667 results match your criteria: "Ibaraki Medical Center[Affiliation]"

Aims: Diabetic chorea refers to sudden involuntary movements developing in people with diabetes mellitus and is known to occur mainly in those with severe hyperglycemia. We conducted a questionnaire survey of case-reporting facilities in Japan to elucidate their clinical characteristics.

Methods: We searched the PubMed and Ichushi databases for case reports published from January 1, 2012, to December 31, 2017, using "diabetes" and "chorea" as keywords, and sent a questionnaire to the reporting institutions.

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Edwardsiella tarda is a Gram-negative intracellular pathogen within the Enterobacterales order, recognized as a causative agent of hemorrhagic septicemia in fish but also pathogenic to humans. However, the clinical course and prognostic factors of E. tarda bacteremia are not fully understood.

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Article Synopsis
  • The study assessed the effectiveness of serum type 4 collagen 7S (COL4-7S) compared to the Enhanced Liver Fibrosis (ELF) score in detecting liver fibrosis in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).
  • Among 1,368 patients, 794 were analyzed, revealing that both COL4-7S and ELF scores rise with increasing fibrosis, but COL4-7S showed significantly better performance for identifying advanced fibrosis (≥2) especially in diabetic patients.
  • Overall, COL4-7S proved to be at least as effective as the ELF score in diagnosing advanced liver disease in MASLD patients.
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Background: Wild-type (WT) mice fed a conventional high-fat/high-sucrose diet (HFHSD) rarely develop metabolic dysfunction-associated steatohepatitis (MASH) with HCC. Because mouse bile acid (BA) is highly hydrophilic, we hypothesized that making it hydrophobic would lead to MASH with HCC.

Methods: Eleven-week-old WT and Cyp2a12/Cyp2c70 double knockout (DKO) mice were divided into two groups, including one which was fed a normal chow diet, and one which was fed an HFHSD.

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  • The case discusses a 36-year-old man who developed a severe visceral disseminated varicella zoster virus (VZV) infection after starting immunosuppressive therapy for lupus nephritis, leading to a rapid decline in health and multiple organ failure.
  • Key symptoms included severe abdominal pain, blistering rashes, hyperferritinemia, and laboratory signs indicating hemophagocytic lymphohistiocytosis (HLH), ultimately resulting in the patient's death.
  • This case highlights the rare but critical complication of VZV infections in patients receiving specific immunosuppressive treatments, stressing the importance of early diagnosis through VZV-DNA testing.
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  • The study focuses on finding the best screw insertion angles for polyaxial volar locking plates (VLP) to prevent joint penetration in distal radius fractures.
  • Researchers used 30 X-rays and CT scans of healthy wrists to assess the optimal plate positions and their relationship to the transverse diameter of the radius.
  • The findings indicate that the most distal screw position varies with screw angle and increases in proximity to the articular surface as the radius's transverse diameter increases, providing crucial information for preoperative planning.
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Asymptomatic hypertension in the emergency department: A potential opportunity for diagnostic stewardship.

Am J Emerg Med

November 2024

Division of General Internal Medicine, Department of Internal Medicine, Tokyo Medical University Ibaraki Medical Center, Inashiki, Ibaraki, Japan. Electronic address:

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Article Synopsis
  • The study aims to analyze the characteristics and treatment of plexiform neurofibromas (PNs) in Japanese children with neurofibromatosis 1 (NF1), particularly with the introduction of the MEK inhibitor selumetinib.
  • Primary and secondary surveys were conducted across numerous pediatric and dermatology departments in Japan, tracking 49 patients aged 3.3 to 18.8 years with PNs, commonly found on the face, neck, and head.
  • The findings highlight early onset and significant morbidities like cosmetic disfigurement and pain, showing that selumetinib use is linked to these symptoms, stressing the importance of early diagnosis and the need for a multicenter registry to improve management strategies.
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Purpose: This study aimed to evaluate the comfort and discomfort of two types of soft contact lenses (SCLs) by comparing their quality of vision, fit, subjective dryness, and handling.

Methods: A total of 62 SCL wearers with contact lens (CL) discomfort were recruited. They were fitted with narafilcon A and verofilcon A for two weeks each by crossover.

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Infections associated with percutaneous pinning of the fingers occur in a certain percentage of cases; however, osteomyelitis rarely leads to more severe suppurative arthritis of the hand. A 26-year-old woman presented with scapholunate dissociation and underwent percutaneous pinning. Although some signs of infection were found around the pin site at five weeks, the pins were removed seven weeks postoperatively.

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Distal ulnar metaphyseal fractures are often treated conservatively with good clinical outcomes. Extensor carpi ulnaris (ECU) tendinopathy after conservative treatment for distal ulnar metaphyseal fractures has not been reported. We present a case of a 20-year-old university baseball player who developed ECU tendinopathy after conservative treatment for a distal ulnar metaphyseal fracture.

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Pulmonary infection caused by , an obligate anaerobic gram-negative bacterium, most commonly occurs as a part of Lemierre's syndrome, i.e., pharyngotonsillitis complicated by septic thrombophlebitis of the internal jugular vein and secondary lung abscesses.

