315 results match your criteria: "IRCCS Azienda Ospedaliera Universitaria San Martino - IST[Affiliation]"

Article Synopsis
  • * The study analyzed a large group of 105,163 individuals recently diagnosed with T2D to assess how prevalent rapid eGFR decline is and identified significant predictors like age, gender, and medical conditions.
  • * Findings revealed that 12.9% of subjects experienced a rapid decline in eGFR, emphasizing the need to consider eGFR changes as an important factor in defining chronic kidney disease (CK
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Methods to Study NLR in Human Blood Cells.

Methods Mol Biol

August 2023

UO Pediatria 2, Istituto G. Gaslini, Genova, Italy.

Article Synopsis
  • Autoinflammatory diseases are inherited and multifactorial disorders marked by excessive innate immune response, mainly due to the hyperactivity of the NLRP3 inflammasome and increased IL-1β secretion.
  • Researching these diseases is challenging due to their rarity, the young age of patients, and issues with modifying gene expression in primary immune cells.
  • Studying freshly drawn blood monocytes from patients with IL-1-mediated diseases helps ensure that findings are relevant to the disease's development and not affected by long-term cell culture or gene manipulation methods.
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Introduction: US National Cancer Institute's (NCI) Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) is a library of 78 symptom terms and 124 items enabling patient reporting of symptomatic adverse events in cancer trials. This multicenter study used mixed methods to develop an Italian language version of this widely accepted measure, and describe the content validity and reliability in a diverse sample of Italian-speaking patients.

Methods: All PRO-CTCAE items were translated in accordance with international guidelines.

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Background: Cabazitaxel improves overall survival (OS) in metastatic castration-resistant prostate cancer (mCRPC) patients progressing after docetaxel. In this prospective study, we evaluated the prognostic role of CTC gene expression on cabazitaxel-treated patients and its association with plasma androgen receptor (AR) copy number (CN).

Methods: Patients receiving cabazitaxel 20 or 25 mg/sqm for mCRPC were enrolled.

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Background: Considering the growing genitourinary (GU) cancer population undergoing systemic treatment with immune checkpoint inhibitors (ICIs) in the context of the COVID-19 pandemic, we planned a clinical audit in 24 Italian institutions treating GU malignancies.

Objective: The primary objective was investigating the clinical impact of COVID-19 in GU cancer patients undergoing ICI-based therapy during the first outbreak of SARS-CoV-2 contagion in Italy.

Design Setting And Participants: The included centers were 24 Oncology Departments.

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Objectives: The aim of our study was to collect data about of the outcome of metastatic renal cell carcinoma patients who progressed after immune checkpoint inhibitors in order to enhance data about efficacy and safety of treatment beyond immune-oncology (IO).

Materials And Methods: A total of 162 eligible patients, progressing to IO, were enrolled from 16 Italian referral centers adhering to the Meet-Uro association. Baseline characteristics, outcome data and toxicities were retrospectively collected.

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Introduction: Mantle-cell lymphoma (MCL) with relapsed/refractory (R/R) disease after intensive chemotherapy have few effective treatment options. Ibrutinib showed a promising median progression-free survival (PFS) with manageable toxicity. The BCL2 inhibitor venetoclax showed encouraging results in R/R MCL patients and preclinical models suggest a potential synergistic effect of dual BTK and BCL2 inhibition.

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Major complications in extreme lateral interbody fusion access: multicentric study by Italian S.O.L.A.S. group.

Eur Spine J

January 2021

School of Medicine, Department of Basic Medical Sciences, Neuroscience and Sense Organs, Orthopaedic, Trauma and Spine Unit, University of Bari "Aldo Moro"-AOU Policlinico Consorziale, Bari, Italy.

Article Synopsis
  • The eXtreme Lateral Interbody Fusion (XLIF) approach has become more prominent in spinal surgery, and this study examines the occurrence of major complications linked to it.
  • Nine Italian surgeons were surveyed about their experiences with complications in XLIF procedures, which were classified as major if they required reoperation or resulted in long-term functional limitations for patients.
  • The findings revealed a low major complication rate of 0.7722%, with no significant correlation between the surgeons' experience and complication rates, indicating that XLIF is a safe procedure when conducted by skilled surgeons.
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Purpose: The retinal rod outer segment (OS) disk membranes, devoid of mitochondria, conducts oxidative phosphorylation (OxPhos). This study aimed at identifying which proteins expressed in the retinal rod OS disks determined the considerable adenosine-5'-triphosphate production and oxygen consumption observed in comparison with retinal mitochondria.

Procedures: Characterization was conducted by immunogold transmission electron microscopy on retinal sections.

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Cabozantinib in Renal Cell Carcinoma With Brain Metastases: Safety and Efficacy in a Real-World Population.

