Tuberculous meningitis associated with the absence of pleocytosis in cerebrospinal fluid in an immunocompetent patient: A case report.

We report a case of tuberculous meningitis without pleocytosis of the cerebrospinal fluid (CSF) in a 27-year-old patient admitted for a meningeal syndrome with signs of basilar involvement and an infectious syndrome associated with a hacking cough with whitish sputum and night sweats, evolving for 15 days before her admission, in a context of weight loss of 2 kg, asthenia, and anorexia. Cytobacteriological and chemical analysis of the CSF revealed less than 3 cells/mm white blood cells, high protein levels of 2.54 g/l, and low glucose levels of 0.

Phenotype-genotype correlation in children with familial Mediterranean fever in Morocco.

Background: Familial Mediterranean fever (FMF) is an autosomal recessive disease caused by mutations in the MEFV gene and is characterized by recurrent febrile episodes of abdominal pain, chest pain, and joint involvement. We aim to study the clinical and genetic features of FMF in Moroccan children and to establish a phenotype-genotype correlation in this group of patients.

Methods: A total of 35 patients were included in this study.

Giant intracranial tuberculomas in children: An unexpected diagnosis and difficult management - About two cases and review of the literature.

Background: Giant intracranial tuberculomas are rare space-occupying lesions in the brain parenchyma, with a diameter >2.5 cm. They can mimic gliomas, meningiomas, and metastases.

Irreducible posterior fracture-dislocation of the hip associated with an ipsilateral femoral shaft fracture: A case report and review of the literature.

Introduction: Ipsilateral fractures of the shaft of the femur combined with hip dislocations are extremely rare injuries, presenting a difficult diagnostic and therapeutic challenge. Diagnosis of hip dislocation is often delayed, due to the focus on femoral fracture.

Case Presentation: This article presents a case never described before of a 19-year-old patient who sustained this unusual combination of injuries as a result of a road traffic accident.

Neurological and Cardiovascular Complications Revealing Biermer's Disease: A Case Report.

Biermer's disease (BD) or pernicious anemia (PA) is an autoimmune atrophic gastritis characterized by the absence of intrinsic factor (IF) secretion, leading to malabsorption of vitamin B12 in the ileum. Its clinical manifestations are primarily hematological, with neuropsychiatric and cardiovascular manifestations being less common. We present the case of a patient with PA diagnosed based on neurological and cardiovascular complications.

Prognostic Value of ATRX and p53 Status in High-Grade Glioma Patients in Morocco.

Introduction: Glioblastoma and astrocytoma, grade 4, are the most common and aggressive brain tumors. Several biomarkers, such as the isocitrate dehydrogenase mutation (IDH-1), alpha-thalassemia/mental retardation, and the X-linked mutation (ATRX), enable more accurate glioma classification and facilitate patient management. This study aimed to determine the prognostic value of clinical and molecular factors (IDH, TP53, and ATRX mutations).

An overview of risk factors in children with febrile seizures.

Introduction: Febrile seizures (FS) are the most common neurologic disorder seen in children. Caused mainly by fever without any damage to the central nervous system (CNS). The associations of several factors, which we can find in the inflammatory response and genetic predisposition, are involved in the occurrence of FS.

Erythromelalgia Secondary to Anti-Tumor Necrosis Factor (TNF) Alpha Therapy: A Report of Two Cases.

Erythromelalgia is a rare syndrome with a generally unknown etiology. Whether primary or secondary, this condition is characterized by paroxysmal episodes of erythema, pain, and heat in the extremities. We report two cases of erythromelalgia occurring after the initiation of treatment with infliximab.

A Rare Case of Tuberculosis Revealed by Acute Appendicitis: A Case Report.

According to the World Health Organization (WHO), tuberculosis (TB) is the 13th cause of death worldwide and the second infectious killer after HIV. It is an endemic disease in Morocco. Isolated appendicular TB is an uncommon form of extrapulmonary TB.

A rare occurrence of a giant synovial sarcoma in the plantar region of the foot: A case report.

Unlabelled: Introduction and Significance. Synovial sarcoma, accounting for 7-8 % of malignant sarcomas, typically manifests in adulthood, but it is noteworthy that adolescents and children make up 30 % of reported cases. Contrary to its name, this malignancy often originates from multipotent stem cells rather than the synovium.

Deep brain stimulation for movement disorders treatment in Africa: The current status, outcomes, and challenges.

Movement disorders (MDs), a diverse group of neurological conditions characterized by abnormal and involuntary movements, have a profound impact on individuals, families, and healthcare systems. Deep Brain Stimulation (DBS) has emerged as a promising therapeutic intervention, offering relief from symptoms and improved quality of life. By implanting electrodes in specific brain regions and connecting them to a pulse generator, DBS modulates aberrant neural activity underlying these disorders.

Juxta articular myxoma of the foot: An exceptional entity.

Introduction: Myxoma, a benign and uncommon tumor, is primarily characterized by undifferentiated spindle cells and a myxoid matrix with muscular infiltration. While the intramuscular form is predominant, the juxta-articular variant is rare, especially in the foot. Juxta-articular myxomas had a heightened risk of recurrence post-surgical excision, emphasizing the need for effective management strategies.

Expert Recommendations to Bridge Gaps in Heart Failure Patient Support in the Middle East and Africa Region.

Heart failure (HF) remains a serious health and socioeconomic problem in the Middle East and Africa (MEA). The age-standardized prevalence rate for HF in the MEA region is higher compared to countries in Eastern Europe, Latin America, and Southeast Asia. Also cardiovascular-related deaths remain high compared to their global counterparts.

Variant of the terrible triad of the elbow, a CASE report with a review of the literature.

Introduction: The terrible triad described by Hotchkiss in 1996 is a complex lesion of the elbow, following a trauma combining forced valgus and external rotation. It is a lesion that puts the elbow at risk of developing complications such as instability, stiffness, or synostosis of the proximal radio-cubital joint.

Case Report: We report the case of a patient who suffered a closed trauma to the right elbow following a fall onto the palm of the hand with a valgus lateral rotation mechanism.

Trans-scaphoid trans-lunate trans-triquetral volar perilunate dislocation: A case report.

Introduction: Translunate volar perilunate dislocations are extremely rare, with few documented cases. Only eight instances of volar translunate perilunate dislocation have been described in the literature. This report presents a successfully treated case using early reduction and internal fixation that led to a very satisfying outcome at 9 months follow-up.

The Prevalence and Contributing Factors of Burnout Among Anesthesiologists and Intensive Care Unit Staff in Morocco: A Cross-Sectional Analysis.

Introduction Burnout is a common issue in the medical field, particularly in specialties like anaesthesiology and intensive care. It carries significant personal and professional consequences for healthcare providers and can impact the relationship between caregivers and patients. Despite its seriousness, there's been limited research on its causes in North Africa.

Prevalence of epilepsy in Morocco: A population-based study.

Objective: In Morocco, there was a lack of data related to the epidemiology of epilepsy. This data serves as a useful basis for the development of any national intervention or action program against epilepsy in Morocco. Through this study, we aimed to estimate the active and lifetime prevalence of epilepsy in Morocco.

The immune checkpoint adenosine 2A receptor is associated with aggressive clinical outcomes and reflects an immunosuppressive tumor microenvironment in human breast cancer.

Background: The crosstalk between the immune system and cancer cells has aroused considerable interest over the past decades. To escape immune surveillance cancer cells evolve various strategies orchestrating tumor microenvironment. The discovery of the inhibitory immune checkpoints was a major breakthrough due to their crucial contribution to immune evasion.