2,793 results match your criteria: "IWK Health Centre[Affiliation]"
J Sex Res
December 2024
Department of Psychology and Neuroscience, Dalhousie University.
Pregnancy loss has been linked to poorer mental and relationship well-being. Given that strong sexual well-being is associated with better mental and physical health, understanding sexual well-being following a recent pregnancy loss may contribute to education and treatment models. Yet, little research has examined the effects of pregnancy loss on both couple members' sexual well-being.
View Article and Find Full Text PDFPediatr Blood Cancer
December 2024
Division of Oncology, Children's National Hospital and Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA.
Purpose: National Wilms Tumor Study-5 (NWTS-5) and AREN0321 evaluated the outcomes of children with rhabdoid tumor of the kidney (RTK) and malignant rhabdoid tumor of soft tissues (MRT).
Patients And Methods: Eligible patients with RTK were enrolled prospectively on NWTS-5 (1995-2002) and treated with carboplatin and etoposide alternating with cyclophosphamide (Regimen RTK). Patients with RTK or MRT were enrolled on AREN0321 (2005-2012) and received vincristine, doxorubicin, and cyclophosphamide alternating with carboplatin, cyclophosphamide, and etoposide (Regimens UH-1 or dose-reduced Revised UH-1).
Allergy Asthma Clin Immunol
December 2024
Department of Pediatrics, Division of Allergy, Dalhousie University, IWK Health Centre, Halifax, NS, Canada.
The body has a collection of physical barriers to prevent infection, but once these are overcome, we rely on our immune systems to protect us against a wide variety of infections. The complex mechanisms through which this is achieved are grouped into two lines of defense called the "innate" and "adaptive" immune systems. The innate immune system provides a rapid and tailored response to infection or injury often associated with inflammation.
View Article and Find Full Text PDFAllergy Asthma Clin Immunol
December 2024
Division of Allergy, Department of Pediatrics, Dalhousie University, IWK Health Centre, Halifax, NS, Canada.
Non-immunoglobulin E (IgE)-mediated food allergies are characterized by delayed gastrointestinal (GI) manifestations that occur after exposure to an inciting food protein; they include food protein-induced allergic proctocolitis (FPIAP), food protein-induced enteropathy (FPE), and food protein-induced enterocolitis syndrome (FPIES). Although the exact mechanisms underlying these disorders are not well understood, non-IgE-mediated food allergies likely represent a spectrum of disease with shared pathophysiological processes. Typically, these non-IgE-mediated food allergies begin in infancy or early childhood, although FPIES can present across the lifespan, with increasing reports in adults in recent years.
View Article and Find Full Text PDFAllergy Asthma Clin Immunol
December 2024
Department of Pediatrics, Division of Allergy, Dalhousie University, IWK Health Centre, Halifax, NS, Canada.
Food allergy typically begins early in life and persists as a lifelong condition. Delayed introduction of allergenic foods followed by years of hesitancy to introduce these foods early may have contributed to the increase in food allergy prevalence in recent decades. Most infant feeding guidelines focus on the importance of early introduction of allergenic foods in infants at around age 4-6 months.
View Article and Find Full Text PDFAllergy Asthma Clin Immunol
December 2024
Division of Allergy, Department of Pediatrics, Dalhousie University, IWK Health Centre, Halifax, NS, Canada.
Eosinophilic esophagitis (EoE) is an atopic condition of the esophagus that has become increasingly recognized. Diagnosis of the disorder is dependent on the patient's clinical manifestations and must be confirmed by histologic findings on esophageal mucosal biopsies. The epidemiology, pathophysiology, diagnosis, treatment, and prognosis of EoE are discussed in this review.
View Article and Find Full Text PDFCochrane Database Syst Rev
December 2024
Department of Pediatrics, University of British Columbia, Vancouver, Canada.
Background: The ductus arteriosus is a blood vessel connecting the main pulmonary artery and the proximal descending aorta. After birth, the ductus arteriosus usually closes completely. However, sometimes it remains patent in the neonate, which is called patent ductus arteriosus (PDA).
