Current Updates on Nanotechnology-based Drug Delivery Platforms for Treating Alzheimer's with Herbal Drugs.

Alzheimer's disease (AD) is an irreversible brain disorder that led to memory loss and disrupts daily life. Earlier strategies to treat AD such as acetylcholinesterase inhibitor (AChEI) drugs are not showing effectiveness due to the inability to cross the blood-brain barrier. Moreover, traditional AChEI provides limited efficacy in terms of bioavailability and solubility for treating AD treatment.

Sun Exposure Awareness and Sunscreen Use Among College Students in Saudi Arabia: A Cross-Sectional Analysis.

Background: Excessive sun exposure is a significant risk factor for various skin conditions, including sunburn, premature aging, and skin cancer. This study aimed to assess the awareness, attitudes, and practices regarding sun exposure and sunscreen use among college students in Saudi Arabia.

Methodology: A cross-sectional study was conducted with 388 college students from various disciplines.

An integrated computational and graphical approach for evaluating the geochemistry and health risks of nitrate-contaminated water for six age groups.

Nitrate contamination in drinking water poses significant health risks, particularly in rapidly urbanizing areas of developing countries. This study presents an integrated computational and graphical approach to evaluate the geochemistry and health risks of nitrate-contaminated water for six age groups in Southeast, Nigeria. The research employed a detailed methodology combining water nutrient pollution index (WNPI), nitrate pollution index (NPI), water pollution index (WPI), geochemical plotting techniques, stoichiometry, and health risk computations.

Protective Effects of Kaempferol on Hepatic Apoptosis via miR-26a-5p Enhancement and Regulation of TLR4/NF-κB and PKCδ in a Rat Model of Non-Alcoholic Fatty Liver.

This study aimed to evaluate kaempferol's, a dietary flavonoid widely present in plants, potential impact on nonalcoholic fatty liver disease (NAFLD) and its underlying mechanisms. In this study, 60 adult male rats were used and divided into a control group receiving a standard pellet diet, a kaempferol-treated group receiving kaempferol (250 mg/kg), a high-fat diet (HFD) group receiving HFD, and a kaempferol-treated HFD group. At the end of the experiment, the total lipid profile and liver enzymes were assayed in the serum.

Urinary Incontinence (UI) in Saudi Female Population: Prevalence, Risk Factors, and Impact on Quality of Life.

Background: Urinary incontinence (UI) is a prevalent health concern among women globally. However, its prevalence, associated risk factors, and impact on quality of life among Saudi women remain underexplored.

Objective: This study aimed to assess the prevalence of UI, identify its risk factors, and understand its impact on the quality of life among Saudi women.

A comprehensive evaluation of safety and awareness in eyebrow microblading: a cross-sectional study.

The importance of eyebrows in facial aesthetics has long been recognized, and eyebrows restoration is carried out by carefully depositing pigments into the epidermis. This cosmetic procedure is known as microblading, and it is very popular because of the progress made on social media platforms. This study was designed to determine the awareness of eyebrow microblading, complication and laser removal in general population of Saudi Arabia.

Harnessing the Power of Zinc Oxide Nanoparticles for Accelerated Wound Healing and Antimicrobial Action.

Introduction: Zinc oxide nanoparticles (ZnONPs) have been the subject of substantial research by virtue of their utility across extensive downstream applications. Moreover, the ZnONPs are inexpensive, reliable, and easy to produce. Green synthesis employing biological systems, particularly plant extracts, has arisen as a subject of study in nanotechnology and is gaining importance due to its multiple applications in biology, chemistry, physics, and medicine.

Advances in polysaccharide-based materials for biomedical and pharmaceutical applications: A comprehensive review.

Polysaccharides, the most abundant biopolymers in nature, have attracted the attention of researchers and clinicians due to its practicality in biomedical and pharmaceutical sciences. These biomaterials have high bioavailability and play structural and functional roles in living organisms. Polysaccharides are classified into several groups based on their origin, including plant polysaccharides and marine polysaccharides (like chitosan, hyaluronic acid, dextran, alginates, etc.

Assessment of Thyroid Function in Chronic Kidney Disease Patients at King Abdulaziz Medical City.

Background Chronic kidney disease (CKD) is a progressive and irreversible condition in which the kidneys lose their ability to perform synthetic, excretory, and metabolic functions. CKD is associated with various pathophysiological conditions that impact multiple organs, including the thyroid gland, which primarily secretes triiodothyronine (T3) and thyroxine (T4). This study aims to assess thyroid function in patients with CKD and explore the relationship between renal disease severity and thyroid function.

Recent advances in polysaccharide-based drug delivery systems for cancer therapy: a comprehensive review.

