Serum BDNF and Selenium Levels in Elite Athletes Exposed to Blows.

: The study aimed to investigate the combined acute and long-term effects of exposure to blows and exercise on serum BDNF (brain-derived neurotrophic factor) and selenium levels. : Serum BDNF and selenium levels were determined in 40 male elite athletes before and after vigorous exercise (training match) with a probability of exposure to blows and in 10 sedentary men subjected to exercise (Astrand running protocol). : Serum BDNF levels were found 11.

Identifying highly effective coumarin-based novel cholinesterase inhibitors by in silico and in vitro studies.

Inhibition of high cholinesterase levels including acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), is one of the most important strategies for the treatment of Alzheimer's disease (AD). Clinically limited drugs are used in the treatment of AD, so there is a need to find new effective inhibitors today. Therefore, in this study, synthesized six coumarin carboxamides (A1, A2, B1-B4) were evaluated against AChE and BChE by combined in silico and in vitro studies.

Anti-Inflammatory, Antiallergic and COVID-19 Main Protease (M) Inhibitory Activities of Butenolides from a Marine-Derived Fungus .

Amid the current COVID-19 pandemic, the emergence of several variants in a relatively high mutation rate (twice per month) strengthened the importance of finding out a chemical entity that can be potential for developing an effective medicine. In this study, we explored ethyl acetate (EtOAc) extract of a marine-derived fungus afforded three butenolide derivatives, butyrolactones I, VI and V (-), two naphtho--pyrones, TMC-256 A1 () and rubrofusarin B () and methyl -hydroxyphenyl acetate (). Structure identification was unambiguously determined based on exhaustive spectral analyses including 1D/2D NMR and mass spectrometry.

Understanding the effect of fear of COVID-19 on COVID-19 burnout and job satisfaction: a mediation model of psychological capital.

Healthcare professionals are more at risk than others of being affected by the negative psychological consequences of COVID-19. Therefore, it is necessary to determine the factors protecting healthcare professionals from the negative psychological consequences of the pandemic. The purpose of the present study is to examine the mediating role of psychological capital in the relationship of fear of COVID-19 with COVID-19 burnout and job satisfaction among Turkish healthcare professionals.

Synthesis and antioxidant activities of benzylic bromophenols inclusive of natural products.

The synthesis of natural products 2-(2,3-dibromo-4,5-dihydroxyphenyl)acetic acid () and 2-(2,6-dibromo-3,5-dihydroxyphenyl)acetic acid () and as well as their derivatives and were carried out by substitution, hydrolysis and demethylation reactions of the corresponding four benzyl bromides. The antioxidant potentials of benzylic acid-derived bromophenols were, for the first time, appraised by several outstanding bioanalytical methods. Besides these, we estimated the antioxidant effects which were studied using the methods of DPPH·, ABTS scavenging activities, ferric (Fe) and cupric (Cu) ions and Fe-TPTZ reducing capacities.

Corneal densitometry in patients with arcus senilis and its correlation with serum lipid levels.

Purpose: To evaluate corneal densitometry (CD) of patients with arcus senilis (AS) and its association with the serum lipid markers.

Methods: This is a cross-sectional, case-control study. The AS diagnosis was made clinically.

A hypothetic model for examining the relationship between happiness, forgiveness, emotional reactivity and emotional security.

The ultimate goal of life is happiness, according to Plato. Perhaps the most critical questions in the life of human beings have been on happiness and processes that affect happiness. The present study was planned during the COVID-19 pandemic; perhaps human beings are most needed for happiness.

Protective effect of Smilax excelsa L. pretreatment via antioxidant, anti-inflammatory effects, and activation of Nrf-2/HO-1 pathway in testicular torsion model.

The protective effects of the ethanol extract of Smilax excelsa L. (SE) leaves were investigated on testicular tissue of rats with a torsion model in this study. The chemical composition of the extract was detected by means of liquid chromatography with tandem mass spectrometry (LC-MS/MS).

