidelines are intended for adults and children above age two, but children's energy requirement and intake are lower than those of adults. In this review, reference amounts of food from different food-groups are calculated for children to align with the combination recommended for adults in NNR2023.

Soluble Proteins From Conventional and Organic Eggshell Membranes With Different Proteomic Profiles Show Similar In Vitro Biofunctions.

The eggshell membrane (ESM), resembling the extracellular matrix (ECM), acts as a protective barrier against bacterial invasion and offers various biofunctions due to its porous structure and protein-rich composition, such as ovalbumin, ovotransferrin, collagen, soluble protein, and antimicrobial proteins. However, the structure of ESM primarily comprises disulfide bonds and heterochains, which poses a challenge for protein solubilization/extraction. Therefore, the method of dissolving and extracting bioactive protein components from ESM has significant potential value and importance for exploring the reuse of egg waste and environmental protection.

Host-directed therapies modulating innate immunity against infection in hematologic malignancies.

Patients with hematologic malignancies (HM) are highly susceptible to bloodstream infection (BSI), particularly those undergoing treatments such as chemotherapy. A common and debilitating side effect of chemotherapy is oral and intestinal mucositis. These Patients are also at high risk of developing sepsis, which can arise from mucosal barrier injuries and significantly increases mortality in these patients.

Reassessing the winner-loser gap in satisfaction with democracy.

Citizens who support a party which enters government are systematically more satisfied with democracy compared to voters who supported a party which ends up in the opposition. This relationship is labelled as the "winner-loser gap," but we lack firm causal evidence of this gap. We provide a causal estimate of the effects of voting for a winning or losing party by leveraging data from surveys fielded before and after new government formations in three well established democracies (Netherlands, Norway and Iceland) were announced in contexts of very high uncertainty.

Synthesis of Enantiostructured Triacylglycerols Possessing a Saturated Fatty Acid, a Polyunsaturated Fatty Acid and an Active Drug Intended as Novel Prodrugs.

This report describes the asymmetric synthesis of a focused library of enantiopure structured triacylglycerols (TAGs) comprised of a single saturated fatty acid (C6, C8, C10, C12, C14 or C16), a pure bioactive n-3 polyunsaturated fatty acid (EPA or DHA) and a potent drug (ibuprofen or naproxen) intended as a novel type of prodrug. One of the terminal -1 or -3 positions of the glycerol backbone is occupied with a saturated fatty, the remaining one with a PUFA, and the drug entity is present in the -2 position. This was accomplished by a six-step chemoenzymatic approach starting from enantiopure ()- and ()-solketals.

Lithium Use During Pregnancy in 14 Countries.

Importance: In pregnancy, the benefits of lithium treatment for relapse prevention in psychiatric conditions must be weighed against potential teratogenic effects. Currently, there is a paucity of information on how and when lithium is used by pregnant women.

Objective: To examine lithium use in the perinatal period.

Non-Hermitian polariton-photon coupling in a perovskite open microcavity.

Exploring the non-Hermitian properties of semiconductor materials for optical applications is at the forefront of photonic research. However, the selection of appropriate systems to implement such photonic devices remains a topic of debate. In this work, we demonstrate that a perovskite crystal, characterized by its easy and low-cost manufacturing, when placed between two distributed Bragg reflectors with an air gap, can form a natural double microcavity.

Impulsive Buying and Deferment of Gratification Among Adults With ADHD.

Background: Impulsivity symptoms have been studied thoroughly in adults with ADHD, including hasty actions and decisions without considering possible consequences. The objective of our study was to investigate impulsive buying and deferment of gratification among adults with ADHD and a comparison group.

Method: The participants were 225 adults with ADHD and 121 university students who completed the Buying Impulsiveness Scale (BIS), the Deferment of Gratification Questionnaire (DOGQ), the Adult ADHD Rating Scale-IV (ADHD-RS), as well as background questions.

Glomerular Filtration of Creatinine: Validation of a Novel Index of Muscle Mass Among Older Adults.

Rationale & Objective: Low muscle mass is common among older adults and associated with poor prognosis. Quantifying muscle mass is challenging in routine clinical practice. We hypothesized that glomerular filtration of creatinine (GF) reflects muscle mass, and previously proposed estimated GF (eGF), as a practical index of muscle mass in older adults.

Genetics of female and male reproductive traits and their relationship with health, longevity and consequences for offspring.

