The role of biologics in pediatric food allergy and eosinophilic gastrointestinal disorders.

Continuing insight into the molecular mechanisms of atopic disorders has enabled the development of biologics to precisely target these diseases. Food allergy (FA) and eosinophilic gastrointestinal disorders (EGIDs) are driven by similar inflammatory molecular mechanisms and exist along the same atopic disease spectrum. Therefore, many of the same biologics are being investigated to target key drivers of mechanisms shared across the disease states.

Peanut allergy diagnosis: A 2020 practice parameter update, systematic review, and GRADE analysis.

Given the burden of disease and the consequences of a diagnosis of peanut allergy, it is important that peanut allergy be accurately diagnosed so that an appropriate treatment plan can be developed. However, a test that indicates there is peanut sensitization present (eg, a "positive" test) is not always associated with clinical reactivity. This practice parameter addresses the diagnosis of IgE-mediated peanut allergy, both in children and adults, as pertaining to 3 fundamental questions, and based on the systematic reviews and meta-analyses, makes recommendations for the clinician who is evaluating a patient for peanut allergy.

Physician compliance with updated practice parameters for influenza vaccination in individuals with egg allergies.

Background: Significant recent changes to the recommendations in providing trivalent seasonal influenza vaccine (TIV) to individuals with egg allergy were made, but their implementation has not been studied.

Objectives: To investigate allergist-reported compliance with updated TIV administration guidelines for individuals with egg allergy.

Methods: A 22-question electronic survey was distributed via e-mail to American Academy of Allergy, Asthma, and Immunology members (allergists), which queried practice styles and attitudes that pertain to TIV administration to individuals with egg allergy.