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  • The study explores how childhood nurturing experiences impact adult depression through subjective social status and personality traits, specifically neuroticism.
  • It involved a survey of 404 adults and used statistical analyses to show that both nurturing and subject social status influence neuroticism, which in turn affects depressive symptoms.
  • Findings suggest that understanding these relationships may help clarify the origins of depression and how early life experiences shape mental health in adulthood.
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Occlusive retinal vasculitis and scleritis following brolucizumab treatment: A case report.

Medicine (Baltimore)

October 2024

Department of Ophthalmology, Tokyo Medical University, Ibaraki Medical Center, Inashiki, Ibaraki, Japan.

Rationale: Brolucizumab is an anti-vascular endothelial growth factor agent. Clinical trials have demonstrated excellent efficacy of brolucizumab for neovascular age-related macular degeneration in terms of both visual and anatomic outcomes. However, compared with conventional anti-vascular endothelial growth factor therapy, this new treatment has a higher incidence of complications, particularly the development of occlusive retinal vasculitis.

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  • The study aimed to evaluate the effectiveness of anti-VEGF therapy on visual acuity in patients with diabetic macular edema (DME) over two years.
  • The research involved analyzing data from 1,780 eyes treated from 2015 to 2019, documenting changes in best-corrected visual acuity (BCVA) and treatment methods.
  • Results showed a significant improvement in BCVA, with 73.3% of eyes maintaining good vision, highlighting anti-VEGF therapy as the preferred first-line treatment for DME.
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Background/objectives: We previously reported that traction magnetic resonance imaging (MRI) of the elbow without arthrography increases the width of the radiocapitellar joint (RC) and improves articular cartilage visibility. However, the effects of axial traction on different age groups have not yet been evaluated. We hypothesized that the effect of traction would decrease as the participants' age increased.

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Association of Serum Bile Acid Profile with Diet and Physical Activity Habits in Japanese Middle-Aged Men.

Nutrients

October 2024

Department of Human Immunology and Nutrition Science, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 6028566, Japan.

Background/objectives: Circulating bile acid (BA) profiles change with lifestyle and are closely related to intestinal BA metabolisms such as deconjugation and conversion to secondary BAs. The composition of BA in the blood is involved in systemic nutrient metabolism and intestinal health. Herein, we explored the associations of lifestyle and physical fitness with the circulating BA profile of middle-aged men.

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  • Small-cell lung cancer (SCLC) displays high levels of EZH2, which promotes a process called epithelial-mesenchymal transition (EMT), increasing the cancer's invasive ability.
  • Researchers investigated the relationship between microRNAs (specifically miR-4448) and EZH2 in SCLC, discovering that the downregulation of EZH2 leads to increased miR-4448 expression, which appears to inhibit tumor growth and EMT.
  • miR-4448 targets the girdin gene to suppress its expression, reducing Akt phosphorylation, which subsequently enhances the phosphorylation of AMPK and EZH2, ultimately preventing EZH2-mediated EMT and tumorigenesis in SCLC.
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Public perceptions related to healthcare preparedness to anti-amyloid therapies for Alzheimer's Disease in Japan.

Alzheimers Res Ther

October 2024

Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-Ku, Tokyo, 113-8655, Japan.

Article Synopsis
  • The study investigates public and clinical specialists' perceptions regarding preparedness for administering disease-modifying treatments (DMT) for Alzheimer’s disease, focusing on the newly approved drug lecanemab.
  • Conducted through online and mail surveys, it gathered responses from over 2,000 participants, highlighting significant differences in views about treatment eligibility and efficacy between general public respondents and clinical specialists.
  • While both groups were generally supportive of prioritizing patients for treatment, the public expressed more restrictive views on who qualifies for DMT and appeared more optimistic about its effectiveness compared to specialists.
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Background/aim: Patients with triple-negative breast cancer (TNBC) who obtain a pathological complete response (pCR) after neoadjuvant chemotherapy have an improved prognosis. Lymphocyte-predominant breast cancer is more likely to respond to neoadjuvant chemotherapy. Here, we investigated the correlation between tumor-infiltrating lymphocytes (TILs) in pre-treatment biopsy specimens from patients with TNBC in relation to response to NAC.

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Preoperative planning is important for the osteosynthesis of distal radius fractures. Challenges arise for patients presenting with bilateral wrist injuries or a history of contralateral wrist injuries. In such cases, the estimation of the distal radius morphology and the determination of the plate size from the preoperative physical characteristics could prove beneficial.

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A case of thoracic epidural angiolipoma: CT and MRI findings.

Radiol Case Rep

December 2024

Department of Radiology, Tokyo Medical University Ibaraki Medical Center, 3-20-1, Chuo, Inashiki-gun Ami-machi, Ibaraki 300-0395, Japan.

Spinal angiolipomas are rare benign tumors composed of mature adipose cells and blood vessel walls. We report the case of a patient with a spinal epidural angiolipoma who presented with paraplegia and was treated by urgent tumor resection and decompression. The patient was a 79-year-old man who presented to our hospital with a 6-month history of numbness in both lower limbs.

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