View Article and Find Full Text PDFJAMA Pediatr
December 2024
Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Importance: The American Academy of Pediatrics (AAP) higher-risk criteria for brief resolved unexplained events (BRUE) have a low positive predictive value (4.8%) and misclassify most infants as higher risk (>90%). New BRUE prediction rules from a US cohort of 3283 infants showed improved discrimination; however, these rules have not been validated in an external cohort.
View Article and Find Full Text PDFPain
December 2024
Daphne Cockwell School of Nursing, Toronto Metropolitan University, Toronto, ON, Canada.
Implementation of infant pain practice change (ImPaC) is a multifaceted web-based resource to support pain practice change in neonatal intensive care unit (NICU). We evaluated the (1) intervention effectiveness and (2) implementation effectiveness of ImPaC using a hybrid type 1 effectiveness-implementation study (ie, cluster randomized controlled trial and longitudinal descriptive study). Eligible level 2 and 3 Canadian NICUs were randomized to intervention (INT) or waitlisted to usual care (UC) for 6 months.
View Article and Find Full Text PDFAllergy Asthma Clin Immunol
December 2024
Division of Allergy, IWK Health Centre, Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada.
Atopic dermatitis (AD) is a common, chronic skin disorder that can significantly impact the quality of life (QoL) of affected individuals as well as their families. Although the pathogenesis of the disorder is not yet completely understood, it appears to result from the complex interplay between defects in skin barrier function, environmental and infectious agents, and immune dysregulation. There are no diagnostic tests for AD; therefore, the diagnosis is based on specific clinical criteria that take into account the patient's history and clinical manifestations.
View Article and Find Full Text PDFAllergy Asthma Clin Immunol
December 2024
Division of Allergy, Department of Pediatrics, IWK Health Centre, Dalhousie University, Halifax, NS, Canada.
Urticaria (hives) is a common disorder that may be associated with angioedema (swelling that occurs beneath the skin). It is generally classified as acute or chronic, and chronic urticaria is further classified as spontaneous or inducible Second-generation, non-sedating histamine type 1 (H1)-receptor antihistamines represent the mainstay of therapy for both acute and chronic urticaria. Second-line treatment for uncontrolled chronic urticaria includes omalizumab (a monoclonal anti-immunoglobulin E [IgE] antibody).
View Article and Find Full Text PDFBiochim Biophys Acta Mol Basis Dis
December 2024
Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada; Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada. Electronic address:
Li-Fraumeni syndrome (LFS) is a hereditary cancer predisposition syndrome associated with a highly penetrant cancer spectrum characterized by germline TP53 mutations. We characterized the first LFS zebrafish hotspot mutants, tp53 R217H and R242H (human R248H and R273H), and found these mutants exhibit partial-to-no activation of p53 target genes, have defective cell-cycle checkpoints, and display partial-to-full resistance to apoptosis, although the R217H mutation has hypomorphic characteristics. Spontaneous tumor development histologically resembling human sarcomas was observed as early as 6 months.
View Article and Find Full Text PDFCan Assoc Radiol J
December 2024
Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON, Canada.
The Canadian Association of Radiologists (CAR) Pediatric Expert Panel is made up of pediatric physicians from the disciplines of radiology, emergency medicine, endocrinology, gastroenterology, general surgery, neurology, neurosurgery, respirology, orthopaedic surgery, otolaryngology, urology, a patient advisor, and an epidemiologist/guideline methodologist. After developing a list of 50 clinical/diagnostic scenarios, a rapid scoping review was undertaken to identify systematically produced referral guidelines that provide recommendations for one or more of these clinical/diagnostic scenarios. Recommendations from 32 guidelines and contextualization criteria in the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) for guidelines framework were used to develop 133 recommendation statements across the 50 scenarios.
View Article and Find Full Text PDFPLoS One
December 2024
Division of Infectious Diseases, IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
This article examines the complicated terrain of immunization acceptance and access among Indigenous peoples in northern Ontario by drawing on conversations held prior to 2019 that explored knowledge about Haemophilus influenzae type a (Hia) infection specifically and attitudes toward vaccines more broadly. In the decade preceding COVID-19, Hia emerged as a leading cause of morbidity and mortality in Indigenous communities in northern Canada. Before developing new vaccines, it is imperative to hold conversations with the communities most affected and to learn more about Indigenous peoples' perceptions of and knowledge about vaccines, both generally and Hia specifically.