Cancer has a high rate of incidence and mortality throughout the world. Although several conventional approaches have been developed for the treatment of cancer, such as surgery, chemotherapy, radiotherapy and thermal therapy, they have remarkable disadvantages which result in inefficient treatment of cancer. For example, immunogenicity, prolonged treatment, non-specificity, metastasis and high cost of treatment, are considered as the major drawbacks of chemotherapy.

Comparative Evaluation of Mandibular Ridge Resorption in Post-menopausal Denture and Non-Denture-Wearing Females and Its Relation to Body Mass Index: An In-Vivo Study.

Background Mandibular ridge resorption is a common problem in edentulous individuals, particularly in post-menopausal women. Body mass index (BMI) has been suggested as a potential factor influencing ridge resorption, but the relationship between the two remains unclear. Methods A study was conducted to evaluate mandibular ridge resorption in post-menopausal denture-wearing females and its relation to body mass index.

Bile's Hidden Weapon: Modulating the Microbiome and Tumor Microenvironment.

The human gut microbiome is a dynamic and intricate ecosystem, composed of trillions of microorganisms that play a pivotal role in maintaining overall health and well-being. However, the gut microbiome is constantly exposed to various environmental factors, including the bile produced by the liver, which can significantly impact its composition and function. Bile acids, secreted by the liver and stored in the gallbladder, modulate the gut microbiome, influencing its composition and function.

Molecular Docking, Bioinformatic Analysis, and Experimental Verification for the Effect of Naringin on ADHD: Possible Inhibition of GSK-3β and HSP90.

One of the most abundant and growing neurodevelopmental disorders in recent decades is attention deficit hyperactivity disorder (ADHD). Many trials have been performed on using drugs for the improvement of ADHD signs. This study aimed to detect the possible interaction of naringin with Wnt/β-catenin signaling and its putative anti-inflammatory and protective effects in the mouse ADHD model based on bioinformatic, behavioral, and molecular investigations.

The Association Between Chronic Obstructive Pulmonary Disease (COPD) and Migraine: Systematic Review and Meta-Analysis.

: Migraine and chronic obstructive pulmonary disease (COPD) are both common chronic conditions that may share underlying pathophysiological mechanisms despite presenting with distinct clinical features. Understanding the association between these two conditions could enhance treatment strategies and improve patient outcomes. This review aims to evaluate the relationship between COPD and migraine, highlighting shared risk factors and identifying gaps in the existing literature.

The Role of Intermittent Fasting on Metabolic Syndrome: A Systematic Review and Meta-Analysis.

Intermittent fasting has gained popularity as a dietary intervention to improve metabolic health. Metabolic syndrome may benefit from intermittent fasting by improving weight, cholesterol levels, blood pressure (BP), and glucose control. This study aims to assess the effects of intermittent fasting on weight, BMI, cholesterol levels, BP, and glucose in individuals with metabolic syndrome.

The Knowledge, Concerns, and Beliefs of Mothers Towards Febrile Convulsions and Its Management in Aseer, Saudi Arabia.

Introduction Febrile convulsions are common in children aged six months to five years, causing significant parental distress despite being generally harmless. Various beliefs about their causes exist, including high fever and supernatural factors. Previous studies indicate that mothers' education levels and occupations influence their knowledge and attitudes toward febrile convulsions.

The Efficacy of Botulinum Toxin Type A (BTA) in the Treatment of Hypertrophic Scars and Keloids: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Hypertrophic scars cause significant physical and emotional discomfort. Botulinum toxin type A (BTA) has shown promising outcomes in reducing scar formation. Research suggested its effectiveness in managing hypertrophic scars and keloids.

Bone graft substitutes and dental implant stability in immediate implant surgery: a systematic review and meta-analysis.

Introduction: Implant dentistry is currently being revolutionized by breakthroughs in techniques, technology, and material, there are few systematic reviews and meta-analyses that examine the effects of utilizing different bone graft substitutes in immediate implant placement surgeries.

Aim: The purpose of this research is to systematically review and meta-analyze the effect that different bone graft substitutes have on implant stability when concurrently utilized in patients undergoing immediate implant surgeries.

Methodology: The PICO criteria were used to construct the focused question, and the systematic review has been outlined as per the PRISMA guidelines.

The Impact of Nusinersen Treatment on Respiratory Function in Patients with Spinal Muscular Atrophy: A Systematic Review.

: This systematic review evaluated the impact of nusinersen therapy on respiratory health and function in individuals with spinal muscular atrophy (SMA) and determined whether nusinersen improves pulmonary function, focusing on differences based on patient age and the timing of treatment initiation. : A systematic search of PubMed, Ovid Medline, ScienceDirect, and Web of Science databases was conducted up to January 2024 in accordance with the PRISMA guidelines. Thirteen studies were included, comprising clinical trials, observational studies, and case series that focused on respiratory outcomes in SMA patients treated with nusinersen.