Synthesis and biological evaluation of new pyrazolebenzene-sulphonamides as potential anticancer agents and hCA I and II inhibitors.

Cancer is a disease characterized by the continuous growth of cells without adherence to the rules that healthy normal cells obey. Carbonic anhydrase I and II (CA I and CA II) inhibitors are used for the treatment of some diseases. The available drugs in the market have limitations or side effects, which bring about the need to develop new drug candidate compound(s) to overcome the problems at issue.

Optimism and pessimism mediate the association between parental coronavirus anxiety and depression among healthcare professionals in the era of COVID-19.

Identifying factors related to healthcare professionals' mental health has become an imperative topic for offering mental health services to foster their psychological functioning. This study, for the first time, examined the mediating role of optimism and pessimism in the association between parental coronavirus anxiety and depression among Turkish healthcare professionals during the COVID-19 pandemic. Participants included 429 healthcare professionals whose age ranged between 22 and 61 years (50.

Challenges and lessons learned in mental health research among refugees: a community-based study in Turkey.

Background: Turkey hosts nearly four million refugees and 99% live in urban areas. Research in urban settings pose different challenges and opportunities than research in refugee camps. In this article, we aimed to share the challenges and experiences we encountered in a mixed-methods study to assess mental health problems and barriers to accessing mental health care among refugees in urban areas of Turkey.

Carbonate and silicate dissolving bacteria isolated from home-made yogurt samples.

In the current study, twenty-eight bacterial strains were isolated from home-made yogurt samples from Ağrı Province, Turkey. The bacterial strains were identified by conventional and molecular techniques. Among the twenty- eight isolates, seventeen isolates were identified according to the 16 S rDNA region and determined to belong to five different genus including Sphingomonas (8 isolates), Burkholderia (5 isolates), Lactobacillus (2 isolates), Lactococcus (1 isolate), Staphylococcus (1 isolate).

Reflections of the before processes in early and forced marriages: A meta-synthesis study.

Purpose: To develop analytical themes through a descriptive synthesis of qualitative studies to create a broader and more conscious understanding of the before processes in early and forced marriages.

Methods: Twenty-five qualitative studies were analyzed and synthesized according to meta-synthesis methods.

Findings: The analytical themes of the main theme "The process leading to early and forced marriages" were divided into four groups as cognitive, affective, behavioral, and cultural reflections.

and enzyme inhibition effects of some metal ions and compounds on glutathione S-transferase enzyme purified from L.

Glutathione s-transferase (GST) is a class of enzymes that performs a wide array of biological functions. However, GST enzymes are most famously known for their roles in catalyzing the conjugation of reduced glutathione (GSH) to electrophilic centers on a wide variety of substrates to induce water-solubility to compounds as a protective antioxidant mechanism against toxic substances. In the present study, inhibition effects of coumarin, ascorbic acid, sodium sulfide, sodium azide, citric acid compounds, and Cd, Cu, Ni, Mg metal ions against GST enzyme were determined.

Associations between acculturation, perceived discrimination and subjective well-being among Syrian adolescents living in Turkey.

Although numerous studies have documented the associations between perceived discrimination, acculturation and well-being in immigrants, far fewer have examined these associations in adolescent immigrants in the context of forced displacement. The focus of this study was to refine our understanding of the link between acculturation, perceived discrimination and subjective well-being in understudied forcibly displaced Syrian adolescents residing in Turkey. The data were collected from 181 Syrian adolescents (53.

A Comparison of Depression and Anxiety among University Students in Nine Countries during the COVID-19 Pandemic.

The mental health of young adults, particularly students, is at high risk during the COVID-19 pandemic. The purpose of this study was to examine differences in mental health between university students in nine countries during the pandemic. The study encompassed 2349 university students (69% female) from Colombia, the Czech Republic (Czechia), Germany, Israel, Poland, Russia, Slovenia, Turkey, and Ukraine.

Anti-Inflammatory, Antiallergic, and COVID-19 Main Protease (M) Inhibitory Activities of Butenolides from a Marine-Derived Fungus .

In December 2020, the U.K. authorities reported to the World Health Organization (WHO) that a new COVID-19 variant, considered to be a variant under investigation from December 2020 (VUI-202012/01), was identified through viral genomic sequencing.

Effects of on cisplatin induced ocular toxicity: an experimental study.

Cisplatin is a widely used and highly effective anti-cancer agent and one of the limiting side effects of cisplatin is ocular toxicity. , also known as yarrow, is a plant that has been used for many years to treat various health problems including chemotherapy-related toxicities. The present investigation was designed to evaluate the biochemical, molecular and histopathological effects of on cisplatin-induced oxidative and inflammatory ocular damage in rats.

Coronavirus anxiety, fear of COVID-19, hope and resilience in healthcare workers: a moderated mediation model study.

Background: In the era of the global health crisis, mental health and well-being of people have been severely affected because of experiencing high levels of anxiety, stress, fear, and uncertainty related to COVID-19. This study investigated a moderated mediation model in which resilience mediated the link between coronavirus anxiety and fear of COVID-19, and this mediation effect was moderated by hope.

Participants And Procedure: A cross-sectional study was conducted on 168 healthcare workers ( = 29.

Assessment of the Relationship between Ulcerative Colitis and Forkhead Box P3 Polymorphisms.

Background/aims: Ulcerative colitis (UC) is a chronic disease that does not have a definitive treatment and causes repetitive inflammation of the colon and impaired quality of life. The FOXP3 gene codes FOXP3 protein responsible for development and function of regulatory T (Treg) cells. The rs2232365 A/G and the rs3761548 A/C polymorphisms of FOXP3 gene were indicated to be associated with inflammation-related diseases such as ulcerative colitis.