Substantial shifts in reproductive behaviors have recently taken place in many high-income countries including earlier age at menarche, advanced age at childbearing, rising childlessness and a lower number of children. As reproduction shifts to later ages, genetic factors may become increasingly important. Although monogenic genetic effects are known, the genetics underlying human reproductive traits are complex, with both causal effects and statistical bias often confounded by socioeconomic factors.

Automated fingerprint analysis as a diagnostic tool for the genetic disorder Kabuki syndrome.

Purpose: Emerging therapeutic strategies for Kabuki syndrome (KS) make early diagnosis critical. Fingerprint analysis as a diagnostic aid for KS diagnosis could facilitate early diagnosis and expand the current patient base for clinical trials and natural history studies.

Method: Fingerprints of 74 individuals with KS, 1 individual with a KS-like phenotype, and 108 controls were collected through a mobile app.

Mobility Medicine: A call to unify hyper-fragmented specialties by abstracts sent to 2025Pdm3, and typescripts to Ejtm3, and .

Mega scientific conferences increasingly suffer from the need for short and poster presentations without discussion. An alternative is to organize workshops in hotels large enough to accommodate all participants. This significantly increases the opportunities for constructive discussion during breakfasts, lunches, dinners and long evenings that can bring together experts of scientific and clinical sub-specialties and young fellows.

Cognitive impairment in patients with melanoma before adjuvant immune checkpoint inhibitor therapy and associations with brain gray matter, catechol-O-methyltransferase genotype, and psychological factors.

Background: Cancer-related cognitive impairment (CRCI) is a significant concern in patients with cancer but understanding its prevalence and risk factors in patients with malignant melanoma (MMPs) remains limited. This study explores CRCI via a multifaceted approach integrating neurobiological, genetic, and psychological assessments.

Methods: Cognitive functioning across multiple domains was assessed via neuropsychological tests in 47 MMPs before adjuvant immune checkpoint inhibitor therapy, compared with 53 matched healthy controls (HCs).

Early trigeminal and sensory impairment and lysosomal dysfunction in accurate models of Wolfram syndrome.

Wolfram syndrome (WS) is a rare condition caused by homozygous or compound heterozygous mutations in the WFS1 gene primarily. It is diagnosed on the basis of early-onset diabetes mellitus and optic nerve atrophy. Patients complain of trigeminal-like migraines and show deficits in vibration sensation, but the underlying cause is unknown.

Accurate quantification of nascent and mature RNAs from single-cell and single-nucleus RNA-seq.

In single-cell and single-nucleus RNA sequencing (RNA-seq), the coexistence of nascent (unprocessed) and mature (processed) messenger RNA (mRNA) poses challenges in accurate read mapping and the interpretation of count matrices. The traditional transcriptome reference, defining the "region of interest" in bulk RNA-seq, restricts its focus to mature mRNA transcripts. This restriction leads to two problems: reads originating outside of the "region of interest" are prone to mismapping within this region, and additionally, such external reads cannot be matched to specific transcript targets.

Psychometric Evaluation of the Icelandic Version of the Modified Dynamic Gait Index for Community-Dwelling Older Adults With Balance Impairments.

Rationale: Optimal mobility is crucial for healthy aging, particularly among older adults with balance impairments. This research examines the psychometric properties of the modified Dynamic Gait Index (mDGI) translated into Icelandic, highlighting its suitability for evaluating mobility in this demographic group and within the context of healthy aging. Addressing the scarcity of international psychometric research on the mDGI, this study contributes to the translation of geriatric outcome measures into different languages, enhancing clinical applications and international research.

Enhanced warming of European mountain permafrost in the early 21st century.

Mountain permafrost, constituting 30% of the global permafrost area, is sensitive to climate change and strongly impacts mountain ecosystems and communities. This study examines 21st century permafrost warming in European mountains using decadal ground temperature data from sixty-four boreholes in the Alps, Scandinavia, Iceland, Sierra Nevada and Svalbard. During 2013-2022, warming rates at 10 metres depth exceed 1 °C dec in cases, generally surpassing previous estimates because of accelerated warming and the use of a comprehensive data set.

Cross-Modal Cues Improve the Detection of Synchronized Targets during Human Foraging.

In two experiments, we explored whether cross-modal cues can be used to improve foraging for multiple targets in a novel human foraging paradigm. Foraging arrays consisted of a 6 × 6 grid containing outline circles with a small dot on the circumference. Each dot rotated from a random starting location in steps of 30°, either clockwise or counterclockwise, around the circumference.