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Adult advanced chronic lymphocytic leukemia: computational analysis of whole-body CT documents a bone structure alteration.
Radiology
June 2014
From the Departments of Nuclear Medicine Unit (F. Fiz, R.P., F.B., S.M., G.B., G.S.), Hematology (M. Miglino), Hematology and Bone Marrow Transplantation (A.B.), and Epidemiology (P.B.), IRCCS San Martino-IST, University of Genoa, L.go R. Benzi 10, 16132 Genoa, Italy; CNR Institute of Molecular Bioimaging and Physiology, Milan, Section of Genoa, Genoa, Italy (C.M.); Nuclear Medicine Unit, U. Parini Hospital, Aosta, Italy (M. Massollo); Department of Mathematics, University of Genoa, Genoa, Italy (C.C., M.P.); and Stem Cell Laboratory, IRCCS Pediatric Institute G. Gaslini, Genoa, Italy (F. Frassoni).
Purpose: To assess the presence of alteration of bone structure and bone marrow metabolism in adult patients who were suspected of having advanced chronic lymphocytic leukemia (ACLL) by using a computational prognostic model that was based on computational analysis of positron emission tomography (PET)/computed tomography (CT) images.
Materials And Methods: In this retrospective study, all patients signed written informed consent as a requisite to undergo PET/CT examination. However, due to its observational nature, approval from the ethical committee was not deemed necessary.