From Selection to Instruction and Back: Competing Conformational Selection and Induced Fit Pathways in Abiotic Hosts.

Two limiting cases of molecular recognition, induced fit (IF) and conformational selection (CS), play a central role in allosteric regulation of natural systems. The IF paradigm states that a substrate "instructs" the host to change its shape after complexation, while CS asserts that a guest "selects" the optimal fit from an ensemble of preexisting host conformations. With no studies that quantitatively address the interplay of two limiting pathways in abiotic systems, we herein and for the first time describe the way by which twisted capsule M-1, encompassing two conformers M-1(+) and M-1(-), trap CX (X=Cl, Br) to give CX ⊂M-1(+) and CX ⊂M-1(-), with all four states being in thermal equilibrium.

Paracentral Acute Middle Maculopathy Revealing a Giant Aortic Aneurysm.

Background: This report describes a case with paracentral acute middle maculopathy revealing a giant aortic aneurysm.

Case Description: A 41-year-old man presented with unilaterally unexplained sudden vision loss in the left eye. Fundoscopy revealed a slightly pale r -26etinal reflex in the superior retinal hemifield.

Measurement Invariance of the Scale of Positive and Negative Experience Across 13 Countries.

The Scale of Positive and Negative Experience (SPANE) is widely used to measure emotional experiences, but not much is known about its cross-cultural utility. The present study evaluated the measurement invariance of the SPANE across adult samples ( = 12,635; age range = 18-85 years; 58.2% female) from 13 countries (China, Colombia, Germany, Greece, India, Italy, Japan, Poland, Portugal, Serbia, Spain, Turkey, and the United States).

The Prevalence of Pandemic Anxiety, Anxiety and Depression During the COVID-19 Pandemic in Turkey.

Background: This prevalence study involved participants from various cities in Turkey was conducted in April 2020, during the coronavirus pandemic in Turkey, with a view to evaluate the pandemic-related anxiety, generalized anxiety, and depression in the society.

Method: The study was conducted with 1267 people in more than 70 cities in Turkey. The study data were obtained by means of online data collection forms, due to the risks posed by the contagious COVID-19 disease in face to face interviews.

Effects of prolonged fasting on levels of metabolites, oxidative stress, immune-related gene expression, histopathology, and DNA damage in the liver and muscle tissues of rainbow trout (Oncorhynchus mykiss).

This study was conducted to assess the impacts of prolonged fasting (70 and 120 days) on the morphological, biochemical, oxidative stress responses, immune-related gene expression, histopathology, and DNA damage in rainbow trout. Final weight (FW), hepatosomatic index (HSI), and condition factor (CF) significantly decreased in both 70 and 120 days of fasting compared to the pre-fasting group (p < 0.05).

Oxidative stress and cyto-genotoxicity induced by poly-d-glucosamine in human blood cells .

Poly-N-acetyl-d-glucosamine (CH; chitin) is the main component of the insect skeleton, fungal cell wall, and many crustaceans, including crab and shrimp. CH is the most abundant in nature after cellulose, and it has a complex and hardly soluble structure. Poly-d-glucosamine (CHO; chitosan) is a soluble derivative of CH produced by deacetylation used in many fields, including human health.

The novel haptic-twist method for a sutureless double-needle intrascleral haptic fixation technique.

Purpose: Description of a novel modified technique known as haptic-twist method for placing a trailing haptic into a 27 G needle during double-needle intrascleral haptic fixation (Yamane technique) in the absence and/or inadequacy of capsular support.

Methods: The trailing haptic was threaded into the needle lumen using a haptic-twist method in 12 eyes of 11 patients with aphakia. The haptic was grasped by a forceps 2-3 mm from the tip, while the forceps was rotated by 180° counter-clockwise around its own axis.

A Longitudinal Examination of the Association Between Meaning in Life, Resilience, and Mental Well-Being in Times of Coronavirus Pandemic.

The coronavirus disease possesses an important threat to people's health and well-being. The purpose of the present study is to longitudinally examine whether meaning in life before the pandemic increases resilience and mental well-being during the coronavirus pandemic. The sample of the study comprised 172 young adults (72% women) in a public university in an urban city of Turkey.

Design and synthesis of garlic-related unsymmetrical thiosulfonates as potential Alzheimer's disease therapeutics: In vitro and in silico study.

Garlic contains a wide range of organosulfur compounds, which exhibit a broad spectrum of biological activities. Amongst the sulfur-containing compounds in garlic, the thiosulfonates are considerably popular in various fields. In light of this, we decided to investigate the enzyme inhibition ability of thiosulfonates.

Adaptation of the compassion competence scale to Turkish.

Purpose: In this study, we examined the validity and reliability of the Compassion Competence Scale (CCS) by adapting it to Turkish.

Desing And Methods: The data of the methodological research were obtained from 180 nursing students in the 3rd and 4th grades of the nursing department of a public university.

Findings: CCS Cronbach alpha coefficient was determined as 0.

Examining the correlation between intercultural sensitivity and individualized care perception of nursing students.

Background: Intercultural sensitivity is accepting the existence of cultural differences and similarities between individuals without attributing a value to them. In order to provide individualized nursing care, it is required to train nurses who can respond to cultural needs of society, have cultural knowledge and skills regarding society and show a high intercultural sensitivity.

Purpose: The purpose of this study is to examine the correlation between intercultural sensitivity and individualized care perception of nursing students, who will become a member of professional health discipline.