View Article and Find Full Text PDFJAMA Netw Open
December 2024
Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.
Child Abuse Negl
January 2025
Health Promotion and Chronic Disease Prevention Branch, Public Health Agency of Canada, 785 Carling Avenue, Ottawa, ON K1A 0K9, Canada; School of Arctic and Subarctic Studies, Labrador Campus, Memorial University, 171 Hamilton River Road, Happy Valley-Goose Bay, NL A0P 1E0, Canada. Electronic address:
Background: Fatalities are the most severe consequence of child maltreatment, but there are gaps in what is known about the epidemiology of such deaths in Canada.
Objectives: The objectives of this study were to: (1) identify child maltreatment deaths among those classified as homicide or undetermined manner; (2) estimate rates of child maltreatment mortality by sex, age, geography, and year; and (3) measure differences between rates of child maltreatment mortality and homicide mortality.
Methods: We used a cross-sectional design and analyzed mortality data from the Canadian Coroner and Medical Examiner Database for a ten-year period (2007 to 2016).
Arthritis Rheumatol
December 2024
BC Children's Hospital and BC Children's Hospital Research Institute, Vancouver, BC, Canada.
Objectives: We aimed to study the disease course, outcomes, and predictors of outcome in pediatric-onset anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) affecting the kidneys.
Methods: Patients eligible for this study had a diagnosis of granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), or ANCA positive pauci-immune glomerulonephritis, were ≤ 18 years at diagnosis, had renal disease defined by biopsy or dialysis dependence, and had clinical data at diagnosis and either 12- or 24-months. Ambispective data from the ARChiVE/PedVas Registry was used.
Strabismus
December 2024
Clinical Vision Science Program, Faculty of Health, Dalhousie University, Halifax, Canada.
: There remains a lack of compelling objective evidence on whether stereopsis is necessary for an ophthalmic surgical career. It is also unclear if high-grade stereoacuity correlates with better surgical performance. The present study attempts to address this question by comparing the simulated surgical performance of subjects with different levels of stereoacuity using a virtual reality (VR) intraocular surgical simulator (EYESi, VRmagic, Mannheim, Germany).
View Article and Find Full Text PDFCJC Pediatr Congenit Heart Dis
October 2024
Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Eur Respir J
November 2024
Department of Community Health, and Epidemiology, Faculty of Medicine, Dalhousie University, Halifax, Canada.
Children (Basel)
November 2024
School of Nursing, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Background/objectives: Despite strong evidence that breastfeeding, skin-to-skin care, and sucrose reduce pain in newborns during minor painful procedures, these interventions remain underutilized in practice. To address this knowledge-to-practice gap, we produced a five-minute parent-targeted video demonstrating the analgesic effects of these strategies and examined whether the use of newborn pain treatment increased in maternal-newborn care settings following the introduction of the video by nurses.
Methods: The design was a pre-post outcome evaluation.
CMAJ
November 2024
Canadian Center for Vaccinology (Abu-Raya, Langley), Dalhousie University, IWK Health Centre et Nova Scotia Health Authority; Départements de pédiatrie (Abu-Raya, Langley), de microbiologie et d'immunologie (Abu-Raya), et de santé communautaire et épidémiologie (Langley), Dalhousie University, Halifax, N.-É.; Département de pédiatrie (Lavoie), University of British Columbia, Vancouver, C.-B.
CMAJ
November 2024
Canadian Center for Vaccinology (Abu-Raya, Langley), Dalhousie University, IWK Health Centre et le Nova Scotia Health Authority; Départements de pédiatrie (Abu-Raya, Langley), de microbiologie et immunologie (Abu-Raya), et de santé communautaire et épidémiologie (Langley), Dalhousie University, Halifax, N.-É.; Département de pédiatrie (Lavoie), University of British Columbia, Vancouver, C.-B.
Spine Deform
November 2024
Division of Orthopedic Surgery, IWK Health Centre, 5850 University Avenue, P.O. Box 9700, Halifax, NS, B3K6R8, Canada.