Clin Genitourin Cancer

August 2019

Medical Oncology Department, Genitourinary Cancer Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy. Electronic address:

Background: Cabozantinib showed efficacy and manageable toxicity in patients with metastatic renal cell carcinoma (mRCC). In this study we aimed to describe the safety and to collect evidence on the potential efficacy of cabozantinib in mRCC patients with brain metastases (BM) in a real-world experience.

Materials And Methods: We retrospectively collected data of patients treated with cabozantinib within the Italian Managed Access Program.

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Background: The Italian Liver Cancer (ITA.LI.CA) prognostic system for patients with hepatocellular carcinoma (HCC) has recently been proposed and validated.

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Primary mediastinal germ cell tumors.

Semin Oncol

April 2019

Division of Medical Oncology, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Italy; Cellular Therapy and Immunobiology Working Party, EBMT.

Backgroud: Germ cell tumors (GCTs) are a group of neoplasms usually arising in the gonads, and very rarely in sites outside the gonads, mainly in the retroperitoneum, the anterior mediastinum, and pineal gland or the coccyx (mainly in childhood). The prognosis of nonseminoma primary mediastinal GCTs (PMGCTs), is considered to be poorer compared to its retroperitoneal or gonadal counterparts and, according to the International Germ Cell Cancer Collaborative Group, it is considered by definition as a "poor risk" disease.

Material And Methods: Our review highlights the clinical features, prognostic factors, and therapeutic strategies in PMGCTs, as described in medical literature.

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Objectives: To investigate if a first-line treatment delay (TD) can negatively affect the outcomes of patients affected by metastatic renal cancer.

Patients And Methods: Patients with a diagnosis of metastatic renal cancer who were ineligible for active surveillance were included in the sample. A TD was defined as the time from the diagnosis of metastatic disease to the start of first-line therapy with tyrosine kinase inhibitors.

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The aim of this study was to investigate the relationship between endothelin-1, nitric oxide, insulin resistance, and blood pressure in young subjects with a high prevalence of excess weight and/or elevated blood pressure. In a cohort of 238 children (mean age = 11.1 years), height, weight, waist circumference, and blood pressure were assessed.

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Article Synopsis
  • The study explores the relationship between variability in clinical parameters (like HbA, blood pressure, cholesterol, and uric acid) and the quality of diabetes care as measured by a quality score (Q-score) ranging from 0 to 40.
  • Analyzing data from 273,888 patients, the findings indicate that lower Q-scores correlate with greater variability in clinical parameters, specifically noting that a Q-score below 15 shows larger fluctuations in key health metrics compared to scores above 25.
  • The research concludes that improving the quality of diabetes care could lead to more consistent management of these risk factors, ultimately aiming to enhance patient outcomes.
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Lenalidomide-RCHOP (R2-CHOP21) has been shown to be safe and effective in patients with untreated diffuse large B-cell lymphoma (DLBCL). The aim of this analysis is to report long-term outcome and toxicities in newly diagnosed DLBCL patients who received R2-CHOP21 in two independent phase 2 trials, conducted by Mayo Clinic (MC) and Fondazione Italiana Linfomi (FIL). All patients received R-CHOP21 plus lenalidomide.

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Purpose: We performed a pharmacovigilance study of 10 drugs used in patients with relapsing-remitting multiple sclerosis (RR-MS). Our aim was to provide an overview of the safety of these drugs by the evaluation of reported expected and unexpected adverse reactions.

Patients And Methods: We collected and analyzed adverse drug reactions from RR-MS patients belonging to four hospitals in three Italian regions, for a period of 24 months.

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Objective: The activity of cabozantinib in nonclear cell histologies has not been evaluated.

Materials And Methods: Data were collected across 24 Italian hospitals. Patients were aged 18 years and older with advanced nonclear cell renal cell carcinoma (RCC), with an Eastern Cooperative Oncology Group Performance Status 0 to 2, who had relapsed after previous systemic treatments for metastatic disease.

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Introduction: Early toxic death (≤60 days of diagnosis) in elderly multiple myeloma (MM) patients is attributable to active disease, age and co-morbidities. Rate of early toxic deaths is 10% with conventional chemotherapy mainly due to infection and renal failure. Novel agents have improved MM outcome at the expense of newer toxicity.

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Background: Treatment guidelines recommend a stepwise approach to primary biliary cholangitis: all patients begin treatment with ursodeoxycholic acid (UDCA) monotherapy and those with an inadequate biochemical response after 12 months are subsequently considered for second-line therapies. However, as a result, patients at the highest risk can wait the longest for effective treatment. We determined whether UDCA response can be accurately predicted using pretreatment clinical parameters.

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Triple negative breast cancer (TNBC) represents the 15-20% of all breast cancers (BC) and is characterized by a very aggressive behavior. Recent data suggest that TNBC is not a single disease, but it is rather an umbrella for different ontology-profiles such as basal like 1 and 2, mesenchymal, and the luminal androgen receptor (LAR). The LAR subtype is characterized by the expression of the Androgen Receptor (AR) and its downstream effects.

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