Retinal ultrastructural, electrophysiological, and microvascular morphological outcomes in diabetic macular edema treated with intravitreal bevacizumab.

Background: Investigation of retinal ultrastructural, electrophysiological, and microvascular morphological changes, as well as correlations between these changes and visual outcome in naïve diabetic macular edema (DME) patients after intravitreal bevacizumab therapy (IVBT).

Methods: This prospective interventional study enrolled 31 DME patients' eyes treated with monthly IVBT for three months. Best-corrected visual acuity (BCVA) and intraocular pressure (IOP) were measured, and fundus fluorescein angiography, optical coherence tomography (OCT), microperimetry, as well as optical coherence tomography angiography (OCTA) were performed before and after IVBT.

The effect of gene polymorphisms and paraoxonase enzyme activity on Non-Hodgkin lymphoma.

Non-Hodgkin Lymphoma (NHL) is a malignant lymphoproliferative disease. Antioxidant paraoxonase enzyme (PON1) has a vital role in the elimination of potential carcinogenic organophosphate molecules. The polymorphisms in the PON1 gene, especially Q192R and L55M, may affect negatively the activity and synthesis of PON1 enzyme.

Some phenolic natural compounds as carbonic anhydrase inhibitors: An in vitro and in silico study.

This paper presents experimental and molecular docking studies on the inhibitory effects of tyrosol, hydroxytyrosol, luteolin, diosmetin, caffeic acid, luteolin 7-O-glycoside, and apigenin 7-O-glycoside from olive (Olea europaea L.) leaf against human carbonic anhydrase (hCA, E.C.

A new approach to sepsis treatment by rasagiline: a molecular, biochemical and histopathological study.

Aim: We aimed to investigate the effects of rasagiline on acute lung injury that develops in the sepsis model induced with the cecal ligation and puncture in rats.

Main Methods: The rats were separated into the following six groups, Group 1: Sham, Group 2: Sham + Rasagiline 4 mg/kg, Group 3: Sepsis, Group 4: Sepsis + Rasagiline 1 mg/kg, Group 5: Sepsis + Rasagiline 2 mg/kg, Group 6: Sepsis + Rasagiline 4 mg/kg. A total of four holes were opened with a 16-gauge needle through the cecum distal to the point of ligation.

The effect of potassium lactate on the free amino acid composition, lipid oxidation, colour, microbiological, and sensory properties of ready-to-eat pastırma, a dry-cured and dried meat product.

In this study, the effects of potassium lactate (PL, Potassium-L-2-hydroxy-propionate, Potassium-L-Lactate) usage (0%, 0.5%, 1.0%, 2.

A new specific method for isolation of tomentosin with a high yield from Inula viscosa (L.) and determination of its bioactivities.

Introduction: Tomentosin, the characteristic component of Inula viscosa (L.) is an important sesquiterpene lactone with anticarcinogenic effects. Methods of obtaining pure tomentosin are not sufficient for anticancer drug research.

Emotional outcomes of e-learning adoption during compulsory online education.

Information on the emotional outcomes of e-learning system use and emotional aspects of user experience in higher education is quite limited. Accordingly, the aim of the study is to identify the factors that influence university students' intention to continue using e-learning systems and to examine the emotional outcomes of the continuance intention. The core constructs of the Technology Acceptance Model formed the basis of the proposed model, and the model was extended with a framework of emotions (challenge, achievement, deterrence, loss) and external variables.

Perceived stress and life satisfaction during COVID-19 pandemic: the mediating role of social adaptation and the moderating role of emotional resilience.

The present study mainly focused on college students during the COVID-19 outbreak and aimed to develop and examine a moderated mediation model between perceived stress and life satisfaction, with social adaptation during COVID-19 as a mediator, and emotional resilience as a moderator. A sample of 1032 college students participated in this study and completed questionnaires regarding perceived stress, social adaptation during COVID-19, emotional resilience, and life satisfaction. Findings indicated that 1) social adaptation during COVID-19 partially mediated the association between perceived stress and life satisfaction; and 2) emotional resilience moderated the relationship between perceived stress and social adaptation during COVID-19 as well as perceived stress and life satisfaction.

A new carbonic anhydrase identified in the Gram-negative bacterium (Chromohalobacter sp.) and the interaction of anions with the enzyme.

In this study, the characterization and inhibition characteristic of α-class carbonic anhydrase from Chromohalobacter (ChCA) was documented for the first time. The carbonic anhydrase enzyme had 47.77% yield and 54.

Breastfeeding Practices During the SARS-CoV-2 Pandemic Were Influenced by Women's Life Event.

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, which affects the whole world, negatively affects breastfeeding mothers and newborns. This study aimed to evaluate the breastfeeding practices influenced by women's life events and the breastfeeding women compliance with the rules established against the risk of SARS-CoV-2. This prospective cross-sectional online survey design study was carried out on 339 breastfeeding mothers between April 21 and May 10, 2020, in Turkey.

Chemical, microbial, color, oxidative and sensory properties of clean-label pastırma produced with raspberry water extracts as a novel ingredient.

In recent years, plant extracts are used as colorant and antioxidant in meat products. Therefore, the effects of cemen pastes produced using different concentrations (0%, 3%, 4% and 5%) of raspberry water extract (RWE) on pastırma were investigated. RWE was tested to improve the color quality of pastırma and decrease lipid and pigment oxidation during production and storage at 4 °C for 150 days.

Relationship between social exclusion and anxiety in older people during the COVID-19 pandemic.

Aim: This study aims to determine the relationship between social exclusion and anxiety in older people during the COVID-19 pandemic.

Methods: This descriptive research was conducted with individuals aged ≥65 years who were registered with Family Health Centers between July and September 2021. The sample size was calculated using a sampling method with an unknown population and was determined as 400 individuals; a random sampling method was utilized for selecting the participants.

Benefits of Positive Psychology-Based Story Reading on Adolescent Mental Health and Well-Being.

The importance of complete mental health in school context has recently begun to attract a lot of attention. Positive psychology interventions are often associated with improvement in mental health outcomes, but few studies have examined whether story reading is an intervention that is linked with indicators of complete mental health. This study investigated the effects of story reading interventions on both positive and negative indicators of mental health over time for a group of Turkish grade 10 high school students ( = 53).

Psychological maltreatment, coping flexibility, and death obsession during the COVID-19 pandemic: A multi-mediation analysis.

Recent psychological studies have reported that child maltreatment is a common issue during the COVID-19 pandemic, with negative factor leading to greater risk of occurrence of mental health problems. However, the relationship between psychological maltreatment and psychological factors is complex. Understanding the factors, which may help to provide interventions, is a critical step for mental health providers.

Diversity and Plant Growth-Promoting Ability of Endophytic, Halotolerant Bacteria Associated with (Pall.) Kuntze.

The diversity of salt-tolerant cultivable endophytic bacteria associated with the halophyte New Zealand spinach ( (Pall.) Kuntze) was studied, and their plant beneficial properties were evaluated. The bacteria isolated from leaves and roots belonged to , , , , , , , , , and .

Synthesis, characterization, and biological evaluation of some novel Schiff bases as potential metabolic enzyme inhibitors.

In this study, a series of novel Schiff base derivatives containing a pyrazolone ring (2a-e) were designed, successfully synthesized for the first time, and characterized by elemental analysis and some spectroscopic methods. These compounds were tested for their inhibitory activities on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and the human carbonic anhydrase isoenzymes I and II (hCA I and II). All synthesized molecules indicated significant inhibition effects with IC values ranging from 14.

A longitudinal study of depression, anxiety, and stress among Indians during COVID-19 pandemic.

The COVID-19 has caused significant public health chaos. Whether infected or uninfected, people have reported significant mental health issues during the COVID-19 pandemic. The present study explored symptoms of depression, anxiety, and stress of uninfected people with the disease over three time periods.